Details of the Target

General Information of Target

Target ID LDTP08979
Target Name Prostaglandin reductase 2 (PTGR2)
Gene Name PTGR2
Gene ID 145482
Synonyms
ZADH1; Prostaglandin reductase 2; PRG-2; EC 1.3.1.48; 15-oxoprostaglandin 13-reductase; Zinc-binding alcohol dehydrogenase domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIVQRVVLNSRPGKNGNPVAENFRMEEVYLPDNINEGQVQVRTLYLSVDPYMRCRMNEDT
GTDYITPWQLSQVVDGGGIGIIEESKHTNLTKGDFVTSFYWPWQTKVILDGNSLEKVDPQ
LVDGHLSYFLGAIGMPGLTSLIGIQEKGHITAGSNKTMVVSGAAGACGSVAGQIGHFLGC
SRVVGICGTHEKCILLTSELGFDAAINYKKDNVAEQLRESCPAGVDVYFDNVGGNISDTV
ISQMNENSHIILCGQISQYNKDVPYPPPLSPAIEAIQKERNITRERFLVLNYKDKFEPGI
LQLSQWFKEGKLKIKETVINGLENMGAAFQSMMTGGNIGKQIVCISEEISL
Target Bioclass
Enzyme
Family
NADP-dependent oxidoreductase L4BD family
Subcellular location
Cytoplasm
Function
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
Uniprot ID
Q8N8N7
Ensemble ID
ENST00000267568.8
HGNC ID
HGNC:20149

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.Q258E DBIA    Probe Info 
EFO21 SNV: p.S127L DBIA    Probe Info 
JURKAT Deletion: p.D49IfsTer8 .
L428 SNV: p.A204T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 2
 Probe Info  		15.00  LDD0391  [1]
FBPP2
 Probe Info  		18.17  LDD0318  [2]
TH211
 Probe Info  		Y100(19.73); Y265(7.55); Y51(5.47)  LDD0257  [3]
TH214
 Probe Info  		Y51(11.38); Y259(5.14)  LDD0258  [3]
TH216
 Probe Info  		Y259(20.00); Y51(15.69)  LDD0259  [3]
STPyne
 Probe Info  		K210(2.27)  LDD0277  [4]
Probe 1
 Probe Info  		Y29(13.57); Y265(10.39)  LDD3495  [5]
DBIA
 Probe Info  		C187(1.16)  LDD3311  [6]
BTD
 Probe Info  		C187(1.00)  LDD2093  [7]
HHS-482
 Probe Info  		Y100(1.35); Y259(2.92); Y265(1.99)  LDD0285  [8]
HHS-475
 Probe Info  		Y100(1.18); Y265(1.54); Y64(1.81); Y45(2.55)  LDD0264  [9]
HHS-465
 Probe Info  		Y100(8.66); Y265(2.47)  LDD2237  [10]
Acrolein
 Probe Info  		N.A.  LDD0222  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [12]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
SF
 Probe Info  		N.A.  LDD0028  [14]
1d-yne
 Probe Info  		N.A.  LDD0357  [15]
NAIA_5
 Probe Info  		C167(0.00); C187(0.00); C180(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
PARPYnD
 Probe Info  		2.17  LDD0374  [16]
C038
 Probe Info  		5.17  LDD1738  [17]
C040
 Probe Info  		16.34  LDD1740  [17]
C041
 Probe Info  		10.63  LDD1741  [17]
C078
 Probe Info  		5.21  LDD1771  [17]
C082
 Probe Info  		8.46  LDD1774  [17]
C121
 Probe Info  		5.21  LDD1807  [17]
C131
 Probe Info  		7.78  LDD1813  [17]
C141
 Probe Info  		11.55  LDD1823  [17]
C145
 Probe Info  		15.35  LDD1827  [17]
C159
 Probe Info  		7.46  LDD1839  [17]
C193
 Probe Info  		5.06  LDD1869  [17]
C239
 Probe Info  		6.77  LDD1912  [17]
C241
 Probe Info  		7.41  LDD1914  [17]
C256
 Probe Info  		6.32  LDD1929  [17]
C258
 Probe Info  		5.82  LDD1931  [17]
C301
 Probe Info  		6.15  LDD1970  [17]
C320
 Probe Info  		8.82  LDD1986  [17]
C333
 Probe Info  		7.84  LDD1996  [17]
C346
 Probe Info  		10.48  LDD2007  [17]
C354
 Probe Info  		10.20  LDD2015  [17]
C398
 Probe Info  		5.13  LDD2057  [17]
C424
 Probe Info  		7.36  LDD2079  [17]
C432
 Probe Info  		5.70  LDD2087  [17]
FFF probe11
 Probe Info  		5.18  LDD0472  [18]
FFF probe12
 Probe Info  		20.00  LDD0487  [18]
FFF probe13
 Probe Info  		16.76  LDD0475  [18]
FFF probe14
 Probe Info  		11.54  LDD0477  [18]
FFF probe15
 Probe Info  		13.12  LDD0490  [18]
FFF probe2
 Probe Info  		19.98  LDD0463  [18]
FFF probe3
 Probe Info  		20.00  LDD0464  [18]
FFF probe6
 Probe Info  		20.00  LDD0482  [18]
FFF probe7
 Probe Info  		13.12  LDD0483  [18]
