Details of the Target

General Information of Target

Target ID LDTP13167
Target Name Peflin (PEF1)
Gene Name PEF1
Gene ID 553115
Synonyms
ABP32; Peflin; PEF protein with a long N-terminal hydrophobic domain; Penta-EF hand domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFPSRRKAAQLPWEDGRSGLLSGGLPRKCSVFHLFVACLSLGFFSLLWLQLSCSGDVARA
VRGQGQETSGPPRACPPEPPPEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLS
RKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLNEELDYGFPEA
GPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGREDDEFYRRIKGAGL
QLFRPSGITTGYKTFRHLHDPAWRKRDQKRIAAQKQEQFKVDREGGLNTVKYHVASRTAL
SVGGAPCTVLNIMLDCDKTATPWCTFS
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats. In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification. Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium. Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6. Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31.
Uniprot ID
Q9UBV8
Ensemble ID
ENST00000373703.5
HGNC ID
HGNC:30009
ChEMBL ID
CHEMBL4105771

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.84  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
ONAyne
 Probe Info  		K260(4.17)  LDD0274  [3]
DBIA
 Probe Info  		C247(1.10)  LDD3325  [4]
MCL-14
 Probe Info  		1.70  LDD0050  [5]
MCL-4
 Probe Info  		1.50  LDD0049  [5]
AHL-Pu-1
 Probe Info  		C156(2.24); C146(2.23)  LDD0171  [6]
EA-probe
 Probe Info  		N.A.  LDD0440  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
IPM
 Probe Info  		C247(0.00); C146(0.00)  LDD2156  [9]
NHS
 Probe Info  		N.A.  LDD0010  [10]
SF
 Probe Info  		N.A.  LDD0028  [11]
STPyne
 Probe Info  		N.A.  LDD0009  [10]
AOyne
 Probe Info  		15.00  LDD0443  [12]
NAIA_5
 Probe Info  		C247(0.00); C230(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C233
 Probe Info  		10.13  LDD1906  [14]
C429
 Probe Info  		12.04  LDD2084  [14]
FFF probe13
 Probe Info  		5.55  LDD0475  [15]
FFF probe2
 Probe Info  		7.10  LDD0463  [15]
FFF probe3
 Probe Info  		13.10  LDD0480  [15]
JN0003
 Probe Info  		5.90  LDD0469  [15]
VE-P
 Probe Info  		N.A.  LDD0396  [16]
OEA-DA
 Probe Info  		12.67  LDD0046  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C156(2.24); C146(2.23)  LDD0171  [6]
 LDCM0214  AC1 HEK-293T C146(0.81)  LDD0812  [18]
 LDCM0215  AC10 PaTu 8988t C146(0.84); C156(0.84)  LDD1094  [18]
 LDCM0226  AC11 PaTu 8988t C146(0.66); C156(0.66)  LDD1105  [18]
 LDCM0230  AC113 HEK-293T C156(1.08)  LDD0828  [18]
 LDCM0231  AC114 HEK-293T C156(0.75)  LDD0829  [18]
 LDCM0232  AC115 HEK-293T C156(0.94)  LDD0830  [18]
 LDCM0233  AC116 HEK-293T C156(1.01)  LDD0831  [18]
 LDCM0234  AC117 HEK-293T C156(0.93)  LDD0832  [18]
 LDCM0235  AC118 HEK-293T C156(0.98)  LDD0833  [18]
 LDCM0236  AC119 HEK-293T C156(1.07)  LDD0834  [18]
 LDCM0237  AC12 PaTu 8988t C146(1.04); C156(1.04)  LDD1116  [18]
 LDCM0238  AC120 HEK-293T C156(0.82)  LDD0836  [18]
 LDCM0239  AC121 HEK-293T C156(0.96)  LDD0837  [18]
 LDCM0240  AC122 HEK-293T C156(0.95)  LDD0838  [18]
 LDCM0241  AC123 HEK-293T C156(0.90)  LDD0839  [18]
 LDCM0242  AC124 HEK-293T C156(0.99)  LDD0840  [18]
 LDCM0243  AC125 HEK-293T C156(1.02)  LDD0841  [18]
 LDCM0244  AC126 HEK-293T C156(0.77)  LDD0842  [18]
