Details of the Target

General Information of Target

Target ID LDTP12293
Target Name Adipocyte plasma membrane-associated protein (APMAP)
Gene Name APMAP
Gene ID 57136
Synonyms
C20orf3; Adipocyte plasma membrane-associated protein; Protein BSCv
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGGYTWPSGNTY
QGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGV
ETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLRTSLASLRSEQSNGSVLHDAA
AAADSPAGTRGGFVLNFHADAELAGKKKGGLFRRGSLLGSMKLRKSESKSSISSKRSSVR
SDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDATTTETYMGEWKNDKRNGFGVSERSN
GMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNILVRGIRKQLIPIRHTKTREKVDRAI
EGAQRAAAMARTKVEIANSRTAHARAKADAADQAALAARQECDIARAVARELSPDFYQPG
PDYVKQRFQEGVDAKENPEEKVPEKPPTPKESPHFYRKGTTPPRSPEASPKHSHSPASSP
KPLKKQNPSSGARLNQDKRSVADEQVTAIVNKPLMSKAPTKEAGAVVPQSKYSGRHHIPN
PSNGELHSQYHGYYVKLNAPQHPPVDVEDGDGSSQSSSALVHKPSANKWSPSKSVTKPVA
KESKAEPKAKKSELAIPKNPASNDSCPALEKEANSGPNSIMIVLVMLLNIGLAILFVHFL
T
Target Bioclass
Enzyme
Family
Strictosidine synthase family
Subcellular location
Membrane
Function Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation.
Uniprot ID
Q9HDC9
Ensemble ID
ENST00000217456.3
HGNC ID
HGNC:13238

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 SNV: p.I323T DBIA    Probe Info 
K562 Insertion: p.L228PfsTer10 .
KMS12BM SNV: p.D22Y DBIA    Probe Info 
MCC13 SNV: p.P380S DBIA    Probe Info 
OPM2 SNV: p.H394Q .
SHP77 SNV: p.P159S DBIA    Probe Info 
TE4 SNV: p.R134Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		2.87  LDD0197  [1]
CHEMBL5175495
 Probe Info  		6.14  LDD0196  [2]
STPyne
 Probe Info  		K179(10.00); K183(6.67); K250(10.00); K347(3.23)  LDD0277  [3]
BTD
 Probe Info  		C409(6.72)  LDD1699  [4]
IPM
 Probe Info  		N.A.  LDD0241  [5]
OPA-S-S-alkyne
 Probe Info  		K356(2.37)  LDD3494  [6]
Jackson_1
 Probe Info  		2.50  LDD0120  [7]
HPAP
 Probe Info  		3.07  LDD0062  [8]
Acrolein
 Probe Info  		N.A.  LDD0221  [9]
DBIA
 Probe Info  		C140(1.63); C149(1.33)  LDD0531  [10]
5E-2FA
 Probe Info  		N.A.  LDD2235  [11]
m-APA
 Probe Info  		N.A.  LDD2231  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [12]
IA-alkyne
 Probe Info  		C149(0.00); C140(0.00)  LDD0036  [12]
Lodoacetamide azide
 Probe Info  		C149(0.00); C140(0.00)  LDD0037  [12]
ATP probe
 Probe Info  		N.A.  LDD0035  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [14]
NHS
 Probe Info  		N.A.  LDD0010  [14]
TFBX
 Probe Info  		N.A.  LDD0148  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
Crotonaldehyde
 Probe Info  		C409(0.00); C149(0.00)  LDD0219  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
PARPYnD
 Probe Info  		1.51  LDD0374  [18]
C027
 Probe Info  		11.88  LDD1733  [19]
C094
 Probe Info  		45.57  LDD1785  [19]
C107
 Probe Info  		5.94  LDD1794  [19]
C143
 Probe Info  		14.22  LDD1825  [19]
C158
 Probe Info  		72.00  LDD1838  [19]
C159
 Probe Info  		15.35  LDD1839  [19]
C213
 Probe Info  		32.67  LDD1887  [19]
C219
 Probe Info  		4.99  LDD1893  [19]
C228
 Probe Info  		27.28  LDD1901  [19]
C231
 Probe Info  		12.30  LDD1904  [19]
C235
 Probe Info  		39.67  LDD1908  [19]
C290
 Probe Info  		14.32  LDD1960  [19]
C292
 Probe Info  		8.88  LDD1962  [19]
C310
 Probe Info  		9.58  LDD1977  [19]
C349
 Probe Info  		9.65  LDD2010  [19]
C355
 Probe Info  		44.02  LDD2016  [19]
C356
 Probe Info  		8.88  LDD2017  [19]
C357
 Probe Info  		15.03  LDD2018  [19]
C361
 Probe Info  		18.51  LDD2022  [19]
C383
 Probe Info  		13.45  LDD2042  [19]
C424
 Probe Info  		45.57  LDD2079  [19]
C430
 Probe Info  		24.93  LDD2085  [19]
FFF probe11
 Probe Info  		19.27  LDD0471  [20]
FFF probe13
 Probe Info  		20.00  LDD0475  [20]
FFF probe2
 Probe Info  		20.00  LDD0463  [20]
FFF probe3
 Probe Info  		20.00  LDD0464  [20]
FFF probe4
 Probe Info  		9.66  LDD0466  [20]
STS-1
 Probe Info  		4.00  LDD0136  [21]
STS-2
 Probe Info  		N.A.  LDD0138  [21]
VE-P
 Probe Info  		N.A.  LDD0396  [22]
A-DA
 Probe Info  		2.10  LDD0143  [23]
OEA-DA
 Probe Info  		8.89  LDD0046  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C409(0.29)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C409(0.50)  LDD2112  [4]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C140(0.52)  LDD2095  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C140(0.92); C409(0.97)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C140(0.81); C409(0.97); C149(0.83)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C409(1.32); C149(1.11)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C409(1.15)  LDD2103  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C140(0.73); C409(0.36)  LDD2132  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C140(0.97)  LDD2131  [4]
 LDCM0214  AC1 HCT 116 C140(1.63); C149(1.33)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C140(1.38); C149(1.11)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C140(1.24); C149(0.83)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C140(0.91); C149(0.78)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C140(1.00); C149(0.75)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C140(1.05); C149(0.69)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C140(1.03); C149(0.69)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C140(1.06); C149(0.72)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C140(1.17); C149(0.74)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C140(1.12); C149(0.67)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C140(1.07); C149(0.79)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C140(1.27); C149(0.87)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C140(1.20); C149(1.10)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C140(1.03); C149(0.75)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C140(0.84); C149(0.67)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C140(0.93); C149(0.69)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C140(1.22); C149(1.14)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C140(0.96); C149(1.01)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C140(0.94); C149(1.32)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C140(0.85); C149(1.37)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C140(0.98); C149(1.48)