Details of the Target

General Information of Target

Target ID LDTP06152
Target Name Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2)
Gene Name ITPR2
Gene ID 3709
Synonyms
Inositol 1,4,5-trisphosphate receptor type 2; IP3 receptor isoform 2; IP3R 2; InsP3R2; Type 2 inositol 1,4,5-trisphosphate receptor; Type 2 InsP3 receptor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKV
CPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNV
IQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGD
KVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVV
RLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWN
SLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHG
NDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTC
QTKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDLI
FFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLED
LGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLH
NNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPG
NADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGT
KADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCR
LMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEE
YLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPM
SSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTE
HEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPDTLLP
SAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLL
FKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGE
IGESQVKGGEEPIEESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCR
NQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHL
NLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKAD
GKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERDRGDESGPLAYHITLVE
LLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKE
IYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPFSDNST
SLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNRGIAIPVDLDSQVN
TLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEHQFSPM
MQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLRE
MLEKKDSFVEEGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQDSDKMGI
SMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQTQYSFYQQLHEQ
KKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLK
EGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQP
ILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEK
NVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQL
KNNASKLLLAIMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDDEGGDDGVS
PKDVGHNIYILAHQLARHNKLLQQMLKPGSDPDEGDEALKYYANHTAQIEIVRHDRTMEQ
IVFPVPNICEYLTRESKCRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALF
WFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGTLSPLFSVLLWIAVAICTSMLFF
FSKPVGIRPFLVSIMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAV
ILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAV
LALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSPT
IPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVY
DLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFE
EHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGD
SEQNEIRSLQEKLESTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHHMPP
H
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
InsP3 receptor family
Subcellular location
Endoplasmic reticulum membrane
Function Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
TTD ID
T76678
Uniprot ID
Q14571
DrugMap ID
TTK9OV3
Ensemble ID
ENST00000242737.5
HGNC ID
HGNC:6181
ChEMBL ID
CHEMBL2111451

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.V2635A DBIA    Probe Info 
CAKI1 SNV: p.D1405Y DBIA    Probe Info 
COLO792 SNV: p.Q911Ter DBIA    Probe Info 
EFO27 SNV: p.R2630Ter DBIA    Probe Info 
HCT15 SNV: p.L560M; p.S1792F .
HEC1 SNV: p.P186H DBIA    Probe Info 
HEC1B SNV: p.A776V; p.G913R .
HLF SNV: p.A2615S DBIA    Probe Info 
HT115 SNV: p.A87T; p.E248D; p.V1508F; p.Y1949S .
IGR1 SNV: p.E1690K DBIA    Probe Info 
IPC298 SNV: p.T221I DBIA    Probe Info 
JHH6 SNV: p.T969I DBIA    Probe Info 
JHH7 Deletion: p.E1614_M1621delinsV .
JURKAT SNV: p.T2576M .
LS123 SNV: p.E905K DBIA    Probe Info 
MDAMB453 SNV: p.E905K DBIA    Probe Info 
MFE296 SNV: p.H2225Y DBIA    Probe Info 
MFE319 SNV: p.F737L DBIA    Probe Info 
NCIH1155 SNV: p.A1007T DBIA    Probe Info 
NCIH2286 SNV: p.V1761F; p.D2103N DBIA    Probe Info 
NCIH661 SNV: p.D321N .