 LDCM0245  AC127 HEK-293T C156(0.91)  LDD0843  [18]
 LDCM0259  AC14 PaTu 8988t C146(1.05); C156(1.05)  LDD1138  [18]
 LDCM0263  AC143 HEK-293T C146(0.84); C156(0.53)  LDD0861  [18]
 LDCM0264  AC144 HEK-293T C146(0.79); C156(0.74)  LDD0862  [18]
 LDCM0265  AC145 HEK-293T C146(0.60); C156(1.00)  LDD0863  [18]
 LDCM0266  AC146 HEK-293T C146(0.74); C156(0.84)  LDD0864  [18]
 LDCM0267  AC147 HEK-293T C146(0.65); C156(0.64)  LDD0865  [18]
 LDCM0268  AC148 HEK-293T C146(0.99); C156(0.65)  LDD0866  [18]
 LDCM0269  AC149 HEK-293T C146(0.86); C156(0.81)  LDD0867  [18]
 LDCM0270  AC15 PaTu 8988t C146(0.73); C156(0.73)  LDD1149  [18]
 LDCM0271  AC150 HEK-293T C146(0.69); C156(0.97)  LDD0869  [18]
 LDCM0272  AC151 HEK-293T C146(0.72); C156(0.56)  LDD0870  [18]
 LDCM0273  AC152 HEK-293T C146(0.78); C156(0.48)  LDD0871  [18]
 LDCM0274  AC153 HEK-293T C146(0.89); C156(0.79)  LDD0872  [18]
 LDCM0621  AC154 HEK-293T C146(1.09); C156(0.52)  LDD2162  [18]
 LDCM0622  AC155 HEK-293T C146(0.75); C156(0.68)  LDD2163  [18]
 LDCM0623  AC156 HEK-293T C146(0.70); C156(0.69)  LDD2164  [18]
 LDCM0624  AC157 HEK-293T C146(0.44); C156(0.68)  LDD2165  [18]
 LDCM0276  AC17 HEK-293T C146(1.30); C156(1.05)  LDD0874  [18]
 LDCM0277  AC18 HEK-293T C146(1.86); C156(1.29)  LDD0875  [18]
 LDCM0278  AC19 HEK-293T C146(2.32); C156(1.16)  LDD0876  [18]
 LDCM0279  AC2 HEK-293T C146(0.91)  LDD0877  [18]
 LDCM0280  AC20 HEK-293T C146(0.79); C156(0.75)  LDD0878  [18]
 LDCM0281  AC21 HEK-293T C146(0.52); C156(0.57)  LDD0879  [18]
 LDCM0282  AC22 HEK-293T C146(1.55); C156(0.75)  LDD0880  [18]
 LDCM0283  AC23 HEK-293T C146(1.89); C156(1.39)  LDD0881  [18]
 LDCM0284  AC24 HEK-293T C146(1.69); C156(1.06)  LDD0882  [18]
 LDCM0285  AC25 HEK-293T C247(0.88); C146(1.16)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C247(0.87); C146(1.02)  LDD1525  [19]
 LDCM0287  AC27 HEK-293T C247(1.11); C146(1.09)  LDD1526  [19]
 LDCM0288  AC28 HEK-293T C247(1.07); C146(1.17)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C247(1.08); C146(1.07)  LDD1528  [19]
 LDCM0290  AC3 HEK-293T C146(1.05)  LDD0888  [18]
 LDCM0291  AC30 HEK-293T C247(1.03); C146(1.12)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C247(1.11); C146(1.17)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C247(1.35); C146(1.19)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C247(1.01); C146(1.28)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C247(0.94); C146(1.19)  LDD1534  [19]
 LDCM0296  AC35 HEK-293T C156(1.00)  LDD0894  [18]
 LDCM0297  AC36 HEK-293T C156(0.88)  LDD0895  [18]
 LDCM0298  AC37 HEK-293T C156(0.75)  LDD0896  [18]
 LDCM0299  AC38 HEK-293T C156(0.97)  LDD0897  [18]
 LDCM0300  AC39 HEK-293T C156(0.90)  LDD0898  [18]
 LDCM0301  AC4 HEK-293T C146(0.59)  LDD0899  [18]
 LDCM0302  AC40 HEK-293T C156(0.79)  LDD0900  [18]
 LDCM0303  AC41 HEK-293T C156(0.99)  LDD0901  [18]
 LDCM0304  AC42 HEK-293T C156(0.84)  LDD0902  [18]
 LDCM0305  AC43 HEK-293T C156(0.95)  LDD0903  [18]
 LDCM0306  AC44 HEK-293T C156(0.91)  LDD0904  [18]
 LDCM0307  AC45 HEK-293T C156(0.94)  LDD0905  [18]
 LDCM0308  AC46 HEK-293T C156(1.32)  LDD0906  [18]
 LDCM0309  AC47 HEK-293T C156(1.61)  LDD0907  [18]
 LDCM0310  AC48 HEK-293T C156(1.72)  LDD0908  [18]