FFF probe9
 Probe Info  		12.00  LDD0470  [18]
JN0003
 Probe Info  		20.00  LDD0469  [18]
A-DA
 Probe Info  		12.00  LDD0141  [19]
AEA-DA
 Probe Info  		5.15  LDD0146  [19]
Kambe_22
 Probe Info  		13.27  LDD0132  [20]
Kambe_26
 Probe Info  		4.88  LDD0134  [20]
Kambe_31
 Probe Info  		3.02  LDD0135  [20]
Kambe_8
 Probe Info  		3.84  LDD0131  [20]
OEA-DA
 Probe Info  		20.00  LDD0046  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C187(0.98); C344(1.07)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C187(0.97); C344(1.09); C253(0.79)  LDD1508  [22]
 LDCM0226  AC11 HEK-293T C187(1.04); C344(1.01)  LDD1509  [22]
 LDCM0237  AC12 HEK-293T C187(0.99); C344(1.10)  LDD1510  [22]
 LDCM0259  AC14 HEK-293T C344(0.94)  LDD1512  [22]
 LDCM0270  AC15 HEK-293T C187(1.01); C344(1.03)  LDD1513  [22]
 LDCM0276  AC17 HEK-293T C187(0.98); C344(0.84)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C187(1.00); C344(0.95); C253(0.85)  LDD1516  [22]
 LDCM0278  AC19 HEK-293T C187(0.89); C344(0.88)  LDD1517  [22]
 LDCM0279  AC2 HEK-293T C187(1.04); C344(1.07); C253(1.37)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C187(1.05); C344(1.04)  LDD1519  [22]
 LDCM0281  AC21 HEK-293T C187(1.08); C344(0.99)  LDD1520  [22]
 LDCM0282  AC22 HEK-293T C344(0.95)  LDD1521  [22]
 LDCM0283  AC23 HEK-293T C187(0.98); C344(1.14)  LDD1522  [22]
 LDCM0284  AC24 HEK-293T C187(1.07); C344(1.11)  LDD1523  [22]
 LDCM0285  AC25 HEK-293T C187(0.96); C344(1.09)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C187(0.99); C344(0.98); C253(0.99)  LDD1525  [22]
 LDCM0287  AC27 HEK-293T C187(1.02); C344(1.05)  LDD1526  [22]
 LDCM0288  AC28 HEK-293T C187(1.00); C344(1.01)  LDD1527  [22]
 LDCM0289  AC29 HEK-293T C187(1.06); C344(0.94)  LDD1528  [22]
 LDCM0290  AC3 HEK-293T C187(1.10); C344(1.12)  LDD1529  [22]
 LDCM0291  AC30 HEK-293T C344(0.92)  LDD1530  [22]
 LDCM0292  AC31 HEK-293T C187(0.96); C344(1.11)  LDD1531  [22]
 LDCM0293  AC32 HEK-293T C187(0.96); C344(0.93)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C187(0.94); C344(1.15)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C187(1.02); C344(0.97); C253(0.93)  LDD1534  [22]
 LDCM0296  AC35 HEK-293T C187(0.97); C344(0.90)  LDD1535  [22]
 LDCM0297  AC36 HEK-293T C187(0.98); C344(0.85)  LDD1536  [22]
 LDCM0298  AC37 HEK-293T C187(1.05); C344(0.97)  LDD1537  [22]
 LDCM0299  AC38 HEK-293T C344(1.04)  LDD1538  [22]
 LDCM0300  AC39 HEK-293T C187(0.99); C344(1.05)  LDD1539  [22]
 LDCM0301  AC4 HEK-293T C187(1.12); C344(1.14)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C187(0.87); C344(0.88)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C187(0.94); C344(0.84)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C187(1.06); C344(1.02); C253(1.02)  LDD1543  [22]
 LDCM0305  AC43 HEK-293T C187(0.94); C344(1.02)  LDD1544  [22]
 LDCM0306  AC44 HEK-293T C187(0.98); C344(0.95)  LDD1545  [22]
 LDCM0307  AC45 HEK-293T C187(1.06); C344(0.98)  LDD1546  [22]
 LDCM0308  AC46 HEK-293T C344(1.02)  LDD1547  [22]
 LDCM0309  AC47 HEK-293T C187(1.08); C344(0.86)  LDD1548  [22]
 LDCM0310  AC48 HEK-293T C187(0.92); C344(1.06)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C187(0.98); C344(0.83)  LDD1550  [22]
 LDCM0312  AC5 HEK-293T C187(1.03); C344(0.98)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C187(1.03); C344(1.06); C253(1.03)  LDD1552  [22]
 LDCM0314  AC51 HEK-293T C187(1.03); C344(1.01)  LDD1553  [22]
 LDCM0315  AC52 HEK-293T C187(1.11); C344(1.19)  LDD1554  [22]
 LDCM0316  AC53 HEK-293T C187(1.06); C344(0.95)  LDD1555  [22]
