Details of the Target

General Information of Target

Target ID LDTP10101
Target Name Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10)
Gene Name FKBP10
Gene ID 60681
Synonyms
FKBP65; Peptidyl-prolyl cis-trans isomerase FKBP10; PPIase FKBP10; EC 5.2.1.8; 65 kDa FK506-binding protein; 65 kDa FKBP; FKBP-65; FK506-binding protein 10; FKBP-10; Immunophilin FKBP65; Rotamase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAP
ELFSPPVPEIAETVTQTQPVRLLSSESEDEEEFIPLAQRLTCKFLTHKQLSPEDSSSPVK
SVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRM
KAQRPEECLKHIIVVLDPVLLQMEGGGQLLGALQTMECRCVIEAQAVPCSVTWRRRAGPS
EDREDWVEEPTVLVLLRAEAFVSMIDNGKQGSLDSTMKGKETLQGFVTDITAKTAGKALS
LVIVDQEKCFSAQNPPRRGKQGANKQTKKQQQRQPEASIGSMVSRVDAEEALVDLQLHTE
AQAQIVQSWKELADFTCAFTKAVAEAPFKKLRDETTFSFCLESDWAGGVKVDLAGRGLAL
VWRRQIQQLNRVSLEMASAVVNAYPSPQLLVQAYQQCFSDKERQNLLADIQVRRGEGVTS
TSRRIGPELSRRIYLQMTTLQPHLSLDSAD
Target Bioclass
Enzyme
Subcellular location
Endoplasmic reticulum lumen
Function PPIases accelerate the folding of proteins during protein synthesis.
TTD ID
T01603
Uniprot ID
Q96AY3
DrugMap ID
TT4P8O2
Ensemble ID
ENST00000321562.9
HGNC ID
HGNC:18169

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ETK1 SNV: p.P7H DBIA    Probe Info 
HCT116 Deletion: p.S8AfsTer151 DBIA    Probe Info 
HGC27 SNV: p.V435A DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.T139N DBIA    Probe Info 
LNCaP clone FGC SNV: p.R309H; p.M509I DBIA    Probe Info 
MFE319 SNV: p.R104P DBIA    Probe Info 
P31FUJ SNV: p.V92M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		4.33  LDD0066  [1]
HHS-482
 Probe Info  		Y201(1.07)  LDD0285  [2]
HHS-475
 Probe Info  		Y201(0.67); Y204(0.81); Y237(0.84)  LDD0264  [3]
HHS-465
 Probe Info  		Y201(1.55); Y204(1.47)  LDD2237  [4]
DBIA
 Probe Info  		C447(1.63)  LDD0080  [5]
5E-2FA
 Probe Info  		H166(0.00); H346(0.00)  LDD2235  [6]
ATP probe
 Probe Info  		K568(0.00); K570(0.00); K534(0.00)  LDD0199  [7]
m-APA
 Probe Info  		H498(0.00); H166(0.00); H346(0.00); H459(0.00)  LDD2231  [6]
IA-alkyne
 Probe Info  		C110(0.00); C222(0.00)  LDD0032  [8]
IPM
 Probe Info  		N.A.  LDD2156  [9]
NHS
 Probe Info  		N.A.  LDD0010  [10]
SF
 Probe Info  		N.A.  LDD0028  [11]
STPyne
 Probe Info  		N.A.  LDD0009  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
1c-yne
 Probe Info  		N.A.  LDD0228  [13]
Acrolein
 Probe Info  		C447(0.00); C222(0.00); C279(0.00); H462(0.00)  LDD0217  [14]
Crotonaldehyde
 Probe Info  		C447(0.00); C110(0.00); C279(0.00)  LDD0219  [14]
Methacrolein
 Probe Info  		C447(0.00); C279(0.00); C110(0.00); C222(0.00)  LDD0218  [14]
NAIA_5
 Probe Info  		C222(0.00); C279(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C002
 Probe Info  		8.57  LDD1712  [16]
C017
 Probe Info  		8.40  LDD1725  [16]
C022
 Probe Info  		6.82  LDD1728  [16]
C027
 Probe Info  		5.31  LDD1733  [16]
C041
 Probe Info  		6.28  LDD1741  [16]
C105
 Probe Info  		6.73  LDD1792  [16]
C106
 Probe Info  		18.25  LDD1793  [16]
C139
 Probe Info  		18.13  LDD1821  [16]
C147
 Probe Info  		13.83  LDD1829  [16]
C159
 Probe Info  		7.21  LDD1839  [16]
C160
 Probe Info  		8.88  LDD1840  [16]
C161
 Probe Info  		10.13  LDD1841  [16]
C173
 Probe Info  		5.31  LDD1853  [16]
C178
 Probe Info  		51.63  LDD1857  [16]
C206
 Probe Info  		19.84  LDD1881  [16]
C220
 Probe Info  		14.22  LDD1894  [16]
C236
 Probe Info  		6.36  LDD1909  [16]
C238
 Probe Info  		11.16  LDD1911  [16]
C265
 Probe Info  		22.63  LDD1936  [16]
C282
 Probe Info  		15.03  LDD1952  [16]
C342
 Probe Info  		9.85  LDD2004  [16]
C343
 Probe Info  		14.72  LDD2005  [16]
C351
 Probe Info  		7.67  LDD2012  [16]
C361
 Probe Info  		75.06  LDD2022  [16]
C376
 Probe Info  		6.41  LDD2036  [16]
C430
 Probe Info  		5.21  LDD2085  [16]
C431
 Probe Info  		20.97  LDD2086  [16]
FFF probe11
 Probe Info  		16.50  LDD0471  [17]
FFF probe13
 Probe Info  		20.00  LDD0475  [17]
FFF probe14
 Probe Info  		20.00  LDD0477  [17]
FFF probe15
 Probe Info  		12.73  LDD0478  [17]
OEA-DA
 Probe Info  		20.00  LDD0046  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C392(1.05); C222(1.06); C447(0.99); C279(1.04)  LDD1507  [19]
 LDCM0215  AC10 HCT 116 C222(1.04)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C110(1.28); C222(0.36)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C110(0.79); C222(0.43)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C110(0.49); C222(0.32)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C110(0.72); C222(0.28)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C110(0.63); C222(0.29)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C110(0.73); C222(0.29)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C110(0.60); C222(0.26)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C110(0.94); C222(0.43)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C110(0.74); C222(0.29)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C110(0.69); C222(0.30)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C222(1.04)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C110(0.91); C222(0.28)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C110(1.22); C222(0.30)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C110(0.51); C222(0.40)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C110(0.93); C222(1.27)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C110(0.91); C222(1.19)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C110(1.61); C222(1.09)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C110(0.74); C222(1.29)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C110(0.77); C222(1.24)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C110(1.27); C222(1.14)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C110(1.36); C222(1.18)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C222(1.10)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C110(0.82); C222(1.15)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C110(0.81); C222(0.98)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C110(0.59); C222(1.29)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C110(1.48); C222(0.87)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