Details of the Target

General Information of Target

Target ID LDTP08073
Target Name Tetratricopeptide repeat protein 21B (TTC21B)
Gene Name TTC21B
Gene ID 79809
Synonyms
IFT139; KIAA1992; Tetratricopeptide repeat protein 21B; TPR repeat protein 21B; Intraflagellar transport 139 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSQELKTLINYYCQERYFHHVLLVASEGIKRYGSDPVFRFYHAYGTLMEGKTQEALREF
EAIKNKQDVSLCSLLALIYAHKMSPNPDREAILESDARVKEQRKGAGEKALYHAGLFLWH
IGRHDKAREYIDRMIKISDGSKQGHVLKAWLDITRGKEPYTKKALKYFEEGLQDGNDTFA
LLGKAQCLEMRQNYSGALETVNQIIVNFPSFLPAFVKKMKLQLALQDWDQTVETAQRLLL
QDSQNVEALRMQALYYVCREGDIEKASTKLENLGNTLDAMEPQNAQLFYNITLAFSRTCG
RSQLILQKIQTLLERAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLDETSVSA
LVGFIQCQLIEGQLQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNKRQEEVINLLN
DVLDTHFSQLEGLPLGIQYFEKLNPDFLLEIVMEYLSFCPMQPASPGQPLCPLLRRCISV
LETVVRTVPGLLQTVFLIAKVKYLSGDIEAAFNNLQHCLEHNPSYADAHLLLAQVYLSQE
KVKLCSQSLELCLSYDFKVRDYPLYHLIKAQSQKKMGEIADAIKTLHMAMSLPGMKRIGA
STKSKDRKTEVDTSHRLSIFLELIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIAN
ADLALAQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMA
NPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYE
AALKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKV
YSKMEKLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQRDY
EKAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAATMMMAD
LMFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDVPRFFSMAEKRNSRAK
LEPGFQYCKGLYLWYTGEPNDALRHFNKARKDRDWGQNALYNMIEICLNPDNETVGGEVF
ENLDGDLGNSTEKQESVQLAVRTAEKLLKELKPQTVQGHVQLRIMENYCLMATKQKSNVE
QALNTFTEIAASEKEHIPALLGMATAYMILKQTPRARNQLKRIAKMNWNAIDAEEFEKSW
LLLADIYIQSAKYDMAEDLLKRCLRHNRSCCKAYEYMGYIMEKEQAYTDAALNYEMAWKY
SNRTNPAVGYKLAFNYLKAKRYVDSIDICHQVLEAHPTYPKIRKDILDKARASLRP
Target Bioclass
Other
Family
TTC21 family
Subcellular location
Cytoplasm, cytoskeleton, cilium axoneme
Function
Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Essential for retrograde trafficking of IFT-1, IFT-B and GPCRs. Negatively modulates the SHH signal transduction.
Uniprot ID
Q7Z4L5
Ensemble ID
ENST00000243344.8
HGNC ID
HGNC:25660

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 Deletion: p.D174AfsTer3 .
EFO27 SNV: p.W1034Ter DBIA    Probe Info 
G402 SNV: p.L992W DBIA    Probe Info 
HT115 SNV: p.L640V .
KMCH1 SNV: p.C1223Y DBIA    Probe Info 
LS180 Deletion: p.A903QfsTer54
SNV: p.Q143H		 .
MCC13 Substitution: p.L945S DBIA    Probe Info 
NCIH1155 SNV: p.L397S DBIA    Probe Info 
NCIH146 SNV: p.H113N DBIA    Probe Info 
OSRC2 SNV: p.L374V .
SKN SNV: p.Q438Ter .
SKNAS SNV: p.L293V DBIA    Probe Info 
TOV21G SNV: p.H521Y .
