Details of the Probe

General Information of Probe

Probe ID
LDPC0011
Probe Name
Diazir
Synonyms
1450754-41-2; 2-(3-but-3-ynyl-3H-diazirin-3-yl)-ethanol; 3-(3-Butyn-1-yl)-3H-diazirine-3-ethanol; 2-(3-but-3-ynyldiazirin-3-yl)ethanol; MFCD29918290; 2-(3-(but-3-yn-1-yl)-3H-diazirin-3-yl)ethan-1-ol; 3H-Diazirine-3-ethanol, 3-(3-butyn-1-yl)-; 2-[3-(but-3-yn-1-yl)-3H-diazirin-3-yl]ethan-1-ol; 3-(3-Butynyl)-3H-diazirine-3-ethanol; SCHEMBL20680946; DTXSID801278943; AKOS026720521; DS-19296; SY106324; DB-121580; CS-0106038; 2-(3-But-3-ynyl-3H-diazirin-3-yl)ethanol; EN300-227135; N11436; A920636; 2-[3-(BUT-3-YN-1-YL)DIAZIRIN-3-YL]ETHANOL; 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol, >=95%; F2197-0240; Z1898593365
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 138.17
Lipid-water partition coefficient (xlogp) 0.8
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C7H10N2O
IUPAC Name
2-(3-but-3-ynyldiazirin-3-yl)ethanol
Canonical SMILES
C#CCCC1(N=N1)CCO
InChI
InChI=1S/C7H10N2O/c1-2-3-4-7(5-6-10)8-9-7/h1,10H,3-6H2
InChIKey
NMIZSJAOOMXKDJ-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