OVISE Deletion: p.V187_A189del DBIA    Probe Info 
SKMEL30 Substitution: p.T84I DBIA    Probe Info 
TE4 SNV: p.A1238G DBIA    Probe Info 
WM2664 Insertion: p.D425EfsTer2; p.V2599GfsTer4 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C1536(0.67)  LDD2137  [2]
MCL-14
 Probe Info  		4.00  LDD0050  [3]
AHL-Pu-1
 Probe Info  		C2087(2.07); C1893(6.48); C1879(2.41)  LDD0168  [4]
DBIA
 Probe Info  		C1879(9.26)  LDD0209  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
CY4
 Probe Info  		K1110(0.00); Y1109(0.00); Q1111(0.00)  LDD0247  [7]
N1
 Probe Info  		E1680(0.00); E1683(0.00); K1684(0.00); R1679(0.00)  LDD0245  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1536(0.00); C1397(0.00); C1246(0.00); C2169(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C1536(0.00); C1649(0.00); C420(0.00); C579(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C1246(0.00); C1929(0.00); C379(0.00); C1649(0.00)  LDD0037  [8]
IPM
 Probe Info  		C379(0.00); C1879(0.00)  LDD0005  [9]
TFBX
 Probe Info  		C1536(0.00); C2087(0.00); C379(0.00); C1397(0.00)  LDD0148  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
W1
 Probe Info  		C1462(0.00); C420(0.00); C1522(0.00); C2087(0.00)  LDD0236  [12]
NAIA_5
 Probe Info  		C2565(0.00); C1929(0.00); C61(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C2087(2.07); C1893(6.48); C1879(2.41)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C2087(3.12); C1893(4.76)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C1522(1.31); C379(1.31)  LDD0812  [15]
 LDCM0215  AC10 HEK-293T C1522(1.22); C379(1.22)  LDD0813  [15]
 LDCM0226  AC11 HEK-293T C1522(1.21); C379(1.21)  LDD0824  [15]
 LDCM0230  AC113 HEK-293T C1522(1.00); C379(1.00)  LDD0828  [15]
 LDCM0231  AC114 HEK-293T C1522(1.16); C379(1.16)  LDD0829  [15]
 LDCM0232  AC115 HEK-293T C1522(1.03); C379(1.03)  LDD0830  [15]
 LDCM0233  AC116 HEK-293T C1522(0.93); C379(0.93)  LDD0831  [15]
 LDCM0234  AC117 HEK-293T C1522(1.05); C379(1.05)  LDD0832  [15]
 LDCM0235  AC118 HEK-293T C1522(1.15); C379(1.15)  LDD0833  [15]
 LDCM0236  AC119 HEK-293T C1522(1.00); C379(1.00)  LDD0834  [15]
 LDCM0237  AC12 HEK-293T C1522(1.37); C379(1.37)  LDD0835  [15]
 LDCM0238  AC120 HEK-293T C1522(0.91); C379(0.91)  LDD0836  [15]
 LDCM0239  AC121 HEK-293T C1522(1.11); C379(1.11)  LDD0837  [15]
 LDCM0240  AC122 HEK-293T C1522(1.15); C379(1.15)  LDD0838  [15]
 LDCM0241  AC123 HEK-293T C1522(0.98); C379(0.98)  LDD0839  [15]
 LDCM0242  AC124 HEK-293T C1522(0.99); C379(0.99)  LDD0840  [15]
 LDCM0243  AC125 HEK-293T C1522(1.14); C379(1.14)  LDD0841  [15]
 LDCM0244  AC126 HEK-293T C1522(1.10); C379(1.10)  LDD0842  [15]
 LDCM0245  AC127 HEK-293T C1522(1.17); C379(1.17)  LDD0843  [15]
 LDCM0259  AC14 HEK-293T C1522(1.12); C379(1.12)  LDD0857  [15]
 LDCM0263  AC143 HEK-293T C1522(1.01); C379(1.01)  LDD0861  [15]
 LDCM0264  AC144 HEK-293T C1522(1.05); C379(1.05)  LDD0862  [15]
