Details of the Target

General Information of Target

Target ID LDTP00639
Target Name ATP-binding cassette sub-family C member 4 (ABCC4)
Gene Name ABCC4
Gene ID 10257
Synonyms
MOATB; MRP4; ATP-binding cassette sub-family C member 4; EC 7.6.2.-; EC 7.6.2.2; EC 7.6.2.3; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B; Multidrug resistance-associated protein 4
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEEL
QGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYF
ENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAG
MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLIT
NLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD
KASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ
QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAA
SQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVW
SQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL
NTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGI
ARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTF
LDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPV
FSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFV
IIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLE
KEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAG
KSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNE
HTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILII
DEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYV
LLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQPSTLTI
FETAL
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
Subcellular location
Basolateral cell membrane
Function
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins . Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate.
TTD ID
T39919
Uniprot ID
O15439
DrugMap ID
TTUEAFL
Ensemble ID
ENST00000536256.3
HGNC ID
HGNC:55
ChEMBL ID
CHEMBL1743128

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.L883WfsTer7 .
CALU1 SNV: p.L604V .
CCK81 SNV: p.P1315S .
CHL1 SNV: p.E1280K .
COLO800 SNV: p.E1280K .
DU145 SNV: p.S804P .
HCC1937 SNV: p.K758M .
HCC44 SNV: p.Q387Ter .
HCT116 SNV: p.V412A .
MDST8 SNV: p.D124N .
NCIH1944 SNV: p.P870S .
NCIH1993 SNV: p.E1280K ATP probe    Probe Info 
NCIH2052 SNV: p.I283V .
NOMO1 SNV: p.M1245L .
OAW28 SNV: p.N823I .
RL952 SNV: p.W1025L .
TCCSUP SNV: p.A449P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K451(8.33)  LDD0274  [1]
STPyne
 Probe Info  		K1081(8.71); K264(6.14)  LDD0277  [1]
DBIA
 Probe Info  		C577(0.41); C579(0.41)  LDD1093  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0164  [4]
ATP probe
 Probe Info  		N.A.  LDD0035  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C304
 Probe Info  		5.90  LDD1973  [8]
C305
 Probe Info  		9.58  LDD1974  [8]
C430
 Probe Info  		5.66  LDD2085  [8]
C433
 Probe Info  		5.86  LDD2088  [8]
STS-2
 Probe Info  		N.A.  LDD0138  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C577(0.41); C579(0.41)  LDD1093  [2]
 LDCM0215  AC10 PaTu 8988t C577(0.67); C579(0.67)  LDD1094  [2]
 LDCM0216  AC100 PaTu 8988t C577(0.88); C579(0.88)  LDD1095  [2]
 LDCM0217  AC101 PaTu 8988t C577(1.00); C579(1.00)  LDD1096  [2]
 LDCM0218  AC102 PaTu 8988t C577(0.78); C579(0.78)  LDD1097  [2]
 LDCM0219  AC103 PaTu 8988t C577(1.08); C579(1.08)  LDD1098  [2]
 LDCM0220  AC104 PaTu 8988t C577(1.02); C579(1.02)  LDD1099  [2]
 LDCM0221  AC105 PaTu 8988t C577(0.94); C579(0.94)  LDD1100  [2]
 LDCM0222  AC106 PaTu 8988t C577(0.91); C579(0.91)  LDD1101  [2]
 LDCM0223  AC107 PaTu 8988t C577(0.96); C579(0.96)  LDD1102  [2]
 LDCM0224  AC108 PaTu 8988t C577(0.79); C579(0.79)  LDD1103  [2]
 LDCM0225  AC109 PaTu 8988t C577(0.81); C579(0.81)  LDD1104  [2]
 LDCM0226  AC11 PaTu 8988t C577(0.68); C579(0.68)  LDD1105  [2]
 LDCM0227  AC110 PaTu 8988t C577(0.79); C579(0.79)  LDD1106  [2]
 LDCM0228  AC111 PaTu 8988t C577(0.73); C579(0.73)  LDD1107  [2]
 LDCM0229  AC112 PaTu 8988t C577(0.81); C579(0.81)  LDD1108  [2]
 LDCM0237  AC12 PaTu 8988t C577(0.71); C579(0.71)  LDD1116  [2]
 LDCM0259  AC14 PaTu 8988t C577(0.89); C579(0.89)  LDD1138  [2]
 LDCM0263  AC143 PaTu 8988t C577(0.76); C579(0.76)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C577(0.85); C579(0.85)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C577(0.85); C579(0.85)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C577(0.85); C579(0.85)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C577(0.83); C579(0.83)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C577(0.77); C579(0.77)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C577(0.75); C579(0.75)  LDD1148  [2]
 LDCM0270  AC15 PaTu 8988t C577(0.85); C579(0.85)  LDD1149  [2]
