Details of the Target

General Information of Target

Target ID LDTP17305
Target Name Glycosyltransferase 8 domain-containing protein 1 (GLT8D1)
Gene Name GLT8D1
Gene ID 55830
Synonyms
GALA4A; Glycosyltransferase 8 domain-containing protein 1; EC 2.4.1.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKPFFRLQKFLRRTQFLLFFLTAAYLMTGSLLLLQRVRVALPQGPRAPGPLQTLPVAAV
ALGVGLLDSRALHDPRVSPELLLGVDMLQSPLTRPRPGPRWLRSRNSELRQLRRRWFHHF
MSDSQGPPALGPEAARPAIHSRGTYIGCFSDDGHERTLKGAVFYDLRKMTVSHCQDACAE
RSYVYAGLEAGAECYCGNRLPAVSVGLEECNHECKGEKGSVCGAVDRLSVYRVDELQPGS
RKRRTATYRGCFRLPENITHAFPSSLIQANVTVGTCSGFCSQKEFPLAILRGWECYCAYP
TPRFNLRDAMDSSVCGQDPEAQRLAEYCEVYQTPVQDTRCTDRRFLPNKSKVFVALSSFP
GAGNTWARHLIEHATGFYTGSYYFDGTLYNKGFKGEKDHWRSRRTICVKTHESGRREIEM
FDSAILLIRNPYRSLVAEFNRKCAGHLGYAADRNWKSKEWPDFVNSYASWWSSHVLDWLK
YGKRLLVVHYEELRRSLVPTLREMVAFLNVSVSEERLLCVENNKEGSFRRRGRRSHDPEP
FTPEMKDLINGYIRTVDQALRDHNWTGLPREYVPR
Target Bioclass
Enzyme
Family
Glycosyltransferase 8 family
Subcellular location
Membrane
Uniprot ID
Q68CQ7
Ensemble ID
ENST00000266014.11
HGNC ID
HGNC:24870

