Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Kambe_8  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name kambe_cp62  Competitor Info 
Competitor Concentration 20 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Prostate
Disease Model Prostate carcinoma [ICD-11:2C82]
Model Name Human prostate carcinoma cells (PC-3)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) 9.0
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 3.8
 LDTP06227  Prostaglandin reductase 1 (PTGR1) 3.8
 LDTP03730  Sepiapterin reductase (SPR) 2.9
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 2.8
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 2.2
 LDTP03816  Oxidized purine nucleoside triphosphate hydrolase (NUDT1) 2.1
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 3.5
Other
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01075  Protein CutA (CUTA) 3.5
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 2.4

References

1 Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.