U937 SNV: p.A570S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C833(9.49)  LDD0204  [1]
IPM
 Probe Info  		C833(0.44)  LDD1701  [2]
IA-alkyne
 Probe Info  		C914(0.00); C187(0.00); C1028(0.00); C72(0.00)  LDD0165  [3]
TFBX
 Probe Info  		C937(0.00); C999(0.00)  LDD0148  [4]
AOyne
 Probe Info  		12.40  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C063
 Probe Info  		10.70  LDD1760  [6]
C091
 Probe Info  		12.13  LDD1782  [6]
C092
 Probe Info  		26.17  LDD1783  [6]
C105
 Probe Info  		5.06  LDD1792  [6]
C129
 Probe Info  		7.21  LDD1811  [6]
C145
 Probe Info  		8.75  LDD1827  [6]
C174
 Probe Info  		5.39  LDD1854  [6]
C187
 Probe Info  		16.68  LDD1865  [6]
C313
 Probe Info  		15.14  LDD1980  [6]
C317
 Probe Info  		6.50  LDD1983  [6]
C338
 Probe Info  		14.83  LDD2001  [6]
C339
 Probe Info  		5.21  LDD2002  [6]
C382
 Probe Info  		11.79  LDD2041  [6]
C403
 Probe Info  		14.93  LDD2061  [6]
C420
 Probe Info  		19.70  LDD2075  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C792(1.18); C937(0.53); C711(0.59)  LDD1093  [7]
 LDCM0215  AC10 PaTu 8988t C792(1.08); C14(1.11); C711(1.00)  LDD1094  [7]
 LDCM0216  AC100 HEK-293T C14(1.18); C937(1.18)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C14(0.95); C937(0.95)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C14(1.14); C937(1.14)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C14(1.13); C937(1.13)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C14(1.11); C937(1.11)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C14(0.88); C937(0.88)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C14(0.94); C937(0.94)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C14(1.01); C937(1.01)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C14(1.30); C937(1.30)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C14(1.01); C937(1.01)  LDD0823  [7]
 LDCM0226  AC11 PaTu 8988t C792(1.12); C14(1.22); C711(1.12)  LDD1105  [7]
 LDCM0227  AC110 HEK-293T C14(1.15); C937(1.15)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C14(1.12); C937(1.12)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C14(1.13); C937(1.13)  LDD0827  [7]
 LDCM0230  AC113 HEK-293T C14(0.94); C937(0.94)  LDD0828  [7]
 LDCM0231  AC114 HEK-293T C14(2.02); C937(2.02)  LDD0829  [7]
 LDCM0232  AC115 HEK-293T C14(1.54); C937(1.54)  LDD0830  [7]
 LDCM0233  AC116 HEK-293T C14(1.16); C937(1.16)  LDD0831  [7]
 LDCM0234  AC117 HEK-293T C14(0.96); C937(0.96)  LDD0832  [7]
 LDCM0235  AC118 HEK-293T C14(1.03); C937(1.03)  LDD0833  [7]
 LDCM0236  AC119 HEK-293T C14(1.16); C937(1.16)  LDD0834  [7]
 LDCM0237  AC12 PaTu 8988t C792(1.16); C14(1.11); C711(1.23)  LDD1116  [7]
 LDCM0238  AC120 HEK-293T C14(1.11); C937(1.11)  LDD0836  [7]
 LDCM0239  AC121 HEK-293T C14(1.13); C937(1.13)  LDD0837  [7]
 LDCM0240  AC122 HEK-293T C14(1.13); C937(1.13)  LDD0838  [7]
 LDCM0241  AC123 HEK-293T C14(1.44); C937(1.44)  LDD0839  [7]
 LDCM0242  AC124 HEK-293T C14(1.42); C937(1.42)  LDD0840  [7]
 LDCM0243  AC125 HEK-293T C14(1.24); C937(1.24)  LDD0841  [7]
 LDCM0244  AC126 HEK-293T C14(1.53); C937(1.53)  LDD0842  [7]
 LDCM0245  AC127 HEK-293T C14(1.12); C937(1.12)  LDD0843  [7]
 LDCM0246  AC128 HEK-293T C14(0.73); C187(1.05); C711(1.05); C937(0.73)  LDD0844  [7]
 LDCM0247  AC129 HEK-293T C14(1.02); C187(1.28); C711(1.28); C937(1.02)  LDD0845  [7]