 LDCM0271  AC150 PaTu 8988t C577(0.72); C579(0.72)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C577(0.66); C579(0.66)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C577(0.76); C579(0.76)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C577(0.60); C579(0.60)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C577(0.77); C579(0.77)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C577(0.74); C579(0.74)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C577(0.64); C579(0.64)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C577(0.82); C579(0.82)  LDD2169  [2]
 LDCM0276  AC17 PaTu 8988t C577(0.78); C579(0.78)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C577(0.64); C579(0.64)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C577(0.66); C579(0.66)  LDD1157  [2]
 LDCM0279  AC2 PaTu 8988t C577(0.56); C579(0.56)  LDD1158  [2]
 LDCM0280  AC20 PaTu 8988t C577(0.73); C579(0.73)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C577(0.52); C579(0.52)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C577(0.57); C579(0.57)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C577(0.61); C579(0.61)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C577(0.61); C579(0.61)  LDD1163  [2]
 LDCM0285  AC25 PaTu 8988t C577(1.12); C579(1.12)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C577(1.09); C579(1.09)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C577(1.19); C579(1.19)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C577(1.01); C579(1.01)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C577(1.14); C579(1.14)  LDD1168  [2]
 LDCM0290  AC3 PaTu 8988t C577(0.48); C579(0.48)  LDD1169  [2]
 LDCM0291  AC30 PaTu 8988t C577(1.19); C579(1.19)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C577(1.16); C579(1.16)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C577(1.05); C579(1.05)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C577(0.95); C579(0.95)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C577(0.98); C579(0.98)  LDD1174  [2]
 LDCM0296  AC35 PaTu 8988t C577(0.83); C579(0.83)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C577(0.66); C579(0.66)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C577(0.73); C579(0.73)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C577(0.78); C579(0.78)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C577(0.73); C579(0.73)  LDD1179  [2]
 LDCM0301  AC4 PaTu 8988t C577(0.60); C579(0.60)  LDD1180  [2]
 LDCM0302  AC40 PaTu 8988t C577(0.59); C579(0.59)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C577(0.84); C579(0.84)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C577(0.83); C579(0.83)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C577(0.86); C579(0.86)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C577(0.72); C579(0.72)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C577(0.75); C579(0.75)  LDD1186  [2]
 LDCM0308  AC46 PaTu 8988t C577(0.91); C579(0.91)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C577(0.90); C579(0.90)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C577(0.88); C579(0.88)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C577(0.56); C579(0.56)  LDD1190  [2]
 LDCM0312  AC5 PaTu 8988t C577(0.43); C579(0.43)  LDD1191  [2]
 LDCM0313  AC50 PaTu 8988t C577(0.52); C579(0.52)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C577(0.24); C579(0.24)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C577(0.79); C579(0.79)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C577(0.52); C579(0.52)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C577(0.52); C579(0.52)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C577(0.79); C579(0.79)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C577(0.58); C579(0.58)  LDD1198  [2]
 LDCM0320  AC57 PaTu 8988t C577(0.88); C579(0.88)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C577(0.87); C579(0.87)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C577(0.83); C579(0.83)  LDD1201  [2]
 LDCM0323  AC6 PaTu 8988t C577(0.83); C579(0.83)  LDD1202  [2]
 LDCM0324  AC60 PaTu 8988t C577(0.91); C579(0.91)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C577(0.93); C579(0.93)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C577(0.95); C579(0.95)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C577(0.91); C579(0.91)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C577(1.12); C579(1.12)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C577(0.98); C579(0.98)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C577(0.92); C579(0.92)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C577(1.00); C579(1.00)  LDD1210  [2]
 LDCM0332  AC68 PaTu 8988t C577(0.96); C579(0.96)  LDD1211  [2]
 LDCM0333  AC69 PaTu 8988t C577(1.13); C579(1.13)  LDD1212  [2]
 LDCM0334  AC7 PaTu 8988t C577(1.04); C579(1.04)  LDD1213  [2]
 LDCM0335  AC70 PaTu 8988t C577(1.01); C579(1.01)  LDD1214  [2]
