Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name	C105			Probe Info
Probe concentration	Probe:50uM; negative probe:50uM
Criteria	Quantification: AfBPP Probe vs Negative Probe
Quantitative Method	TMT
*In Vivo* Experiment Model**	Model Type		Living cell
	Derived Tissue		Peripheral blood
	Disease Model	Normal
	Model Name	Human normal cells (HEK-293T)
Note	Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme

Click to Show/Hide to Show 2 Protein Related to This Bioclass

Target ID	Target Name					Binding Ratio
LDTP06333	Serum paraoxonase/arylesterase 2 (PON2)					7.2
LDTP10101	Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10)					6.7

Transporter and channel

Click to Show/Hide to Show 3 Protein Related to This Bioclass

Target ID	Target Name	Binding Ratio
LDTP01059	Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B)	9.3
LDTP07885	Mitochondrial S-adenosylmethionine carrier protein (SLC25A26)	6.7
LDTP03277	ER lumen protein-retaining receptor 1 (KDELR1)	6.2

Other

Click to Show/Hide to Show 1 Protein Related to This Bioclass

Target ID	Target Name					Binding Ratio
LDTP08073	Tetratricopeptide repeat protein 21B (TTC21B)					5.1

References

1	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587