50 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
26S proteasome regulatory subunit 8 (PSMC5) LDTP04963 E381  LDD0011 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 E416; E492; C442; E107  LDD0011 
Actin, cytoplasmic 1 (ACTB) LDTP04876 C17; E253; E99; E107  LDD0011 
Actin, cytoplasmic 2 (ACTG1) LDTP05059 Y240; E99; E241; E364  LDD0011 
Actin, gamma-enteric smooth muscle (ACTG2) LDTP05060 E242; E254; E84; Y241  LDD0011 
Adenine phosphoribosyltransferase (APRT) LDTP02220 E10  LDD0011 
Arginine--tRNA ligase, cytoplasmic (RARS1) LDTP04601 E552; E553  LDD0011 
ATP-dependent RNA helicase A (DHX9) LDTP05550 E831  LDD0011 
Bifunctional glutamate/proline--tRNA ligase (EPRS1) LDTP02222 C856  LDD0011 
Creatine kinase B-type (CKB) LDTP02616 E94  LDD0011 
Cystathionine beta-synthase (CBS) LDTP03753 C15  LDD0011 
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) LDTP05724 E197  LDD0011 
Elongation factor 2 (EEF2) LDTP02672 E585  LDD0011 
Endoplasmic reticulum chaperone BiP (HSPA5) LDTP02534 E51  LDD0011 
Eukaryotic initiation factor 4A-I (EIF4A1) LDTP04878 Y70  LDD0011 
Exonuclease 1 (EXO1) LDTP13751 Y149  LDD0011 
Fatty acid synthase (FASN) LDTP04243 C2202; E1115  LDD0011 
Glucosidase 2 subunit beta (PRKCSH) LDTP02718 E212; E210  LDD0011 
Heat shock cognate 71 kDa protein (HSPA8) LDTP02541 E231; Y371; E27  LDD0011 
Heat shock protein HSP 90-alpha (HSP90AA1) LDTP02225 Y465; E353; E451; E199  LDD0011 
Histone-lysine N-methyltransferase NSD2 (NSD2) LDTP01759 E272  LDD0011 
Histone-lysine N-methyltransferase NSD3 (NSD3) LDTP11518 E318  LDD0011 
Inorganic pyrophosphatase (PPA1) LDTP14854 C274; E271  LDD0011 
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) LDTP02611 Y110  LDD0011 
L-lactate dehydrogenase A chain (LDHA) LDTP01766 E313; C163; E240; Y239  LDD0011 
L-lactate dehydrogenase B chain (LDHB) LDTP02179 C164; E14  LDD0011 
Mannose-6-phosphate isomerase (MPI) LDTP03697 C289  LDD0011 
Mitogen-activated protein kinase 1 (MAPK1) LDTP03445 Y64  LDD0011 
Myosin-9 (MYH9) LDTP03764 E772; E773; E1013; E1147  LDD0011 
NEDD8-conjugating enzyme Ubc12 (UBE2M) LDTP04898 Y172  LDD0011 
Nucleolar RNA helicase 2 (DDX21) LDTP12469 E553  LDD0011 
Peptidyl-prolyl cis-trans isomerase A (PPIA) LDTP05028 E140  LDD0011 
Peroxiredoxin-4 (PRDX4) LDTP05773 E193  LDD0011 
Phosphoglycerate kinase 1 (PGK1) LDTP01787 E404  LDD0011 
Poly [ADP-ribose] polymerase 1 (PARP1) LDTP02375 E491  LDD0011 
Probable ATP-dependent RNA helicase DDX17 (DDX17) LDTP09899 E538  LDD0011 
Proliferation-associated protein 2G4 (PA2G4) LDTP13750 E4  LDD0011 
Proteasome subunit beta type-3 (PSMB3) LDTP04284 E106  LDD0011 
Proteasome subunit beta type-5 (PSMB5) LDTP03419 E176  LDD0011 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 Y224  LDD0011 
Pyruvate kinase PKM (PKM) LDTP02733 Y175; E418  LDD0011 
Ribosomal protein S6 kinase alpha-1 (RPS6KA1) LDTP06384 C432  LDD0011 
Septin-7 (SEPTIN7) LDTP06513 C204  LDD0011 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 C97  LDD0011 
Thioredoxin (TXN) LDTP02502 E13  LDD0011 
Trifunctional purine biosynthetic protein adenosine-3 (GART) LDTP03156 E43; C41  LDD0011 
Triosephosphate isomerase (TPI1) LDTP04851 E184; E187  LDD0011 
Tubulin alpha-1B chain (TUBA1B) LDTP05074 E55; E77; Y357; E71  LDD0011 
Tubulin alpha-1C chain (TUBA1C) LDTP11074 E77; E71; Y357; E55  LDD0011 
X-ray repair cross-complementing protein 6 (XRCC6) LDTP02640 E491; E479; Y103  LDD0011 
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⏷ Show the Full List of 50 Enzyme
14 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14-3-3 protein epsilon (YWHAE) LDTP04969 Y131; C98; E212  LDD0011 
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) LDTP05510 E171; E159; E161  LDD0011 
Cystatin-B (CSTB) LDTP02009 C3  LDD0011 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 E324  LDD0011 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (RPN2) LDTP02058 E452  LDD0011 
Exportin-T (XPOT) LDTP00810 E326  LDD0011 
Heat shock protein HSP 90-beta (HSP90AB1) LDTP02262 E300; E549; E194  LDD0011 
Hypoxia up-regulated protein 1 (HYOU1) LDTP14066 E184  LDD0011 
Leucine-rich repeat-containing protein 59 (LRRC59) LDTP10081 E19  LDD0011 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 E365  LDD0011 
Nucleoporin Nup37 (NUP37) LDTP09203 E136; E139  LDD0011 
Protein SEC13 homolog (SEC13) LDTP04707 C187  LDD0011 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 E73  LDD0011 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 C210; E84; C47  LDD0011 
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⏷ Show the Full List of 14 Transporter and channel
1 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
