Details of the Target

General Information of Target

Target ID LDTP08024
Target Name Probable helicase senataxin (SETX)
Gene Name SETX
Gene ID 23064
Synonyms
ALS4; KIAA0625; SCAR1; Probable helicase senataxin; EC 3.6.4.-; Amyotrophic lateral sclerosis 4 protein; SEN1 homolog; Senataxin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTCCWCTPGGASTIDFLKRYASNTPSGEFQTADEDLCYCLECVAEYHKARDELPFLHEV
LWELETLRLINHFEKSMKAEIGDDDELYIVDNNGEMPLFDITGQDFENKLRVPLLEILKY
PYLLLHERVNELCVEALCRMEQANCSFQVFDKHPGIYLFLVHPNEMVRRWAILTARNLGK
VDRDDYYDLQEVLLCLFKVIELGLLESPDIYTSSVLEKGKLILLPSHMYDTTNYKSYWLG
ICMLLTILEEQAMDSLLLGSDKQNDFMQSILHTMEREADDDSVDPFWPALHCFMVILDRL
GSKVWGQLMDPIVAFQTIINNASYNREIRHIRNSSVRTKLEPESYLDDMVTCSQIVYNYN
PEKTKKDSGWRTAICPDYCPNMYEEMETLASVLQSDIGQDMRVHNSTFLWFIPFVQSLMD
LKDLGVAYIAQVVNHLYSEVKEVLNQTDAVCDKVTEFFLLILVSVIELHRNKKCLHLLWV
SSQQWVEAVVKCAKLPTTAFTRSSEKSSGNCSKGTAMISSLSLHSMPSNSVQLAYVQLIR
SLLKEGYQLGQQSLCKRFWDKLNLFLRGNLSLGWQLTSQETHELQSCLKQIIRNIKFKAP
PCNTFVDLTSACKISPASYNKEESEQMGKTSRKDMHCLEASSPTFSKEPMKVQDSVLIKA
DNTIEGDNNEQNYIKDVKLEDHLLAGSCLKQSSKNIFTERAEDQIKISTRKQKSVKEISS
YTPKDCTSRNGPERGCDRGIIVSTRLLTDSSTDALEKVSTSNEDFSLKDDALAKTSKRKT
KVQKDEICAKLSHVIKKQHRKSTLVDNTINLDENLTVSNIESFYSRKDTGVQKGDGFIHN
LSLDPSGVLDDKNGEQKSQNNVLPKEKQLKNEELVIFSFHENNCKIQEFHVDGKELIPFT
EMTNASEKKSSPFKDLMTVPESRDEEMSNSTSVIYSNLTREQAPDISPKSDTLTDSQIDR
DLHKLSLLAQASVITFPSDSPQNSSQLQRKVKEDKRCFTANQNNVGDTSRGQVIIISDSD
DDDDERILSLEKLTKQDKICLEREHPEQHVSTVNSKEEKNPVKEEKTETLFQFEESDSQC
FEFESSSEVFSVWQDHPDDNNSVQDGEKKCLAPIANTTNGQGCTDYVSEVVKKGAEGIEE
HTRPRSISVEEFCEIEVKKPKRKRSEKPMAEDPVRPSSSVRNEGQSDTNKRDLVGNDFKS
IDRRTSTPNSRIQRATTVSQKKSSKLCTCTEPIRKVPVSKTPKKTHSDAKKGQNRSSNYL
SCRTTPAIVPPKKFRQCPEPTSTAEKLGLKKGPRKAYELSQRSLDYVAQLRDHGKTVGVV
DTRKKTKLISPQNLSVRNNKKLLTSQELQMQRQIRPKSQKNRRRLSDCESTDVKRAGSHT
AQNSDIFVPESDRSDYNCTGGTEVLANSNRKQLIKCMPSEPETIKAKHGSPATDDACPLN
QCDSVVLNGTVPTNEVIVSTSEDPLGGGDPTARHIEMAALKEGEPDSSSDAEEDNLFLTQ
NDPEDMDLCSQMENDNYKLIELIHGKDTVEVEEDSVSRPQLESLSGTKCKYKDCLETTKN
QGEYCPKHSEVKAADEDVFRKPGLPPPASKPLRPTTKIFSSKSTSRIAGLSKSLETSSAL
SPSLKNKSKGIQSILKVPQPVPLIAQKPVGEMKNSCNVLHPQSPNNSNRQGCKVPFGESK
YFPSSSPVNILLSSQSVSDTFVKEVLKWKYEMFLNFGQCGPPASLCQSISRPVPVRFHNY
GDYFNVFFPLMVLNTFETVAQEWLNSPNRENFYQLQVRKFPADYIKYWEFAVYLEECELA
KQLYPKENDLVFLAPERINEEKKDTERNDIQDLHEYHSGYVHKFRRTSVMRNGKTECYLS
IQTQENFPANLNELVNCIVISSLVTTQRKLKAMSLLGSRNQLARAVLNPNPMDFCTKDLL
TTTSERIIAYLRDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRL
LTENQRKGHSDENSNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGD
INLVRLGPEKSINSEVLKFSLDSQVNHRMKKELPSHVQAMHKRKEFLDYQLDELSRQRAL
CRGGREIQRQELDENISKVSKERQELASKIKEVQGRPQKTQSIIILESHIICCTLSTSGG
LLLESAFRGQGGVPFSCVIVDEAGQSCEIETLTPLIHRCNKLILVGDPKQLPPTVISMKA
QEYGYDQSMMARFCRLLEENVEHNMISRLPILQLTVQYRMHPDICLFPSNYVYNRNLKTN
RQTEAIRCSSDWPFQPYLVFDVGDGSERRDNDSYINVQEIKLVMEIIKLIKDKRKDVSFR
NIGIITHYKAQKTMIQKDLDKEFDRKGPAEVDTVDAFQGRQKDCVIVTCVRANSIQGSIG
FLASLQRLNVTITRAKYSLFILGHLRTLMENQHWNQLIQDAQKRGAIIKTCDKNYRHDAV
KILKLKPVLQRSLTHPPTIAPEGSRPQGGLPSSKLDSGFAKTSVAASLYHTPSDSKEITL
TVTSKDPERPPVHDQLQDPRLLKRMGIEVKGGIFLWDPQPSSPQHPGATPPTGEPGFPVV
HQDLSHIQQPAAVVAALSSHKPPVRGEPPAASPEASTCQSKCDDPEEELCHRREARAFSE
GEQEKCGSETHHTRRNSRWDKRTLEQEDSSSKKRKLL
Target Bioclass
Enzyme
Family
DNA2/NAM7 helicase family
Subcellular location
Nucleus
Function
Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription. Contributes to the mRNA splicing efficiency and splice site selection. Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination. Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation. Involved in DNA double-strand breaks damage response generated by oxidative stress. In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage. Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription. Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis.
Uniprot ID
Q7Z333
Ensemble ID
ENST00000224140.6
HGNC ID
HGNC:445

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.S571F DBIA    Probe Info 
CAKI1 SNV: p.Y378D .
CAL33 SNV: p.W238Ter .
CCK81 Deletion: p.K473NfsTer8 DBIA    Probe Info 
HEC1B SNV: p.N2001S .
HT115 SNV: p.K75Q; p.D681N; p.V1388I; p.K2032N .
IPC298 Deletion: p.E2644del DBIA    Probe Info 
JHH6 SNV: p.S714C DBIA    Probe Info 
JURKAT Insertion: p.R989KfsTer7 .
KNS42 Insertion: p.I2020NfsTer4 DBIA    Probe Info 
MCC26 SNV: p.V465M DBIA    Probe Info 
MDST8 Deletion: p.I614SfsTer37 DBIA    Probe Info 
NCIH1155 SNV: p.S2398L DBIA    Probe Info 
NUGC3 Deletion: p.F1748SfsTer3 DBIA    Probe Info 
OV56 SNV: p.L2463V DBIA    Probe Info 
RL952 SNV: p.M140V DBIA    Probe Info 
SNU1 Deletion: p.S214del DBIA    Probe Info 