 LDCM0249  AC130 HEK-293T C14(1.03); C187(1.10); C711(1.10); C937(1.03)  LDD0847  [7]
 LDCM0250  AC131 HEK-293T C14(0.87); C187(1.00); C711(1.00); C937(0.87)  LDD0848  [7]
 LDCM0251  AC132 HEK-293T C14(0.86); C187(1.09); C711(1.09); C937(0.86)  LDD0849  [7]
 LDCM0252  AC133 HEK-293T C14(0.88); C187(1.41); C711(1.41); C937(0.88)  LDD0850  [7]
 LDCM0253  AC134 HEK-293T C14(0.85); C187(1.29); C711(1.29); C937(0.85)  LDD0851  [7]
 LDCM0254  AC135 HEK-293T C14(0.96); C187(1.31); C711(1.31); C937(0.96)  LDD0852  [7]
 LDCM0255  AC136 HEK-293T C14(1.19); C187(1.15); C711(1.15); C937(1.19)  LDD0853  [7]
 LDCM0256  AC137 HEK-293T C14(1.24); C187(1.72); C711(1.72); C937(1.24)  LDD0854  [7]
 LDCM0257  AC138 HEK-293T C14(1.11); C187(1.16); C711(1.16); C937(1.11)  LDD0855  [7]
 LDCM0258  AC139 HEK-293T C14(1.14); C187(1.29); C711(1.29); C937(1.14)  LDD0856  [7]
 LDCM0259  AC14 PaTu 8988t C792(1.00); C14(1.37); C711(0.99)  LDD1138  [7]
 LDCM0260  AC140 HEK-293T C14(0.92); C187(0.94); C711(0.94); C937(0.92)  LDD0858  [7]
 LDCM0261  AC141 HEK-293T C14(1.21); C187(1.49); C711(1.49); C937(1.21)  LDD0859  [7]
 LDCM0262  AC142 HEK-293T C14(1.07); C187(1.53); C711(1.53); C937(1.07)  LDD0860  [7]
 LDCM0263  AC143 PaTu 8988t C711(1.19)  LDD1142  [7]
 LDCM0264  AC144 PaTu 8988t C711(0.90)  LDD1143  [7]
 LDCM0265  AC145 PaTu 8988t C711(0.87)  LDD1144  [7]
 LDCM0266  AC146 PaTu 8988t C711(0.93)  LDD1145  [7]
 LDCM0267  AC147 PaTu 8988t C711(1.10)  LDD1146  [7]
 LDCM0268  AC148 PaTu 8988t C711(0.87)  LDD1147  [7]
 LDCM0269  AC149 PaTu 8988t C711(0.80)  LDD1148  [7]
 LDCM0270  AC15 PaTu 8988t C792(1.03); C14(1.01); C711(0.95)  LDD1149  [7]
 LDCM0271  AC150 PaTu 8988t C711(0.81)  LDD1150  [7]
 LDCM0272  AC151 PaTu 8988t C711(1.16)  LDD1151  [7]
 LDCM0273  AC152 PaTu 8988t C711(0.69)  LDD1152  [7]
 LDCM0274  AC153 PaTu 8988t C711(0.96)  LDD1153  [7]
 LDCM0621  AC154 PaTu 8988t C711(0.90)  LDD2166  [7]
 LDCM0622  AC155 PaTu 8988t C711(0.85)  LDD2167  [7]
 LDCM0623  AC156 PaTu 8988t C711(0.83)  LDD2168  [7]
 LDCM0624  AC157 PaTu 8988t C711(0.95)  LDD2169  [7]
 LDCM0276  AC17 PaTu 8988t C937(0.87); C711(0.94)  LDD1155  [7]
 LDCM0277  AC18 PaTu 8988t C937(0.72); C711(0.95)  LDD1156  [7]
 LDCM0278  AC19 PaTu 8988t C937(0.83); C711(0.96)  LDD1157  [7]
 LDCM0279  AC2 PaTu 8988t C792(1.01); C937(0.66); C711(0.70)  LDD1158  [7]
 LDCM0280  AC20 PaTu 8988t C937(0.83); C711(0.89)  LDD1159  [7]
 LDCM0281  AC21 PaTu 8988t C937(0.85); C711(0.94)  LDD1160  [7]
 LDCM0282  AC22 PaTu 8988t C937(0.77); C711(1.06)  LDD1161  [7]
 LDCM0283  AC23 PaTu 8988t C937(0.71); C711(0.96)  LDD1162  [7]
 LDCM0284  AC24 PaTu 8988t C937(0.86); C711(1.00)  LDD1163  [7]
 LDCM0285  AC25 HCT 116 C711(0.91)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C711(0.65)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C711(0.79)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C711(0.90)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C711(0.86)  LDD0606  [7]
 LDCM0290  AC3 PaTu 8988t C792(1.04); C937(0.69); C711(0.54)  LDD1169  [7]