 LDCM0311  AC49 HEK-293T C156(0.99)  LDD0909  [18]
 LDCM0312  AC5 HEK-293T C146(0.97)  LDD0910  [18]
 LDCM0313  AC50 HEK-293T C156(1.14)  LDD0911  [18]
 LDCM0314  AC51 HEK-293T C156(1.24)  LDD0912  [18]
 LDCM0315  AC52 HEK-293T C156(1.78)  LDD0913  [18]
 LDCM0316  AC53 HEK-293T C156(2.04)  LDD0914  [18]
 LDCM0317  AC54 HEK-293T C156(1.55)  LDD0915  [18]
 LDCM0318  AC55 HEK-293T C156(2.12)  LDD0916  [18]
 LDCM0319  AC56 HEK-293T C156(2.86)  LDD0917  [18]
 LDCM0320  AC57 HEK-293T C146(0.97); C156(1.19)  LDD0918  [18]
 LDCM0321  AC58 HEK-293T C146(1.44); C156(0.95)  LDD0919  [18]
 LDCM0322  AC59 HEK-293T C146(1.25); C156(0.61)  LDD0920  [18]
 LDCM0323  AC6 PaTu 8988t C146(0.86); C156(0.86)  LDD1202  [18]
 LDCM0324  AC60 HEK-293T C146(1.09); C156(2.25)  LDD0922  [18]
 LDCM0325  AC61 HEK-293T C146(1.09); C156(0.91)  LDD0923  [18]
 LDCM0326  AC62 HEK-293T C146(1.05); C156(1.82)  LDD0924  [18]
 LDCM0327  AC63 HEK-293T C146(1.28); C156(1.17)  LDD0925  [18]
 LDCM0328  AC64 HEK-293T C146(0.85); C156(1.17)  LDD0926  [18]
 LDCM0329  AC65 HEK-293T C146(0.96); C156(1.06)  LDD0927  [18]
 LDCM0330  AC66 HEK-293T C146(1.12); C156(1.32)  LDD0928  [18]
 LDCM0331  AC67 HEK-293T C146(1.57); C156(1.19)  LDD0929  [18]
 LDCM0334  AC7 PaTu 8988t C146(0.96); C156(0.96)  LDD1213  [18]
 LDCM0345  AC8 PaTu 8988t C146(0.71); C156(0.71)  LDD1224  [18]
 LDCM0349  AC83 HEK-293T C146(0.91); C156(0.82)  LDD0947  [18]
 LDCM0350  AC84 HEK-293T C146(0.80); C156(1.08)  LDD0948  [18]
 LDCM0351  AC85 HEK-293T C146(1.12); C156(1.00)  LDD0949  [18]
 LDCM0352  AC86 HEK-293T C146(1.08); C156(1.13)  LDD0950  [18]
 LDCM0353  AC87 HEK-293T C146(1.14); C156(1.06)  LDD0951  [18]
 LDCM0354  AC88 HEK-293T C146(0.92); C156(1.53)  LDD0952  [18]
 LDCM0355  AC89 HEK-293T C146(0.99); C156(1.31)  LDD0953  [18]
 LDCM0357  AC90 HEK-293T C146(0.97); C156(0.77)  LDD0955  [18]
 LDCM0358  AC91 HEK-293T C146(1.23); C156(0.79)  LDD0956  [18]
 LDCM0359  AC92 HEK-293T C146(1.08); C156(0.72)  LDD0957  [18]
 LDCM0360  AC93 HEK-293T C146(0.94); C156(1.15)  LDD0958  [18]
 LDCM0361  AC94 HEK-293T C146(0.80); C156(1.34)  LDD0959  [18]
 LDCM0362  AC95 HEK-293T C146(0.80); C156(0.93)  LDD0960  [18]
 LDCM0363  AC96 HEK-293T C146(0.81); C156(0.89)  LDD0961  [18]
 LDCM0364  AC97 HEK-293T C146(0.75); C156(1.92)  LDD0962  [18]
 LDCM0248  AKOS034007472 PaTu 8988t C146(0.75); C156(0.75)  LDD1127  [18]
 LDCM0356  AKOS034007680 PaTu 8988t C146(0.70); C156(0.70)  LDD1235  [18]
 LDCM0275  AKOS034007705 PaTu 8988t C146(0.61); C156(0.61)  LDD1154  [18]
 LDCM0156  Aniline NCI-H1299 13.16  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C247(0.67); C146(1.21)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C247(0.61); C146(1.10)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C146(0.62)  LDD0967  [18]
 LDCM0370  CL101 PaTu 8988t C146(1.32); C156(1.32)  LDD1249  [18]
 LDCM0371  CL102 PaTu 8988t C146(1.14); C156(1.14)  LDD1250  [18]
 LDCM0372  CL103 PaTu 8988t C146(0.99); C156(0.99)  LDD1251  [18]
 LDCM0373  CL104 PaTu 8988t C146(1.64); C156(1.64)  LDD1252  [18]
 LDCM0374  CL105 HEK-293T C146(1.28); C156(0.73)  LDD0972  [18]
 LDCM0375  CL106 HEK-293T C146(1.20); C156(0.67)  LDD0973  [18]