TE4 SNV: p.T3I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K2019(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y673(45.65)  LDD3495  [3]
BTD
 Probe Info  		C511(0.67)  LDD2099  [4]
MCL-14
 Probe Info  		3.70  LDD0050  [5]
AHL-Pu-1
 Probe Info  		C1277(7.28)  LDD0168  [6]
DBIA
 Probe Info  		C555(12.92); C1262(5.53); C1959(32.95)  LDD0209  [7]
CY-1
 Probe Info  		Q2134(0.00); Q2138(0.00)  LDD0246  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [9]
NAIA_4
 Probe Info  		C511(0.00); C587(0.00); C997(0.00); C1915(0.00)  LDD2226  [10]
TFBX
 Probe Info  		C1229(0.00); C1227(0.00); C997(0.00); C1262(0.00)  LDD0027  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [12]
IPM
 Probe Info  		C555(0.00); C688(0.00)  LDD0005  [12]
AOyne
 Probe Info  		12.70  LDD0443  [13]
NAIA_5
 Probe Info  		C1123(0.00); C2646(0.00); C511(0.00); C2451(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C511(1.09)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1959(0.71)  LDD2152  [4]
 LDCM0025  4SU-RNA HEK-293T C1277(7.28)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C352(3.30); C1277(7.70)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C1368(1.09); C1915(1.12); C688(0.98); C195(1.07)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C1277(1.00); C997(1.12); C1959(1.01); C1915(0.77)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C1277(1.00); C1368(1.05); C1959(0.99); C1915(1.06)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C1277(0.88); C997(1.05); C1368(1.04); C1959(1.02)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C1277(1.19); C997(0.84); C1368(1.25); C1959(1.03)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C1277(0.94); C997(1.21); C1368(0.91); C1959(1.10)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C1368(1.00); C1915(1.12); C688(1.05); C195(0.91)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C1277(0.92); C997(0.90); C1959(1.11); C1915(0.91)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C1277(1.59); C1368(1.25); C1959(1.22); C1915(1.07)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C1277(1.00); C997(1.27); C1959(1.09); C1915(0.81)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C1277(0.84); C997(0.87); C1368(1.13); C1959(0.91)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C1277(1.02); C1368(1.03); C1959(1.01); C1797(1.00)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C1277(1.04); C997(1.16); C1368(1.08); C1959(1.01)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C1277(1.05); C997(1.07); C1368(1.07); C1959(1.02)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C1277(0.88); C1368(0.79); C1959(1.01); C2618(1.10)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C1368(0.97); C1915(1.04); C688(1.09); C195(0.82)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C1277(1.01); C997(1.34); C1959(1.09); C1915(0.87)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C1277(1.03); C1368(0.99); C1959(0.98); C1915(1.11)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C1277(0.90); C997(1.06); C1368(0.97); C1959(0.86)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C1277(1.15); C1368(0.90); C1959(1.02); C1797(0.98)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C1277(1.16); C1368(1.05); C1959(0.96); C1915(1.07)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C1277(1.04); C997(0.96); C1368(1.40); C1959(0.99)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C1277(1.02); C997(1.18); C1368(0.94); C1959(0.96)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C1277(0.89); C1368(0.79); C1959(1.02); C2618(1.05)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C1368(1.18); C1915(0.99); C688(1.02); C195(0.85)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C1277(0.95); C997(1.32); C1959(0.91); C1915(0.82)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C1277(1.01); C1368(1.07); C1959(0.94); C1915(1.27)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C1277(1.00); C997(1.02); C1368(1.08); C1959(0.93)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C1277(1.05); C1368(0.75); C1959(1.12); C1797(1.00)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C1277(1.07); C997(0.91); C1368(1.20); C1959(1.05)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C1277(0.96); C997(1.14); C1368(0.99); C1959(1.16)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C1277(0.95); C997(1.12); C1368(1.20); C1959(0.95)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C1277(0.89); C1368(1.03); C1959(1.19); C2618(1.34)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C1368(0.94); C1915(1.17