 LDCM0265  AC145 HEK-293T C1522(1.09); C379(1.09)  LDD0863  [15]
 LDCM0266  AC146 HEK-293T C1522(1.08); C379(1.08)  LDD0864  [15]
 LDCM0267  AC147 HEK-293T C1522(1.15); C379(1.15)  LDD0865  [15]
 LDCM0268  AC148 HEK-293T C1522(1.15); C379(1.15)  LDD0866  [15]
 LDCM0269  AC149 HEK-293T C1522(1.24); C379(1.24)  LDD0867  [15]
 LDCM0270  AC15 HEK-293T C1522(1.19); C379(1.19)  LDD0868  [15]
 LDCM0271  AC150 HEK-293T C1522(1.07); C379(1.07)  LDD0869  [15]
 LDCM0272  AC151 HEK-293T C1522(1.25); C379(1.25)  LDD0870  [15]
 LDCM0273  AC152 HEK-293T C1522(1.11); C379(1.11)  LDD0871  [15]
 LDCM0274  AC153 HEK-293T C1522(1.13); C379(1.13)  LDD0872  [15]
 LDCM0621  AC154 HEK-293T C1522(0.87); C379(0.87)  LDD2162  [15]
 LDCM0622  AC155 HEK-293T C1522(0.99); C379(0.99)  LDD2163  [15]
 LDCM0623  AC156 HEK-293T C1522(0.93); C379(0.93)  LDD2164  [15]
 LDCM0624  AC157 HEK-293T C1522(1.33); C379(1.33)  LDD2165  [15]
 LDCM0276  AC17 HEK-293T C420(0.91); C2087(0.98); C379(1.04); C1415(0.99)  LDD1515  [16]
 LDCM0277  AC18 HEK-293T C420(0.91); C2087(0.99); C379(0.97); C253(1.02)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C420(0.80); C379(1.06); C253(0.86); C1522(0.80)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C1522(1.15); C379(1.15)  LDD0877  [15]
 LDCM0280  AC20 HEK-293T C420(1.16); C379(1.02); C1415(0.98); C253(1.05)  LDD1519  [16]
 LDCM0281  AC21 HEK-293T C2087(0.89); C379(0.97); C1415(1.02); C1522(1.13)  LDD1520  [16]
 LDCM0282  AC22 HEK-293T C420(1.08); C379(1.00); C1415(1.01); C253(1.24)  LDD1521  [16]
 LDCM0283  AC23 HEK-293T C420(1.02); C2087(1.06); C379(0.97); C1415(1.03)  LDD1522  [16]
 LDCM0284  AC24 HEK-293T C420(1.17); C2087(0.99); C379(1.06); C1522(1.18)  LDD1523  [16]
 LDCM0285  AC25 HEK-293T C1522(0.95); C379(0.95)  LDD0883  [15]
 LDCM0286  AC26 HEK-293T C1522(0.93); C379(0.93)  LDD0884  [15]
 LDCM0287  AC27 HEK-293T C1522(0.97); C379(0.97)  LDD0885  [15]
 LDCM0288  AC28 HEK-293T C1522(1.99); C379(1.99)  LDD0886  [15]
 LDCM0289  AC29 HEK-293T C1522(0.88); C379(0.88)  LDD0887  [15]
 LDCM0290  AC3 HEK-293T C1522(1.07); C379(1.07)  LDD0888  [15]
 LDCM0291  AC30 HEK-293T C1522(0.91); C379(0.91)  LDD0889  [15]
 LDCM0292  AC31 HEK-293T C1522(0.82); C379(0.82)  LDD0890  [15]
 LDCM0293  AC32 HEK-293T C1522(0.87); C379(0.87)  LDD0891  [15]
 LDCM0294  AC33 HEK-293T C1522(0.83); C379(0.83)  LDD0892  [15]
 LDCM0295  AC34 HEK-293T C1522(0.87); C379(0.87)  LDD0893  [15]
 LDCM0296  AC35 HEK-293T C420(1.00); C379(1.06); C253(0.97); C1522(1.02)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C420(1.34); C379(1.06); C1415(1.00); C253(1.07)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C2087(0.74); C379(1.00); C1415(1.07); C1522(1.01)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C420(0.91); C379(1.03); C1415(1.03); C253(1.07)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C420(1.08); C2087(1.07); C379(0.99); C1415(1.10)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C1522(1.22); C379(1.22)  LDD0899  [15]