 LDCM0336  AC71 PaTu 8988t C577(1.27); C579(1.27)  LDD1215  [2]
 LDCM0337  AC72 PaTu 8988t C577(1.29); C579(1.29)  LDD1216  [2]
 LDCM0338  AC73 PaTu 8988t C577(1.10); C579(1.10)  LDD1217  [2]
 LDCM0339  AC74 PaTu 8988t C577(0.98); C579(0.98)  LDD1218  [2]
 LDCM0340  AC75 PaTu 8988t C577(1.06); C579(1.06)  LDD1219  [2]
 LDCM0341  AC76 PaTu 8988t C577(1.03); C579(1.03)  LDD1220  [2]
 LDCM0342  AC77 PaTu 8988t C577(0.93); C579(0.93)  LDD1221  [2]
 LDCM0343  AC78 PaTu 8988t C577(0.99); C579(0.99)  LDD1222  [2]
 LDCM0344  AC79 PaTu 8988t C577(0.95); C579(0.95)  LDD1223  [2]
 LDCM0345  AC8 PaTu 8988t C577(0.94); C579(0.94)  LDD1224  [2]
 LDCM0346  AC80 PaTu 8988t C577(1.21); C579(1.21)  LDD1225  [2]
 LDCM0347  AC81 PaTu 8988t C577(1.22); C579(1.22)  LDD1226  [2]
 LDCM0348  AC82 PaTu 8988t C577(1.09); C579(1.09)  LDD1227  [2]
 LDCM0349  AC83 PaTu 8988t C577(0.94); C579(0.94)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C577(0.92); C579(0.92)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C577(1.04); C579(1.04)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C577(1.21); C579(1.21)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C577(1.22); C579(1.22)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C577(1.19); C579(1.19)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C577(1.23); C579(1.23)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C577(1.23); C579(1.23)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C577(1.00); C579(1.00)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C577(1.13); C579(1.13)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C577(1.23); C579(1.23)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C577(1.18); C579(1.18)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C577(1.16); C579(1.16)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C577(1.26); C579(1.26)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C577(1.11); C579(1.11)  LDD1243  [2]
 LDCM0365  AC98 PaTu 8988t C577(0.89); C579(0.89)  LDD1244  [2]
 LDCM0366  AC99 PaTu 8988t C577(0.97); C579(0.97)  LDD1245  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C577(0.79); C579(0.79)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C577(0.76); C579(0.76)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C577(0.70); C579(0.70)  LDD1154  [2]
 LDCM0367  CL1 PaTu 8988t C577(2.03); C579(2.03)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C577(1.23); C579(1.23)  LDD1247  [2]
 LDCM0369  CL100 PaTu 8988t C577(0.59); C579(0.59)  LDD1248  [2]
 LDCM0370  CL101 PaTu 8988t C577(0.83); C579(0.83)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C577(0.79); C579(0.79)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C577(0.70); C579(0.70)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C577(0.78); C579(0.78)  LDD1252  [2]
 LDCM0374  CL105 PaTu 8988t C577(0.77); C579(0.77)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C577(0.72); C579(0.72)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C577(0.96); C579(0.96)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C577(0.75); C579(0.75)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C577(0.67); C579(0.67)  LDD1257  [2]
 LDCM0379  CL11 PaTu 8988t C577(0.92); C579(0.92)  LDD1258  [2]
 LDCM0380  CL110 PaTu 8988t C577(0.66); C579(0.66)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C577(0.54); C579(0.54)  LDD1260  [2]
 LDCM0382  CL112 PaTu 8988t C577(1.19); C579(1.19)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C577(0.99); C579(0.99)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C577(1.04); C579(1.04)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C577(1.16); C579(1.16)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C577(1.04); C579(1.04)  LDD1265  [2]
 LDCM0387  CL117 PaTu 8988t C577(1.03); C579(1.03)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C577(0.84); C579(0.84)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C577(0.80); C579(0.80)  LDD1268  [2]
 LDCM0390  CL12 PaTu 8988t C577(0.98); C579(0.98)  LDD1269  [2]
 LDCM0391  CL120 PaTu 8988t C577(0.73); C579(0.73)  LDD1270  [2]
 LDCM0392  CL121 PaTu 8988t C577(0.98); C579(0.98)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C577(0.81); C579(0.81)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C577(0.74); C579(0.74)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C577(0.58); C579(0.58)  LDD1274  [2]
 LDCM0396  CL125 PaTu 8988t C577(0.91); C579(0.91)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C577(0.95); C579(0.95)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C577(0.89); C579(0.89)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C577(0.93); C579(0.93)  LDD1278  [2]
