Details of the Target

General Information of Target

Target ID LDTP07525
Target Name Protein arginine N-methyltransferase 9 (PRMT9)
Gene Name PRMT9
Gene ID 90826
Synonyms
PRMT10; Protein arginine N-methyltransferase 9; Protein arginine N-methyltransferase 10; EC 2.1.1.320
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSNSRPRSRRDAGGGAGAAGRDELVSRSLQSAEHCLGVQDFGTAYAHYLLVLSLAPELKH
DVKETFQYTLFRWAEELDALSRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEA
AGYFHKAVKLNPDFSDAKENFYRVANWLVERWHFIMLNDTKRNTIYNAAIQKAVCLGSKS
VLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEAGIKLLHTKSLDIE
IPKHIPERVSLVVTETVDAGLFGEGIVESLIHAWEHLLLQPKTKGESANCEKYGKVIPAS
AVIFGMAVECAEIRRHHRVGIKDIAGIHLPTNVKFQSPAYSSVDTEETIEPYTTEKMSRV
PGGYLALTECFEIMTVDFNNLQELKSLATKKPDKIGIPVIKEGILDAIMVWFVLQLDDEH
SLSTSPSEETCWEQAVYPVQDLADYWIKPGDHVMMEVSCQDCYLRIQSISVLGLECEMDV
AKSFTQNKDLLSLGNEAELCSALANLQTSKPDAVEQTCILESTEIALLNNIPYHEGFKMA
MSKVLSSLTPEKLYQTMDTHCQNEMSSGTGQSNTVQNILEPFYVLDVSEGFSVLPVIAGT
LGQVKPYSSVEKDQHRIALDLISEANHFPKETLEFWLRHVEDESAMLQRPKSDKLWSIII
LDVIEPSGLIQQEIMEKAAISRCLLQSGGKIFPQYVLMFGLLVESQTLLEENAVQGTERT
LGLNIAPFINQFQVPIRVFLDLSSLPCIPLSKPVELLRLDLMTPYLNTSNREVKVYVCKS
GRLTAIPFWYHMYLDEEIRLDTSSEASHWKQAAVVLDNPIQVEMGEELVLSIQHHKSNVS
ITVKQ
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family
Subcellular location
Cytoplasm
Function
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA.
Uniprot ID
Q6P2P2
Ensemble ID
ENST00000322396.7
HGNC ID
HGNC:25099
ChEMBL ID
CHEMBL4105724

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC15 SNV: p.E312D DBIA    Probe Info 
HCT116 Deletion: p.G14VfsTer45 .
HDQP1 SNV: p.K210R .
HT115 SNV: p.R359Q .
JURKAT SNV: p.R318I .
LNCaP clone FGC SNV: p.Q694H DBIA    Probe Info 
MFE319 SNV: p.A169T .
REH SNV: p.I659L .
SAOS2 SNV: p.A12D .