 LDCM0317  AC54 HEK-293T C344(1.02)  LDD1556  [22]
 LDCM0318  AC55 HEK-293T C187(1.01); C344(0.93)  LDD1557  [22]
 LDCM0319  AC56 HEK-293T C187(1.05); C344(1.06)  LDD1558  [22]
 LDCM0320  AC57 HEK-293T C187(0.95); C344(0.97)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C187(1.03); C344(1.01); C253(1.14)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C187(0.99); C344(1.03)  LDD1561  [22]
 LDCM0323  AC6 HEK-293T C344(1.07)  LDD1562  [22]
 LDCM0324  AC60 HEK-293T C187(0.83); C344(0.96)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C187(0.96); C344(0.91)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C344(0.95)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C187(0.98); C344(1.02)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C187(1.03); C344(1.03)  LDD1567  [22]
 LDCM0334  AC7 HEK-293T C187(1.04); C344(1.06)  LDD1568  [22]
 LDCM0345  AC8 HEK-293T C187(0.87); C344(1.12)  LDD1569  [22]
 LDCM0248  AKOS034007472 HEK-293T C187(1.05); C344(1.01)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C187(0.95); C344(0.98)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C187(1.03); C344(1.07)  LDD1514  [22]
 LDCM0147  AZ0108 MDA-MB-468 1.60  LDD0376  [16]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C167(0.61)  LDD2227  [13]
 LDCM0367  CL1 HEK-293T C187(0.95); C344(0.88)  LDD1571  [22]
 LDCM0368  CL10 HEK-293T C344(1.08)  LDD1572  [22]
 LDCM0369  CL100 HEK-293T C187(0.98); C344(1.11)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C187(0.96); C344(0.79)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C187(0.90); C344(0.93); C167(0.75)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C187(0.99)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C187(1.06); C344(1.29)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C187(1.02); C344(0.79)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C187(0.91); C344(0.88); C167(0.89)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C187(1.01)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C187(1.05); C344(1.07)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C187(1.06); C344(0.78)  LDD1582  [22]
 LDCM0379  CL11 HEK-293T C187(1.05); C344(1.25)  LDD1583  [22]
 LDCM0380  CL110 HEK-293T C187(0.92); C344(1.12); C167(0.79)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C187(1.01)  LDD1585  [22]
 LDCM0382  CL112 HEK-293T C187(0.92); C344(1.11)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C187(1.02); C344(0.93)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C187(0.95); C344(0.93); C167(0.80)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C187(1.09)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C187(1.02); C344(0.96)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C187(0.99); C344(1.09)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C187(1.03); C344(1.01); C167(0.81)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C187(1.15)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C187(1.19); C344(1.20)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C187(1.12); C344(1.33)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C187(0.93); C344(0.79)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C187(0.93); C344(0.91); C167(0.83)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C187(0.99)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C187(1.01); C344(1.07)  LDD1599  [22]
