Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C317  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 55 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 29.9
 LDTP09799  DCN1-like protein 4 (DCUN1D4) 18.3
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 14.4
 LDTP03608  RAC-beta serine/threonine-protein kinase (AKT2) 14.4
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 13.9
 LDTP03540  Heme oxygenase 2 (HMOX2) 13.5
 LDTP00988  Protein O-GlcNAcase (OGA) 13.3
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 13.1
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 12.8
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 11.5
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 10.9
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 10.9
 LDTP06617  Ceramide glucosyltransferase (UGCG) 10.8
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 10.5
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 10.2
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 10.2
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 9.8
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 9.7
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 9.6
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 9.6
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 9.4
 LDTP03677  Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1) 9.1
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 8.8
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 8.6
 LDTP09074  UDP-glucuronic acid decarboxylase 1 (UXS1) 8.2
 LDTP01803  Adenosine deaminase (ADA) 8.2
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 8.2
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 8.1
 LDTP10329  Ceramide synthase 2 (CERS2) 7.6
 LDTP02359  Heme oxygenase 1 (HMOX1) 7.6
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 7.5
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 7.4
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 7.3
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 7.3
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 7.2
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 7.1
 LDTP00697  Cytochrome b5 type B (CYB5B) 7.0
 LDTP04542  Thimet oligopeptidase (THOP1) 6.8
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 6.8
 LDTP11127  ADP-dependent glucokinase (ADPGK) 6.7
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 6.3
 LDTP07503  Endoplasmic reticulum aminopeptidase 2 (ERAP2) 6.3
 LDTP08598  NAD-dependent protein deacetylase sirtuin-2 (SIRT2) 6.3
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 6.2
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 6.2
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 6.2
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 6.1
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 6.1
 LDTP12109  Ribitol 5-phosphate transferase FKRP (FKRP) 6.1
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 6.0
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 5.9
 LDTP10495  Ubiquitin carboxyl-terminal hydrolase 47 (USP47) 5.8
 LDTP09285  Atypical kinase COQ8A, mitochondrial (COQ8A) 5.7
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 5.7
 LDTP07525  Protein arginine N-methyltransferase 9 (PRMT9) 5.7
Transporter and channel
Click to Show/Hide to Show 26 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 28.6
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 20.3
 LDTP05900  Metaxin-1 (MTX1) 14.0
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 12.2
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 10.7
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 10.4
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 10.3
 LDTP01804  ATP synthase subunit a (MT-ATP6) 10.3
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 9.9
 LDTP03546  Translocator protein (TSPO) 9.9
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 9.7
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 9.6
 LDTP07236  Protein GPR107 (GPR107) 9.2
 LDTP15648  BRI3-binding protein (BRI3BP) 8.9
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 8.2
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 8.1
 LDTP14970  Metaxin-3 (MTX3) 7.1
 LDTP08881  Transmembrane protein 199 (TMEM199) 6.9
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 6.8
 LDTP07156  Protein wntless homolog (WLS) 6.6
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 6.5
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 6.4
 LDTP20002  Transmembrane protein 160 (TMEM160) 6.1
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 5.9
 LDTP07531  Sideroflexin-4 (SFXN4) 5.8
 LDTP00592  Surfeit locus protein 4 (SURF4) 5.7
Other
Click to Show/Hide to Show 50 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15269  Large ribosomal subunit protein mL55 (MRPL55) 39.4
 LDTP08000  Dymeclin (DYM) 29.4
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 19.7
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 15.8
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 13.8
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 13.2
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 13.1
 LDTP15623  Neuferricin (CYB5D2) 11.4
 LDTP05160  Nucleobindin-2 (NUCB2) 11.4
 LDTP11076  Apolipoprotein L2 (APOL2) 11.2
 LDTP01711  Protein ecdysoneless homolog (ECD) 10.6
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 10.5
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 10.2
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 10.2
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 10.1
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 10.1
 LDTP09069  Kinetochore protein Spc24 (SPC24) 9.6
 LDTP16080  Protein FAM114A2 (FAM114A2) 9.6
 LDTP09994  BLOC-2 complex member HPS3 (HPS3) 9.5
 LDTP05277  Protein SET (SET) 9.3
 LDTP06097  Reticulocalbin-2 (RCN2) 8.9
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 8.6
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 8.2
 LDTP01075  Protein CutA (CUTA) 8.1
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 8.0
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 7.7
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 7.6
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 7.2
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 7.1
 LDTP02297  Vimentin (VIM) 7.1
 LDTP01652  Centrosomal protein 43 (CEP43) 6.9
 LDTP05993  Exosome complex component RRP4 (EXOSC2) 6.9
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 6.9
 LDTP02351  Tropomyosin alpha-1 chain (TPM1) 6.8
 LDTP08707  Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) 6.7
 LDTP11044  Polyadenylate-binding protein-interacting protein 2 (PAIP2) 6.6
 LDTP13086  Syntaxin-18 (STX18) 6.6
 LDTP06515  Coiled-coil domain-containing protein 6 (CCDC6) 6.6
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 6.5
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 6.5
 LDTP08073  Tetratricopeptide repeat protein 21B (TTC21B) 6.5
 LDTP02180  Neurofilament light polypeptide (NEFL) 6.4
 LDTP13338  Vacuolar protein sorting-associated protein 51 homolog (VPS51) 6.3
 LDTP06255  GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) 6.1
 LDTP05089  Immunoglobulin-binding protein 1 (IGBP1) 6.1
 LDTP04111  Small ribosomal subunit protein eS10 (RPS10) 6.1
 LDTP00887  Calumenin (CALU) 6.0
 LDTP04483  Hepatoma-derived growth factor (HDGF) 5.9
 LDTP04249  T-complex protein 1 subunit gamma (CCT3) 5.9
 LDTP09183  Periphilin-1 (PPHLN1) 5.8

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587