Details of the Target

General Information of Target

Target ID LDTP00890
Target Name S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1)
Gene Name AHCYL1
Gene ID 10768
Synonyms
DCAL; IRBIT; XPVKONA; S-adenosylhomocysteine hydrolase-like protein 1; DC-expressed AHCY-like molecule; IP(3)Rs binding protein released with IP(3); IRBIT; Putative adenosylhomocysteinase 2; S-adenosyl-L-homocysteine hydrolase 2; AdoHcyase 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKQIQFADDMQEFTKFPTKTGR
RSLSRSISQSSTDSYSSAASYTDSSDDEVSPREKQQTNSKGSSNFCVKNIKQAEFGRREI
EIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQCRWSACNIY
STQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHWVYKK
YPNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDG
LKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGFRVVKL
NEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVR
SQVDHVIWPDGKRVVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQD
VYLLPKKMDEYVASLHLPSFDAHLTELTDDQAKYLGLNKNGPFKPNYYRY
Target Bioclass
Enzyme
Family
Adenosylhomocysteinase family
Subcellular location
Endoplasmic reticulum
Function
Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria. Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1. When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid. Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion. Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation. Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2. Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition. May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state. Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression. In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity.
Uniprot ID
O43865
Ensemble ID
ENST00000359172.3
HGNC ID
HGNC:344
ChEMBL ID
CHEMBL3751646

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 SNV: p.S400A DBIA    Probe Info 
HCT15 SNV: p.R410C DBIA    Probe Info 
HEC1 SNV: p.R410H DBIA    Probe Info 
HEC1B SNV: p.S74R .
HT29 SNV: p.I393L DBIA    Probe Info 
IM95 Deletion: p.E140RfsTer9 DBIA    Probe Info 
JURKAT SNV: p.H235Q .
KYSE410 SNV: p.A329S DBIA    Probe Info 
MV411 SNV: p.C392Y; p.I393L DBIA    Probe Info 
NCIH1048 SNV: p.C392Y; p.I393L DBIA    Probe Info 
NCIH1975 SNV: p.C392Y .
SW756 SNV: p.S181Ter DBIA    Probe Info 
TOV21G SNV: p.R410S DBIA    Probe Info 
U2OS SNV: p.Q49Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y514(20.00); Y491(7.58)  LDD0257  [2]
STPyne
 Probe Info  		K359(9.18)  LDD0277  [3]
ONAyne
 Probe Info  		K57(10.00)  LDD0275  [3]
OPA-S-S-alkyne
 Probe Info  		K302(1.25)  LDD3494  [4]
Probe 1
 Probe Info  		Y28(16.69); Y241(41.97); Y482(8.85); Y514(25.66)  LDD3495  [5]
BTD
 Probe Info  		C106(1.52)  LDD1700  [6]
MCL-14
 Probe Info  		2.00  LDD0050  [7]
AHL-Pu-1
 Probe Info  		C272(2.12)  LDD0169  [8]
HHS-475
 Probe Info  		Y491(0.75); Y514(0.90); Y527(0.95)  LDD0264  [9]
HHS-465
 Probe Info  		Y514(10.00)  LDD2237  [10]
DBIA
 Probe Info  		C292(0.96)  LDD0078  [11]
5E-2FA
 Probe Info  		N.A.  LDD2235  [12]
ATP probe
 Probe Info  		K284(0.00); K286(0.00); K267(0.00); K270(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C373(0.00); C106(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
Lodoacetamide azide
 Probe Info  		C215(0.00); C211(0.00); C106(0.00); C272(0.00)  LDD0037  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [16]
TFBX
 Probe Info  		N.A.  LDD0027  [16]
WYneN
 Probe Info  		N.A.  LDD0021  [17]
WYneO
 Probe Info  		N.A.  LDD0022  [17]
ENE
 Probe Info  		N.A.  LDD0006  [17]
IPM
 Probe Info  		C293(0.00); C292(0.00)  LDD0005  [17]
NHS
 Probe Info  		N.A.  LDD0010  [17]
PF-06672131
 Probe Info  		N.A.  LDD0017  [18]
VSF
 Probe Info  		N.A.  LDD0007  [17]
Phosphinate-6
 Probe Info  		C293(0.00); C272(0.00)  LDD0018  [19]
Acrolein
 Probe Info  		N.A.  LDD0217  [20]
W1
 Probe Info  		C292(0.00); C293(0.00)  LDD0236  [21]
AOyne
 Probe Info  		15.00  LDD0443  [22]
NAIA_5
 Probe Info  		C272(0.00); C215(0.00); C106(0.00); C211(0.00)  LDD2223  [23]
HHS-482
 Probe Info  		Y491(1.04)  LDD2239  [10]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		6.54  LDD1740  [24]
C087
 Probe Info  		7.84  LDD1779  [24]
C166
 Probe Info  		7.16  LDD1846  [24]
C174
 Probe Info  		5.31  LDD1854  [24]
C187
 Probe Info  		15.24  LDD1865  [24]
C210
 Probe Info  		49.18  LDD1884  [24]
C216
 Probe Info  		5.62  LDD1890  [24]
C218
 Probe Info  		11.00  LDD1892  [24]
C258
 Probe Info  		5.21  LDD1931  [24]
C269
 Probe Info  		5.70  LDD1939  [24]
C403
 Probe Info  		14.22  LDD2061  [24]
C420
 Probe Info  		11.16  LDD2075  [24]
FFF probe11
 Probe Info  		20.00  LDD0471  [25]
FFF probe13
 Probe Info  		8.01  LDD0476  [25]
FFF probe3
 Probe Info  		20.00  LDD0464  [25]
FFF probe6
 Probe Info  		17.03  LDD0467  [25]
STS-1