); C688(0.98); C195(1.24)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C1277(1.03); C997(1.13); C1959(1.06); C1915(0.93)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C1277(1.00); C1368(1.10); C1959(0.95); C1915(1.06)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C1277(0.91); C997(1.04); C1368(1.16); C1959(0.90)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C1277(1.05); C1368(0.93); C1959(1.11); C1797(1.11)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C1277(1.06); C997(0.89); C1368(1.12); C1959(1.19)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C1277(0.89); C997(0.98); C1368(0.93); C1959(1.11)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C1277(0.90); C1368(0.80); C1959(0.99); C2618(1.03)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C1368(0.92); C1915(0.98); C688(0.99); C195(0.98)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C1277(0.95); C1368(1.03); C1959(1.05); C1797(1.08)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C1277(0.98); C997(1.40); C1959(1.04); C1915(0.91)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C1277(1.00); C1368(1.05); C1959(0.96); C1915(0.99)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C1277(1.06); C997(0.96); C1368(1.08); C1959(1.01)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C1277(1.00); C1368(0.96); C1959(1.19); C1797(1.15)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C1277(0.98); C997(1.24); C1368(0.81); C1959(1.08)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C1277(0.89); C997(0.96); C1368(0.98); C1959(1.04)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C1277(0.96); C1368(1.02); C1959(1.00); C2618(1.15)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C1368(0.99); C1915(1.27); C688(0.99); C195(0.97)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C1277(1.00); C997(1.09); C1959(0.97); C1915(0.89)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C1277(1.03); C1368(1.01); C1959(0.90); C1915(1.10)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C1277(1.08); C997(0.93); C1368(1.12); C1959(1.07)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C1277(0.89); C997(1.08); C1368(1.18); C1959(1.01)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C1277(0.95); C1368(0.91); C1959(1.08); C1797(1.07)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C1277(1.06); C997(0.97); C1368(0.90); C1959(1.03)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C1277(0.98); C997(0.96); C1368(0.93); C1959(1.11)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C1277(0.82); C1368(0.95); C1959(1.09); C2618(1.15)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C1277(0.93); C997(0.81); C1368(0.97); C1959(1.04)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C1277(0.99); C1368(0.67); C1959(0.97); C2618(1.09)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C1277(1.06); C1368(1.13); C1959(1.12); C1797(1.14)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C1368(1.06); C1915(1.07); C688(1.03); C195(1.13)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C1277(0.95); C1368(0.86); C1959(1.00); C2618(1.24)  LDD1514  [14]
 LDCM0632  CL-Sc Hep-G2 C788(1.06); C2646(0.62); C2451(0.62)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C1277(0.92); C1368(0.98); C1959(0.98); C1797(1.10)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C1277(1.11); C997(0.92); C1368(1.13); C1959(1.13)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C1277(0.93); C1368(1.12); C1959(1.29); C1915(1.20)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C1277(0.99); C1368(1.00); C1959(1.05); C1797(1.08)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C1277(1.10); C1368(2.36); C1959(0.97); C1915(1.05)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C997(0.96); C1368(0.92); C1959(0.94); C1915(1.08)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C1277(0.98); C1368(1.15); C1959(1.17); C1915(1.05)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C1277(0.91); C1368(0.97); C1959(0.99); C1797(0.96)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C1277(0.95); C1368(1.32); C1959(1.06); C1915(0.97)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C997(1.11); C1368(1.00); C1959(0.89); C1915(0.98)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C1277(0.89); C1368(1.18); C1959(0.89); C1915(1.01)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C1277(1.08); C1368(0.87); C1959(0.93); C1797(0.95)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C1277(1.22); C997(1.02); C1368(1.20); C1959(1.31)