C110(1.19); C222(1.06)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C110(0.63); C222(1.25)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C110(0.93); C222(1.03)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C110(0.67); C222(1.21)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C110(0.63); C222(0.65)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C110(1.08); C222(0.66)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C110(1.04); C222(0.64)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C110(1.15); C222(0.75)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C110(1.23); C222(0.75)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C110(1.04); C222(0.71)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C110(1.19); C222(0.74)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C110(1.02); C222(0.71)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C110(1.29); C222(0.73)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C110(0.91); C222(0.67)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C110(1.46); C222(0.76)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C110(1.08); C222(0.74)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C222(1.02)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C110(1.33); C222(0.76)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C110(1.24); C222(0.81)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C110(1.31); C222(0.68)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C110(1.04); C222(1.34)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C110(0.49); C222(0.66)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C110(0.66); C222(0.76)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C110(0.58); C222(0.73)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C222(0.68); C110(0.75)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C222(0.60); C110(0.76)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C110(0.53); C222(0.75)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C222(0.99)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C222(1.27); C110(1.36)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C222(1.11); C110(1.31)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C222(0.64); C110(0.71)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C222(0.58); C110(0.66)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C110(0.67); C222(0.68)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C110(0.71); C222(0.71)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C110(1.39); C222(0.93)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C110(0.91); C222(0.80)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C222(1.07)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C222(1.23)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C222(1.24)  LDD0595  [5]
 LDCM0279  AC2 HEK-293T C392(0.93); C222(0.94); C447(0.99); C279(1.00)  LDD1518  [19]
 LDCM0280  AC20 HCT 116 C222(1.17)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C222(1.28)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C222(1.02)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C222(1.22)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C222(1.14)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C110(0.92); C222(0.97)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C222(0.81); C110(1.05)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C110(0.75); C222(0.79)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C110(0.60); C222(0.71)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C222(0.66); C110(0.79)  LDD0606  [5]
 LDCM0290  AC3 HEK-293T C392(1.07); C222(1.05); C447(1.05); C279(1.29)  LDD1529  [19]
 LDCM0291  AC30 HCT 116 C222(0.64); C110(0.82)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C222(0.68); C110(0.74)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C222(0.62); C110(0.74)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C222(0.63); C110(0.69)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C222(0.70); C110(0.71)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C222(1.38)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C222(1.47)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C222(1.27)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C222(1.42)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C222(1.35)  LDD0617  [5]
 LDCM0301  AC4 HEK-293T C392(0.84); C222(1.16); C447(1.04); C279(1.05)  LDD1540  [19]
 LDCM0302  AC40 HCT 116 C222(1.06)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C222(1.42)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C222(1.23)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C222(1.15)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C222(1.25)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C222(1.08)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C222(1.03)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C222(0.94)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C222(0.81)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C222(1.00)  LDD0628  [5]
 LDCM0312  AC5 HEK-293T C392(0.98); C222(1.04); C447(1.01); C279(0.98)  LDD1551  [19]
 LDCM0313  AC50 HCT 116 C222(0.89)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C222(1.11)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C222(1.05)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C222(0.90)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C222(1.01)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C222(0.97)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C222(0.83)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C222(0.49)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C222(0.39)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C222(0.50)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C222(0.82)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C222(0.53)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C222(0.42)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C222(0.49)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C222(0.46)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C222(0