Details of the Target

General Information of Target

Target ID LDTP04284
Target Name Proteasome subunit beta type-3 (PSMB3)
Gene Name PSMB3
Gene ID 5691
Synonyms
Proteasome subunit beta type-3; Proteasome chain 13; Proteasome component C10-II; Proteasome theta chain
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDV
QTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPF
ICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAV
SGMGVIVHIIEKDKITTRTLKARMD
Target Bioclass
Enzyme
Family
Peptidase T1B family
Subcellular location
Cytoplasm
Function
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Uniprot ID
P49720
Ensemble ID
ENST00000619426.5
HGNC ID
HGNC:9540
ChEMBL ID
CHEMBL3308923

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.11  LDD0402  [1]
TH211
 Probe Info  		Y104(12.39)  LDD0257  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
OPA-S-S-alkyne
 Probe Info  		K77(2.88)  LDD3494  [5]
Probe 1
 Probe Info  		Y104(9.31)  LDD3495  [6]
BTD
 Probe Info  		C19(1.86)  LDD1700  [7]
DBIA
 Probe Info  		C19(4.08)  LDD0204  [8]
HHS-475
 Probe Info  		Y104(0.82)  LDD0264  [9]
HHS-465
 Probe Info  		Y104(6.70)  LDD2237  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [12]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [13]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [13]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [12]
IPM
 Probe Info  		N.A.  LDD0025  [14]
NAIA_4
 Probe Info  		N.A.  LDD2226  [15]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
NHS
 Probe Info  		N.A.  LDD0010  [16]
SF
 Probe Info  		K77(0.00); Y104(0.00)  LDD0028  [17]
STPyne
 Probe Info  		N.A.  LDD0009  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [18]
AOyne
 Probe Info  		11.70  LDD0443  [19]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
HHS-482
 Probe Info  		Y104(1.26)  LDD2239  [10]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C108
 Probe Info  		9.51  LDD1795  [20]
C178
 Probe Info  		29.45  LDD1857  [20]
C226
 Probe Info  		10.63  LDD1899  [20]
C252
 Probe Info  		9.00  LDD1925  [20]
C277
 Probe Info  		7.57  LDD1947  [20]
C282
 Probe Info  		16.45  LDD1952  [20]
C387
 Probe Info  		5.70  LDD2046  [20]
C431
 Probe Info  		28.64  LDD2086  [20]
FFF probe12
 Probe Info  		5.25  LDD0473  [21]
FFF probe13
 Probe Info  		20.00  LDD0475  [21]
FFF probe14
 Probe Info  		12.09  LDD0477  [21]
FFF probe15
 Probe Info  		6.60  LDD0478  [21]
FFF probe2
 Probe Info  		12.84  LDD0463  [21]
FFF probe3
 Probe Info  		9.42  LDD0465  [21]
FFF probe6
 Probe Info  		12.40  LDD0467  [21]
Diazir
 Probe Info  		N.A.  LDD0011  [16]
Photonaproxen
 Probe Info  		E106(0.00); Y104(0.00)  LDD0157  [22]
OEA-DA
 Probe Info  		20.00  LDD0046  [23]
STS-1
 Probe Info  		N.A.  LDD0068  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C19(0.36)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C19(0.43)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C19(0.54)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C19(0.80)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C19(0.85)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C19(1.18)  LDD2152  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C19(0.68)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C19(0.45)  LDD2131  [7]
 LDCM0237  AC12 HEK-293T C19(1.05)  LDD1510  [25]
 LDCM0259  AC14 HEK-293T C19(0.89)  LDD1512  [25]
 LDCM0270  AC15 HEK-293T C19(0.95)  LDD1513  [25]
 LDCM0280  AC20 HEK-293T C19(0.95)  LDD1519  [25]
 LDCM0282  AC22 HEK-293T C19(1.04)  LDD1521  [25]
 LDCM0283  AC23 HEK-293T C19(0.99)  LDD1522  [25]
 LDCM0284  AC24 HEK-293T C19(1.06)  LDD1523  [25]
 LDCM0285  AC25 HCT 116 C19(1.05)  LDD0602  [26]
 LDCM0286  AC26 HCT 116 C19(1.13)  LDD0603  [26]
 LDCM0287  AC27 HCT 116 C19(1.02)  LDD0604  [26]
 LDCM0288  AC28 HCT 116 C19(1.01)  LDD0605  [26]
