Details of the Probe-central Interaction Altas
General Information of Experiment
| Probe Name | C430 | Probe Info | ||||
|---|---|---|---|---|---|---|
| Probe concentration | Probe:50uM; negative probe:50uM | |||||
| Criteria | Quantification: AfBPP Probe vs Negative Probe | |||||
| Quantitative Method |
TMT
|
|||||
| In Vivo Experiment Model | Model Type |
|
Living cell | |||
| Derived Tissue |
|
Peripheral blood | ||||
| Disease Model | Normal | |||||
| Model Name | Human normal cells (HEK-293T) | |||||
| Note | Negative probe:C#CCCC1(CCC(NC)=O)N=N1 | |||||
Interaction Altas of This Experiment [1]
Enzyme
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP01803 | Adenosine deaminase (ADA) | 25.3 | ||||
| LDTP12293 | Adipocyte plasma membrane-associated protein (APMAP) | 24.9 | ||||
| LDTP12363 | Lysophosphatidic acid phosphatase type 6 (ACP6) | 23.9 | ||||
| LDTP01773 | Cytochrome c oxidase subunit 2 (MT-CO2) | 17.8 | ||||
| LDTP02175 | Epoxide hydrolase 1 (EPHX1) | 17.8 | ||||
| LDTP12628 | Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) | 14.6 | ||||
| LDTP04004 | Lysosomal Pro-X carboxypeptidase (PRCP) | 13.9 | ||||
| LDTP15484 | Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) | 12.4 | ||||
| LDTP05758 | S-methyl-5'-thioadenosine phosphorylase (MTAP) | 11.6 | ||||
| LDTP03540 | Heme oxygenase 2 (HMOX2) | 10.3 | ||||
| LDTP13282 | Prenylcysteine oxidase 1 (PCYOX1) | 10.3 | ||||
| LDTP13972 | Oligoribonuclease, mitochondrial (REXO2) | 10.1 | ||||
| LDTP01419 | Retinal dehydrogenase 2 (ALDH1A2) | 10.0 | ||||
| LDTP04051 | Nicotinamide phosphoribosyltransferase (NAMPT) | 9.9 | ||||
| LDTP04008 | Endothelin-converting enzyme 1 (ECE1) | 9.8 | ||||
| LDTP11225 | Deoxyhypusine hydroxylase (DOHH) | 9.2 | ||||
| LDTP04712 | Puromycin-sensitive aminopeptidase (NPEPPS) | 8.9 | ||||
| LDTP03417 | Proteasome subunit beta type-4 (PSMB4) | 8.5 | ||||
| LDTP04285 | Proteasome subunit beta type-2 (PSMB2) | 7.8 | ||||
| LDTP13358 | Leucyl-cystinyl aminopeptidase (LNPEP) | 7.5 | ||||
| LDTP00544 | Sphingolipid delta(4)-desaturase DES1 (DEGS1) | 7.4 | ||||
| LDTP03560 | Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) | 7.2 | ||||
| LDTP00832 | NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) | 7.2 | ||||
| LDTP01687 | Apoptosis-inducing factor 1, mitochondrial (AIFM1) | 7.2 | ||||
| LDTP02254 | ATP-dependent translocase ABCB1 (ABCB1) | 6.6 | ||||
| LDTP05724 | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) | 6.5 | ||||
| LDTP04531 | Hexokinase-2 (HK2) | 6.4 | ||||
| LDTP09088 | Phospholipase A2 group XV (PLA2G15) | 6.0 | ||||
| LDTP17247 | 5'-nucleotidase domain-containing protein 1 (NT5DC1) | 5.9 | ||||
| LDTP05632 | Mitochondrial-processing peptidase subunit alpha (PMPCA) | 5.9 | ||||
| LDTP05862 | NAD(P) transhydrogenase, mitochondrial (NNT) | 5.9 | ||||
| LDTP04211 | Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) | 5.8 | ||||
| LDTP08476 | 5'-3' exonuclease PLD3 (PLD3) | 5.8 | ||||
| LDTP02522 | 60 kDa heat shock protein, mitochondrial (HSPD1) | 5.8 | ||||
| LDTP06375 | Delta(24)-sterol reductase (DHCR24) | 5.8 | ||||
| LDTP08265 | N-alpha-acetyltransferase 40 (NAA40) | 5.7 | ||||
| LDTP05476 | 3-ketodihydrosphingosine reductase (KDSR) | 5.7 | ||||
| LDTP03257 | Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) | 5.7 | ||||
| LDTP00639 | ATP-binding cassette sub-family C member 4 (ABCC4) | 5.7 | ||||
| LDTP06618 | ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) | 5.4 | ||||
| LDTP12279 | Endoplasmic reticulum transmembrane helix translocase (ATP13A1) | 5.4 | ||||
| LDTP03189 | Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) | 5.3 | ||||
| LDTP10101 | Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) | 5.2 | ||||