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.A80PfsTer5 .
IGR39 Deletion: p.K166del .
JURKAT SNV: p.A58V .
OVK18 Insertion: p.A80GfsTer37 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K124(1.46); K165(10.00); K225(9.09); K314(5.05)  LDD0277  [1]
DBIA
 Probe Info  		C200(0.91)  LDD0812  [2]
PAL-AfBPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		12.21  LDD1752  [3]
C056
 Probe Info  		25.81  LDD1753  [3]
C130
 Probe Info  		9.19  LDD1812  [3]
C186
 Probe Info  		13.45  LDD1864  [3]
C264
 Probe Info  		36.50  LDD1935  [3]
C265
 Probe Info  		19.03  LDD1936  [3]
C269
 Probe Info  		5.90  LDD1939  [3]
C270
 Probe Info  		7.89  LDD1940  [3]
C310
 Probe Info  		26.54  LDD1977  [3]
C313
 Probe Info  		13.27  LDD1980  [3]
C314
 Probe Info  		15.89  LDD1981  [3]
C362
 Probe Info  		70.52  LDD2023  [3]
C363
 Probe Info  		24.93  LDD2024  [3]
C364
 Probe Info  		21.86  LDD2025  [3]
C388
 Probe Info  		74.54  LDD2047  [3]
C397
 Probe Info  		9.92  LDD2056  [3]
C399
 Probe Info  		11.39  LDD2058  [3]
C403
 Probe Info  		56.10  LDD2061  [3]
FFF probe11
 Probe Info  		20.00  LDD0471  [4]
FFF probe12
 Probe Info  		20.00  LDD0473  [4]
LD-F
 Probe Info  		V37(0.00); I42(0.00)  LDD0015  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C200(0.91)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C200(1.18)  LDD0813  [2]
 LDCM0226  AC11 HEK-293T C200(1.32)  LDD0824  [2]
 LDCM0230  AC113 HEK-293T C200(0.88)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C200(0.86)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C200(0.98)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C200(1.23)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C200(1.29)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C200(1.33)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C200(1.26)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C200(1.25)  LDD0835  [2]
 LDCM0238  AC120 HEK-293T C200(1.07)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C200(1.47)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C200(1.31)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C200(1.47)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C200(1.07)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C200(1.22)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C200(1.90)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C200(1.89)  LDD0843  [2]
 LDCM0259  AC14 HEK-293T C200(1.25)  LDD0857  [2]
 LDCM0270  AC15 HEK-293T C200(1.45)  LDD0868  [2]
 LDCM0279  AC2 HEK-293T C200(1.21)  LDD0877  [2]
 LDCM0281  AC21 HEK-293T C200(0.84)  LDD1520  [6]
 LDCM0284  AC24 HEK-293T C200(0.89)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C200(1.35)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C200(1.51)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C200(1.35)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C200(1.39)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C200(1.34)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C200(1.28)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C200(1.32)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C200(1.20)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C200(1.28)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C200(1.31)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C200(1.33)  LDD0893  [2]
 LDCM0296  AC35 HEK-293T C200(0.89)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C200(0.96)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C200(0.86)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C200(0.63)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C200(0.91)  LDD0898  [2]
 LDCM0301  AC4 HEK-293T C200(1.16)  LDD0899  [2]
 LDCM0302  AC40 HEK-293T C200(0.88)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C200(0.72)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C200(0.90)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C200(1.37)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C200(1.33)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C200(1.02)  LDD0905  [2]
 LDCM0310  AC48 HEK-293T C200(0.82)  LDD1549  [6]
 LDCM0312  AC5 HEK-293T C200(0.99)  LDD0910  [2]
 LDCM0316  AC53 HEK-293T C200(0.89)  LDD1555  [6]
 LDCM0319  AC56 HEK-293T C200(0.89)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C200(0.48)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C200(0.49)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C200(0.60)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C200(1.28)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C200(0.47)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C200(0.74)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C200(0.48)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C200(0.47)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C200(0.48)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C200(0.55)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C200(0.41)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C200(0.52)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C200(0.99)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C200(1.10)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C200(1.30)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C200(1.03)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C200(1.27)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C200(0.98)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C200(1.13)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C200(1.23)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C200(1.08)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C200(0.97)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C200(0.93)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C200(0.92)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C200(0.99)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C200(1.43)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C200(1.27)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C200(1.13)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C200(1.51)  LDD0946  [2]
 LDCM0349  AC83 HEK-293T C200(1.02)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C200(1.48)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C200(1.25)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C200(1.23)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C200(1.57)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C200(1.27)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C200(1.53)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C200(1.75)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C200(1.19)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C200(1.15)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C200(1.31)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C200(1.41)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C200(1.47)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C200(1.67)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C200(2.42)  LDD0962  [2]
 LDCM0248  AKOS034007472 HEK-293T C200(1.13)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C200(1.53)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C200(1.36)  LDD0873  [2]
 LDCM0367  CL1 HEK-293T C200(0.83)  LDD1571  [6]
 LDCM0369  CL100 HEK-293T C200(1.67)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C200(1.25)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C200(1.39)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C200(1.36)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C200(1.38)  LDD0971  [2]
 LDCM0374  CL105 HEK-293T C200(0.82)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C200(1.05)  LDD1579  [6]
 LDCM0378  CL109 HEK-293T C200(0.74)  LDD1582  [6]
 LDCM0380  CL110 HEK-293T C200(0.95)  LDD1584  [6]
 LDCM0382  CL112 HEK-293T C200(1.35)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C200(1.23)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C200(1.58)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C200(1.57)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C200(1.58)  LDD0984  [2]
 LDCM0387  CL117 HEK-293T C200(0.58)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C200(0.67)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C200(1.05)  LDD0987  [2]
 LDCM0390  CL12 HEK-293T C200(1.05)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C200(0.94)  LDD0989  [2]
 LDCM0392  CL121 HEK-293T C200(0.92)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C200(0.88)  LDD1597  [6]
 LDCM0396  CL125 HEK-293T C200(0.55)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C200(0.48)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C200(0.67)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C200(0.71)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C200(1.22)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C200(1.19)  LDD1605  [6]
 LDCM0407  CL2 HEK-293T C200(0.94)  LDD1611  [6]
 LDCM0409  CL21 HEK-293T C200(1.90)  LDD1613  [6]
 LDCM0412  CL24 HEK-293T C200(2.32)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C200(0.76)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C200(1.28)  LDD1618  [6]
 LDCM0422  CL33 HEK-293T C200(1.94)  LDD1626  [6]
 LDCM0425  CL36 HEK-293T C200(3.14)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C200(0.77)  LDD1630  [6]
 LDCM0435  CL45 HEK-293T C200(2.28)  LDD1639  [6]
 LDCM0438  CL48 HEK-293T C200(2.02)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C200(0.90)  LDD1643  [6]
 LDCM0441  CL50 HEK-293T C200(0.85)  LDD1645  [6]
 LDCM0448  CL57 HEK-293T C200(1.26)  LDD1651  [6]
 LDCM0452  CL60 HEK-293T C200(1.93)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C200(1.31)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C200(1.20)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C200(1.36)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C200(1.02)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C200(1.25)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C200(1.10)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C200(1.06)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C200(1.14)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C200(1.06)  LDD1059  [2]
 LDCM0463  CL70 HEK-293T C200(1.05)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C200(1.20)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C200(0.99)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C200(0.97)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C200(1.64)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C200(1.00)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C200(1.28)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C200(0.73)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C200(0.81)  LDD1070  [2]
 LDCM0474  CL80 HEK-293T C200(0.98)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C200(1.06)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C200(1.42)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C200(1.28)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C200(1.10)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C200(0.92)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C200(0.83)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C200(1.27)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C200(1.21)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C200(1.20)  LDD1081  [2]
 LDCM0484  CL9 HEK-293T C200(2.11)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C200(1.42)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C200(1.12)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C200(1.08)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C200(1.05)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C200(1.42)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C200(1.23)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C200(1.29)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C200(1.29)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C200(1.09)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C200(1.85)  LDD1092  [2]
 LDCM0468  Fragment33 HEK-293T C200(1.81)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C200(1.05)  LDD1631  [6]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
4 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
5 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402