 LDCM0289  AC29 HCT 116 C19(1.27)  LDD0606  [26]
 LDCM0291  AC30 HCT 116 C19(1.23)  LDD0608  [26]
 LDCM0292  AC31 HCT 116 C19(1.20)  LDD0609  [26]
 LDCM0293  AC32 HCT 116 C19(1.29)  LDD0610  [26]
 LDCM0294  AC33 HCT 116 C19(1.06)  LDD0611  [26]
 LDCM0295  AC34 HCT 116 C19(1.07)  LDD0612  [26]
 LDCM0296  AC35 HCT 116 C19(0.93)  LDD0613  [26]
 LDCM0297  AC36 HCT 116 C19(0.89)  LDD0614  [26]
 LDCM0298  AC37 HCT 116 C19(0.91)  LDD0615  [26]
 LDCM0299  AC38 HCT 116 C19(1.02)  LDD0616  [26]
 LDCM0300  AC39 HCT 116 C19(0.97)  LDD0617  [26]
 LDCM0301  AC4 HEK-293T C19(1.24)  LDD1540  [25]
 LDCM0302  AC40 HCT 116 C19(1.01)  LDD0619  [26]
 LDCM0303  AC41 HCT 116 C19(1.01)  LDD0620  [26]
 LDCM0304  AC42 HCT 116 C19(1.03)  LDD0621  [26]
 LDCM0305  AC43 HCT 116 C19(1.38)  LDD0622  [26]
 LDCM0306  AC44 HCT 116 C19(1.06)  LDD0623  [26]
 LDCM0307  AC45 HCT 116 C19(0.92)  LDD0624  [26]
 LDCM0308  AC46 HCT 116 C19(0.83)  LDD0625  [26]
 LDCM0309  AC47 HCT 116 C19(0.91)  LDD0626  [26]
 LDCM0310  AC48 HCT 116 C19(1.20)  LDD0627  [26]
 LDCM0311  AC49 HCT 116 C19(0.93)  LDD0628  [26]
 LDCM0313  AC50 HCT 116 C19(1.05)  LDD0630  [26]
 LDCM0314  AC51 HCT 116 C19(0.99)  LDD0631  [26]
 LDCM0315  AC52 HCT 116 C19(0.94)  LDD0632  [26]
 LDCM0316  AC53 HCT 116 C19(1.06)  LDD0633  [26]
 LDCM0317  AC54 HCT 116 C19(0.98)  LDD0634  [26]
 LDCM0318  AC55 HCT 116 C19(0.79)  LDD0635  [26]
 LDCM0319  AC56 HCT 116 C19(0.99)  LDD0636  [26]
 LDCM0323  AC6 HEK-293T C19(1.07)  LDD1562  [25]
 LDCM0324  AC60 HEK-293T C19(1.07)  LDD1563  [25]
 LDCM0326  AC62 HEK-293T C19(1.20)  LDD1565  [25]
 LDCM0327  AC63 HEK-293T C19(0.99)  LDD1566  [25]
 LDCM0328  AC64 HEK-293T C19(1.00)  LDD1567  [25]
 LDCM0334  AC7 HEK-293T C19(0.98)  LDD1568  [25]
 LDCM0345  AC8 HEK-293T C19(0.98)  LDD1569  [25]
 LDCM0545  Acetamide MDA-MB-231 C19(1.01)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C19(0.50)  LDD2113  [7]
 LDCM0275  AKOS034007705 HEK-293T C19(1.11)  LDD1514  [25]
 LDCM0020  ARS-1620 HCC44 C19(1.23)  LDD2171  [26]
 LDCM0103  BDHI 10 Jurkat C19(4.03)  LDD0205  [8]
 LDCM0102  BDHI 8 Jurkat C19(4.08)  LDD0204  [8]
 LDCM0498  BS-3668 MDA-MB-231 C19(0.50)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [18]
 LDCM0367  CL1 HEK-293T C19(0.96)  LDD1571  [25]
 LDCM0368  CL10 HEK-293T C19(0.56)  LDD1572  [25]
 LDCM0370  CL101 HEK-293T C19(1.06)  LDD1574  [25]
 LDCM0374  CL105 HEK-293T C19(1.13)  LDD1578  [25]
 LDCM0378  CL109 HEK-293T C19(1.09)  LDD1582  [25]
 LDCM0379  CL11 HEK-293T C19(0.57)  LDD1583  [25]
 LDCM0382  CL112 HCT 116 C19(1.10)  LDD0699  [26]
 LDCM0383  CL113 HCT 116 C19(1.17)  LDD0700  [26]
 LDCM0384  CL114 HCT 116 C19(1.30)  LDD0701  [26]
 LDCM0385  CL115 HCT 116 C19(1.03)  LDD0702  [26]
 LDCM0386  CL116 HCT 116 C19(1.04)  LDD0703  [26]
 LDCM0387  CL117 HCT 116 C19(1.04)  LDD0704  [26]
 LDCM0388  CL118 HCT 116 C19(1.14)  LDD0705  [26]
 LDCM0389  CL119 HCT 116 C19(1.30)  LDD0706  [26]
 LDCM0390  CL12 HEK-293T C19(1.03)  LDD1594  [25]
 LDCM0391  CL120 HCT 116 C19(1.25)  LDD0708  [26]
 LDCM0392  CL121 HCT 116 C19(0.92)  LDD0709  [26]
 LDCM0393  CL122 HCT 116 C19(0.77)  LDD0710  [26]
 LDCM0394  CL123 HCT 116 C19(0.73)  LDD0711  [26]
 LDCM0395  CL124 HCT 116 C19(0.82)  LDD0712  [26]
 LDCM0396  CL125 HEK-293T C19(0.96)  LDD1600  [25]
 LDCM0400  CL13 HEK-293T C19(0.88)  LDD1604  [25]
 LDCM0408  CL20 HEK-293T C19(0.84)  LDD1612  [25]
 LDCM0410  CL22 HEK-293T C19(0.67)  LDD1614  [25]
 LDCM0411  CL23 HEK-293T C19(0.71)  LDD1615  [25]
 LDCM0412  CL24 HEK-293T C19(1.18)  LDD1616  [25]
 LDCM0413  CL25 HEK-293T C19(1.08)  LDD1617  [25]
 LDCM0421  CL32 HEK-293T C19(0.96)  LDD1625  [25]
 LDCM0423  CL34 HEK-293T C19(0.78)  LDD1627  [25]
 LDCM0424  CL35 HEK-293T C19(0.64)  LDD1628  [25]
 LDCM0425  CL36 HEK-293T C19(1.21)  LDD1629  [25]
 LDCM0426  CL37 HEK-293T C19(0.98)  LDD1630  [25]