 LDCM0376  CL107 HEK-293T C146(1.17); C156(0.99)  LDD0974  [18]
 LDCM0377  CL108 HEK-293T C146(1.57); C156(0.99)  LDD0975  [18]
 LDCM0378  CL109 HEK-293T C146(1.09); C156(0.81)  LDD0976  [18]
 LDCM0379  CL11 HEK-293T C247(1.00); C146(0.85)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C146(1.24); C156(0.87)  LDD0978  [18]
 LDCM0381  CL111 HEK-293T C146(1.29); C156(0.87)  LDD0979  [18]
 LDCM0382  CL112 HEK-293T C247(1.25); C146(1.03)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C247(1.14); C146(1.22)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C247(0.81); C146(1.36)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C247(0.99); C146(1.11)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C247(1.05); C146(1.21)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C156(1.63)  LDD0985  [18]
 LDCM0388  CL118 HEK-293T C156(0.81)  LDD0986  [18]
 LDCM0389  CL119 HEK-293T C156(0.76)  LDD0987  [18]
 LDCM0390  CL12 HEK-293T C247(1.11); C146(0.87)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C156(1.04)  LDD0989  [18]
 LDCM0392  CL121 HEK-293T C156(1.16)  LDD0990  [18]
 LDCM0393  CL122 HEK-293T C156(1.17)  LDD0991  [18]
 LDCM0394  CL123 HEK-293T C156(1.63)  LDD0992  [18]
 LDCM0395  CL124 HEK-293T C156(2.22)  LDD0993  [18]
 LDCM0396  CL125 HEK-293T C146(1.05); C156(0.74)  LDD0994  [18]
 LDCM0397  CL126 HEK-293T C146(0.98); C156(0.80)  LDD0995  [18]
 LDCM0398  CL127 HEK-293T C146(1.56); C156(0.83)  LDD0996  [18]
 LDCM0399  CL128 HEK-293T C146(1.46); C156(0.97)  LDD0997  [18]
 LDCM0400  CL13 HEK-293T C247(1.00); C146(1.26)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C247(1.03); C146(1.25)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C247(0.67); C146(1.25)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C247(0.95); C146(1.21)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C247(0.97); C146(1.29)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C247(1.23); C146(1.10)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C247(1.07); C146(1.02)  LDD1610  [19]
 LDCM0407  CL2 HEK-293T C247(1.07); C146(1.16)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C247(1.03); C146(1.03)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C247(0.89); C146(1.13)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C247(0.95); C146(0.85)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C247(0.98); C146(0.86)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C247(1.20); C146(0.85)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C247(0.80); C146(1.46)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C247(0.99); C146(1.22)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C247(0.83); C146(1.20)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C247(0.92); C146(1.17)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C247(0.91); C146(1.13)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C247(1.04); C146(1.17)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C247(1.14); C146(1.05)  LDD1623  [19]
 LDCM0420  CL31 HEK-293T C146(1.37); C156(0.73)  LDD1018  [18]
 LDCM0421  CL32 HEK-293T C146(1.46); C156(0.81)  LDD1019  [18]
 LDCM0422  CL33 HEK-293T C146(0.84); C156(0.81)  LDD1020  [18]
