Details of the Target

General Information of Target

Target ID LDTP02220
Target Name Adenine phosphoribosyltransferase (APRT)
Gene Name APRT
Gene ID 353
Synonyms
Adenine phosphoribosyltransferase; APRT; EC 2.4.2.7
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MADSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDY
IAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPG
QRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE
Target Bioclass
Enzyme
Family
Purine/pyrimidine phosphoribosyltransferase family
Subcellular location
Cytoplasm
Function Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Uniprot ID
P07741
Ensemble ID
ENST00000378364.8
HGNC ID
HGNC:626
ChEMBL ID
CHEMBL4105819

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU6 Deletion: p.F39WfsTer5 DBIA    Probe Info 
ETK1 SNV: p.M136T DBIA    Probe Info 
MOLT4 SNV: p.E111D IA-alkyne    Probe Info 
NCIH1155 SNV: p.R27K DBIA    Probe Info 
SKNSH SNV: p.H54N .
SNU245 SNV: p.S4F; p.Q7H DBIA    Probe Info 
SSP25 SNV: p.M136T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		7.42  LDD0215  [1]
CHEMBL5175495
 Probe Info  		6.02  LDD0196  [2]
TH211
 Probe Info  		Y60(6.63)  LDD0260  [3]
C-Sul
 Probe Info  		2.67  LDD0066  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K51(7.79)  LDD0277  [6]
AZ-9
 Probe Info  		D3(0.97)  LDD2208  [7]
THZ1-DTB
 Probe Info  		C83(1.07)  LDD0460  [8]
MCL-14
 Probe Info  		1.60  LDD0050  [9]
EA-probe
 Probe Info  		C140(0.77)  LDD2210  [10]
HHS-475
 Probe Info  		Y105(1.07)  LDD0264  [11]
HHS-465
 Probe Info  		Y101(10.00); Y105(10.00)  LDD2237  [12]
DBIA
 Probe Info  		C83(1.00)  LDD0593  [13]
ATP probe
 Probe Info  		K91(0.00); K114(0.00); K34(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C83(0.00); C153(0.00); C140(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C83(0.00); C153(0.00); C140(0.00)  LDD0036  [15]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [16]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C83(0.00); C153(0.00); C140(0.00)  LDD0037  [15]
ATP probe
 Probe Info  		K91(0.00); K34(0.00)  LDD0035  [17]
IPM
 Probe Info  		N.A.  LDD0025  [18]
JW-RF-010
 Probe Info  		C153(0.00); C140(0.00)  LDD0026  [18]
TFBX
 Probe Info  		N.A.  LDD0027  [18]
WYneN
 Probe Info  		N.A.  LDD0021  [19]
NHS
 Probe Info  		N.A.  LDD0010  [19]
SF
 Probe Info  		Y105(0.00); Y60(0.00)  LDD0028  [20]
NAIA_5
 Probe Info  		C83(0.00); C153(0.00); C140(0.00)  LDD2223  [21]
HHS-482
 Probe Info  		Y105(1.01)  LDD2239  [12]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C338
 Probe Info  		17.63  LDD2001  [22]
FFF probe12
 Probe Info  		19.45  LDD0473  [23]
FFF probe13
 Probe Info  		10.08  LDD0475  [23]
FFF probe3
 Probe Info  		5.71  LDD0464  [23]
Diazir
 Probe Info  		N.A.  LDD0011  [19]
DA-2
 Probe Info  		N.A.  LDD0070  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C83(0.46)  LDD1093  [13]
 LDCM0215  AC10 PaTu 8988t C140(0.49); C83(0.52)  LDD1094  [13]
 LDCM0216  AC100 PaTu 8988t C83(1.00)  LDD1095  [13]
 LDCM0217  AC101 PaTu 8988t C83(0.82)  LDD1096  [13]
 LDCM0218  AC102 PaTu 8988t C83(0.78)  LDD1097  [13]
 LDCM0219  AC103 PaTu 8988t C83(0.82)  LDD1098  [13]
 LDCM0220  AC104 PaTu 8988t C83(1.21)  LDD1099  [13]
 LDCM0221  AC105 PaTu 8988t C83(0.75)  LDD1100  [13]
 LDCM0222  AC106 PaTu 8988t C83(1.03)  LDD1101  [13]
 LDCM0223  AC107 PaTu 8988t C83(0.41)  LDD1102  [13]
 LDCM0224  AC108 PaTu 8988t C83(0.81)  LDD1103  [13]
 LDCM0225  AC109 PaTu 8988t C83(0.96)  LDD1104  [13]
 LDCM0226  AC11 PaTu 8988t C140(0.47); C83(0.63)  LDD1105  [13]
 LDCM0227  AC110 PaTu 8988t C83(0.83)  LDD1106  [13]