 LDCM0396  CL125 HEK-293T C187(1.02); C344(1.05)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C187(1.00); C344(1.09); C167(0.80)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C187(1.09)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C187(1.06); C344(0.98)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C187(0.86); C344(0.97)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C187(0.94); C344(1.15); C167(1.00)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C187(0.85)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C187(1.11); C344(1.11)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C187(0.89); C344(0.93)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C187(0.98); C344(1.06); C253(0.88)  LDD1609  [22]
 LDCM0406  CL19 HEK-293T C187(1.01); C344(1.08)  LDD1610  [22]
 LDCM0407  CL2 HEK-293T C187(0.93); C344(1.14); C167(0.84)  LDD1611  [22]
 LDCM0408  CL20 HEK-293T C187(1.07); C344(0.98)  LDD1612  [22]
 LDCM0409  CL21 HEK-293T C187(0.94); C344(0.94)  LDD1613  [22]
 LDCM0410  CL22 HEK-293T C344(1.19)  LDD1614  [22]
 LDCM0411  CL23 HEK-293T C187(1.09); C344(1.20)  LDD1615  [22]
 LDCM0412  CL24 HEK-293T C187(1.19); C344(1.19)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C187(0.91); C344(0.84)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C187(0.97); C344(1.01); C167(1.03)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C187(1.00)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C187(1.00); C344(1.16)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C187(1.07); C344(1.15)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C187(1.06)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C187(1.06); C344(0.93); C253(0.99)  LDD1623  [22]
 LDCM0420  CL31 HEK-293T C187(1.03); C344(1.17)  LDD1624  [22]
 LDCM0421  CL32 HEK-293T C187(1.09); C344(1.30)  LDD1625  [22]
 LDCM0422  CL33 HEK-293T C187(0.99); C344(1.00)  LDD1626  [22]
 LDCM0423  CL34 HEK-293T C344(1.09)  LDD1627  [22]
 LDCM0424  CL35 HEK-293T C187(1.11); C344(1.04)  LDD1628  [22]
 LDCM0425  CL36 HEK-293T C187(0.99); C344(1.12)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C187(0.97); C344(0.94)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C187(1.04)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C187(0.94); C344(1.22)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C187(1.02); C344(1.13)  LDD1634  [22]
 LDCM0431  CL41 HEK-293T C187(0.92); C344(1.21)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C187(1.05); C344(0.95); C253(1.05)  LDD1636  [22]
 LDCM0433  CL43 HEK-293T C187(1.14); C344(1.15)  LDD1637  [22]
 LDCM0434  CL44 HEK-293T C187(1.04); C344(1.07)  LDD1638  [22]
 LDCM0435  CL45 HEK-293T C187(1.00); C344(1.02)  LDD1639  [22]
 LDCM0436  CL46 HEK-293T C344(0.98)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C187(1.11); C344(0.99)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C187(1.12); C344(0.98)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C187(0.99); C344(0.97)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C187(0.94); C344(0.92)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C187(0.90); C344(1.01); C167(0.89)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C187(1.08); C344(1.18)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C187(0.96); C344(1.05)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C187(0.96); C344(1.12); C253(0.99)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C187(1.09); C344(0.95)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C187(1.07); C344(1.08)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C187(1.07); C344(0.98)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C344(1.04)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C187(1.23); C344(1.27)  LDD1653  [22]