 LDCM0291  AC30 HCT 116 C711(0.88)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C711(0.81)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C711(0.79)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C711(0.84)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C711(0.85)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C711(1.02)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C711(0.84)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C711(0.82)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C711(0.94)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C711(0.80)  LDD0617  [7]
 LDCM0301  AC4 PaTu 8988t C792(1.00); C937(0.68); C711(0.66)  LDD1180  [7]
 LDCM0302  AC40 HCT 116 C711(0.82)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C711(0.97)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C711(0.87)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C711(0.96)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C711(0.75)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C711(0.78)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C711(0.98)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C711(0.92)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C711(0.83)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C711(0.95)  LDD0628  [7]
 LDCM0312  AC5 PaTu 8988t C792(1.10); C937(0.65); C711(0.71)  LDD1191  [7]
 LDCM0313  AC50 HCT 116 C711(0.90)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C711(1.03)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C711(0.83)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C711(0.96)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C711(1.14)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C711(0.99)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C711(1.01)  LDD0636  [7]
 LDCM0320  AC57 HEK-293T C187(1.09); C711(1.09)  LDD0918  [7]
 LDCM0321  AC58 HEK-293T C187(1.43); C711(1.43)  LDD0919  [7]
 LDCM0322  AC59 HEK-293T C187(1.20); C711(1.20)  LDD0920  [7]
 LDCM0323  AC6 PaTu 8988t C792(0.98); C14(1.13); C711(1.11)  LDD1202  [7]
 LDCM0324  AC60 HEK-293T C187(1.40); C711(1.40)  LDD0922  [7]
 LDCM0325  AC61 HEK-293T C187(1.73); C711(1.73)  LDD0923  [7]
 LDCM0326  AC62 HEK-293T C187(0.89); C711(0.89)  LDD0924  [7]
 LDCM0327  AC63 HEK-293T C187(1.79); C711(1.79)  LDD0925  [7]
 LDCM0328  AC64 HEK-293T C187(1.33); C711(1.33)  LDD0926  [7]
 LDCM0329  AC65 HEK-293T C187(1.58); C711(1.58)  LDD0927  [7]
 LDCM0330  AC66 HEK-293T C187(1.34); C711(1.34)  LDD0928  [7]
 LDCM0331  AC67 HEK-293T C187(1.05); C711(1.05)  LDD0929  [7]
 LDCM0332  AC68 HCT 116 C711(0.99)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C711(0.96)  LDD0650  [7]
 LDCM0334  AC7 PaTu 8988t C792(1.01); C14(1.23); C711(1.20)  LDD1213  [7]
 LDCM0335  AC70 HCT 116 C711(0.92)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C711(1.09)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C711(1.15)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C711(1.11)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C711(1.06)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C711(1.32)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C711(1.01)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C711(0.98)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C711(0.98)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C711(1.01)  LDD0661  [7]
 LDCM0345  AC8 PaTu 8988t C792(1.02); C14(0.88); C711(1.10)  LDD1224  [7]
 LDCM0346  AC80 HCT 116 C711(1.15)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C711(1.34)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C711(1.51)  LDD0665  [7]