 LDCM0228  AC111 PaTu 8988t C83(0.82)  LDD1107  [13]
 LDCM0229  AC112 PaTu 8988t C83(0.83)  LDD1108  [13]
 LDCM0230  AC113 PaTu 8988t C83(1.46)  LDD1109  [13]
 LDCM0231  AC114 PaTu 8988t C83(0.85)  LDD1110  [13]
 LDCM0232  AC115 PaTu 8988t C83(1.22)  LDD1111  [13]
 LDCM0233  AC116 PaTu 8988t C83(1.36)  LDD1112  [13]
 LDCM0234  AC117 PaTu 8988t C83(1.37)  LDD1113  [13]
 LDCM0235  AC118 PaTu 8988t C83(0.89)  LDD1114  [13]
 LDCM0236  AC119 PaTu 8988t C83(1.06)  LDD1115  [13]
 LDCM0237  AC12 PaTu 8988t C140(0.40); C83(0.56)  LDD1116  [13]
 LDCM0238  AC120 PaTu 8988t C83(1.18)  LDD1117  [13]
 LDCM0239  AC121 PaTu 8988t C83(1.01)  LDD1118  [13]
 LDCM0240  AC122 PaTu 8988t C83(0.94)  LDD1119  [13]
 LDCM0241  AC123 PaTu 8988t C83(1.26)  LDD1120  [13]
 LDCM0242  AC124 PaTu 8988t C83(1.20)  LDD1121  [13]
 LDCM0243  AC125 PaTu 8988t C83(0.93)  LDD1122  [13]
 LDCM0244  AC126 PaTu 8988t C83(1.14)  LDD1123  [13]
 LDCM0245  AC127 PaTu 8988t C83(1.15)  LDD1124  [13]
 LDCM0259  AC14 PaTu 8988t C140(0.63); C83(0.87)  LDD1138  [13]
 LDCM0263  AC143 PaTu 8988t C83(0.61)  LDD1142  [13]
 LDCM0264  AC144 PaTu 8988t C83(0.70)  LDD1143  [13]
 LDCM0265  AC145 PaTu 8988t C83(0.65)  LDD1144  [13]
 LDCM0266  AC146 PaTu 8988t C83(0.81)  LDD1145  [13]
 LDCM0267  AC147 PaTu 8988t C83(1.10)  LDD1146  [13]
 LDCM0268  AC148 PaTu 8988t C83(0.86)  LDD1147  [13]
 LDCM0269  AC149 PaTu 8988t C83(0.86)  LDD1148  [13]
 LDCM0270  AC15 PaTu 8988t C140(0.45); C83(0.59)  LDD1149  [13]
 LDCM0271  AC150 PaTu 8988t C83(0.69)  LDD1150  [13]
 LDCM0272  AC151 PaTu 8988t C83(0.68)  LDD1151  [13]
 LDCM0273  AC152 PaTu 8988t C83(1.01)  LDD1152  [13]
 LDCM0274  AC153 PaTu 8988t C83(0.62)  LDD1153  [13]
 LDCM0621  AC154 PaTu 8988t C83(0.63)  LDD2166  [13]
 LDCM0622  AC155 PaTu 8988t C83(0.77)  LDD2167  [13]
 LDCM0623  AC156 PaTu 8988t C83(0.66)  LDD2168  [13]
 LDCM0624  AC157 PaTu 8988t C83(0.79)  LDD2169  [13]
 LDCM0276  AC17 HCT 116 C83(1.00)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C83(0.84)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C83(0.84)  LDD0595  [13]
 LDCM0279  AC2 PaTu 8988t C83(0.62)  LDD1158  [13]
 LDCM0280  AC20 HCT 116 C83(1.04)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C83(0.89)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C83(0.79)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C83(0.94)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C83(1.30)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C83(0.96); C140(1.29)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C83(0.87); C140(0.95)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C140(0.95); C83(1.01)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C83(1.00); C140(1.22)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C140(1.04); C83(1.13)  LDD0606  [13]
 LDCM0290  AC3 PaTu 8988t C83(0.76)  LDD1169  [13]
 LDCM0291  AC30 HCT 116 C83(1.09); C140(1.10)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C83(0.93); C140(1.11)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C83(0.67); C140(0.69)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C83(0.82); C140(0.94)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C83(0.78); C140(0.80)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C140(1.17)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C140(1.39)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C140(1.40)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C140(1.54)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C140(1.12)  LDD0617  [13]
 LDCM0301  AC4 PaTu 8988t C83(0.73)  LDD1180  [13]