 Probe Info  		N.A.  LDD0136  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C106(0.92)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C106(1.01); C327(0.96)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C106(1.71)  LDD2152  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C272(2.12)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C106(2.60); C211(1.03); C272(1.11); C292(0.80)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C211(0.94); C272(0.87); C292(0.62); C293(0.64)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C106(0.38); C211(0.59); C292(1.09); C293(1.23)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C106(0.43); C211(0.66); C292(1.03); C293(1.11)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C106(0.58); C211(0.67); C292(0.95); C293(1.14)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C106(0.38); C211(0.53); C292(1.06); C293(1.18)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C106(0.61); C211(0.77); C292(0.89); C293(1.00)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C106(0.44); C211(0.63); C292(1.04); C293(1.13)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C106(0.45); C211(0.65); C292(1.13); C293(1.27)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C106(0.53); C211(0.63); C292(1.08); C293(1.13)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C106(0.40); C211(0.92); C292(1.17); C293(1.34)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C106(0.70); C211(0.89); C292(1.00); C293(1.06)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C211(0.96); C272(0.91); C292(0.59); C293(0.67)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C106(0.43); C211(0.66); C292(1.07); C293(1.18)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C106(0.42); C211(0.66); C292(1.14); C293(1.24)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C106(0.44); C211(0.58); C292(1.10); C293(1.23)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C106(1.19); C211(1.11); C272(0.99); C292(1.11)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C106(1.03); C211(1.05); C272(1.01); C292(1.00)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C106(0.84); C211(0.95); C272(0.94); C292(0.93)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C106(1.16); C211(1.18); C272(1.40); C292(0.96)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C106(1.02); C211(0.97); C272(1.01); C292(0.93)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C106(1.12); C211(0.94); C272(1.30); C292(0.97)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C106(1.44); C211(1.01); C272(0.97); C292(0.96)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C211(0.97); C272(0.79); C292(0.75); C293(0.85)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C106(1.29); C211(1.06); C272(1.31); C292(1.15)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C106(1.18); C211(0.93); C272(1.03); C292(0.99)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C106(1.34); C211(0.95); C272(1.25); C292(0.94)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C106(1.07); C211(0.96); C272(0.90); C292(1.05)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C106(1.34); C211(1.04); C272(1.15); C292(0.95)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C106(1.40); C211(1.07); C272(1.27); C292(1.07)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C106(1.35); C211(0.98); C272(1.36); C292(1.05)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C106(1.19); C211(1.00); C272(1.37); C292(0.90)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C106(0.95); C211(2.46); C272(1.11); C292(2.14)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C106(0.94); C211(2.52); C272(1.16); C292(1.83)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C106(0.66); C211(1.61); C272(1.22); C292(2.02)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C106(0.66); C211(1.33); C272(1.01); C292(1.43)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C106(0.54); C211(1.20); C272(1.18); C292(2.12)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C106(0.63); C211(1.39); C272(1.36); C292(1.70)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C106(0.44); C211(0.79); C272(1.11); C292(1.70)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C106(0.75); C211(1.47); C272(0.99); C292(1.78)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C106(0.71); C211(1.25); C272(1.34); C292(2.12)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C106(0.60); C211(1.39); C272(1.09); C292(1.76)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C106(0.37); C211(0.71); C272(1.26); C292(2.70)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C106(0.46); C211(0.85); C272(1.25); C292(2.23)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C211(0.88); C272(0.89); C292(0.74); C293(0.79)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C106(0.36); C211(0.65); C272(1.18); C292(1.87)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C106(0.38); C211(0.64); C272(1.25); C292(1.82)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C106(0.47); C211(0.90); C272(1.42); C292(1.79)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C106(0.68); C272(1.13); C292(1.03); C293(1.15)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C293(0.93