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C140(1.14); C149(1.35)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C140(0.94); C149(1.42)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C140(1.81); C149(1.34)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C140(1.08); C149(1.00)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C140(1.02); C149(1.40)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C140(0.98); C149(1.45)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C140(0.91); C149(1.25)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C140(1.07); C149(1.24)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C140(1.15); C149(1.17)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C140(0.93); C149(1.28)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C140(0.95); C149(1.45)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C140(1.27); C149(0.98)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C140(1.11); C149(1.20)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C140(1.22); C149(1.13)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C140(1.07); C149(0.81)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C140(0.95); C149(0.70)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C140(1.16); C149(0.76)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C140(0.93); C149(0.51)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C140(1.02); C149(0.53)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C140(0.90); C149(0.76)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C140(0.96); C149(0.79)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C140(0.71); C149(0.57)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C140(0.71); C149(0.97)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C140(1.37); C149(1.12)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C140(0.72); C149(0.65)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C140(0.65); C149(0.66)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C140(0.92); C149(0.86)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C140(1.01); C149(0.89)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C149(0.86); C140(1.15)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C149(0.65); C140(1.19)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C149(0.63); C140(1.28)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C149(0.74); C140(1.22)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C149(0.47); C140(1.42)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C149(0.50); C140(1.46)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C149(1.09); C140(1.19)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C149(0.58); C140(1.32)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C149(0.62); C140(0.86)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C149(0.52); C140(1.09)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C149(0.46); C140(1.43)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C140(1.01); C149(0.71)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C140(1.25); C149(0.71)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C140(1.15); C149(0.57)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C140(1.23); C149(0.82)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C149(1.26); C140(1.39)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C149(1.00); C140(1.26)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C140(1.10); C149(1.15)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C149(1.23); C140(1.27)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C149(0.90); C140(1.25)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C149(0.94); C140(1.15)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C149(1.00); C140(1.25)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C149(0.97); C140(1.51)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C149(0.80); C140(1.11)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C149(0.94); C140(1.09)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C140(0.82); C149(1.10)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C140(0.72); C149(1.31)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C140(0.77); C149(1.07)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C140(0.60); C149(0.98)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C149(1.61); C140(1.64)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C140(0.58); C149(0.77)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C140(0.67); C149(1.01)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C140(0.62); C149(1.12)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C140(0.87); C149(0.98)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C149(0.76); C140(0.86)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C149(0.94); C140(1.11)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C140(0.96); C149(0.97)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C149(0.93); C140(1.27)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C149(0.78); C140(0.89)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C149(0.73); C140(1.11)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C149(1.50); C140(1.63)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C149(0.67); C140(0.97)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C149(0.79); C140(0.91)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C149(0.75); C140(0.87)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C140(0.83); C149(1.36)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C149(0.86); C140(1.02)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C149(0.82); C140(1.10)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C140(0.82); C149(0.96)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C140(0.81); C149(0.83)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C140(0.83); C149(0.83)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C140(0.87); C149(1.06)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C149(1.43); C140(1.59)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C149(0.79); C140(0.92)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C149(0.77); C140(0.91)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C149(0.71); C140(0.95)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