 LDCM0302  AC40 HEK-293T C420(1.08); C2087(0.93); C379(1.04); C1522(0.96)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C420(0.98); C2087(1.03); C379(1.07); C1415(1.06)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C420(0.98); C2087(1.01); C379(1.11); C253(1.05)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C420(1.01); C379(1.09); C253(0.98); C1522(0.88)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C420(1.40); C379(1.00); C1415(0.99); C253(1.14)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C2087(0.86); C379(1.05); C1415(1.09); C1522(1.11)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C1522(1.07); C379(1.07)  LDD0906  [15]
 LDCM0309  AC47 HEK-293T C1522(1.19); C379(1.19)  LDD0907  [15]
 LDCM0310  AC48 HEK-293T C1522(1.16); C379(1.16)  LDD0908  [15]
 LDCM0311  AC49 HEK-293T C1522(1.09); C379(1.09)  LDD0909  [15]
 LDCM0312  AC5 HEK-293T C1522(1.14); C379(1.14)  LDD0910  [15]
 LDCM0313  AC50 HEK-293T C1522(0.97); C379(0.97)  LDD0911  [15]
 LDCM0314  AC51 HEK-293T C1522(0.97); C379(0.97)  LDD0912  [15]
 LDCM0315  AC52 HEK-293T C1522(1.06); C379(1.06)  LDD0913  [15]
 LDCM0316  AC53 HEK-293T C1522(1.08); C379(1.08)  LDD0914  [15]
 LDCM0317  AC54 HEK-293T C1522(0.96); C379(0.96)  LDD0915  [15]
 LDCM0318  AC55 HEK-293T C1522(1.12); C379(1.12)  LDD0916  [15]
 LDCM0319  AC56 HEK-293T C1522(1.07); C379(1.07)  LDD0917  [15]
 LDCM0320  AC57 HEK-293T C420(0.99); C2087(0.99); C379(1.09); C1415(1.04)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C420(0.96); C2087(1.00); C379(0.99); C253(0.97)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C420(0.99); C379(1.04); C253(0.91); C1522(0.90)  LDD1561  [16]
 LDCM0323  AC6 HEK-293T C1522(1.08); C379(1.08)  LDD0921  [15]
 LDCM0324  AC60 HEK-293T C420(1.28); C379(1.07); C1415(0.96); C253(1.06)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C2087(1.13); C379(0.99); C1415(1.14); C1522(1.07)  LDD1564  [16]
 LDCM0326  AC62 HEK-293T C420(0.99); C379(0.96); C1415(1.07); C253(1.18)  LDD1565  [16]
 LDCM0327  AC63 HEK-293T C420(1.07); C2087(0.96); C379(0.92); C1415(1.10)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C420(1.10); C2087(1.08); C379(0.99); C1522(0.97)  LDD1567  [16]
 LDCM0332  AC68 HEK-293T C1522(1.09); C379(1.09)  LDD0930  [15]
 LDCM0333  AC69 HEK-293T C1522(1.28); C379(1.28)  LDD0931  [15]
 LDCM0334  AC7 HEK-293T C1522(1.09); C379(1.09)  LDD0932  [15]
 LDCM0335  AC70 HEK-293T C1522(1.25); C379(1.25)  LDD0933  [15]
 LDCM0336  AC71 HEK-293T C1522(1.27); C379(1.27)  LDD0934  [15]
 LDCM0337  AC72 HEK-293T C1522(1.18); C379(1.18)  LDD0935  [15]
 LDCM0338  AC73 HEK-293T C1522(1.41); C379(1.41)  LDD0936  [15]
 LDCM0339  AC74 HEK-293T C1522(1.71); C379(1.71)  LDD0937  [15]
 LDCM0340  AC75 HEK-293T C1522(1.38); C379(1.38)  LDD0938  [15]