 LDCM0451  CL6 HEK-293T C187(0.97); C344(0.97); C253(0.92)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C187(1.10); C344(1.17)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C187(0.99); C344(1.27)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C187(0.97); C344(1.08); C167(0.91)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C187(1.06)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C187(1.00); C344(0.95)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C187(0.94); C344(1.13)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C187(0.96); C344(0.98); C253(0.70)  LDD1661  [22]
 LDCM0459  CL67 HEK-293T C187(1.13); C344(1.07)  LDD1662  [22]
 LDCM0460  CL68 HEK-293T C187(1.13); C344(0.95)  LDD1663  [22]
 LDCM0461  CL69 HEK-293T C187(1.11); C344(1.02)  LDD1664  [22]
 LDCM0462  CL7 HEK-293T C187(1.02); C344(1.09)  LDD1665  [22]
 LDCM0463  CL70 HEK-293T C344(1.03)  LDD1666  [22]
 LDCM0464  CL71 HEK-293T C187(1.17); C344(1.02)  LDD1667  [22]
 LDCM0465  CL72 HEK-293T C187(0.93); C344(1.07)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C187(1.05); C344(0.87)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C187(1.10); C344(1.01); C167(1.02)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C187(1.19); C344(1.39)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C187(0.95); C344(0.20)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C187(1.12); C344(1.05); C253(0.81)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C187(1.19); C344(0.99)  LDD1675  [22]
 LDCM0473  CL8 HEK-293T C187(0.78); C344(0.80)  LDD1676  [22]
 LDCM0474  CL80 HEK-293T C187(1.22); C344(1.06)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C187(1.10); C344(0.98)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C344(0.97)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C187(1.16); C344(1.09)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C187(1.02); C344(0.94)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C187(0.99); C344(0.91)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C187(0.99); C344(0.78); C167(0.92)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C187(1.13)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C187(1.06); C344(1.09)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C187(0.99); C344(0.88)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C187(1.06); C344(1.02)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C187(0.84); C344(1.04); C253(0.30)  LDD1688  [22]
 LDCM0486  CL91 HEK-293T C187(1.06); C344(1.08)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C187(1.02); C344(1.09)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C187(1.08); C344(0.97)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C344(1.16)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C187(0.96); C344(1.21)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C187(1.00); C344(1.12)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C187(0.97); C344(0.83)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C187(0.93); C344(0.90); C167(0.96)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C187(1.12)  LDD1697  [22]
 LDCM0189  Compound 16 HEK-293T 18.87  LDD0492  [18]
 LDCM0185  Compound 17 HEK-293T 6.41  LDD0504  [18]
 LDCM0191  Compound 21 HEK-293T 7.52  LDD0493  [18]
 LDCM0187  Compound 32 HEK-293T 31.69  LDD0507  [18]
 LDCM0188  Compound 33 HEK-293T 6.95  LDD0505  [18]
 LDCM0192  Compound 35 HEK-293T 7.87  LDD0491  [18]
 LDCM0193  Compound 36 HEK-293T 13.25  LDD0494  [18]