 LDCM0400  CL13 PaTu 8988t C577(0.81); C579(0.81)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C577(0.95); C579(0.95)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C577(0.84); C579(0.84)  LDD1281  [2]
 LDCM0403  CL16 PaTu 8988t C577(0.72); C579(0.72)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C577(0.81); C579(0.81)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C577(0.78); C579(0.78)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C577(0.83); C579(0.83)  LDD1285  [2]
 LDCM0407  CL2 PaTu 8988t C577(0.93); C579(0.93)  LDD1286  [2]
 LDCM0408  CL20 PaTu 8988t C577(0.79); C579(0.79)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C577(0.83); C579(0.83)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C577(0.66); C579(0.66)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C577(0.77); C579(0.77)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C577(0.98); C579(0.98)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C577(0.82); C579(0.82)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C577(0.86); C579(0.86)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C577(0.75); C579(0.75)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C577(0.88); C579(0.88)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C577(0.87); C579(0.87)  LDD1296  [2]
 LDCM0418  CL3 PaTu 8988t C577(0.70); C579(0.70)  LDD1297  [2]
 LDCM0419  CL30 PaTu 8988t C577(0.74); C579(0.74)  LDD1298  [2]
 LDCM0420  CL31 PaTu 8988t C577(0.93); C579(0.93)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C577(0.76); C579(0.76)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C577(0.70); C579(0.70)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C577(0.71); C579(0.71)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C577(0.70); C579(0.70)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C577(0.40); C579(0.40)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C577(0.69); C579(0.69)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C577(0.69); C579(0.69)  LDD1307  [2]
 LDCM0429  CL4 PaTu 8988t C577(0.89); C579(0.89)  LDD1308  [2]
 LDCM0430  CL40 PaTu 8988t C577(0.82); C579(0.82)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C577(0.72); C579(0.72)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C577(0.70); C579(0.70)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C577(0.74); C579(0.74)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C577(0.60); C579(0.60)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C577(0.60); C579(0.60)  LDD1314  [2]
 LDCM0436  CL46 PaTu 8988t C577(0.80); C579(0.80)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C577(0.88); C579(0.88)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C577(0.78); C579(0.78)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C577(0.80); C579(0.80)  LDD1318  [2]
 LDCM0440  CL5 PaTu 8988t C577(0.85); C579(0.85)  LDD1319  [2]
 LDCM0441  CL50 PaTu 8988t C577(0.73); C579(0.73)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C577(0.77); C579(0.77)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C577(0.74); C579(0.74)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C577(0.75); C579(0.75)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C577(0.76); C579(0.76)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C577(0.71); C579(0.71)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C577(0.60); C579(0.60)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C577(0.63); C579(0.63)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C577(0.63); C579(0.63)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C577(0.63); C579(0.63)  LDD1329  [2]
 LDCM0451  CL6 PaTu 8988t C577(0.80); C579(0.80)  LDD1330  [2]
 LDCM0452  CL60 PaTu 8988t C577(0.64); C579(0.64)  LDD1331  [2]
 LDCM0453  CL61 PaTu 8988t C577(1.06); C579(1.06)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C577(1.33); C579(1.33)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C577(0.96); C579(0.96)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C577(0.92); C579(0.92)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C577(0.91); C579(0.91)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C577(0.97); C579(0.97)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C577(0.84); C579(0.84)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C577(0.90); C579(0.90)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C577(0.79); C579(0.79)  LDD1340  [2]
 LDCM0462  CL7 PaTu 8988t C577(0.82); C579(0.82)  LDD1341  [2]
 LDCM0463  CL70 PaTu 8988t C577(0.87); C579(0.87)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C577(1.00); C579(1.00)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C577(1.08); C579(1.08)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C577(0.70); C579(0.70)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C577(0.76); C579(0.76)  LDD1346  [2]