 LDCM0434  CL44 HEK-293T C19(0.96)  LDD1638  [25]
 LDCM0436  CL46 HCT 116 C19(0.52)  LDD0753  [26]
 LDCM0437  CL47 HCT 116 C19(0.71)  LDD0754  [26]
 LDCM0438  CL48 HCT 116 C19(0.64)  LDD0755  [26]
 LDCM0439  CL49 HCT 116 C19(0.62)  LDD0756  [26]
 LDCM0441  CL50 HCT 116 C19(0.56)  LDD0758  [26]
 LDCM0442  CL51 HCT 116 C19(0.58)  LDD0759  [26]
 LDCM0443  CL52 HCT 116 C19(0.61)  LDD0760  [26]
 LDCM0444  CL53 HCT 116 C19(0.95)  LDD0761  [26]
 LDCM0445  CL54 HCT 116 C19(0.49)  LDD0762  [26]
 LDCM0446  CL55 HCT 116 C19(0.57)  LDD0763  [26]
 LDCM0447  CL56 HCT 116 C19(0.76)  LDD0764  [26]
 LDCM0448  CL57 HCT 116 C19(0.76)  LDD0765  [26]
 LDCM0449  CL58 HCT 116 C19(0.61)  LDD0766  [26]
 LDCM0450  CL59 HCT 116 C19(0.74)  LDD0767  [26]
 LDCM0452  CL60 HCT 116 C19(0.39)  LDD0769  [26]
 LDCM0453  CL61 HEK-293T C19(0.96)  LDD1656  [25]
 LDCM0460  CL68 HEK-293T C19(1.03)  LDD1663  [25]
 LDCM0463  CL70 HEK-293T C19(0.73)  LDD1666  [25]
 LDCM0464  CL71 HEK-293T C19(0.73)  LDD1667  [25]
 LDCM0465  CL72 HEK-293T C19(1.14)  LDD1668  [25]
 LDCM0466  CL73 HEK-293T C19(0.91)  LDD1669  [25]
 LDCM0473  CL8 HEK-293T C19(0.97)  LDD1676  [25]
 LDCM0474  CL80 HEK-293T C19(1.03)  LDD1677  [25]
 LDCM0476  CL82 HEK-293T C19(0.82)  LDD1679  [25]
 LDCM0477  CL83 HEK-293T C19(0.73)  LDD1680  [25]
 LDCM0478  CL84 HEK-293T C19(1.10)  LDD1681  [25]
 LDCM0479  CL85 HEK-293T C19(0.88)  LDD1682  [25]
 LDCM0487  CL92 HEK-293T C19(1.08)  LDD1690  [25]
 LDCM0489  CL94 HEK-293T C19(0.83)  LDD1692  [25]
 LDCM0490  CL95 HEK-293T C19(0.87)  LDD1693  [25]
 LDCM0491  CL96 HEK-293T C19(1.04)  LDD1694  [25]
 LDCM0492  CL97 HEK-293T C19(1.03)  LDD1695  [25]
 LDCM0625  F8 Ramos C19(0.98)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C19(0.49)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C19(0.64)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C19(0.45)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C19(1.16)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C19(0.83)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C19(0.41)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C19(0.71)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C19(1.49)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C19(0.91)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C19(1.20)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C19(1.33)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C19(0.88)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C19(0.52)  LDD2201  [27]
 LDCM0468  Fragment33 Ramos C19(0.72)  LDD2202  [27]
 LDCM0596  Fragment38 Ramos C19(1.53)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C19(0.64)  LDD2184  [27]
 LDCM0610  Fragment52 Ramos C19(0.90)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C19(1.11)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C19(0.58)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C19(0.28)  LDD2188  [27]
 LDCM0116  HHS-0101 DM93 Y104(0.82)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y104(0.78)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y104(0.88)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y104(1.14)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y104(1.45)  LDD0268  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [18]
 LDCM0022  KB02 Ramos C19(0.54)  LDD2182  [27]
 LDCM0023  KB03 Ramos C19(0.71)  LDD2183  [27]