 LDCM0341  AC76 HEK-293T C1522(1.12); C379(1.12)  LDD0939  [15]
 LDCM0342  AC77 HEK-293T C1522(1.58); C379(1.58)  LDD0940  [15]
 LDCM0343  AC78 HEK-293T C1522(1.28); C379(1.28)  LDD0941  [15]
 LDCM0344  AC79 HEK-293T C1522(1.44); C379(1.44)  LDD0942  [15]
 LDCM0345  AC8 HEK-293T C1522(1.29); C379(1.29)  LDD0943  [15]
 LDCM0346  AC80 HEK-293T C1522(1.14); C379(1.14)  LDD0944  [15]
 LDCM0347  AC81 HEK-293T C1522(1.33); C379(1.33)  LDD0945  [15]
 LDCM0348  AC82 HEK-293T C1522(1.42); C379(1.42)  LDD0946  [15]
 LDCM0248  AKOS034007472 HEK-293T C1522(1.29); C379(1.29)  LDD0846  [15]
 LDCM0356  AKOS034007680 HEK-293T C1522(1.29); C379(1.29)  LDD0954  [15]
 LDCM0275  AKOS034007705 HEK-293T C1522(1.26); C379(1.26)  LDD0873  [15]
 LDCM0156  Aniline NCI-H1299 12.99  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C1522(0.67); C379(0.67)  LDD0965  [15]
 LDCM0368  CL10 HEK-293T C1522(0.98); C379(0.98)  LDD0966  [15]
 LDCM0369  CL100 HEK-293T C1522(1.11); C379(1.11)  LDD0967  [15]
 LDCM0370  CL101 HEK-293T C1522(1.02); C379(1.02)  LDD0968  [15]
 LDCM0371  CL102 HEK-293T C1522(1.13); C379(1.13)  LDD0969  [15]
 LDCM0372  CL103 HEK-293T C1522(1.27); C379(1.27)  LDD0970  [15]
 LDCM0373  CL104 HEK-293T C1522(1.33); C379(1.33)  LDD0971  [15]
 LDCM0374  CL105 HEK-293T C420(0.92); C2087(1.46); C379(1.05); C1415(1.07)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C420(1.01); C379(0.99); C1415(1.07); C1522(0.92)  LDD1579  [16]
 LDCM0376  CL107 HEK-293T C420(0.99); C2087(1.15); C379(0.91); C1522(0.94)  LDD1580  [16]
 LDCM0377  CL108 HEK-293T C420(1.02); C2087(1.03); C379(1.10); C1415(1.00)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C420(0.90); C2087(1.44); C379(1.10); C1415(1.06)  LDD1582  [16]
 LDCM0379  CL11 HEK-293T C1522(1.13); C379(1.13)  LDD0977  [15]
 LDCM0380  CL110 HEK-293T C420(0.93); C379(1.05); C1415(0.81); C1522(0.92)  LDD1584  [16]
 LDCM0381  CL111 HEK-293T C420(0.94); C2087(0.92); C379(0.96); C1522(0.91)  LDD1585  [16]
 LDCM0382  CL112 HEK-293T C1522(0.89); C379(0.89)  LDD0980  [15]
 LDCM0383  CL113 HEK-293T C1522(0.91); C379(0.91)  LDD0981  [15]
 LDCM0384  CL114 HEK-293T C1522(0.84); C379(0.84)  LDD0982  [15]
 LDCM0385  CL115 HEK-293T C1522(0.93); C379(0.93)  LDD0983  [15]
 LDCM0386  CL116 HEK-293T C1522(0.79); C379(0.79)  LDD0984  [15]
 LDCM0387  CL117 HEK-293T C420(0.98); C2087(1.91); C379(1.07); C1415(1.03)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C420(1.01); C379(0.99); C1415(1.19); C1522(0.96)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C420(1.05); C2087(0.96); C379(1.04); C1522(0.89)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C1522(1.15); C379(1.15)  LDD0988  [15]
 LDCM0391  CL120 HEK-293T C420(1.22); C2087(1.03); C379(1.04); C1415(1.00)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C1522(1.09); C379(1.09)  LDD0990  [15]
 LDCM0393  CL122 HEK-293T C1522(1.02); C379(1.02)  LDD0991  [15]