 LDCM0302  AC40 HCT 116 C140(0.94)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C140(1.04)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C140(1.49)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C140(1.05)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C140(1.10)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C140(0.82)  LDD0624  [13]
 LDCM0308  AC46 PaTu 8988t C140(0.76); C83(0.73)  LDD1187  [13]
 LDCM0309  AC47 PaTu 8988t C140(0.88); C83(0.60)  LDD1188  [13]
 LDCM0310  AC48 PaTu 8988t C140(0.67); C83(0.61)  LDD1189  [13]
 LDCM0311  AC49 PaTu 8988t C140(0.66); C83(0.69)  LDD1190  [13]
 LDCM0312  AC5 PaTu 8988t C83(0.48)  LDD1191  [13]
 LDCM0313  AC50 PaTu 8988t C140(0.60); C83(0.59)  LDD1192  [13]
 LDCM0314  AC51 PaTu 8988t C140(0.24); C83(0.58)  LDD1193  [13]
 LDCM0315  AC52 PaTu 8988t C140(0.71); C83(0.57)  LDD1194  [13]
 LDCM0316  AC53 PaTu 8988t C140(0.59); C83(0.57)  LDD1195  [13]
 LDCM0317  AC54 PaTu 8988t C140(0.44); C83(0.50)  LDD1196  [13]
 LDCM0318  AC55 PaTu 8988t C140(0.54); C83(0.54)  LDD1197  [13]
 LDCM0319  AC56 PaTu 8988t C140(0.35); C83(0.43)  LDD1198  [13]
 LDCM0320  AC57 HCT 116 C83(0.58)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C83(0.58)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C83(0.56)  LDD0639  [13]
 LDCM0323  AC6 PaTu 8988t C140(0.35); C83(0.61)  LDD1202  [13]
 LDCM0324  AC60 HCT 116 C83(0.51)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C83(0.51)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C83(0.52)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C83(0.54)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C83(0.54)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C83(0.92)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C83(0.86)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C83(0.37)  LDD0648  [13]
 LDCM0332  AC68 PaTu 8988t C83(1.38)  LDD1211  [13]
 LDCM0333  AC69 PaTu 8988t C83(0.94)  LDD1212  [13]
 LDCM0334  AC7 PaTu 8988t C140(0.49); C83(0.87)  LDD1213  [13]
 LDCM0335  AC70 PaTu 8988t C83(0.95)  LDD1214  [13]
 LDCM0336  AC71 PaTu 8988t C83(1.35)  LDD1215  [13]
 LDCM0337  AC72 PaTu 8988t C83(1.31)  LDD1216  [13]
 LDCM0338  AC73 PaTu 8988t C83(1.26)  LDD1217  [13]
 LDCM0339  AC74 PaTu 8988t C83(1.19)  LDD1218  [13]
 LDCM0340  AC75 PaTu 8988t C83(1.03)  LDD1219  [13]
 LDCM0341  AC76 PaTu 8988t C83(1.12)  LDD1220  [13]
 LDCM0342  AC77 PaTu 8988t C83(1.12)  LDD1221  [13]
 LDCM0343  AC78 PaTu 8988t C83(1.40)  LDD1222  [13]
 LDCM0344  AC79 PaTu 8988t C83(0.97)  LDD1223  [13]
 LDCM0345  AC8 PaTu 8988t C140(0.74); C83(0.77)  LDD1224  [13]
 LDCM0346  AC80 PaTu 8988t C83(1.31)  LDD1225  [13]
 LDCM0347  AC81 PaTu 8988t C83(1.22)  LDD1226  [13]
 LDCM0348  AC82 PaTu 8988t C83(1.24)  LDD1227  [13]
 LDCM0365  AC98 PaTu 8988t C83(0.92)  LDD1244  [13]
 LDCM0366  AC99 PaTu 8988t C83(1.01)  LDD1245  [13]
 LDCM0248  AKOS034007472 PaTu 8988t C140(0.53); C83(0.49)  LDD1127  [13]
 LDCM0356  AKOS034007680 PaTu 8988t C140(0.42); C83(0.59)  LDD1235  [13]
 LDCM0275  AKOS034007705 PaTu 8988t C140(0.49); C83(0.58)  LDD1154  [13]
 LDCM0630  CCW28-3 231MFP C83(1.50)  LDD2214  [25]
 LDCM0367  CL1 HCT 116 C83(0.84); C140(20.00)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C140(0.31); C83(0.49)  LDD0685  [13]
 LDCM0369  CL100 PaTu 8988t C83(0.78)  LDD1248  [13]
 LDCM0370  CL101 PaTu 8988t C140(0.55); C83(0.70)  LDD1249  [13]
 LDCM0371  CL102 PaTu 8988t C140(0.52); C83(0.75)  LDD1250  [13]
 LDCM0372  CL103 PaTu 8988t C140(0.44); C83(0.43)  LDD1251  [13]
 LDCM0373  CL104 PaTu 8988t C140(0.56); C83(0.64)  LDD1252  [13]