 LDCM0423  CL34 HEK-293T C146(1.00); C156(0.84)  LDD1021  [18]
 LDCM0424  CL35 HEK-293T C146(1.27); C156(0.94)  LDD1022  [18]
 LDCM0425  CL36 HEK-293T C146(1.19); C156(1.01)  LDD1023  [18]
 LDCM0426  CL37 HEK-293T C146(1.06); C156(1.18)  LDD1024  [18]
 LDCM0428  CL39 HEK-293T C146(0.75); C156(0.88)  LDD1026  [18]
 LDCM0429  CL4 HEK-293T C247(1.18); C146(1.12)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C146(1.19); C156(0.80)  LDD1028  [18]
 LDCM0431  CL41 HEK-293T C146(0.94); C156(0.85)  LDD1029  [18]
 LDCM0432  CL42 HEK-293T C146(0.88); C156(0.88)  LDD1030  [18]
 LDCM0433  CL43 HEK-293T C146(0.84); C156(0.91)  LDD1031  [18]
 LDCM0434  CL44 HEK-293T C146(1.21); C156(0.83)  LDD1032  [18]
 LDCM0435  CL45 HEK-293T C146(1.63); C156(1.14)  LDD1033  [18]
 LDCM0436  CL46 HEK-293T C146(0.85); C156(0.71)  LDD1034  [18]
 LDCM0437  CL47 HEK-293T C146(0.90); C156(1.14)  LDD1035  [18]
 LDCM0438  CL48 HEK-293T C146(0.83); C156(1.03)  LDD1036  [18]
 LDCM0439  CL49 HEK-293T C146(0.93); C156(0.99)  LDD1037  [18]
 LDCM0440  CL5 HEK-293T C247(0.97); C146(1.28)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C146(0.66); C156(1.01)  LDD1039  [18]
 LDCM0442  CL51 HEK-293T C146(0.76); C156(1.24)  LDD1040  [18]
 LDCM0443  CL52 HEK-293T C146(1.05); C156(1.22)  LDD1041  [18]
 LDCM0444  CL53 HEK-293T C146(0.74); C156(1.04)  LDD1042  [18]
 LDCM0445  CL54 HEK-293T C146(0.88); C156(1.20)  LDD1043  [18]
 LDCM0446  CL55 HEK-293T C146(0.86); C156(1.37)  LDD1044  [18]
 LDCM0447  CL56 HEK-293T C146(0.74); C156(0.98)  LDD1045  [18]
 LDCM0448  CL57 HEK-293T C146(0.82); C156(1.02)  LDD1046  [18]
 LDCM0449  CL58 HEK-293T C146(0.83); C156(1.21)  LDD1047  [18]
 LDCM0450  CL59 HEK-293T C146(0.84); C156(0.91)  LDD1048  [18]
 LDCM0451  CL6 HEK-293T C247(0.70); C146(1.23)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C146(0.85); C156(1.32)  LDD1050  [18]
 LDCM0453  CL61 HEK-293T C146(0.99)  LDD1051  [18]
 LDCM0454  CL62 HEK-293T C146(1.16)  LDD1052  [18]
 LDCM0455  CL63 HEK-293T C146(1.09)  LDD1053  [18]
 LDCM0456  CL64 HEK-293T C146(0.97)  LDD1054  [18]
 LDCM0457  CL65 HEK-293T C146(1.36)  LDD1055  [18]
 LDCM0458  CL66 HEK-293T C146(1.18)  LDD1056  [18]
 LDCM0459  CL67 HEK-293T C146(1.46)  LDD1057  [18]
 LDCM0460  CL68 HEK-293T C146(1.13)  LDD1058  [18]
 LDCM0461  CL69 HEK-293T C146(1.21)  LDD1059  [18]
 LDCM0462  CL7 HEK-293T C247(0.97); C146(1.09)  LDD1665  [19]
 LDCM0463  CL70 HEK-293T C146(1.09)  LDD1061  [18]
 LDCM0464  CL71 HEK-293T C146(0.97)  LDD1062  [18]
 LDCM0465  CL72 HEK-293T C146(1.27)  LDD1063  [18]
 LDCM0466  CL73 HEK-293T C146(1.03)  LDD1064  [18]
 LDCM0467  CL74 HEK-293T C146(1.28)  LDD1065  [18]
 LDCM0469  CL76 HEK-293T C156(0.72)  LDD1067  [18]
 LDCM0470  CL77 HEK-293T C156(0.73)  LDD1068  [18]
 LDCM0471  CL78 HEK-293T C156(0.72)  LDD1069  [18]
 LDCM0472  CL79 HEK-293T C156(0.81)  LDD1070  [18]
 LDCM0473  CL8 HEK-293T C247(0.88); C146(2.80)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C156(0.60)  LDD1072  [18]
 LDCM0475  CL81 HEK-293T C156(0.75)  LDD1073  [18]
 LDCM0476  CL82 HEK-293T C156(1.19)  LDD1074  [18]
 LDCM0477  CL83 HEK-293T C156(0.80)  LDD1075  [18]
 LDCM0478  CL84 HEK-293T C156(0.62)  LDD1076  [18]
 LDCM0479  CL85 HEK-293T C156(0.75)  LDD1077  [18]