.50)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C222(0.55)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C222(0.51)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C222(0.43)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C222(0.83)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C222(0.81)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C222(0.96)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C222(0.62)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C222(1.04)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C222(0.89)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C222(0.78)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C222(0.75)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C222(0.80)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C222(0.80)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C222(0.78)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C222(0.76)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C222(1.02)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C222(0.83)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C222(0.84)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C222(0.87)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C222(0.72)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C222(0.49)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C222(0.46)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C222(0.51)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C222(1.06)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C222(0.63)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C222(0.64)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C222(0.42)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C222(0.65)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C222(0.48)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C222(0.40)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C222(0.72)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C222(0.37)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C222(0.44)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C222(0.38)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C222(0.51)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C222(0.19); C110(0.72)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C222(0.49); C110(0.56)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C222(1.29)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C222(1.12)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C222(0.74)  LDD0592  [5]
 LDCM0108  Chloroacetamide HeLa C447(0.00); C279(0.00); C222(0.00); C110(0.00)  LDD0222  [14]
 LDCM0367  CL1 HEK-293T C222(1.03)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C222(0.80)  LDD0966  [5]
 LDCM0369  CL100 HEK-293T C392(0.94); C222(0.94); C447(1.01); C279(0.99)  LDD1573  [19]
 LDCM0370  CL101 HCT 116 C222(1.09)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C222(0.94)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C222(1.57)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C222(1.12)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C222(1.18)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C222(1.66)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C222(1.05)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C222(1.10)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C222(1.25)  LDD0695  [5]
 LDCM0379  CL11 HEK-293T C222(1.01)  LDD0977  [5]
 LDCM0380  CL110 HCT 116 C222(0.97)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C222(0.99)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C110(0.90); C222(0.99)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C222(0.60); C110(0.90)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C222(0.74); C110(1.01)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C222(0.94); C110(0.98)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C110(0.61); C222(0.83)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C222(1.16)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C222(1.20)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C222(1.07)  LDD0706  [5]
 LDCM0390  CL12 HEK-293T C222(1.30)  LDD0988  [5]
 LDCM0391  CL120 HCT 116 C222(1.14)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C222(1.12)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C222(0.91)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C222(0.92)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C222(0.96)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C222(0.77)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C222(0.74)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C222(0.56)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C222(0.59)  LDD0716  [5]
 LDCM0400  CL13 HEK-293T C222(1.03)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C222(0.98)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C222(0.88)  LDD1000  [5]
 LDCM0403  CL16 HCT 116 C110(0.44); C222(0.77)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C110(0.53); C222(0.66)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C222(0.42); C110(0.51)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C110(0.41); C222(0.55)  LDD0723  [5]
 LDCM0407  CL2 HEK-293T C222(1.18)  LDD1005  [5]
 LDCM0408  CL20 HCT 116 C222(0.68); C110(2.20)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C110(0.58); C222(0.59)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C110(0.37); C222(0.68)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C222(0.72); C110(0.77)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C110(0.60); C222(0.69)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C110(0.47); C222(0.58)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C110(0.80); C222(0.63)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C110(0.52); C222(0.74)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C110(0.63); C222(0.59)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C110(0.74); C222(0.65)  LDD0734  [5]
 LDCM0418  CL3 HEK-293T C222(1.23)  LDD1016  [5]