 LDCM0349  AC83 HEK-293T C14(0.88); C187(0.78); C937(0.88)  LDD0947  [7]
 LDCM0350  AC84 HEK-293T C14(1.23); C187(1.45); C937(1.23)  LDD0948  [7]
 LDCM0351  AC85 HEK-293T C14(0.89); C187(1.02); C937(0.89)  LDD0949  [7]
 LDCM0352  AC86 HEK-293T C14(0.99); C187(0.92); C937(0.99)  LDD0950  [7]
 LDCM0353  AC87 HEK-293T C14(1.05); C187(1.03); C937(1.05)  LDD0951  [7]
 LDCM0354  AC88 HEK-293T C14(1.01); C187(1.16); C937(1.01)  LDD0952  [7]
 LDCM0355  AC89 HEK-293T C14(0.97); C187(1.15); C937(0.97)  LDD0953  [7]
 LDCM0357  AC90 HEK-293T C14(1.08); C187(1.04); C937(1.08)  LDD0955  [7]
 LDCM0358  AC91 HEK-293T C14(1.10); C187(0.94); C937(1.10)  LDD0956  [7]
 LDCM0359  AC92 HEK-293T C14(1.01); C187(0.98); C937(1.01)  LDD0957  [7]
 LDCM0360  AC93 HEK-293T C14(1.11); C187(0.94); C937(1.11)  LDD0958  [7]
 LDCM0361  AC94 HEK-293T C14(0.81); C187(0.95); C937(0.81)  LDD0959  [7]
 LDCM0362  AC95 HEK-293T C14(1.24); C187(1.25); C937(1.24)  LDD0960  [7]
 LDCM0363  AC96 HEK-293T C14(1.15); C187(0.80); C937(1.15)  LDD0961  [7]
 LDCM0364  AC97 HEK-293T C14(1.33); C187(0.96); C937(1.33)  LDD0962  [7]
 LDCM0365  AC98 HEK-293T C14(0.92); C937(0.92)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C14(0.82); C937(0.82)  LDD0964  [7]
 LDCM0248  AKOS034007472 PaTu 8988t C792(0.97); C14(0.95); C711(0.99)  LDD1127  [7]
 LDCM0356  AKOS034007680 PaTu 8988t C792(1.21); C14(0.75); C711(1.11)  LDD1235  [7]
 LDCM0275  AKOS034007705 PaTu 8988t C792(1.17); C14(1.05); C711(1.35)  LDD1154  [7]
 LDCM0102  BDHI 8 Jurkat C833(9.49)  LDD0204  [1]
 LDCM0367  CL1 PaTu 8988t C14(0.79); C711(1.01)  LDD1246  [7]
 LDCM0368  CL10 PaTu 8988t C14(0.83); C711(0.84)  LDD1247  [7]
 LDCM0369  CL100 PaTu 8988t C792(0.99); C937(0.73); C711(0.50)  LDD1248  [7]
 LDCM0370  CL101 PaTu 8988t C792(1.02); C14(0.98); C711(0.95)  LDD1249  [7]
 LDCM0371  CL102 PaTu 8988t C792(1.11); C14(1.15); C711(0.91)  LDD1250  [7]
 LDCM0372  CL103 PaTu 8988t C792(1.14); C14(1.51); C711(1.35)  LDD1251  [7]
 LDCM0373  CL104 PaTu 8988t C792(1.04); C14(1.34); C711(0.99)  LDD1252  [7]
 LDCM0374  CL105 PaTu 8988t C937(0.89); C711(0.87)  LDD1253  [7]
 LDCM0375  CL106 PaTu 8988t C937(0.82); C711(1.21)  LDD1254  [7]
 LDCM0376  CL107 PaTu 8988t C937(0.92); C711(1.07)  LDD1255  [7]
 LDCM0377  CL108 PaTu 8988t C937(0.71); C711(0.89)  LDD1256  [7]
 LDCM0378  CL109 PaTu 8988t C937(0.78); C711(0.94)  LDD1257  [7]
 LDCM0379  CL11 PaTu 8988t C14(0.67); C711(0.84)  LDD1258  [7]
 LDCM0380  CL110 PaTu 8988t C937(0.78); C711(0.82)  LDD1259  [7]
 LDCM0381  CL111 PaTu 8988t C937(0.79); C711(1.04)  LDD1260  [7]
 LDCM0382  CL112 HCT 116 C711(0.80)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C711(0.85)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C711(0.82)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C711(0.97)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C711(0.66)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C711(0.90)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C711(0.81)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C711(0.84)  LDD0706  [7]
 LDCM0390  CL12 PaTu 8988t C14(1.37); C711(0.91)  LDD1269  [7]
 LDCM0391  CL120 HCT 116 C711(0.77)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C711(0.83)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C711(1.01)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C711(1.09)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C711(0.90)  LDD0712  [7]