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C1277(0.91); C1368(0.90); C1959(1.13); C1915(0.89)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C997(0.73); C1368(0.18); C1959(0.88); C1915(1.02)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C1277(1.02); C1368(1.05); C1959(1.11); C1915(1.25)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C1277(0.88); C1368(1.21); C1959(1.11); C1797(1.28)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C1277(1.08); C1368(1.22); C1959(0.90); C1915(1.08)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C997(1.03); C1368(1.05); C1959(0.91); C1915(1.02)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C1277(0.98); C1368(1.13); C1959(1.15); C1915(0.98)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C1277(0.95); C1368(0.96); C1959(1.10); C1797(1.17)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C1277(0.98); C1368(1.27); C1959(0.95); C1915(1.01)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C997(1.08); C1368(1.03); C1959(0.89); C1915(1.07)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C1277(1.12); C1368(1.08); C1959(1.04); C2618(1.19)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C1277(1.00); C1368(1.16); C1959(1.20); C1915(1.07)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C1277(0.96); C1368(0.75); C1959(1.10); C1797(0.90)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C1277(0.90); C1368(0.96); C1959(1.10); C1915(1.01)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C997(0.84); C1368(1.00); C1959(0.95); C1915(1.17)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C1277(0.95); C1368(1.04); C1959(1.14); C1915(1.18)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C1277(0.91); C1368(0.79); C1959(0.97); C1797(1.07)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C1277(0.93); C1368(0.99); C1959(1.07); C1915(1.06)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C997(1.02); C1368(0.94); C1959(0.99); C1915(1.13)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C1277(1.03); C1368(0.98); C1959(1.22); C1915(1.11)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C1277(1.01); C1368(0.92); C1959(1.11); C1797(1.04)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C1277(1.00); C1368(0.83); C1959(1.03); C1915(1.04)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C997(0.86); C1368(1.01); C1959(1.07); C1915(1.18)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C1277(1.06); C1368(1.05); C1959(0.99); C1915(1.20)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C1368(0.91); C1915(1.14); C688(1.13); C195(0.77)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C1277(1.17); C997(0.96); C1959(1.22); C1915(0.90)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C1277(1.04); C1368(1.06); C1959(0.93); C1915(1.00)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C1277(1.07); C1368(1.32); C1959(1.18); C1915(1.01)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C1277(1.00); C997(0.95); C1368(1.17); C1959(1.08)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C1277(0.90); C1368(1.05); C1959(1.27); C1797(1.03)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C1277(1.13); C997(1.11); C1368(1.15); C1959(1.05)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C1277(1.02); C997(1.11); C1368(1.17); C1959(1.22)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C1277(1.31); C1368(1.13); C1959(1.03); C2618(1.31)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C1277(0.93); C1368(1.00); C1959(0.87); C1797(1.00)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C1277(0.77); C1368(1.08); C1959(0.95); C1915(1.00)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C997(1.34); C1368(0.96); C1959(0.84); C1915(1.09)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C1277(0.94); C1368(1.01); C1959(1.01); C1915(1.07)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C1368(0.93); C1915(1.11); C688(1.04); C195(0.92)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C997(1.03); C1368(1.05); C1959(0.98); C1915(1.22)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C1277(1.09); C997(0.95); C1959(1.07); C1915(1.08)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C1277(1.10); C1368(1.03); C1959(0.83); C1915(1.20)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C1277(0.90); C997(1.16); C1368(1.23); C1959(0.97)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C1277(0.96); C1368(1.18); C1959(1.08); C1797(0.81)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C1277(1.04); C997(1.12); C1368(1.00); C1959(1.07)