 LDCM0419  CL30 HCT 116 C110(0.57); C222(0.71)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C222(0.89)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C222(0.72)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C222(0.66)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C222(0.70)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C222(0.74)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C222(0.80)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C222(0.72)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C222(0.92)  LDD0745  [5]
 LDCM0429  CL4 HEK-293T C222(1.12)  LDD1027  [5]
 LDCM0430  CL40 HCT 116 C222(0.68)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C222(0.76)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C222(0.74)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C222(0.86)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C222(0.79)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C222(0.89)  LDD0752  [5]
 LDCM0436  CL46 HEK-293T C222(0.96)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C222(1.10)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C222(1.03)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C222(0.99)  LDD1037  [5]
 LDCM0440  CL5 HEK-293T C222(1.08)  LDD1038  [5]
 LDCM0441  CL50 HEK-293T C222(1.10)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C222(1.00)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C222(1.13)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C222(0.94)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C222(1.11)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C222(1.10)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C222(1.06)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C222(0.91)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C222(0.99)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C222(0.92)  LDD1048  [5]
 LDCM0451  CL6 HEK-293T C222(1.08)  LDD1049  [5]
 LDCM0452  CL60 HEK-293T C222(0.82)  LDD1050  [5]
 LDCM0453  CL61 HCT 116 C222(0.84)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C222(0.92)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C222(1.06)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C222(0.99)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C222(0.85)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C222(0.95)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C222(0.94)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C222(0.78)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C222(0.81)  LDD0778  [5]
 LDCM0462  CL7 HEK-293T C222(1.00)  LDD1060  [5]
 LDCM0463  CL70 HCT 116 C222(0.77)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C222(0.80)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C222(1.00)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C222(0.95)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C222(0.89)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C222(0.57)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C222(0.65)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C222(0.77)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C222(0.62)  LDD0789  [5]
 LDCM0473  CL8 HEK-293T C392(1.26); C222(0.98); C447(0.84); C279(1.05)  LDD1676  [19]
 LDCM0474  CL80 HCT 116 C222(0.46)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C222(0.71)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C222(0.58)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C222(0.54)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C222(0.56)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C222(0.68)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C222(0.78)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C222(0.71)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C222(0.54)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C222(0.58)  LDD0800  [5]
 LDCM0484  CL9 HEK-293T C392(0.99); C222(1.12); C447(0.86); C279(0.91)  LDD1687  [19]
 LDCM0485  CL90 HCT 116 C222(1.33)  LDD0802  [5]
 LDCM0486  CL91 HEK-293T C392(1.00); C222(0.97); C447(0.93); C279(1.06)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C392(1.05); C222(1.03); C447(1.05); C279(1.06)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C392(1.00); C222(1.10); C447(0.85); C279(1.00)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C392(0.82); C222(0.98); C447(0.99); C279(1.12)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C392(1.16); C222(1.33); C447(0.89); C279(1.06)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C392(1.02); C222(1.01); C447(1.03); C279(1.09)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C392(1.11); C222(1.06); C447(0.96); C279(0.97)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C392(1.11); C222(1.02); C447(0.90); C279(0.97)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C392(0.96); C222(0.97); C447(1.01); C279(0.97)  LDD1697  [19]
 LDCM0495  E2913 HEK-293T C392(0.98); C222(1.07); C447(1.01); C279(0.95)  LDD1698  [19]
 LDCM0468  Fragment33 HCT 116 C222(0.83)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C222(0.67)  LDD0744  [5]
 LDCM0116  HHS-0101 DM93 Y201(0.67); Y204(0.81); Y237(0.84)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y201(0.63); Y204(0.72); Y237(0.75)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y201(0.67); Y204(0.75); Y237(1.13)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y204(0.73); Y237(0.76); Y201(0.81)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y237(0.57); Y201(0.73); Y204(0.77)  LDD0268  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [14]
 LDCM0123  JWB131 DM93 Y201(1.07)  LDD0285  [2]
 LDCM0124  JWB142 DM93 Y201(1.45)  LDD0286  [2]
 LDCM0125  JWB146 DM93 Y201(1.08)  LDD0287  [2]
 LDCM0126  JWB150 DM93 Y201(10.89)  LDD0288  [2]
 LDCM0127  JWB152 DM93 Y201(2.03)  LDD0289  [2]
 LDCM0128  JWB198 DM93 Y201(1.89)  LDD0290  [2]
 LDCM0129  JWB202 DM93 Y201(0.93)  LDD0291  [2]
 LDCM0130  JWB211 DM93 Y201(0.89)  LDD0292  [2]
 LDCM0022  KB02 HCT 116 C447(1.63)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C447(1.95)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C447(1.40)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0225  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402