 LDCM0394  CL123 HEK-293T C1522(1.00); C379(1.00)  LDD0992  [15]
 LDCM0395  CL124 HEK-293T C1522(1.13); C379(1.13)  LDD0993  [15]
 LDCM0396  CL125 HEK-293T C420(0.99); C2087(1.14); C379(1.02); C1415(1.11)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C420(1.01); C379(1.01); C1415(1.16); C1522(1.03)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C420(1.04); C2087(0.97); C379(0.96); C1522(1.00)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C420(1.10); C2087(0.95); C379(1.01); C1415(1.00)  LDD1603  [16]
 LDCM0400  CL13 HEK-293T C1522(1.27); C379(1.27)  LDD0998  [15]
 LDCM0401  CL14 HEK-293T C1522(1.01); C379(1.01)  LDD0999  [15]
 LDCM0402  CL15 HEK-293T C1522(1.08); C379(1.08)  LDD1000  [15]
 LDCM0403  CL16 HEK-293T C1522(0.86); C379(0.86)  LDD1001  [15]
 LDCM0404  CL17 HEK-293T C1522(0.87); C379(0.87)  LDD1002  [15]
 LDCM0405  CL18 HEK-293T C1522(1.01); C379(1.01)  LDD1003  [15]
 LDCM0406  CL19 HEK-293T C1522(0.96); C379(0.96)  LDD1004  [15]
 LDCM0407  CL2 HEK-293T C1522(0.91); C379(0.91)  LDD1005  [15]
 LDCM0408  CL20 HEK-293T C1522(0.96); C379(0.96)  LDD1006  [15]
 LDCM0409  CL21 HEK-293T C1522(1.00); C379(1.00)  LDD1007  [15]
 LDCM0410  CL22 HEK-293T C1522(0.91); C379(0.91)  LDD1008  [15]
 LDCM0411  CL23 HEK-293T C1522(1.04); C379(1.04)  LDD1009  [15]
 LDCM0412  CL24 HEK-293T C1522(0.97); C379(0.97)  LDD1010  [15]
 LDCM0413  CL25 HEK-293T C1522(0.88); C379(0.88)  LDD1011  [15]
 LDCM0414  CL26 HEK-293T C1522(0.96); C379(0.96)  LDD1012  [15]
 LDCM0415  CL27 HEK-293T C1522(0.97); C379(0.97)  LDD1013  [15]
 LDCM0416  CL28 HEK-293T C1522(1.04); C379(1.04)  LDD1014  [15]
 LDCM0417  CL29 HEK-293T C1522(1.06); C379(1.06)  LDD1015  [15]
 LDCM0418  CL3 HEK-293T C1522(0.85); C379(0.85)  LDD1016  [15]
 LDCM0419  CL30 HEK-293T C1522(1.00); C379(1.00)  LDD1017  [15]
 LDCM0420  CL31 HEK-293T C1522(0.89); C379(0.89)  LDD1018  [15]
 LDCM0421  CL32 HEK-293T C1522(1.10); C379(1.10)  LDD1019  [15]
 LDCM0422  CL33 HEK-293T C1522(1.15); C379(1.15)  LDD1020  [15]
 LDCM0423  CL34 HEK-293T C1522(1.08); C379(1.08)  LDD1021  [15]
 LDCM0424  CL35 HEK-293T C1522(1.15); C379(1.15)  LDD1022  [15]
 LDCM0425  CL36 HEK-293T C1522(1.10); C379(1.10)  LDD1023  [15]
 LDCM0426  CL37 HEK-293T C1522(1.20); C379(1.20)  LDD1024  [15]
 LDCM0428  CL39 HEK-293T C1522(1.16); C379(1.16)  LDD1026  [15]
 LDCM0429  CL4 HEK-293T C1522(1.03); C379(1.03)  LDD1027  [15]
 LDCM0430  CL40 HEK-293T C1522(1.31); C379(1.31)  LDD1028  [15]
 LDCM0431  CL41 HEK-293T C1522(1.23); C379(1.23)  LDD1029  [15]
 LDCM0432  CL42 HEK-293T C1522(1.12); C379(1.12)  LDD1030  [15]
 LDCM0433  CL43 HEK-293T C1522(1.18); C379(1.18)  LDD1031  [15]
 LDCM0434  CL44 HEK-293T C1522(1.07); C379(1.07)  LDD1032  [15]
 LDCM0435  CL45 HEK-293T C1522(1.09); C379(1.09)  LDD1033  [15]
 LDCM0436  CL46 HEK-293T C1522(1.00); C379(1.00)  LDD1034  [15]
 LDCM0437  CL47 HEK-293T C1522(1.05); C379(1.05)  LDD1035  [15]