 LDCM0374  CL105 HCT 116 C83(0.77)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C83(0.36)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C83(0.66)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C83(0.63)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C83(0.76)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C140(0.29); C83(0.57)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C83(0.63)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C83(0.70)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C83(1.09); C140(1.27)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C140(0.79); C83(0.84)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C140(0.81); C83(1.02)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C140(0.96); C83(1.08)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C83(0.94); C140(1.38)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C140(0.56)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C140(1.43)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C140(1.26)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C140(0.39); C83(0.53)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C140(1.18)  LDD0708  [13]
 LDCM0392  CL121 PaTu 8988t C140(0.95); C83(0.79)  LDD1271  [13]
 LDCM0393  CL122 PaTu 8988t C140(0.73); C83(0.43)  LDD1272  [13]
 LDCM0394  CL123 PaTu 8988t C140(0.55); C83(0.52)  LDD1273  [13]
 LDCM0395  CL124 PaTu 8988t C140(0.61); C83(0.86)  LDD1274  [13]
 LDCM0396  CL125 HCT 116 C83(1.04)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C83(0.99)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C83(0.89)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C83(0.63)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C140(0.47); C83(0.47)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C140(0.51); C83(0.65)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C140(0.22); C83(0.47)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C83(0.86)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C83(0.73)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C83(0.45)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C83(0.60)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C83(0.68); C140(0.78)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C83(0.75)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C83(0.52)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C83(0.33)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C83(0.68)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C83(0.55)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C83(0.63)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C83(0.77)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C83(0.77)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C83(0.78)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C83(0.70)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C140(0.50); C83(0.81)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C83(0.69)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C83(1.01)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C83(1.67)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C83(1.08)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C83(0.96)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C83(1.24)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C83(1.34)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C83(1.07)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C83(1.06)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C140(0.50); C83(0.76)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C83(1.40)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C83(1.10)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C83(0.75)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C83(1.11)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C83(1.29)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C83(0.98)  LDD0752  [13]