| LDTP06750 | Prolyl 3-hydroxylase 1 (P3H1) | 5.2 | ||||
| LDTP00697 | Cytochrome b5 type B (CYB5B) | 5.1 | ||||
Transporter and channel
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP10913 | Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) | 38.9 | ||||
| LDTP01059 | Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) | 29.9 | ||||
| LDTP07885 | Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) | 23.4 | ||||
| LDTP07236 | Protein GPR107 (GPR107) | 14.6 | ||||
| LDTP14970 | Metaxin-3 (MTX3) | 12.8 | ||||
| LDTP17641 | Solute carrier family 35 member F2 (SLC35F2) | 10.1 | ||||
| LDTP03132 | Voltage-dependent anion-selective channel protein 1 (VDAC1) | 9.2 | ||||
| LDTP00865 | Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) | 8.6 | ||||
| LDTP11927 | Essential MCU regulator, mitochondrial (SMDT1) | 8.6 | ||||
| LDTP12383 | Protein GPR108 (GPR108) | 8.6 | ||||
| LDTP05900 | Metaxin-1 (MTX1) | 8.3 | ||||
| LDTP04956 | Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) | 8.2 | ||||
| LDTP14952 | Mpv17-like protein 2 (MPV17L2) | 8.0 | ||||
| LDTP16069 | Peroxisomal membrane protein 2 (PXMP2) | 7.8 | ||||
| LDTP07667 | Transmembrane protein 205 (TMEM205) | 7.7 | ||||
| LDTP01804 | ATP synthase subunit a (MT-ATP6) | 6.9 | ||||
| LDTP17362 | Magnesium transporter NIPA3 (NIPAL1) | 6.7 | ||||
| LDTP09547 | Scavenger receptor class B member 1 (SCARB1) | 6.5 | ||||
| LDTP15845 | Transmembrane 9 superfamily member 2 (TM9SF2) | 6.2 | ||||
| LDTP07462 | MFS-type transporter SLC18B1 (SLC18B1) | 6.0 | ||||
| LDTP13174 | Mitochondrial dicarboxylate carrier (SLC25A10) | 5.9 | ||||
| LDTP03546 | Translocator protein (TSPO) | 5.9 | ||||
| LDTP00592 | Surfeit locus protein 4 (SURF4) | 5.6 | ||||
| LDTP04071 | Voltage-dependent anion-selective channel protein 2 (VDAC2) | 5.3 | ||||
| LDTP08881 | Transmembrane protein 199 (TMEM199) | 5.1 | ||||
| LDTP15948 | Transmembrane protein 126A (TMEM126A) | 5.0 | ||||
| LDTP01671 | STARD3 N-terminal-like protein (STARD3NL) | 4.9 | ||||
Other
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP15623 | Neuferricin (CYB5D2) | 40.2 | ||||
| LDTP15269 | Large ribosomal subunit protein mL55 (MRPL55) | 33.6 | ||||
| LDTP00281 | Golgi integral membrane protein 4 (GOLIM4) | 13.0 | ||||
| LDTP05160 | Nucleobindin-2 (NUCB2) | 11.1 | ||||
| LDTP00105 | Protein unc-119 homolog B (UNC119B) | 9.7 | ||||
| LDTP13630 | Neudesin (NENF) | 9.0 | ||||
| LDTP03678 | ER lumen protein-retaining receptor 2 (KDELR2) | 8.8 | ||||
| LDTP12565 | Mitochondrial import receptor subunit TOM22 homolog (TOMM22) | 7.9 | ||||
| LDTP06097 | Reticulocalbin-2 (RCN2) | 7.8 | ||||
| LDTP04951 | Nuclear transport factor 2 (NUTF2) | 7.8 | ||||
| LDTP08689 | Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) | 6.7 | ||||
| LDTP09881 | TATA-binding protein-associated factor 2N (TAF15) | 6.3 | ||||
| LDTP13902 | Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) | 6.0 | ||||
| LDTP01652 | Centrosomal protein 43 (CEP43) | 5.9 | ||||
| LDTP14486 | Clustered mitochondria protein homolog (CLUH) | 5.7 | ||||
| LDTP15714 | Mdm2-binding protein (MTBP) | 5.6 | ||||
| LDTP06022 | Cold-inducible RNA-binding protein (CIRBP) | 5.5 | ||||
| LDTP15067 | Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) | 5.4 | ||||
| LDTP08594 | Negative elongation factor C/D (NELFCD) | 5.2 | ||||
| LDTP05375 | Nucleobindin-1 (NUCB1) | 5.2 | ||||
| LDTP08364 | Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) | 5.0 | ||||
| LDTP10403 | DDRGK domain-containing protein 1 (DDRGK1) | 5.0 | ||||
| LDTP06887 | Nuclear cap-binding protein subunit 3 (NCBP3) | 5.0 | ||||
| LDTP00887 | Calumenin (CALU) | 5.0 | ||||
| LDTP19963 | TraB domain-containing protein (TRABD) | 5.0 | ||||