PHD finger-like domain-containing protein 5A (PHF5A) LDTP08006 Y54  LDD0011 
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1 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Basigin (BSG) LDTP03772 E288  LDD0011 
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56 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14-3-3 protein beta/alpha (YWHAB) LDTP03617 Y130  LDD0011 
26S proteasome non-ATPase regulatory subunit 11 (PSMD11) LDTP00223 Y327  LDD0011 
Beta-actin-like protein 2 (ACTBL2) LDTP14951 E254; E242; Y241; E101  LDD0011 
Clustered mitochondria protein homolog (CLUH) LDTP14486 C1196  LDD0011 
Coatomer subunit beta' (COPB2) LDTP03767 Y824  LDD0011 
Elongation factor 1-gamma (EEF1G) LDTP03367 E262; E267; C266  LDD0011 
Endoplasmin (HSP90B1) LDTP02734 Y677; Y678  LDD0011 
Eukaryotic translation initiation factor 3 subunit I (EIF3I) LDTP05834 Y308  LDD0011 
Eukaryotic translation initiation factor 3 subunit M (EIF3M) LDTP07947 E11  LDD0011 
Far upstream element-binding protein 1 (FUBP1) LDTP10078 Y58  LDD0011 
Heat shock 70 kDa protein 1B (HSPA1B) LDTP02435 E27  LDD0011 
Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) LDTP10962 Y240  LDD0011 
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) LDTP02364 Y366  LDD0011 
Heterogeneous nuclear ribonucleoprotein L (HNRNPL) LDTP02750 C472  LDD0011 
Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2) LDTP17065 C308  LDD0011 
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) LDTP03182 Y347; E195  LDD0011 
Histone H1.2 (H1-2) LDTP02845 E3; E16  LDD0011 
Histone H1.4 (H1-4) LDTP02494 E16  LDD0011 
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) LDTP05004 Y89  LDD0011 
Histone-binding protein RBBP4 (RBBP4) LDTP05590 Y154  LDD0011 
Histone-binding protein RBBP7 (RBBP7) LDTP06562 Y153  LDD0011 
Immunoglobulin-binding protein 1 family member C (IGBP1C) LDTP18688 Y261  LDD0011 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 E82  LDD0011 
Large ribosomal subunit protein eL18 (RPL18) LDTP05509 C134  LDD0011 
Large ribosomal subunit protein eL6 (RPL6) LDTP05378 Y115  LDD0011 
Large ribosomal subunit protein P2 (RPLP2) LDTP02108 E52; E93  LDD0011 
Large ribosomal subunit protein uL15 (RPL27A) LDTP04105 C70  LDD0011 
Large ribosomal subunit protein uL2 (RPL8) LDTP05027 Y133  LDD0011 
Large ribosomal subunit protein uL3 (RPL3) LDTP03865 E108; Y307  LDD0011 
Large ribosomal subunit protein uL4 (RPL4) LDTP03815 E146  LDD0011 
Large ribosomal subunit protein uL5 (RPL11) LDTP05026 E41  LDD0011 
Microtubule-associated protein RP/EB family member 1 (MAPRE1) LDTP06444 E225; E232  LDD0011 
Myosin regulatory light chain 12B (MYL12B) LDTP00487 E138  LDD0011 
Nascent polypeptide-associated complex subunit alpha (NACA) LDTP05977 E129  LDD0011 
NHP2-like protein 1 (SNU13) LDTP04708 E124  LDD0011 
Nucleolar complex protein 2 homolog (NOC2L) LDTP14011 C585  LDD0011 
Nucleophosmin (NPM1) LDTP02164 E93; E37; E39  LDD0011 
Plastin-3 (PLS3) LDTP02692 C104  LDD0011 
POTE ankyrin domain family member J (POTEJ) LDTP16896 E1027; E1024; Y1025  LDD0011 
Profilin-1 (PFN1) LDTP02218 Y7  LDD0011 
Protein FAM98B (FAM98B) LDTP06879 C216; E217  LDD0011 
Prothymosin alpha (PTMA) LDTP02148 E11  LDD0011 
Putative heat shock protein HSP 90-beta 4 (HSP90AB4P) LDTP17159 E457; E169  LDD0011 
Putative RNA-binding protein Luc7-like 2 (LUC7L2) LDTP13956 E146  LDD0011 
Small ribosomal subunit protein eS10 (RPS10) LDTP04111 Y82  LDD0011 
Small ribosomal subunit protein eS21 (RPS21) LDTP05055 E64  LDD0011 
Small ribosomal subunit protein eS8 (RPS8) LDTP04964 E164; E134  LDD0011 
Small ribosomal subunit protein uS13 (RPS18) LDTP04972 E58  LDD0011 
T-complex protein 1 subunit alpha (TCP1) LDTP02934 E77  LDD0011 
T-complex protein 1 subunit theta (CCT8) LDTP04390 Y426  LDD0011 
Thyroid hormone receptor-associated protein 3 (THRAP3) LDTP13919 Y344  LDD0011 
Transcription elongation factor A protein 2 (TCEA2) LDTP06414 Y271  LDD0011 
Trichohyalin (TCHH) LDTP05516 E851  LDD0011 
Tropomyosin alpha-3 chain (TPM3) LDTP02165 E85; E97; E98  LDD0011 
Tubulin beta chain (TUBB) LDTP02205 Y51; E53; C12  LDD0011 
Vimentin (VIM) LDTP02297 Y61; E329; E354; E134  LDD0011 
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⏷ Show the Full List of 56 Other

Full Information of The Labelling Profiles of This Probe

Qualitation: Labeling site identification
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
100 uM
Quantitative Method
Isotope tag
In Vitro Experiment Model
Model Type
Cell lysate
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cell lysate (HEK-293T)
Interaction Atlas ID
 LDD0011 
Download The Altas

References

1 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764