Probe Name	PARPYnD					Probe Info
Probe concentration	1 uM
Criteria	Quantification: Probe vs DMSO
Quantitative Method	TMT
In Vivo Experiment Model	Model Type			Living cell
	Derived Tissue			Breast
	Disease Model		Breast adenocarcinoma [ICD-11:2C60]
	Model Name		Human breast adenocarcinoma cells (MDA-MB-468)

Target ID	Target Name					Binding Ratio
LDTP13282	Prenylcysteine oxidase 1 (PCYOX1)					4.7
LDTP13240	Poly [ADP-ribose] polymerase 2 (PARP2)					4.5
LDTP04183	Lanosterol synthase (LSS)					4.4
LDTP02175	Epoxide hydrolase 1 (EPHX1)					3.5
LDTP15484	Saccharopine dehydrogenase-like oxidoreductase (SCCPDH)					3.1
LDTP02375	Poly [ADP-ribose] polymerase 1 (PARP1)					2.8
LDTP06375	Delta(24)-sterol reductase (DHCR24)					2.7
LDTP04051	Nicotinamide phosphoribosyltransferase (NAMPT)					2.6
LDTP04689	Adenosine kinase (ADK)					2.4
LDTP14092	Protein phosphatase methylesterase 1 (PPME1)					2.3
LDTP01328	CAAX prenyl protease 1 homolog (ZMPSTE24)					2.3
LDTP08979	Prostaglandin reductase 2 (PTGR2)					2.2
LDTP03257	Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)					2.0
LDTP01767	Aldehyde dehydrogenase 1A1 (ALDH1A1)					2.0
LDTP12915	Methionine adenosyltransferase 2 subunit beta (MAT2B)					1.9
LDTP06307	Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)					1.7
LDTP05348	Sterol 26-hydroxylase, mitochondrial (CYP27A1)					1.7
LDTP04712	Puromycin-sensitive aminopeptidase (NPEPPS)					1.7
LDTP06384	Ribosomal protein S6 kinase alpha-1 (RPS6KA1)					1.6
LDTP03207	Liver carboxylesterase 1 (CES1)					1.5
LDTP03842	Squalene synthase (FDFT1)					1.5
LDTP12293	Adipocyte plasma membrane-associated protein (APMAP)					1.5
LDTP02848	NADPH--cytochrome P450 reductase (POR)					1.5
LDTP05724	Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1)					1.4
LDTP02198	Cathepsin D (CTSD)					1.4
LDTP00886	Nardilysin (NRDC)					1.3

Target ID	Target Name					Binding Ratio
LDTP03798	Monocarboxylate transporter 8 (SLC16A2)					2.5
LDTP03132	Voltage-dependent anion-selective channel protein 1 (VDAC1)					2.1
LDTP06426	Translocating chain-associated membrane protein 1 (TRAM1)					1.7
LDTP00562	Membrane-associated progesterone receptor component 2 (PGRMC2)					1.5
LDTP06633	Reticulon-1 (RTN1)					1.4

1	Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. doi: 10.1021/acschembio.9b00963. Epub 2020 Feb 10.