General Information of Experiment

Probe Name MCL-14  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Micheliolide  Competitor Info 
Competitor Concentration 10 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (M9-ENL1)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01707  Thioredoxin domain-containing protein 12 (TXNDC12) 7.0
 LDTP08024  Probable helicase senataxin (SETX) 3.7
 LDTP01769  Dihydrofolate reductase (DHFR) 3.0
 LDTP00890  S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) 2.0
 LDTP10346  Aurora kinase B (AURKB) 1.7
 LDTP02220  Adenine phosphoribosyltransferase (APRT) 1.6
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 1.5
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06152  Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2) 4.0
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10891  DnaJ homolog subfamily C member 2 (DNAJC2) 2.8
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02805  Immunoglobulin lambda-like polypeptide 1 (IGLL1) 1.5
Other
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06063  ARF GTPase-activating protein GIT2 (GIT2) 5.8
 LDTP12025  UPF0488 protein C8orf33 (C8orf33) 5.2
 LDTP04995  CCHC-type zinc finger nucleic acid binding protein (CNBP) 3.2
 LDTP04290  YLP motif-containing protein 1 (YLPM1) 1.9
 LDTP13167  Peflin (PEF1) 1.7
 LDTP11408  Nucleolar and spindle-associated protein 1 (NUSAP1) 1.6
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) 1.5

References

1 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455