 LDCM0194  Compound 37 HEK-293T 14.93  LDD0498  [18]
 LDCM0195  Compound 38 HEK-293T 6.19  LDD0499  [18]
 LDCM0196  Compound 39 HEK-293T 13.16  LDD0496  [18]
 LDCM0197  Compound 40 HEK-293T 14.39  LDD0495  [18]
 LDCM0181  Compound 41 HEK-293T 6.45  LDD0502  [18]
 LDCM0183  Compound 42 HEK-293T 5.18  LDD0500  [18]
 LDCM0495  E2913 HEK-293T C187(1.05)  LDD1698  [22]
 LDCM0082  FK866 A-549 5.15  LDD0146  [19]
 LDCM0468  Fragment33 HEK-293T C187(1.09)  LDD1671  [22]
 LDCM0427  Fragment51 HEK-293T C187(1.00); C344(1.04); C167(0.93)  LDD1631  [22]
 LDCM0116  HHS-0101 DM93 Y100(1.18); Y265(1.54); Y64(1.81); Y45(2.55)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y64(0.07); Y100(1.57); Y265(1.94); Y45(3.27)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y45(0.88); Y265(1.19); Y100(2.22)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y45(0.77); Y100(2.83); Y265(14.08)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y45(0.80); Y265(2.83); Y64(4.03); Y100(9.91)  LDD0268  [9]
 LDCM0123  JWB131 DM93 Y100(1.35); Y259(2.92); Y265(1.99)  LDD0285  [8]
 LDCM0124  JWB142 DM93 Y100(0.90); Y259(1.35); Y265(1.49)  LDD0286  [8]
 LDCM0125  JWB146 DM93 Y100(1.90); Y259(2.56); Y265(2.24)  LDD0287  [8]
 LDCM0126  JWB150 DM93 Y100(1.76); Y259(1.88); Y265(2.49)  LDD0288  [8]
 LDCM0127  JWB152 DM93 Y100(20.00); Y259(7.93); Y265(20.00)  LDD0289  [8]
 LDCM0128  JWB198 DM93 Y100(1.20); Y259(3.83); Y265(6.16)  LDD0290  [8]
 LDCM0129  JWB202 DM93 Y100(2.32); Y259(4.45); Y265(20.00)  LDD0291  [8]
 LDCM0130  JWB211 DM93 Y100(1.25); Y259(3.10); Y265(4.76)  LDD0292  [8]
 LDCM0075  kambe_cp62 PC-3 3.84  LDD0131  [20]
 LDCM0079  kambe_cp64 PC-3 3.02  LDD0135  [20]
 LDCM0078  kambe_cp70 PC-3 4.88  LDD0134  [20]
 LDCM0076  kambe_cp71 PC-3 13.27  LDD0132  [20]
 LDCM0022  KB02 HEK-293T C187(1.07)  LDD1492  [22]
 LDCM0023  KB03 HEK-293T C187(1.03)  LDD1497  [22]
 LDCM0024  KB05 G361 C187(1.16)  LDD3311  [6]
 LDCM0138  KDT501 HEK-293T 13.39  LDD0335  [21]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C187(1.00)  LDD2093  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C187(1.74)  LDD2099  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C187(0.47)  LDD2120  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C187(0.94)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C187(0.95)  LDD2127  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C187(1.02)  LDD2129  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C187(0.56)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C187(1.12)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C187(0.96)  LDD2136  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C187(1.04)  LDD2140  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C187(0.82)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C187(1.88)  LDD2144  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C187(0.61)  LDD2148  [7]
 LDCM0084  Ro 48-8071 A-549 2.12  LDD0144  [19]
 LDCM0081  Rofecoxib A-549 12.00  LDD0141  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BEN domain-containing protein 5 (BEND5) . Q7L4P6

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Indomethacin Small molecular drug DB00328
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(5e13e)-11-hydroxy-915-dioxoprosta-513-dien-1-oic Acid . DB07177

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. doi: 10.1021/acschembio.9b00963. Epub 2020 Feb 10.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
20 Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.
21 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402