 LDCM0480  CL86 HEK-293T C156(0.46)  LDD1078  [18]
 LDCM0481  CL87 HEK-293T C156(0.55)  LDD1079  [18]
 LDCM0482  CL88 HEK-293T C156(0.84)  LDD1080  [18]
 LDCM0483  CL89 HEK-293T C156(0.63)  LDD1081  [18]
 LDCM0484  CL9 HEK-293T C247(0.97); C146(0.95)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C156(0.78)  LDD1083  [18]
 LDCM0486  CL91 HEK-293T C146(0.76)  LDD1084  [18]
 LDCM0487  CL92 HEK-293T C146(0.74)  LDD1085  [18]
 LDCM0488  CL93 HEK-293T C146(0.90)  LDD1086  [18]
 LDCM0489  CL94 HEK-293T C146(0.61)  LDD1087  [18]
 LDCM0490  CL95 HEK-293T C146(0.57)  LDD1088  [18]
 LDCM0491  CL96 HEK-293T C146(0.73)  LDD1089  [18]
 LDCM0492  CL97 HEK-293T C146(0.99)  LDD1090  [18]
 LDCM0493  CL98 HEK-293T C146(0.84)  LDD1091  [18]
 LDCM0494  CL99 HEK-293T C146(0.79)  LDD1092  [18]
 LDCM0495  E2913 HEK-293T C247(1.08); C146(1.29)  LDD1698  [19]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [7]
 LDCM0468  Fragment33 HEK-293T C146(0.84)  LDD1066  [18]
 LDCM0427  Fragment51 HEK-293T C146(1.22); C156(0.85)  LDD1025  [18]
 LDCM0022  KB02 HEK-293T C247(1.15); C146(0.94); C156(0.94)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C247(1.12); C146(1.00); C156(1.00)  LDD1497  [19]
 LDCM0024  KB05 UACC257 C247(1.10)  LDD3325  [4]
 LDCM0006  Micheliolide M9-ENL1 1.50  LDD0049  [5]
 LDCM0628  OTUB2-COV-1 HEK-293T C247(2.60); C146(0.94)  LDD2207  [20]
 LDCM0131  RA190 MM1.R C146(2.53)  LDD0304  [21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
MTRF1L release factor glutamine methyltransferase (HEMK1) Protein N5-glutamine methyltransferase family Q9Y5R4
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Programmed cell death protein 6 (PDCD6) . O75340
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein ZIC 1 (ZIC1) GLI C2H2-type zinc-finger protein family Q15915
Forkhead box protein R2 (FOXR2) . Q6PJQ5
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 (SOHLH1) . Q5JUK2
Other
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
BPI fold-containing family A member 1 (BPIFA1) Plunc family Q9NP55
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Cilia- and flagella-associated protein 68 (CFAP68) CFAP68 family Q9H5F2
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin-associated protein 12-1 (KRTAP12-1) KRTAP type 12 family P59990
Keratin-associated protein 19-1 (KRTAP19-1) KRTAP type 19 family Q8IUB9
Mediator of RNA polymerase II transcription subunit 25 (MED25) Mediator complex subunit 25 family Q71SY5
Keratin-associated protein 15-1 (KRTAP15-1) PMG family Q3LI76
RNA-binding protein EWS (EWSR1) RRM TET family Q01844
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
DAZ-associated protein 2 (DAZAP2) . Q15038
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Kelch-like protein 12 (KLHL12) . Q53G59
Peflin (PEF1) . Q9UBV8
Protein TFG (TFG) . Q92734
Saitohin (STH) . Q8IWL8

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcium Phosphate Small molecular drug DB11348
Calcium Phosphate Dihydrate Small molecular drug DB14481
Calcium Citrate . DB11093

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
17 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
18 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.