 LDCM0436  CL46 HEK-293T C140(0.97); C153(1.00); C83(1.08)  LDD1640  [26]
 LDCM0437  CL47 HEK-293T C140(0.96); C153(1.06); C83(0.93)  LDD1641  [26]
 LDCM0438  CL48 HEK-293T C140(0.96); C153(1.09); C83(1.23)  LDD1642  [26]
 LDCM0439  CL49 HEK-293T C140(1.05); C153(1.00); C83(1.17)  LDD1643  [26]
 LDCM0440  CL5 HCT 116 C140(0.98); C83(0.93)  LDD0757  [13]
 LDCM0441  CL50 HEK-293T C140(0.99); C153(0.93); C83(1.16)  LDD1645  [26]
 LDCM0443  CL52 HEK-293T C140(1.00); C153(1.00); C83(1.09)  LDD1646  [26]
 LDCM0444  CL53 HEK-293T C140(1.00); C153(0.94); C83(1.39)  LDD1647  [26]
 LDCM0445  CL54 HEK-293T C140(0.88); C153(0.98); C83(1.00)  LDD1648  [26]
 LDCM0446  CL55 HEK-293T C140(1.05); C153(1.03); C83(1.10)  LDD1649  [26]
 LDCM0447  CL56 HEK-293T C140(1.08); C153(0.97); C83(1.07)  LDD1650  [26]
 LDCM0448  CL57 HEK-293T C140(0.92); C153(0.99); C83(0.98)  LDD1651  [26]
 LDCM0449  CL58 HEK-293T C140(0.98); C153(0.93); C83(1.08)  LDD1652  [26]
 LDCM0450  CL59 HEK-293T C140(1.01); C153(1.04); C83(1.01)  LDD1653  [26]
 LDCM0451  CL6 HCT 116 C140(0.41); C83(0.59)  LDD0768  [13]
 LDCM0452  CL60 HEK-293T C140(1.06); C153(1.11); C83(1.17)  LDD1655  [26]
 LDCM0453  CL61 PaTu 8988t C140(0.57); C83(0.77)  LDD1332  [13]
 LDCM0454  CL62 PaTu 8988t C140(1.17); C83(0.91)  LDD1333  [13]
 LDCM0455  CL63 PaTu 8988t C140(1.35); C83(1.11)  LDD1334  [13]
 LDCM0456  CL64 PaTu 8988t C140(1.25); C83(0.80)  LDD1335  [13]
 LDCM0457  CL65 PaTu 8988t C140(1.15); C83(1.10)  LDD1336  [13]
 LDCM0458  CL66 PaTu 8988t C140(1.43); C83(0.71)  LDD1337  [13]
 LDCM0459  CL67 PaTu 8988t C140(0.79); C83(1.49)  LDD1338  [13]
 LDCM0460  CL68 PaTu 8988t C140(0.49); C83(0.86)  LDD1339  [13]
 LDCM0461  CL69 PaTu 8988t C140(0.47); C83(1.06)  LDD1340  [13]
 LDCM0462  CL7 HCT 116 C140(0.33); C83(0.62)  LDD0779  [13]
 LDCM0463  CL70 PaTu 8988t C140(0.58); C83(0.98)  LDD1342  [13]
 LDCM0464  CL71 PaTu 8988t C140(1.48); C83(0.91)  LDD1343  [13]
 LDCM0465  CL72 PaTu 8988t C140(0.91); C83(0.79)  LDD1344  [13]
 LDCM0466  CL73 PaTu 8988t C140(0.63); C83(0.74)  LDD1345  [13]
 LDCM0467  CL74 PaTu 8988t C140(0.46); C83(1.08)  LDD1346  [13]
 LDCM0469  CL76 HCT 116 C140(0.62)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C140(0.80)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C140(0.75)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C140(0.72)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C140(0.32); C83(0.50)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C140(0.46)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C140(0.71)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C140(0.46)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C140(0.43)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C140(0.33)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C140(0.66)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C140(1.38)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C140(0.82)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C140(0.53)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C140(0.23)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C140(0.49); C83(0.74)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C140(0.74)  LDD0802  [13]