C149(0.90); C140(1.12)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C149(0.93); C140(1.19)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C149(1.14); C140(1.16)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C149(0.69); C140(1.00)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C140(1.14); C149(1.27)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C149(0.96); C140(1.25)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C149(1.00); C140(1.05)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C140(0.95); C149(0.97)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C149(0.87); C140(1.05)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C149(1.11); C140(1.20)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C149(1.09); C140(1.16)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C149(1.07); C140(1.29)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C149(1.24); C140(1.30)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C149(0.95); C140(1.25)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C149(1.07); C140(1.11)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C149(0.83); C140(1.09)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C149(0.76); C140(0.94)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C149(0.83); C140(1.08)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C149(1.00); C140(1.14)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C140(1.07); C149(1.20)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C149(0.86); C140(1.15)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C140(1.01); C149(1.28)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C140(1.01); C149(1.09)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C149(0.89); C140(1.01)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C140(1.02); C149(1.12)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C140(1.10); C149(1.12)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C149(0.67); C140(0.95)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C149(0.79); C140(1.25)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C140(1.01); C149(1.02)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C149(0.95); C140(1.10)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C149(1.02); C140(1.08)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C149(1.02); C140(1.10)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C149(0.94); C140(1.12)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C140(1.07); C149(1.42)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C140(0.92); C149(1.25)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C140(1.05); C149(1.42)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C140(0.86); C149(1.25)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C140(1.09); C149(1.41)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C140(0.97); C149(1.26)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C140(0.98); C149(1.23)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C140(0.98); C149(1.53)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C140(1.19); C149(1.38)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C140(1.26); C149(1.57)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C149(1.24); C140(1.30)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C140(1.38); C149(1.57)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C140(1.16); C149(1.46)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C140(1.28); C149(1.47)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C140(1.04); C149(1.46)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C149(0.90); C140(0.91)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C140(0.98); C149(1.01)  LDD0683  [10]
 LDCM0545  Acetamide MDA-MB-231 C140(1.12); C409(1.03)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C140(1.24); C409(0.55)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C140(1.24); C149(1.05)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C149(1.08); C140(1.13)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C149(1.00); C140(1.21)  LDD0592  [10]
 LDCM0083  Avasimibe A-549 2.10  LDD0143  [23]
 LDCM0498  BS-3668 MDA-MB-231 C409(0.98)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C409(0.00); H83(0.00)  LDD0222  [9]
 LDCM0070  Cisar_cp37 MDA-MB-231 2.50  LDD0120  [7]
 LDCM0367  CL1 HCT 116 C140(1.06); C149(1.10)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C140(1.01); C149(1.11)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C140(1.23); C149(1.39)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C149(0.82); C140(0.93)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C149(0.94); C140(1.08)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C149(1.04); C140(1.30)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C149(0.90); C140(1.22)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C149(1.14); C140(1.35)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C149(1.04); C140(1.31)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C149(1.17); C140(1.20)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C140(1.27); C149(1.28)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C140(1.08); C149(1.15)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C140(1.06); C149(1.21)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C149(1.07); C140(1.20)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C149(0.85); C140(1.05)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C140(0.92); C149(1.05)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C140(0.61); C149(0.82)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C140(0.62); C149(0.80)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C140(0.70); C149(0.80)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C140(0.92); C149(0.99)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C149(0.46); C140(0.94)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C149(0.59); C140(0.96)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C140(0.86); C149(0.93)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C140(1.10); C149(1.53)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C140(0.81); C149(0.92)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C149(0.71); C140(0.79)