); C272(0.97); C106(0.97); C292(1.07)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C272(1.00); C292(1.00); C293(1.02); C106(1.10)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C106(0.67); C293(1.00); C292(1.01); C272(1.10)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C292(0.90); C272(0.91); C293(1.03); C106(1.07)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C106(0.64); C292(0.91); C293(1.09); C272(2.70)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C106(0.70); C292(0.99); C293(1.22); C272(1.58)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C211(0.80); C272(0.87); C292(0.94); C293(1.03)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C106(0.65); C292(0.98); C272(1.02); C293(1.23)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C106(0.76); C272(0.91); C293(1.02); C292(1.22)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C106(0.62); C292(0.89); C272(1.06); C293(1.36)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C106(0.54); C292(1.04); C293(1.12); C272(1.40)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C106(0.64); C272(0.91); C292(0.95); C293(0.98)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C106(0.57); C272(1.06); C292(1.11); C293(0.95)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C106(0.69); C272(0.95); C292(1.03); C293(1.04)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C106(0.63); C272(0.97); C292(0.96); C293(1.04)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C373(0.79); C292(0.90); C293(0.97); C272(1.00)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C392(0.34); C395(0.34); C373(0.47); C211(0.82)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C373(0.74); C292(0.83); C293(1.01); C272(1.02)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C392(0.71); C395(0.71); C292(0.74); C211(0.83)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C373(0.71); C317(0.95); C272(1.02); C211(1.16)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C373(0.66); C392(0.76); C395(0.76); C292(0.94)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C373(0.79); C317(0.95); C272(1.07); C211(1.10)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C373(0.69); C392(0.98); C395(0.98); C211(0.98)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C373(0.91); C211(1.00); C272(1.01); C317(1.08)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C272(0.80); C211(0.91); C392(0.93); C395(0.93)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C392(0.57); C395(0.57); C326(0.66); C327(0.66)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C373(0.77); C326(0.78); C327(0.78); C211(0.84)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C392(0.58); C395(0.58); C326(0.70); C327(0.70)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C326(0.50); C327(0.50); C392(0.60); C395(0.60)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C292(0.72); C293(0.73); C211(1.01); C392(1.12)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C326(0.52); C327(0.52); C392(0.57); C395(0.57)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C326(0.62); C327(0.62); C392(0.64); C395(0.64)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C392(0.43); C395(0.43); C326(0.46); C327(0.46)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C211(0.59); C392(0.76); C395(0.76); C292(0.87)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C326(0.55); C327(0.55); C373(0.79); C392(0.81)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C293(0.73); C272(0.91); C292(0.92); C373(1.18)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C293(0.83); C272(0.99); C292(1.04); C326(1.08)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C293(0.80); C292(0.99); C272(0.99); C373(1.04)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C326(0.82); C327(0.82); C373(0.94); C272(1.03)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C326(0.91); C327(0.91); C293(0.93); C373(0.98)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C292(0.73); C293(0.77); C211(1.02); C272(1.11)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C373(0.70); C272(0.97); C292(0.99); C293(1.00)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C272(0.91); C392(0.96); C395(0.96); C292(1.01)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C373(0.76); C292(1.03); C272(1.07); C326(1.09)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C373(0.92); C272(1.05); C292(1.09); C326(1.14)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C272(0.84); C373(0.89); C292(1.00); C392(1.44)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C373(0.80); C272(0.89); C292(1.01); C293(1.37)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C326(0.33); C327(0.33); C211(0.42); C392(0.71)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C326(0.64); C327(0.64); C392(0.77); C395(0.77)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C326(0.40); C327(0.40); C211(0.51); C392(0.75)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C326(0.33); C327(0.33); C211(0.42); C392