 LDCM0438  CL48 HEK-293T C1522(1.18); C379(1.18)  LDD1036  [15]
 LDCM0439  CL49 HEK-293T C1522(1.23); C379(1.23)  LDD1037  [15]
 LDCM0440  CL5 HEK-293T C1522(1.04); C379(1.04)  LDD1038  [15]
 LDCM0441  CL50 HEK-293T C1522(1.32); C379(1.32)  LDD1039  [15]
 LDCM0442  CL51 HEK-293T C1522(1.07); C379(1.07)  LDD1040  [15]
 LDCM0443  CL52 HEK-293T C1522(1.11); C379(1.11)  LDD1041  [15]
 LDCM0444  CL53 HEK-293T C1522(0.99); C379(0.99)  LDD1042  [15]
 LDCM0445  CL54 HEK-293T C1522(1.00); C379(1.00)  LDD1043  [15]
 LDCM0446  CL55 HEK-293T C1522(1.08); C379(1.08)  LDD1044  [15]
 LDCM0447  CL56 HEK-293T C1522(0.96); C379(0.96)  LDD1045  [15]
 LDCM0448  CL57 HEK-293T C1522(1.01); C379(1.01)  LDD1046  [15]
 LDCM0449  CL58 HEK-293T C1522(1.12); C379(1.12)  LDD1047  [15]
 LDCM0450  CL59 HEK-293T C1522(1.22); C379(1.22)  LDD1048  [15]
 LDCM0451  CL6 HEK-293T C1522(0.93); C379(0.93)  LDD1049  [15]
 LDCM0452  CL60 HEK-293T C1522(1.13); C379(1.13)  LDD1050  [15]
 LDCM0453  CL61 HEK-293T C420(1.01); C2087(1.35); C379(1.10); C1415(1.13)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C420(1.18); C379(1.03); C1415(1.17); C1522(0.94)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C420(1.11); C2087(1.06); C379(1.02); C1522(0.93)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C420(1.04); C2087(1.02); C379(1.07); C1415(1.03)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C420(0.97); C2087(1.04); C379(1.01); C1415(1.13)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C420(0.99); C2087(1.17); C379(1.10); C253(1.01)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C420(1.08); C379(1.18); C253(0.91); C1522(0.87)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C420(1.35); C379(1.13); C1415(1.02); C253(1.08)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C2087(1.18); C379(0.97); C1415(1.03); C1522(1.29)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C1522(0.94); C379(0.94)  LDD1060  [15]
 LDCM0463  CL70 HEK-293T C420(1.10); C379(1.12); C1415(1.10); C253(1.15)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C420(1.10); C2087(1.18); C379(1.09); C1415(1.08)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C420(1.33); C2087(1.14); C379(1.13); C1522(1.24)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C420(0.93); C2087(1.78); C379(1.00); C1415(1.09)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C420(0.98); C379(0.93); C1415(1.06); C1522(0.97)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C420(1.14); C2087(0.91); C379(1.09); C1415(1.03)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C420(0.91); C2087(0.97); C379(1.01); C1415(0.93)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C420(1.01); C2087(1.00); C379(1.00); C253(1.11)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C420(1.06); C379(1.10); C253(0.95); C1522(1.01)  LDD1675  [16]