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C1277(0.85); C997(1.04); C1368(1.33); C1959(1.06)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C1277(1.18); C1368(0.94); C1959(1.08); C2618(1.14)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C1277(0.95); C1368(1.05); C1959(1.12); C1797(1.03)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C997(1.04); C1368(0.97); C1959(0.91); C1915(1.30)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C1277(1.02); C1368(1.05); C1959(1.15); C1915(1.14)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C1277(0.97); C1368(1.22); C1959(1.08); C1915(1.17)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C1368(1.08); C1915(1.18); C688(1.00); C195(0.99)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C1277(1.07); C997(1.16); C1959(1.15); C1915(0.79)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C1277(0.95); C1368(1.07); C1959(1.00); C1915(1.15)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C1277(0.92); C997(1.11); C1368(1.09); C1959(1.06)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C1277(1.05); C1368(0.98); C1959(1.07); C1797(1.08)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C1277(1.04); C997(1.01); C1368(1.12); C1959(0.97)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C1277(1.05); C997(0.93); C1368(1.28); C1959(0.99)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C1277(1.19); C1368(1.14); C1959(1.07); C2618(1.17)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C1277(0.91); C1368(0.81); C1959(1.18); C1797(1.04)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C1368(0.86); C1915(1.07); C688(1.08); C195(1.03)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C1277(0.97); C1368(1.04); C1959(0.90); C1915(0.97)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C1277(0.92); C1368(0.91); C1959(1.13); C1915(1.13)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C1368(1.12); C1915(0.90); C688(1.00); C195(1.03)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C1277(1.02); C997(0.92); C1959(1.13); C1915(0.74)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C1277(1.29); C1368(1.23); C1959(0.95); C1915(1.21)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C1277(0.84); C997(1.03); C1368(1.42); C1959(0.95)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C1277(1.05); C1368(0.98); C1959(1.24); C1797(1.08)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C1277(1.06); C997(1.10); C1368(1.06); C1959(1.15)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C1277(0.83); C997(1.15); C1368(1.06); C1959(1.13)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C1277(1.20); C997(1.43); C1959(1.28); C1915(0.99)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C1277(1.10); C1368(1.09); C1959(1.09); C2618(1.22)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C1277(0.92); C1368(1.11); C1959(0.95); C1797(0.89)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C1277(0.95); C1368(0.97); C1959(0.97); C1915(1.04)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C997(0.76); C1368(1.13); C1959(0.74); C1915(1.14)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C1277(1.02); C1368(1.18); C1959(1.24); C1915(0.98)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C1368(1.10); C1915(1.03); C688(1.07); C195(1.06)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C1277(1.07); C997(1.19); C1959(0.94); C1915(0.77)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C1277(1.15); C1368(1.12); C1959(0.82); C1915(1.07)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C1277(0.86); C997(0.89); C1368(1.17); C1959(1.01)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C1277(1.23); C1368(1.23); C1959(1.36); C1797(1.06)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C1277(0.99); C1368(1.14); C1959(1.11); C1915(1.12)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C1277(1.19); C997(0.99); C1368(1.03); C1959(1.05)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C1277(0.92); C997(1.30); C1368(1.10); C1959(1.11)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C1277(1.19); C1368(1.01); C1959(1.17); C2618(1.26)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C1277(1.06); C1368(1.01); C1959(1.01); C1797(1.05)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C1277(0.87); C1368(1.65); C1959(1.00); C1915(1.07)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C1277(1.06); C1368(1.18); C1959(1.22); C1915(1.04)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C1368(0.98); C1915(1.20); C688(1.03); C195(0.98)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