(0.52)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C293(0.79); C292(0.81); C272(1.12); C211(1.13)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C326(0.34); C327(0.34); C211(0.46); C373(0.74)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C326(0.33); C327(0.33); C211(0.42); C392(0.91)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C326(0.36); C327(0.36); C211(0.53); C292(0.90)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C373(0.77); C211(0.79); C392(0.88); C395(0.88)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C326(0.39); C327(0.39); C211(0.53); C392(0.66)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C373(0.73); C293(0.99); C211(1.13); C292(1.13)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C326(0.67); C327(0.67); C373(0.74); C211(0.74)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C373(0.79); C392(0.85); C395(0.85); C272(0.89)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C373(0.69); C326(0.70); C327(0.70); C272(0.80)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C373(0.62); C392(0.93); C395(0.93); C272(0.98)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C326(0.71); C327(0.71); C392(0.75); C395(0.75)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C373(0.85); C272(0.99); C211(1.09); C392(1.24)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C373(0.85); C272(0.93); C392(1.08); C395(1.08)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C373(0.60); C293(1.01); C272(1.03); C292(1.11)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C373(0.90); C272(0.98); C392(1.15); C395(1.15)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C373(0.68); C293(0.99); C272(1.02); C292(1.04)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C392(0.71); C395(0.71); C326(0.91); C327(0.91)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C392(0.72); C395(0.72); C272(0.82); C373(0.94)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C373(0.61); C392(0.62); C395(0.62); C272(1.03)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C211(0.54); C317(0.66); C392(0.77); C395(0.77)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C211(0.68); C317(0.77); C272(0.87); C292(0.97)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C392(0.83); C395(0.83); C211(0.83); C292(0.85)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C317(0.48); C211(0.50); C326(0.78); C327(0.78)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C211(0.75); C272(0.89); C292(0.98); C317(1.00)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C211(0.55); C317(0.56); C326(0.82); C327(0.82)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C317(0.55); C211(0.56); C326(0.71); C327(0.71)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C272(0.87); C292(0.90); C211(0.95); C317(0.95)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C317(0.53); C211(0.55); C293(0.82); C326(0.87)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C272(0.86); C293(0.89); C211(0.89); C317(0.89)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C317(0.58); C211(0.62); C326(0.81); C327(0.81)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C211(0.64); C317(0.71); C272(0.90); C326(0.93)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C211(0.49); C317(0.53); C326(0.85); C327(0.85)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C326(0.85); C327(0.85); C292(0.87); C211(0.88)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C293(0.80); C211(0.84); C272(0.92); C292(0.95)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C211(0.50); C317(0.60); C272(0.88); C292(0.94)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C211(0.63); C272(0.88); C293(0.99); C292(1.00)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C392(0.27); C395(0.27); C211(0.74); C292(0.81)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C392(0.24); C395(0.24); C211(0.67); C106(0.75)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C392(0.31); C395(0.31); C106(0.70); C211(0.75)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C392(0.43); C395(0.43); C211(0.64); C106(0.71)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C106(0.55); C211(0.67); C392(0.73); C395(0.73)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C106(0.54); C211(0.57); C392(0.75); C395(0.75)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C106(0.59); C392(0.62); C395(0.62); C211(0.72)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C211(0.54); C106(0.65); C293(0.86); C292(0.89)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C392(0.28); C395(0.28); C293(0.85); C292(0.94)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C392(0.34); C395(0.34); C106(0.69); C292(0.83)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C392(0.37); C395(0.37); C106(0.75); C211(0.81)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C392(0.33); C395(0.33); C293(0.82); C292(0.96)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C106(0.43); C211(0.46); C292(0.93); C293(0.96)