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C149(0.73); C140(1.03)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C149(0.77); C140(1.04)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C149(0.80); C140(1.03)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C149(1.13); C140(1.24)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C149(1.01); C140(1.14)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C149(0.92); C140(1.25)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C140(1.15); C149(1.23)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C140(1.10); C149(1.23)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C140(1.26); C149(1.29)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C140(1.13); C149(1.45)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C140(0.81); C149(1.38)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C140(1.13); C149(1.30)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C140(0.91); C149(1.21)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C140(0.78); C149(1.45)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C140(1.22); C149(1.23)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C140(0.75); C149(1.25)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C140(0.94); C149(1.27)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C140(0.96); C149(1.26)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C140(0.80); C149(1.06)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C140(0.90); C149(1.23)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C140(0.96); C149(1.16)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C140(0.99); C149(1.33)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C140(0.91); C149(1.32)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C140(0.82); C149(1.58)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C140(0.88); C149(1.56)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C140(1.33); C149(1.14)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C140(0.87); C149(1.47)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C140(0.84); C149(1.04)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C140(0.80); C149(0.79)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C140(0.86); C149(1.43)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C140(0.89); C149(0.95)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C140(1.04); C149(0.73)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C140(1.00); C149(0.74)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C140(1.08); C149(0.90)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C140(1.00); C149(0.86)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C140(1.08); C149(0.96)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C140(0.99); C149(0.73)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C140(0.90); C149(0.80)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C140(1.14); C149(1.05)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C140(0.90); C149(0.91)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C140(1.08); C149(0.99)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C140(1.12); C149(0.71)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C140(1.07); C149(1.57)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C140(0.92); C149(1.07)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C140(0.96); C149(1.12)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C140(1.12); C149(1.91)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C140(1.32); C149(1.36)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C140(1.03); C149(1.24)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C140(0.97); C149(1.48)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C140(0.81); C149(1.08)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C140(0.97); C149(0.93)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C140(1.04); C149(1.04)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C140(1.19); C149(1.02)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C140(1.06); C149(0.92)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C140(1.12); C149(1.03)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C140(0.97); C149(1.44)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C140(1.02); C149(1.13)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C140(1.11); C149(1.65)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C140(1.04); C149(1.30)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C140(1.15); C149(2.25)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C140(1.14); C149(2.00)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C140(1.17); C149(1.20)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C140(1.10); C149(1.45)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C140(1.12); C149(1.35)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C140(0.97); C149(1.35)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C140(1.29); C149(1.21)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C140(1.27); C149(1.41)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C140(1.03); C149(1.47)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C140(1.27); C149(1.70)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C140(1.11); C149(1.30)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C140(1.21); C149(1.17)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C140(0.91); C149(1.07)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C140(1.00); C149(1.12)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C140(1.11); C149(1.37)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C140(1.22); C149(0.83)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C140(1.33); C149(0.78)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C140(0.97); C149(1.12)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C140(1.01); C149(1.11)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C140(1.26); C149(1.00)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C140(1.20); C149(0.99)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C140(1.23); C149(1.11)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C140(1.24); C149(1.60)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C140(1.25); C149(1.14)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