 LDCM0024  KB05 COLO792 C19(2.00)  LDD3310  [28]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C19(1.40)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C19(0.59)  LDD2121  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [18]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C19(0.54)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C19(1.26)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C19(1.34)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C19(0.98)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C19(2.60)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C19(0.20)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C19(0.55)  LDD2097  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C19(0.98)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C19(0.47)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C19(0.71)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C19(0.34)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C19(2.37)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C19(0.30)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C19(1.04)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C19(0.26)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C19(0.44)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C19(0.60)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C19(0.99)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C19(0.77)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C19(0.38)  LDD2115  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C19(0.43)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C19(0.36)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C19(1.48)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C19(0.55)  LDD2120  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C19(0.82)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C19(0.76)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C19(0.25)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C19(0.88)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C19(0.53)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C19(0.95)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C19(0.51)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C19(0.48)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C19(1.41)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C19(1.05)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C19(0.74)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C19(1.86)  LDD1700  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C19(0.66)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C19(0.37)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C19(2.05)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C19(0.16)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C19(0.92)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C19(1.80)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C19(0.46)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C19(0.26)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C19(0.54)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C19(0.27)  LDD2151  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C19(2.61)  LDD2153  [7]
 LDCM0021  THZ1 HCT 116 C19(1.23)  LDD2173  [26]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit alpha type-7 (PSMA7) Peptidase T1A family O14818
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Proteasome subunit beta type-10 (PSMB10) Peptidase T1B family P40306
Proteasome subunit beta type-2 (PSMB2) Peptidase T1B family P49721
Proteasome subunit beta type-5 (PSMB5) Peptidase T1B family P28074
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 ubiquitin-protein ligase FANCL (FANCL) . Q9NW38
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome maturation protein (POMP) POMP/UMP1 family Q9Y244

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(3ar6r6as)-6-((S)-((S)-cyclohex-2-enyl)(Hydroxy)Methyl)-6a-methyl-4-oxo-hexahydro-2h-furo[32-c]Pyrrole-6-carbaldehyde . DB08515

References

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2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
23 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
24 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840