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C392(0.52); C395(0.52); C293(0.78); C292(0.93)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C392(0.28); C395(0.28); C211(0.49); C106(0.61)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C326(0.29); C327(0.29); C106(0.36); C392(0.41)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C392(0.32); C395(0.32); C326(0.33); C327(0.33)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C106(0.45)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C106(0.90)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C211(0.81); C272(0.99); C292(0.73); C293(0.82)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C292(0.75); C293(0.79); C272(0.92); C211(0.94)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C392(0.57); C395(0.57); C326(0.70); C327(0.70)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 11.51  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C292(0.96)  LDD0078  [11]
 LDCM0498  BS-3668 MDA-MB-231 C272(0.59)  LDD2091  [6]
 LDCM0630  CCW28-3 231MFP C272(1.18)  LDD2214  [27]
 LDCM0108  Chloroacetamide HeLa C106(0.00); C395(0.00)  LDD0222  [20]
 LDCM0367  CL1 HCT 116 C392(0.72); C395(0.72); C292(0.85); C211(0.91)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C292(0.66); C392(0.68); C395(0.68); C293(0.92)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C292(0.75); C293(0.82); C211(0.86); C272(1.11)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C292(0.75); C293(0.77); C392(0.92); C395(0.92)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C292(0.62); C293(0.66); C392(0.68); C395(0.68)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C293(0.64); C292(0.65); C272(0.97); C211(1.04)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C392(0.73); C395(0.73); C211(0.79); C292(0.88)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C373(0.62); C392(0.77); C395(0.77); C211(0.80)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C373(0.45); C392(0.48); C395(0.48); C211(0.77)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C392(0.43); C395(0.43); C373(0.48); C211(0.88)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C392(0.31); C395(0.31); C373(0.44); C272(0.96)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C373(0.62); C392(0.80); C395(0.80); C211(0.88)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C292(0.69); C211(0.82); C293(0.89); C272(0.93)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C373(0.45); C392(0.57); C395(0.57); C211(0.88)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C211(0.55); C373(0.62); C392(0.78); C395(0.78)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C392(0.66); C395(0.66); C211(0.84); C292(0.85)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C326(0.46); C327(0.46); C392(0.50); C395(0.50)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C326(0.37); C327(0.37); C373(0.43); C392(0.65)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C326(0.54); C327(0.54); C392(0.54); C395(0.54)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C326(0.63); C327(0.63); C392(0.73); C395(0.73)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C373(0.73); C326(0.80); C327(0.80); C392(0.84)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C373(0.94); C272(1.01); C293(1.04); C292(1.15)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C373(0.85); C272(0.97); C293(1.10); C292(1.17)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C292(0.72); C211(0.91); C293(0.96); C272(1.04)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C272(1.00); C392(1.04); C395(1.04); C326(1.05)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C211(0.65); C326(0.69); C327(0.69); C373(0.81)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C326(0.53); C327(0.53); C211(0.58); C392(0.82)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C326(0.59); C327(0.59); C392(0.65); C395(0.65)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C326(0.46); C327(0.46); C211(0.58); C392(0.65)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C392(0.76); C395(0.76); C326(0.80); C327(0.80)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C326(0.77); C327(0.77); C373(0.83); C272(0.88)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C272(1.01); C373(1.05); C326(1.05); C327(1.05)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C373(0.67); C392(0.71); C395(0.71); C326(0.96)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C392(0.92); C395(0.92); C211(0.93); C292(0.94)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C292(0.87); C272(0.96); C293(1.02); C211(1.05)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C272(0.83); C211(0.90); C292(0.99); C293(1.08)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C373(0.75); C272(1.02); C293(1.14); C292(1.15)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C373(0.61); C293(0.72); C292(0.89)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C373(0.70); C293(0.75); C292(0.88)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C373(0.89