 LDCM0396  CL125 HEK-293T C187(1.19); C711(1.19)  LDD0994  [7]
 LDCM0397  CL126 HEK-293T C187(1.22); C711(1.22)  LDD0995  [7]
 LDCM0398  CL127 HEK-293T C187(1.38); C711(1.38)  LDD0996  [7]
 LDCM0399  CL128 HEK-293T C187(1.48); C711(1.48)  LDD0997  [7]
 LDCM0400  CL13 PaTu 8988t C14(1.12); C711(0.93)  LDD1279  [7]
 LDCM0401  CL14 PaTu 8988t C14(1.42); C711(0.88)  LDD1280  [7]
 LDCM0402  CL15 PaTu 8988t C14(1.09); C711(0.95)  LDD1281  [7]
 LDCM0403  CL16 HEK-293T C187(1.24)  LDD1001  [7]
 LDCM0404  CL17 HEK-293T C187(0.96)  LDD1002  [7]
 LDCM0405  CL18 HEK-293T C187(0.95)  LDD1003  [7]
 LDCM0406  CL19 HEK-293T C187(1.08)  LDD1004  [7]
 LDCM0407  CL2 PaTu 8988t C14(0.74); C711(1.10)  LDD1286  [7]
 LDCM0408  CL20 HEK-293T C187(1.31)  LDD1006  [7]
 LDCM0409  CL21 HEK-293T C187(0.87)  LDD1007  [7]
 LDCM0410  CL22 HEK-293T C187(1.53)  LDD1008  [7]
 LDCM0411  CL23 HEK-293T C187(0.85)  LDD1009  [7]
 LDCM0412  CL24 HEK-293T C187(0.78)  LDD1010  [7]
 LDCM0413  CL25 HEK-293T C187(0.87)  LDD1011  [7]
 LDCM0414  CL26 HEK-293T C187(1.10)  LDD1012  [7]
 LDCM0415  CL27 HEK-293T C187(0.75)  LDD1013  [7]
 LDCM0416  CL28 HEK-293T C187(0.67)  LDD1014  [7]
 LDCM0417  CL29 HEK-293T C187(1.12)  LDD1015  [7]
 LDCM0418  CL3 PaTu 8988t C14(0.82); C711(0.91)  LDD1297  [7]
 LDCM0419  CL30 HEK-293T C187(1.17)  LDD1017  [7]
 LDCM0420  CL31 HEK-293T C187(2.81); C711(2.81)  LDD1018  [7]
 LDCM0421  CL32 HEK-293T C187(1.13); C711(1.13)  LDD1019  [7]
 LDCM0422  CL33 HEK-293T C187(0.97); C711(0.97)  LDD1020  [7]
 LDCM0423  CL34 HEK-293T C187(1.56); C711(1.56)  LDD1021  [7]
 LDCM0424  CL35 HEK-293T C187(1.18); C711(1.18)  LDD1022  [7]
 LDCM0425  CL36 HEK-293T C187(1.24); C711(1.24)  LDD1023  [7]
 LDCM0426  CL37 HEK-293T C187(1.04); C711(1.04)  LDD1024  [7]
 LDCM0428  CL39 HEK-293T C187(1.52); C711(1.52)  LDD1026  [7]
 LDCM0429  CL4 PaTu 8988t C14(0.81); C711(0.99)  LDD1308  [7]
 LDCM0430  CL40 HEK-293T C187(1.25); C711(1.25)  LDD1028  [7]
 LDCM0431  CL41 HEK-293T C187(1.29); C711(1.29)  LDD1029  [7]
 LDCM0432  CL42 HEK-293T C187(1.35); C711(1.35)  LDD1030  [7]
 LDCM0433  CL43 HEK-293T C187(1.64); C711(1.64)  LDD1031  [7]
 LDCM0434  CL44 HEK-293T C187(1.36); C711(1.36)  LDD1032  [7]
 LDCM0435  CL45 HEK-293T C187(1.30); C711(1.30)  LDD1033  [7]
 LDCM0436  CL46 PaTu 8988t C711(0.83)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C711(0.76)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C711(0.90)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C711(1.48)  LDD1318  [7]
 LDCM0440  CL5 PaTu 8988t C14(1.23); C711(0.95)  LDD1319  [7]
 LDCM0441  CL50 PaTu 8988t C711(0.74)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C711(0.73)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C711(0.93)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C711(0.88)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C711(0.84)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C711(0.97)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C711(0.20)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C711(1.23)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C711(0.94)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C711(1.12)  LDD1329  [7]
 LDCM0451  CL6 PaTu 8988t C14(1.04); C711(0.92)  LDD1330  [7]
 LDCM0452  CL60 PaTu 8988t C711(0.95)  LDD1331  [7]