TC71 SNV: p.G403D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
YN-4
 Probe Info  		100.00  LDD0445  [2]
DBIA
 Probe Info  		C683(1.74)  LDD0080  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		C175(0.00); C683(0.00); C747(0.00); C290(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C206(0.00); C175(0.00); C683(0.00); C747(0.00)  LDD0037  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
IPM
 Probe Info  		C683(0.00); C175(0.00); C206(0.00)  LDD0005  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
NAIA_5
 Probe Info  		C683(0.00); C290(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		5.54  LDD1714  [10]
C165
 Probe Info  		13.18  LDD1845  [10]
C232
 Probe Info  		38.32  LDD1905  [10]
C235
 Probe Info  		18.25  LDD1908  [10]
C249
 Probe Info  		15.56  LDD1922  [10]
C264
 Probe Info  		48.84  LDD1935  [10]
C265
 Probe Info  		15.67  LDD1936  [10]
C266
 Probe Info  		10.13  LDD1937  [10]
C269
 Probe Info  		6.96  LDD1939  [10]
C270
 Probe Info  		9.06  LDD1940  [10]
C287
 Probe Info  		16.68  LDD1957  [10]
C314
 Probe Info  		11.39  LDD1981  [10]
C317
 Probe Info  		5.74  LDD1983  [10]
C361
 Probe Info  		17.51  LDD2022  [10]
C363
 Probe Info  		17.27  LDD2024  [10]
C364
 Probe Info  		24.59  LDD2025  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C683(0.39)  LDD1093  [3]
 LDCM0215  AC10 HCT 116 C683(0.77)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C683(0.81)  LDD0543  [3]
 LDCM0230  AC113 PaTu 8988t C683(1.01)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C683(1.36)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C683(1.21)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C683(1.06)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C683(1.31)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C683(1.09)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C683(0.82)  LDD1115  [3]
 LDCM0237  AC12 HCT 116 C683(0.91)  LDD0554  [3]
 LDCM0238  AC120 PaTu 8988t C683(1.12)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C683(0.88)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C683(0.72)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C683(1.20)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C683(0.81)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C683(0.97)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C683(0.99)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C683(0.78)  LDD1124  [3]
 LDCM0246  AC128 HEK-293T C683(1.10)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C683(0.95)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C683(1.02)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C683(1.13)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C683(1.28)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C683(1.10)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C683(1.12)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C683(1.04)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C683(1.25)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C683(1.11)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C683(1.14)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C683(1.35)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C683(0.80)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C683(1.19)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C683(1.11)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C683(1.12)  LDD0860  [3]
 LDCM0270  AC15 HCT 116 C683(0.83)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C683(1.09)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C683(1.20)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C683(1.24)  LDD0595  [3]
 LDCM0279  AC2 PaTu 8988t C683(0.46)  LDD1158  [3]
 LDCM0280  AC20 HCT 116 C683(1.22)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C683(1.09)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C683(1.30)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C683(1.01)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C683(1.12)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C290(1.03); C206(1.03); C476(0.95); C175(1.03)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C290(1.04); C206(1.01); C476(1.20); C683(0.98)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C290(0.99); C206(1.10); C476(1.14); C683(0.99)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C290(1.01); C206(1.02); C476(1.00); C683(0.91)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C290(1.10); C206(0.96); C476(0.92); C175(0.98)  LDD1528  [11]
 LDCM0290  AC3 PaTu 8988t C683(0.46)  LDD1169  [3]
 LDCM0291  AC30 HEK-293T C290(1.10); C206(0.99); C476(1.10); C175(0.89)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C290(1.09); C206(0.98); C476(0.82); C683(0.94)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C290(1.00); C206(0.98); C476(0.90); C747(0.92)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C290(1.08); C206(1.14); C476(1.07); C175(1.09)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C290(0.97); C206(1.07); C476(0.99); C683(0.95)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C290(0.88); C206(1.14); C476(0.96); C683(0.91)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C290(1.15); C206(0.97); C476(0.95); C683(0.96)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C290(1.22); C206(1.04); C476(0.87); C175(0.96)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C290(1.03); C206(1.05); C476(1.00); C175(0.83)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C290(0.97); C206(1.03); C476(0.93); C683(0.94)  LDD1539  [11]
 LDCM0301  AC4 PaTu 8988t C683(0.45)  LDD1180  [3]
 LDCM0302  AC40 HEK-293T C290(1.11); C206(1.08); C476(0.89); C747(1.03)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C290(1.05); C206(1.10); C476(0.92); C175(1.09)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C290(1.05); C206(1.09); C476(1.01); C683(0.90)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C290(0.91); C206(1.13); C476(0.99); C683(1.03)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C290(1.12); C206(1.01); C476(1.01); C683(0.87)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C290(1.29); C206(1.05); C476(0.90); C175(0.96)  LDD1546  [11]
 LDCM0308  AC46 HCT 116 C683(1.20)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C683(1.01)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C683(1.10)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C683(1.19)  LDD0628  [3]
 LDCM0312  AC5 PaTu 8988t C683(0.46)  LDD1191  [3]