); C293(0.91); C292(1.01)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C392(0.83); C395(0.83); C292(0.92); C211(0.94)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C373(0.54); C293(0.92); C292(1.02)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C373(0.28); C293(0.71); C292(0.89)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C373(0.50); C292(1.04); C293(1.16)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C373(0.61); C292(1.13); C293(1.68)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C373(0.33); C293(0.98); C292(0.99)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C292(0.98); C293(0.96); C373(0.39)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C292(1.02); C293(0.99); C373(0.49)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C292(1.06); C293(1.00); C373(0.69)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C292(0.98); C293(0.84); C373(0.56)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C292(1.10); C293(1.12); C373(0.43)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C211(0.88); C272(0.91); C292(0.86); C293(0.98)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C292(0.95); C293(0.76); C373(0.49)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C106(0.74); C272(0.92); C292(0.98); C293(0.90)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C106(0.70); C272(1.06); C292(1.13); C293(1.15)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C106(0.69); C272(1.04); C292(1.08); C293(1.06)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C106(0.54); C272(1.05); C292(1.11); C293(1.09)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C106(0.42); C272(1.04); C292(1.23); C293(1.19)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C106(0.45); C272(0.92); C292(1.16); C293(1.25)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C106(0.32); C272(0.94); C292(1.24); C293(1.22)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C106(0.41); C272(1.02); C292(1.17); C293(1.12)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C211(0.82); C272(0.85); C292(0.98); C293(1.16)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C106(0.54); C272(0.93); C292(1.04); C293(1.05)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C106(0.52); C272(0.92); C292(1.19); C293(1.02)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C106(0.31); C272(0.97); C292(1.10); C293(1.07)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C106(0.41); C272(0.99); C292(1.12); C293(1.09)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C106(0.54); C272(0.98); C292(1.19); C293(1.17)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C106(0.43); C272(0.90); C292(1.22); C293(1.24)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C272(1.12); C292(1.08); C293(1.23); C392(1.20)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C272(1.06); C292(1.10); C293(1.14); C392(0.90)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C272(1.00); C292(1.12); C293(1.17); C392(0.94)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C272(1.21); C292(1.13); C293(1.25); C392(0.93)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C211(1.06); C272(0.91); C292(0.82); C293(0.94)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C272(0.96); C292(1.13); C293(1.25); C392(0.86)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C272(0.97); C292(1.15); C293(1.26); C392(1.12)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C272(1.19); C292(1.03); C293(1.27); C392(0.92)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C272(0.83); C292(1.16); C293(1.16); C392(0.75)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C272(1.00); C292(1.06); C293(1.17); C392(0.87)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C272(0.95); C292(0.99); C293(1.04); C392(0.92)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C272(1.00); C292(1.11); C293(1.07); C392(0.96)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C272(1.03); C292(1.15); C293(1.13); C392(0.95)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C272(1.17); C292(1.15); C293(1.19); C392(0.87)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C272(1.07); C292(1.06); C293(1.17); C392(0.87)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C211(0.88); C272(0.97); C292(0.79); C293(0.97)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C272(1.05); C292(1.12); C293(1.13); C392(0.90)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C292(0.85); C293(1.19); C317(0.73); C392(1.17)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C292(0.81); C293(0.94); C317(0.79); C392(0.67)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C292(0.96); C293(1.32); C317(0.75); C392(0.68)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C292(0.76); C293(0.93); C317(0.84); C392(0.57)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C292(0.85); C293(0.98); C317(1.20); C392(0.78)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C292(0.86); C293(1.05); C317(1.04); C392(0.47)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