 LDCM0453  CL61 HCT 116 C711(0.82)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C711(0.82)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C711(0.86)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C711(1.02)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C711(0.87)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C711(0.93)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C711(1.03)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C711(0.85)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C711(0.97)  LDD0778  [7]
 LDCM0462  CL7 PaTu 8988t C14(0.96); C711(1.04)  LDD1341  [7]
 LDCM0463  CL70 HCT 116 C711(0.88)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C711(0.84)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C711(0.94)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C711(1.20)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C711(0.95)  LDD0784  [7]
 LDCM0469  CL76 PaTu 8988t C14(0.58); C711(0.78)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C14(0.81); C711(0.69)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C14(0.67); C711(0.64)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C14(0.61); C711(0.75)  LDD1351  [7]
 LDCM0473  CL8 PaTu 8988t C14(0.81); C711(0.87)  LDD1352  [7]
 LDCM0474  CL80 PaTu 8988t C14(0.70); C711(0.66)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C14(0.68); C711(0.67)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C14(0.63); C711(0.73)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C14(0.64); C711(0.67)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C14(0.79); C711(0.70)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C14(0.66); C711(0.70)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C14(0.77); C711(0.75)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C14(0.76); C711(0.81)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C14(0.87); C711(0.68)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C14(0.96); C711(0.78)  LDD1362  [7]
 LDCM0484  CL9 PaTu 8988t C14(1.04); C711(0.96)  LDD1363  [7]
 LDCM0485  CL90 PaTu 8988t C14(0.77); C711(0.97)  LDD1364  [7]
 LDCM0486  CL91 PaTu 8988t C792(0.98); C937(0.55); C711(0.57)  LDD1365  [7]
 LDCM0487  CL92 PaTu 8988t C792(1.04); C937(0.74); C711(0.66)  LDD1366  [7]
 LDCM0488  CL93 PaTu 8988t C792(1.08); C937(0.66); C711(0.59)  LDD1367  [7]
 LDCM0489  CL94 PaTu 8988t C792(1.04); C937(0.64); C711(0.75)  LDD1368  [7]
 LDCM0490  CL95 PaTu 8988t C792(1.07); C937(0.54); C711(0.73)  LDD1369  [7]
 LDCM0491  CL96 PaTu 8988t C792(0.97); C937(0.58); C711(0.57)  LDD1370  [7]
 LDCM0492  CL97 PaTu 8988t C792(1.06); C937(0.73); C711(0.62)  LDD1371  [7]
 LDCM0493  CL98 PaTu 8988t C792(1.21); C937(0.57); C711(0.50)  LDD1372  [7]
 LDCM0494  CL99 PaTu 8988t C792(0.98); C937(0.71); C711(0.57)  LDD1373  [7]
 LDCM0495  E2913 HEK-293T C187(0.97); C833(0.97); C72(1.07); C792(1.01)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C711(0.77)  LDD0785  [7]
 LDCM0427  Fragment51 HEK-293T C187(1.46); C711(1.46)  LDD1025  [7]
 LDCM0022  KB02 HEK-293T C914(1.00); C187(0.74); C833(0.93); C477(0.91)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C914(1.02); C187(1.02); C833(0.98); C477(0.91)  LDD1497  [8]
 LDCM0024  KB05 MKN-1 C833(5.15)  LDD3331  [9]

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840