 LDCM0313  AC50 HCT 116 C683(1.11)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C683(1.07)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C683(1.08)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C683(0.96)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C683(1.05)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C683(1.07)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C683(1.06)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C683(0.93)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C683(1.05)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C683(1.04)  LDD0920  [3]
 LDCM0323  AC6 HCT 116 C683(0.92)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C683(1.17)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C683(1.18)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C683(1.12)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C683(1.28)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C683(1.25)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C683(1.10)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C683(1.17)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C683(1.14)  LDD0929  [3]
 LDCM0332  AC68 HCT 116 C683(0.96)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C683(0.96)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C683(0.84)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C683(0.99)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C683(1.03)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C683(0.91)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C683(0.88)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C683(1.06)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C683(0.85)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C683(1.03)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C683(1.05)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C683(0.98)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C683(0.90)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C683(0.85)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C683(1.08)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C683(0.98)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C683(0.86)  LDD0665  [3]
 LDCM0349  AC83 HEK-293T C683(0.89)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C683(1.20)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C683(0.97)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C683(1.14)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C683(0.95)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C683(0.93)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C683(1.04)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C683(0.95)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C683(0.80)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C683(0.91)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C683(0.94)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C683(0.92)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C683(1.03)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C683(1.00)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C683(1.04)  LDD0962  [3]
 LDCM0248  AKOS034007472 HCT 116 C683(0.77)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C683(0.80)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C683(0.94)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 11.57  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C290(4.30)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C290(0.99); C206(1.56); C476(0.85)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C290(1.48); C206(2.02); C476(1.33); C175(1.33)  LDD1572  [11]
 LDCM0369  CL100 PaTu 8988t C683(0.34)  LDD1248  [3]
 LDCM0370  CL101 HCT 116 C683(0.91)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C683(0.79)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C683(0.81)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C683(0.83)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C683(1.34)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C683(1.20)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C683(1.25)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C683(1.34)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C683(1.35)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C290(0.88); C206(1.93); C476(1.37); C683(1.23)  LDD1583  [11]
 LDCM0380  CL110 HCT 116 C683(1.32)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C683(1.19)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C206(1.04); C476(1.03); C35(0.76)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C290(0.99); C206(0.96); C476(0.91)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C290(1.01); C206(1.76); C476(1.13); C175(1.29)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C290(0.99); C206(0.97); C476(0.99); C683(1.11)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C206(1.12); C476(0.94); C35(0.79)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C290(1.00); C206(1.05); C476(1.02)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C290(0.99); C206(1.01); C476(1.38); C175(1.04)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C290(1.03); C206(1.02); C476(0.93); C683(1.08)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C290(1.10); C206(1.21); C476(1.32); C747(0.64)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C206(1.07); C476(1.10); C35(1.10)  LDD1595  [11]
 LDCM0392  CL121 HCT 116 C683(1.01)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C683(0.99)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C683(0.86)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C683(1.04)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C683(1.11)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C683(1.01)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C683(1.10)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C683(1.01)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C290(1.09); C206(1.10); C476(1.08)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C290(0.93); C206(1.06); C476(1.01); C175(1.16)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C290(1.24); C206(2.16); C476(1.14); C683(0.97)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C683(1.06)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C683(0.59)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C683(1.15)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C683(0.73)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C290(0.96); C206(1.14); C476(1.06); C175(1.14)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C683(0.76)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C683(0.93)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C683(0.90)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C683(1.10)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C683(0.74)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C683(0.96)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C683(0.86)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C683(0.60)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C683(1.35)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C683(0.88)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C290(1.02); C206(1.34); C476(1.01); C683(1.14)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C683(1.00)  LDD1017  [3]