C292(0.85); C293(0.91); C317(1.15); C392(0.61)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C292(1.20); C293(1.41); C317(0.57); C392(0.63)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C292(0.92); C293(1.08); C317(0.49); C392(1.16)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C211(0.85); C272(1.00); C292(0.66); C293(0.87)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C292(1.09); C293(1.25); C317(0.71); C392(1.39)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C292(0.97); C293(1.18); C317(0.61); C392(0.57)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C292(1.03); C293(1.26); C317(0.51); C392(0.61)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C292(0.96); C293(1.04); C317(0.65); C392(0.63)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C292(1.02); C293(1.15); C317(0.71); C392(0.92)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C272(0.79); C292(1.30); C293(1.26); C392(1.04)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C272(0.77); C292(1.54); C293(1.46); C392(1.12)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C272(0.84); C292(1.10); C293(1.09); C392(1.12)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C272(0.87); C292(1.15); C293(1.11); C392(0.79)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C211(0.86); C272(0.84); C292(0.90); C293(1.02)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C272(0.95); C292(1.19); C293(1.29); C392(1.21)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C272(0.92); C292(1.26); C293(1.24); C392(1.30)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C272(0.82); C292(1.10); C293(0.98); C392(1.02)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C272(0.85); C292(0.97); C293(1.06); C392(0.65)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C272(0.88); C292(0.99); C293(1.05); C392(0.72)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C272(0.88); C292(1.19); C293(1.20); C392(0.94)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C272(0.81); C292(1.23); C293(1.20); C392(0.93)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C272(0.94); C292(1.08); C293(1.14); C392(0.96)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C272(0.92); C292(1.24); C293(1.18); C392(0.98)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C272(0.80); C292(1.14); C293(1.17); C392(0.80)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C211(0.94); C272(0.96); C292(1.02); C293(1.15)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C272(0.90); C292(1.07); C293(1.15); C392(1.10)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C106(0.63); C211(0.72); C272(1.25); C292(0.94)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C106(1.01); C211(0.78); C272(1.14); C292(1.11)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C106(1.36); C211(1.06); C272(0.95); C292(0.88)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C106(1.75); C211(1.10); C272(0.89); C292(0.81)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C106(0.87); C211(0.74); C272(1.09); C292(0.90)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C106(0.88); C211(0.85); C272(1.28); C292(0.87)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C106(0.84); C211(0.86); C272(1.14); C292(0.89)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C106(1.39); C211(0.72); C272(1.13); C292(0.81)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C106(1.99); C211(0.85); C272(1.10); C292(0.76)  LDD0811  [11]
 LDCM0191  Compound 21 HEK-293T 12.12  LDD0508  [25]
 LDCM0192  Compound 35 HEK-293T 5.01  LDD0509  [25]
 LDCM0193  Compound 36 HEK-293T 8.40  LDD0511  [25]
 LDCM0634  CY-0357 Hep-G2 C272(1.15)  LDD2228  [23]
 LDCM0495  E2913 HEK-293T C106(0.96); C373(0.95)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C292(14.50); C293(6.29); C272(2.71); C373(1.47)  LDD1702  [6]
 LDCM0625  F8 Ramos C272(1.28)  LDD2187  [29]
 LDCM0572  Fragment10 Ramos C272(1.23)  LDD2189  [29]
 LDCM0573  Fragment11 Ramos C272(0.00)  LDD2190  [29]
 LDCM0574  Fragment12 Ramos C272(0.86)  LDD2191  [29]
 LDCM0575  Fragment13 Ramos C272(0.96)  LDD2192  [29]
 LDCM0576  Fragment14 Ramos C272(0.65)  LDD2193  [29]
 LDCM0579  Fragment20 Ramos C272(0.69)  LDD2194  [29]
 LDCM0580  Fragment21 Ramos C272(0.97)  LDD2195  [29]
 LDCM0582  Fragment23 Ramos C272(1.14)  LDD2196  [29]
 LDCM0578  Fragment27 Ramos C272(1.03)  LDD2197  [29]
 LDCM0586  Fragment28 Ramos C272(0.78)  LDD2198  [29]
 LDCM0588  Fragment30 Ramos C272(1.19)  LDD2199  [29]
 LDCM0589  Fragment31 Ramos C272(0.91)  LDD2200  [29]
 LDCM0590  Fragment32 Ramos C272(0.74)  LDD2201  [29]
 LDCM0468  Fragment33 HCT 116 C292(1.01); C293(1.09); C317(0.71); C392(0.69)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C272(0.81)  LDD2203  [29]
 LDCM0566  Fragment4 Ramos C272(0.85)  LDD2184  [29]
 LDCM0427  Fragment51 HCT 116 C106(0.52); C272(0.85); C292(1.00); C293(0.96)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C272(1.13)  LDD2204  [29]
 LDCM0614  Fragment56 Ramos C272(1.22)  LDD2205  [29]