C1277(1.01); C997(1.81); C1959(1.08); C1915(0.85)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C1277(1.09); C1368(1.03); C1959(1.02); C1915(1.01)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C1277(0.97); C997(0.92); C1368(1.04); C1959(1.26)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C1277(0.88); C997(0.94); C1368(1.16); C1959(1.01)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C1277(1.16); C1368(1.09); C1959(1.17); C1797(0.83)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C1277(1.09); C997(1.12); C1368(0.84); C1959(1.08)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C1277(0.94); C997(0.98); C1368(1.15); C1959(1.11)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C1277(1.16); C1368(1.07); C1959(0.97); C2618(1.11)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C1277(0.99); C1368(0.92); C1959(0.96); C1797(1.25)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C1277(0.91); C1368(0.99); C1959(1.00); C1915(0.95)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C997(0.94); C1368(0.91); C1959(0.73); C1915(0.90)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C1277(1.00); C1368(1.12); C1959(1.48); C1915(1.06)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C1368(1.05); C1915(1.07); C688(0.95); C195(0.87)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C1277(1.07); C1368(1.09); C1959(1.23); C1797(1.10)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C1277(1.13); C997(1.41); C1959(1.15); C1915(0.97)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C1277(0.95); C1368(0.97); C1959(1.03); C1915(1.12)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C1277(1.05); C997(1.07); C1368(1.06); C1959(0.95)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C1277(0.98); C1368(0.89); C1959(1.07); C1797(0.92)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C1277(1.06); C997(0.77); C1368(1.01); C1959(1.06)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C1277(0.91); C997(1.07); C1368(1.05); C1959(1.10)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C1277(1.06); C1368(0.95); C1959(1.18); C2618(1.32)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C1277(0.95); C1368(0.81); C1959(1.21); C1797(1.06)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C1277(0.99); C1368(1.00); C1959(0.94); C1915(0.96)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C997(0.85); C1368(0.99); C1959(0.85); C1915(1.13)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C997(0.98); C1368(1.05); C1959(1.03); C1915(1.32)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1229(2.41); C1262(0.94)  LDD1702  [4]
 LDCM0625  F8 Ramos C511(0.69)  LDD2187  [15]
 LDCM0575  Fragment13 Ramos C511(0.91)  LDD2192  [15]
 LDCM0580  Fragment21 Ramos C511(0.97)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C511(1.05)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C511(0.83)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C511(0.62)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C511(1.34)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C511(0.77)  LDD2200  [15]
 LDCM0468  Fragment33 HEK-293T C997(0.90); C1368(0.99); C1959(0.87); C1915(1.11)  LDD1671  [14]
 LDCM0596  Fragment38 Ramos C511(0.94)  LDD2203  [15]
 LDCM0427  Fragment51 HEK-293T C1277(0.95); C1368(1.26); C1959(0.97); C1915(1.02)  LDD1631  [14]
 LDCM0610  Fragment52 Ramos C511(1.17)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C511(1.19)  LDD2205  [15]
 LDCM0022  KB02 HEK-293T C1277(1.05); C1368(1.04); C555(0.85); C1959(0.99)  LDD1492  [14]
 LDCM0023  KB03 Jurkat C555(12.92); C1262(5.53); C1959(32.95)  LDD0209  [7]
 LDCM0024  KB05 COLO792 C1959(2.61)  LDD3310  [16]
 LDCM0006  Micheliolide M9-ENL1 3.70  LDD0050  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C511(0.67)  LDD2099  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C511(0.66)  LDD2125  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1959(1.64)  LDD2144  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1959(0.35)  LDD2150  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable helicase senataxin (SETX) DNA2/NAM7 helicase family Q7Z333
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) RNA polymerase beta' chain family P24928
SUMO-conjugating enzyme UBC9 (UBE2I) Ubiquitin-conjugating enzyme family P63279
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Survival motor neuron protein (SMN1; SMN2) SMN family Q16637
Superkiller complex protein 8 (SKIC8) . Q9GZS3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840