C140(0.98); C149(0.94)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C140(0.98); C149(0.74)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C140(1.07); C149(0.77)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C140(1.24); C149(1.19)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C140(1.20); C149(1.03)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C140(1.10); C149(1.17)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C140(1.07); C149(1.48)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C140(1.06); C149(0.94)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C140(1.18); C149(1.02)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C140(1.30); C149(1.06)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C140(1.39); C149(1.39)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C140(1.20); C149(1.40)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C140(1.48); C149(1.25)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C140(1.30); C149(1.22)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C140(1.19); C149(1.25)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C140(0.97); C149(1.28)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C140(1.17); C149(1.42)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C140(0.89)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C140(1.12); C409(0.73)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C140(1.31); C149(1.88)  LDD0785  [10]
 LDCM0427  Fragment51 HCT 116 C140(1.02); C149(0.43)  LDD0744  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [9]
 LDCM0022  KB02 42-MG-BA C409(1.44)  LDD2244  [26]
 LDCM0023  KB03 MDA-MB-231 C409(2.31); C140(1.53)  LDD1701  [4]
 LDCM0024  KB05 COLO792 C149(2.40); C409(2.34)  LDD3310  [26]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C409(1.04)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C140(0.58); C409(0.89)  LDD2121  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [9]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C140(0.49); C409(0.88)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C409(1.24)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C409(1.23)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C140(0.98); C409(1.24); C149(0.67)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C409(2.17)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C409(0.28)  LDD2096  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C140(0.80); C409(0.58)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C409(0.84)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C140(0.98); C409(1.08); C149(1.03)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C409(0.30); C149(0.58)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C140(1.70); C409(0.69)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C409(0.31)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C409(1.55)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C409(0.25)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C140(0.82); C409(0.91); C149(0.91)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C409(0.37)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C140(0.97); C409(0.67); C149(0.89)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C409(0.32)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C409(1.29)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C409(0.38)  LDD2114  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C140(0.76); C409(0.42)  LDD2115  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C409(0.69)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C409(2.00); C149(1.80)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C140(0.95); C409(1.01)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C409(0.34)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C140(0.91); C409(1.18); C149(0.84)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C409(0.46)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C140(0.77); C409(1.08); C149(0.78)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C409(0.38)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C140(0.93); C409(1.22); C149(0.99)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C140(0.96); C409(1.00)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C140(1.04); C409(1.35); C149(1.02)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C409(0.48)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C140(0.46); C409(0.36)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C140(1.39); C409(1.79); C149(1.05)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C140(1.21); C409(1.41); C149(1.10)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C140(1.11); C409(1.18); C149(1.01)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C409(2.77); C149(2.10)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C140(0.73); C409(1.00); C149(0.83)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C409(0.45)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C140(1.13); C409(0.63)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C140(2.90); C409(2.20)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C409(0.15)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C140(0.74); C409(0.99); C149(0.71)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C409(1.43)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C140(0.81); C409(0.42); C149(0.88)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C409(0.41)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C140(0.71); C409(0.87); C149(0.36)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C409(0.35)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C409(2.33)  LDD2153  [4]
 LDCM0014  Panhematin HEK-293T 3.07  LDD0062  [8]
 LDCM0084  Ro 48-8071 A-549 8.84  LDD0145  [23]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM209A (FAM209A) FAM209 family Q5JX71

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
8 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. doi: 10.1021/acschembio.9b00963. Epub 2020 Feb 10.
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
22 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
23 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
24 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840