 LDCM0420  CL31 HCT 116 C683(0.83)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C683(0.93)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C683(0.94)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C683(1.00)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C683(0.92)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C683(0.93)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C683(0.87)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C683(0.88)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C206(1.53); C476(1.10); C35(0.70)  LDD1633  [11]
 LDCM0430  CL40 HCT 116 C683(0.74)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C683(1.04)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C683(0.83)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C683(1.07)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C683(0.96)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C683(0.92)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C683(1.08)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C683(0.87)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C683(0.93)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C683(1.00)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C290(1.02); C206(1.05); C476(1.10); C175(1.19)  LDD1644  [11]
 LDCM0441  CL50 HCT 116 C683(0.98)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C683(1.05)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C683(1.10)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C683(0.90)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C683(0.88)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C683(0.80)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C683(0.93)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C683(0.80)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C683(0.94)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C683(1.02)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C290(1.02); C206(2.13); C476(1.13); C683(1.11)  LDD1654  [11]
 LDCM0452  CL60 HCT 116 C683(1.06)  LDD0769  [3]
 LDCM0453  CL61 PaTu 8988t C290(0.72)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C290(0.82)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C290(1.38)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C290(1.35)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C290(0.99)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C290(1.30)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C290(1.01)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C290(1.28)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C290(1.00)  LDD1340  [3]
 LDCM0462  CL7 HEK-293T C290(0.98); C206(1.29); C476(1.19); C683(1.46)  LDD1665  [11]
 LDCM0463  CL70 PaTu 8988t C290(1.19)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C290(1.09)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C290(1.18)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C290(1.52)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C290(1.43)  LDD1346  [3]
 LDCM0469  CL76 PaTu 8988t C290(1.09)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C290(1.08)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C290(1.47)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C290(1.20)  LDD1351  [3]
 LDCM0473  CL8 HEK-293T C290(1.44); C206(3.60); C476(1.29); C683(0.84)  LDD1676  [11]
 LDCM0474  CL80 PaTu 8988t C290(1.11)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C290(1.52)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C290(1.16)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C290(1.11)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C290(1.38)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C290(1.12)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C290(1.22)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C290(1.53)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C290(1.57)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C290(1.42)  LDD1362  [3]
 LDCM0484  CL9 HEK-293T C290(0.69); C206(1.38); C476(1.26); C175(1.11)  LDD1687  [11]
 LDCM0485  CL90 PaTu 8988t C290(1.32)  LDD1364  [3]
 LDCM0486  CL91 PaTu 8988t C683(0.34)  LDD1365  [3]
 LDCM0487  CL92 PaTu 8988t C683(0.34)  LDD1366  [3]
 LDCM0488  CL93 PaTu 8988t C683(0.39)  LDD1367  [3]
 LDCM0489  CL94 PaTu 8988t C683(0.33)  LDD1368  [3]
 LDCM0490  CL95 PaTu 8988t C683(0.43)  LDD1369  [3]
 LDCM0491  CL96 PaTu 8988t C683(0.39)  LDD1370  [3]
 LDCM0492  CL97 PaTu 8988t C683(0.39)  LDD1371  [3]
 LDCM0493  CL98 PaTu 8988t C683(0.38)  LDD1372  [3]
 LDCM0494  CL99 PaTu 8988t C683(0.39)  LDD1373  [3]
 LDCM0495  E2913 HEK-293T C290(1.00); C206(1.01); C476(0.95); C683(1.06)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C175(1.90)  LDD1702  [12]
 LDCM0625  F8 Ramos C290(0.66)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C290(0.93)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C290(5.75)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C290(0.73)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C290(1.10)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C290(0.69)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C290(0.88)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C290(0.59)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C290(1.32)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C290(1.63)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C290(0.27)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C290(1.04)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C290(0.64)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C290(1.17)  LDD2201  [13]
 LDCM0468  Fragment33 PaTu 8988t C290(1.79)  LDD1347  [3]
 LDCM0596  Fragment38 Ramos C290(0.85)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C290(0.72)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C683(0.96)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C290(1.77)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C290(1.24)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C290(0.94)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C290(1.57)  LDD2188  [13]
 LDCM0022  KB02 HCT 116 C683(1.74)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C683(1.71)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C683(1.71)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Splicing factor 3B subunit 4 (SF3B4) SF3B4 family Q15427
Splicing factor 3B subunit 2 (SF3B2) . Q13435

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578