 LDCM0569  Fragment7 Ramos C272(1.31)  LDD2186  [29]
 LDCM0571  Fragment9 Ramos C272(0.98)  LDD2188  [29]
 LDCM0116  HHS-0101 DM93 Y491(0.75); Y514(0.90); Y527(0.95)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y514(0.84); Y491(0.94); Y527(0.97)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y491(0.77); Y527(0.77); Y514(0.78)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y491(0.53); Y527(0.85); Y514(0.86)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y491(0.76); Y514(0.93); Y527(1.75)  LDD0268  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [20]
 LDCM0022  KB02 HCT 116 C392(2.79); C395(2.79); C211(1.79); C292(3.18)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C392(2.79); C395(2.79); C211(3.19); C292(2.33)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C392(2.50); C395(2.50); C211(2.50); C292(2.43)  LDD0082  [11]
 LDCM0006  Micheliolide M9-ENL1 2.00  LDD0050  [7]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C106(0.47)  LDD2089  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C106(0.54)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C106(1.05)  LDD2097  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C106(0.81)  LDD2099  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C106(1.08)  LDD2101  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C106(0.63)  LDD2109  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C106(1.00)  LDD2115  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C106(0.89)  LDD2118  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C106(0.89)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C106(0.57); C272(0.32)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C106(0.94); C327(0.66)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C106(0.68); C272(0.31)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C106(0.99); C327(1.17)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C106(0.73); C272(0.23)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C106(1.07)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C106(0.91)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C106(1.01)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C106(0.56)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C106(1.14)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C106(1.25); C327(1.05)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C106(1.11); C327(1.00)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C106(1.52)  LDD1700  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C106(1.02)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C106(3.49)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C106(1.04)  LDD2146  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C272(0.62)  LDD2150  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C272(0.80)  LDD2206  [30]
 LDCM0628  OTUB2-COV-1 HEK-293T C272(0.70); C272(0.07)  LDD2207  [30]
 LDCM0021  THZ1 HCT 116 C292(1.02); C293(1.02)  LDD2173  [11]
 LDCM0112  W16 Hep-G2 C292(0.73); C293(0.73)  LDD0239  [21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) Adenosylhomocysteinase family O43865
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
E3 SUMO-protein ligase PIAS4 (PIAS4) PIAS family Q8N2W9
Serine/threonine-protein phosphatase with EF-hands 1 (PPEF1) PPP phosphatase family O14829
26S proteasome non-ATPase regulatory subunit 9 (PSMD9) Proteasome subunit p27 family O00233
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
GTP-binding protein GEM (GEM) RGK family P55040
Tryptophan 2,3-dioxygenase (TDO2) Tryptophan 2,3-dioxygenase family P48775
Josephin-2 (JOSD2) . Q8TAC2
Protein MFI (MFI) . Q8NCR3
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) InsP3 receptor family Q14643
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) Mitochondrial carrier (TC 2.A.29) family Q02978
Solute carrier family 23 member 1 (SLC23A1) Nucleobase:cation symporter-2 (NCS2) family Q9UHI7
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 165 (ZNF165) Krueppel C2H2-type zinc-finger protein family P49910
Homeobox protein MOX-2 (MEOX2) . P50222
Transcription factor SOX-30 (SOX30) . O94993
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 10 (BCL2L10) Bcl-2 family Q9HD36
Cyclin-dependent kinase 4 inhibitor C (CDKN2C) CDKN2 cyclin-dependent kinase inhibitor family P42773
Hemoglobin subunit theta-1 (HBQ1) Globin family P09105
Heat shock 70 kDa protein 6 (HSPA6) Heat shock protein 70 family P17066
Protein HEXIM2 (HEXIM2) HEXIM family Q96MH2
NXPE family member 1 (NXPE1) NXPE family Q8N323
Periplakin (PPL) Plakin or cytolinker family O60437
BH3-interacting domain death agonist (BID) . P55957
Melanoma-associated antigen 2 (MAGEA2; MAGEA2B) . P43356
Uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA) . Q9BZF9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
24 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
27 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
30 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.