 LDCM0473  CL8 HEK-293T C420(0.96); C379(1.03); C1415(0.88); C253(1.12)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C420(1.24); C379(1.06); C1415(1.04); C253(1.20)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C2087(0.91); C379(1.07); C1415(1.06); C1522(1.24)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C420(1.03); C379(1.12); C1415(1.07); C253(0.98)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C420(1.11); C2087(0.96); C379(1.03); C1415(1.07)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C420(1.18); C2087(0.92); C379(1.12); C1522(0.97)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C420(1.10); C2087(0.95); C379(1.01); C1415(1.09)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C420(1.06); C379(1.02); C1415(1.14); C1522(0.93)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C420(0.98); C2087(0.94); C379(1.01); C1522(0.93)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C420(1.19); C2087(0.90); C379(1.03); C1415(1.06)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C420(1.03); C2087(1.03); C379(1.02); C1415(1.09)  LDD1686  [16]
 LDCM0484  CL9 HEK-293T C2087(0.84); C379(1.01); C1415(1.17); C1522(1.13)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C420(0.82); C2087(1.02); C379(0.89); C253(0.75)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C1522(1.01); C379(1.01)  LDD1084  [15]
 LDCM0487  CL92 HEK-293T C1522(1.12); C379(1.12)  LDD1085  [15]
 LDCM0488  CL93 HEK-293T C1522(0.99); C379(0.99)  LDD1086  [15]
 LDCM0489  CL94 HEK-293T C1522(0.95); C379(0.95)  LDD1087  [15]
 LDCM0490  CL95 HEK-293T C1522(1.11); C379(1.11)  LDD1088  [15]
 LDCM0491  CL96 HEK-293T C1522(1.18); C379(1.18)  LDD1089  [15]
 LDCM0492  CL97 HEK-293T C1522(1.14); C379(1.14)  LDD1090  [15]
 LDCM0493  CL98 HEK-293T C1522(1.05); C379(1.05)  LDD1091  [15]
 LDCM0494  CL99 HEK-293T C1522(1.16); C379(1.16)  LDD1092  [15]
 LDCM0495  E2913 HEK-293T C420(1.02); C2087(0.96); C379(1.04); C1522(0.91)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C420(0.94); C1879(0.92)  LDD1702  [2]
 LDCM0204  EV-97 T cell C379(14.56)  LDD0525  [17]
 LDCM0468  Fragment33 HEK-293T C420(1.03); C2087(0.92); C379(0.96); C1522(0.85)  LDD1671  [16]
 LDCM0427  Fragment51 HEK-293T C1522(1.05); C379(1.05)  LDD1025  [15]
 LDCM0022  KB02 HEK-293T C420(0.91); C2087(0.98); C379(0.97); C1649(0.94)  LDD1492  [16]
 LDCM0023  KB03 Jurkat C1879(9.26)  LDD0209  [5]
 LDCM0024  KB05 COLO792 C1985(3.80)  LDD3310  [18]
 LDCM0006  Micheliolide M9-ENL1 4.00  LDD0050  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1536(0.67)  LDD2137  [2]
 LDCM0112  W16 Hep-G2 C379(0.57)  LDD0239  [12]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Caffeine Small molecular drug DB00201
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Decavanadate Small molecular drug D06KHR
Inositol 2,4,5-trisphosphate Small molecular drug D06YZB

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840