Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C269  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 48 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01803  Adenosine deaminase (ADA) 84.4
 LDTP06810  Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) 64.9
 LDTP09225  sn-1-specific diacylglycerol lipase ABHD11 (ABHD11) 46.2
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 28.4
 LDTP11835  Diphthine methyl ester synthase (DPH5) 25.3
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 25.1
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 21.0
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 17.0
 LDTP02359  Heme oxygenase 1 (HMOX1) 16.6
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) 14.7
 LDTP04689  Adenosine kinase (ADK) 11.2
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 9.9
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 9.7
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 9.1
 LDTP02796  Nucleoside diphosphate kinase A (NME1) 9.0
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 9.0
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 9.0
 LDTP06227  Prostaglandin reductase 1 (PTGR1) 8.9
 LDTP03540  Heme oxygenase 2 (HMOX2) 8.8
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 7.7
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 7.7
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 7.5
 LDTP07525  Protein arginine N-methyltransferase 9 (PRMT9) 7.0
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 6.9
 LDTP12415  Adenosine 5'-monophosphoramidase HINT3 (HINT3) 6.7
 LDTP03394  Ceramide synthase 1 (CERS1) 6.7
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 6.5
 LDTP03816  Oxidized purine nucleoside triphosphate hydrolase (NUDT1) 6.5
 LDTP07577  Serine/threonine-protein kinase ULK3 (ULK3) 6.5
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 6.4
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 6.3
 LDTP04581  Holocytochrome c-type synthase (HCCS) 6.2
 LDTP15132  2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 (OGFOD3) 6.1
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 6.1
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 6.1
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 6.0
 LDTP09095  Diacylglycerol lipase-beta (DAGLB) 6.0
 LDTP05795  Nucleoside diphosphate kinase 3 (NME3) 6.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 6.0
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 5.9
 LDTP17305  Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) 5.9
 LDTP03787  Choline kinase alpha (CHKA) 5.9
 LDTP00886  Nardilysin (NRDC) 5.9
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 5.8
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 5.7
 LDTP04925  Pterin-4-alpha-carbinolamine dehydratase (PCBD1) 5.7
 LDTP00890  S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) 5.7
 LDTP10349  DCN1-like protein 1 (DCUN1D1) 5.6
Transporter and channel
Click to Show/Hide to Show 27 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07667  Transmembrane protein 205 (TMEM205) 30.5
 LDTP08881  Transmembrane protein 199 (TMEM199) 25.1
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 24.6
 LDTP05900  Metaxin-1 (MTX1) 20.8
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 20.8
 LDTP15948  Transmembrane protein 126A (TMEM126A) 13.6
 LDTP01804  ATP synthase subunit a (MT-ATP6) 11.7
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 11.0
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 10.9
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 10.8
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 10.1
 LDTP20002  Transmembrane protein 160 (TMEM160) 10.1
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 9.8
 LDTP07236  Protein GPR107 (GPR107) 9.5
 LDTP04956  Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) 8.9
 LDTP06198  Major facilitator superfamily domain-containing protein 10 (MFSD10) 8.9
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 8.6
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 8.3
 LDTP00592  Surfeit locus protein 4 (SURF4) 7.4
 LDTP15481  Transmembrane protein 87A (TMEM87A) 6.7
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 6.5
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 6.3
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 6.1
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 6.1
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) 5.9
 LDTP00970  Gasdermin-E (GSDME) 5.8
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 5.7
Other
Click to Show/Hide to Show 44 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 68.6
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 24.3
 LDTP11076  Apolipoprotein L2 (APOL2) 18.3
 LDTP15623  Neuferricin (CYB5D2) 16.6
 LDTP05160  Nucleobindin-2 (NUCB2) 12.0
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 11.4
 LDTP18134  Protein CUSTOS (CUSTOS) 11.4
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 10.9
 LDTP02297  Vimentin (VIM) 10.4
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 9.8
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 9.4
 LDTP02180  Neurofilament light polypeptide (NEFL) 9.3
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 8.6
 LDTP14939  Membralin (TMEM259) 8.4
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 8.3
 LDTP16080  Protein FAM114A2 (FAM114A2) 8.3
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 8.2
 LDTP13630  Neudesin (NENF) 8.1
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 7.8
 LDTP06097  Reticulocalbin-2 (RCN2) 7.6
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 7.4
 LDTP11115  Leucine zipper putative tumor suppressor 2 (LZTS2) 7.2
 LDTP06068  MAGUK p55 subfamily member 2 (MPP2) 7.2
 LDTP09069  Kinetochore protein Spc24 (SPC24) 7.1
 LDTP08000  Dymeclin (DYM) 7.0
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 7.0
 LDTP13908  AP-3 complex subunit mu-1 (AP3M1) 6.7
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 6.6
 LDTP01359  Dynactin subunit 3 (DCTN3) 6.4
 LDTP10214  Splicing factor ESS-2 homolog (ESS2) 6.3
 LDTP04206  Nestin (NES) 6.2
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 6.2
 LDTP13519  Proteasome activator complex subunit 2 (PSME2) 6.1
 LDTP19912  Protein NipSnap homolog 1 (NIPSNAP1) 6.0
 LDTP10015  GPI transamidase component PIG-T (PIGT) 5.9
 LDTP07221  Myomegalin (PDE4DIP) 5.9
 LDTP04369  Peroxisomal targeting signal 1 receptor (PEX5) 5.9
 LDTP11277  Tubulin beta-2B chain (TUBB2B) 5.9
 LDTP19963  TraB domain-containing protein (TRABD) 5.9
 LDTP11044  Polyadenylate-binding protein-interacting protein 2 (PAIP2) 5.8
 LDTP05113  T-complex protein 1 subunit beta (CCT2) 5.8
 LDTP15834  Integrator complex subunit 14 (INTS14) 5.7
 LDTP13797  HIG1 domain family member 1A, mitochondrial (HIGD1A) 5.7
 LDTP13309  Prefoldin subunit 2 (PFDN2) 5.7

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587