 LDCM0469  CL76 PaTu 8988t C577(0.82); C579(0.82)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C577(0.82); C579(0.82)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C577(0.85); C579(0.85)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C577(0.90); C579(0.90)  LDD1351  [2]
 LDCM0473  CL8 PaTu 8988t C577(1.16); C579(1.16)  LDD1352  [2]
 LDCM0474  CL80 PaTu 8988t C577(0.68); C579(0.68)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C577(0.84); C579(0.84)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C577(0.88); C579(0.88)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C577(0.83); C579(0.83)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C577(0.78); C579(0.78)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C577(0.85); C579(0.85)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C577(0.71); C579(0.71)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C577(0.75); C579(0.75)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C577(0.65); C579(0.65)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C577(0.69); C579(0.69)  LDD1362  [2]
 LDCM0484  CL9 PaTu 8988t C577(0.78); C579(0.78)  LDD1363  [2]
 LDCM0485  CL90 PaTu 8988t C577(0.70); C579(0.70)  LDD1364  [2]
 LDCM0486  CL91 PaTu 8988t C577(0.60); C579(0.60)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C577(0.61); C579(0.61)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C577(0.60); C579(0.60)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C577(0.56); C579(0.56)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C577(0.50); C579(0.50)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C577(0.57); C579(0.57)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C577(0.59); C579(0.59)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C577(0.44); C579(0.44)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C577(0.53); C579(0.53)  LDD1373  [2]
 LDCM0495  E2913 HEK-293T C579(0.73)  LDD1698  [10]
 LDCM0468  Fragment33 PaTu 8988t C577(0.74); C579(0.74)  LDD1347  [2]
 LDCM0427  Fragment51 PaTu 8988t C577(0.59); C579(0.59)  LDD1306  [2]
 LDCM0022  KB02 HEK-293T C579(0.93); C577(0.94); C579(0.94)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C579(0.93); C577(1.01); C579(1.01)  LDD1497  [10]
 LDCM0024  KB05 HEK-293T C579(0.97); C577(0.88); C579(0.88)  LDD1502  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
55 kDa erythrocyte membrane protein (MPP1) MAGUK family Q00013

The Drug(s) Related To This Target

Approved
Click To Hide/Show 45 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adefovir Dipivoxil Small molecular drug DB00718
Alprostadil Small molecular drug DB00770
Atorvastatin Small molecular drug DB01076
Cefazolin Small molecular drug DB01327
Celecoxib Small molecular drug DB00482
Cholic Acid Small molecular drug DB02659
Conjugated Estrogens Small molecular drug DB00286
Dexibuprofen Small molecular drug DB09213
Diclofenac Small molecular drug DB00586
Dinoprostone Small molecular drug DB00917
Dipyridamole Small molecular drug DB00975
Fluorouracil Small molecular drug DB00544
Flurbiprofen Small molecular drug DB00712
Folic Acid Small molecular drug DB00158
Glutathione Small molecular drug DB00143
Hydrochlorothiazide Small molecular drug DB00999
Ibuprofen Small molecular drug DB01050
Imatinib Small molecular drug DB00619
Indomethacin Small molecular drug DB00328
Ketoprofen Small molecular drug DB01009
Lamivudine Small molecular drug DB00709
Meloxicam Small molecular drug DB00814
Mercaptopurine Small molecular drug DB01033
Methotrexate Small molecular drug DB00563
Nateglinide Small molecular drug DB00731
Oseltamivir Small molecular drug DB00198
Prasterone Small molecular drug DB01708
Probenecid Small molecular drug DB01032
Promethazine Small molecular drug DB01069
Raloxifene Small molecular drug DB00481
Remdesivir Small molecular drug DB14761
Rofecoxib Small molecular drug DB00533
Rosuvastatin Small molecular drug DB01098
Rucaparib Small molecular drug DB12332
Sildenafil Small molecular drug DB00203
Sorafenib Small molecular drug DB00398
Sulfinpyrazone Small molecular drug DB01138
Sunitinib Small molecular drug DB01268
Taurocholic Acid Small molecular drug DB04348
Tenofovir Alafenamide Small molecular drug DB09299
Tenofovir Disoproxil Small molecular drug DB00300
Ursodeoxycholic Acid Small molecular drug DB01586
Verapamil Small molecular drug DB00661
Zidovudine Small molecular drug DB00495
Fluciclovine (18f) . DB13146
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Atp Small molecular drug DB00171
Cyclic Adenosine Monophosphate Small molecular drug DB02527
Tenofovir Small molecular drug DB14126

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402