 LDCM0486  CL91 PaTu 8988t C83(0.77)  LDD1365  [13]
 LDCM0487  CL92 PaTu 8988t C83(0.58)  LDD1366  [13]
 LDCM0488  CL93 PaTu 8988t C83(0.57)  LDD1367  [13]
 LDCM0489  CL94 PaTu 8988t C83(0.50)  LDD1368  [13]
 LDCM0490  CL95 PaTu 8988t C83(0.46)  LDD1369  [13]
 LDCM0491  CL96 PaTu 8988t C83(0.52)  LDD1370  [13]
 LDCM0492  CL97 PaTu 8988t C83(0.63)  LDD1371  [13]
 LDCM0493  CL98 PaTu 8988t C83(0.36)  LDD1372  [13]
 LDCM0494  CL99 PaTu 8988t C83(0.55)  LDD1373  [13]
 LDCM0495  E2913 HEK-293T C140(1.00); C153(1.01); C83(1.05)  LDD1698  [26]
 LDCM0175  Ethacrynic acid HeLa C140(0.77)  LDD2210  [10]
 LDCM0625  F8 Ramos C83(0.46); C140(0.48)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C140(0.82)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C83(2.49)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C140(0.80)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C140(0.42)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C83(0.82); C140(1.09)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C140(0.53)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C140(0.27)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C140(0.61)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C140(0.80)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C83(1.13); C140(0.38)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C140(0.29)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C140(0.64)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C140(0.62)  LDD2201  [27]
 LDCM0468  Fragment33 PaTu 8988t C140(0.78); C83(0.84)  LDD1347  [13]
 LDCM0596  Fragment38 Ramos C140(0.40)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C83(0.67); C140(0.94)  LDD2184  [27]
 LDCM0427  Fragment51 HCT 116 C83(0.87)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C140(0.17)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C140(0.44)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C83(0.48); C140(0.37)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C140(0.53)  LDD2188  [27]
 LDCM0116  HHS-0101 DM93 Y105(1.07)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y105(0.87)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y105(0.91)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y105(0.88)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y105(1.00)  LDD0268  [11]
 LDCM0022  KB02 HEK-293T C140(1.03); C153(1.06); C83(1.04)  LDD1492  [26]
 LDCM0023  KB03 HEK-293T C140(1.04); C153(1.08); C83(1.06)  LDD1497  [26]
 LDCM0024  KB05 COLO792 C83(0.65); C140(0.62)  LDD3310  [28]
 LDCM0006  Micheliolide M9-ENL1 1.60  LDD0050  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C140(0.17)  LDD2206  [29]
 LDCM0628  OTUB2-COV-1 HEK-293T C140(0.40)  LDD2207  [29]
 LDCM0131  RA190 MM1.R C140(1.28)  LDD0304  [30]
 LDCM0021  THZ1 HeLa S3 C83(1.07)  LDD0460  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) TTC19 family Q6DKK2
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
5-o-phosphono-alpha-d-ribofuranosyl Diphosphate Small molecular drug DB01632
Adenine Small molecular drug DB00173
Adenosine Phosphate Small molecular drug DB00131
Citric Acid Small molecular drug DB04272
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
5h-pyrrolo[32-d]Pyrimidin-4-amine . DB03506

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
10 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
25 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
29 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
30 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.