Details of the Target

General Information of Target

Target ID LDTP15422
Target Name Prostaglandin reductase 3 (PTGR3)
Gene Name PTGR3
Gene ID 284273
Synonyms
ZADH2; Prostaglandin reductase 3; PRG-3; EC 1.3.1.48; Zinc-binding alcohol dehydrogenase domain-containing protein 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAGLSGAQIPDGEFTAVVYRLIRNARYAEAVQLLGGELQRSPRSRAGLSLLGYCYYRLQE
FALAAECYEQLGQLHPELEQYRLYQAQALYKACLYAEATRVAFLLLDNPAYHSRVLRLQA
AIKYSEGDLPGSRSLVEQLPSREGGEESGGENETDGQINLGCLLYKEGQYEAACSKFFAA
LQASGYQPDLSYNLALAYYSSRQYASALKHIAEIIERGIRQHPELGVGMTTEGIDVRSVG
NTLVLHQTALVEAFNLKAAIEYQLRNYEAAQEALTDMPPRAEEELDPVTLHNQALMNMDA
RPTEGFEKLQFLLQQNPFPPETFGNLLLLYCKYEYFDLAADVLAENAHLIYKFLTPYLYD
FLDAVITCQTAPEEAFIKLDGLAGMLTEVLRKLTIQVQEARHNRDDEAIKKAVNEYDETM
EKYIPVLMAQAKIYWNLENYPMVEKIFRKSVEFCNDHDVWKLNVAHVLFMQENKYKEAIG
FYEPIVKKHYDNILNVSAIVLANLCVSYIMTSQNEEAEELMRKIEKEEEQLSYDDPDKKM
YHLCIVNLVIGTLYCAKGNYDFGISRVIKSLEPYNKKLGTDTWYYAKRCFLSLLENMSKH
TIMLRDSVIQECVQFLEHCELHGRNIPAVIEQPLEEERMHVGKNTVTYESRQLKALIYEI
IGWNI
Target Bioclass
Enzyme
Family
Zinc-containing alcohol dehydrogenase family, Quinone oxidoreductase subfamily
Subcellular location
Peroxisome
Function
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
Uniprot ID
Q8N4Q0
Ensemble ID
ENST00000322342.4
HGNC ID
HGNC:28697

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.V117D .
HT115 SNV: p.R220C .
KATOIII SNV: p.M1? DBIA    Probe Info 
NCIH1792 SNV: p.G302C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C55(3.01)  LDD0170  [1]
DBIA
 Probe Info  		C198(0.85); C204(0.85)  LDD0078  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		C55(0.00); C218(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
IPM
 Probe Info  		N.A.  LDD0147  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 150 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		5.66  LDD1711  [7]
C003
 Probe Info  		21.26  LDD1713  [7]
C006
 Probe Info  		8.69  LDD1715  [7]
C007
 Probe Info  		11.79  LDD1716  [7]
C027
 Probe Info  		7.16  LDD1733  [7]
C039
 Probe Info  		5.66  LDD1739  [7]
C040
 Probe Info  		16.80  LDD1740  [7]
C055
 Probe Info  		13.55  LDD1752  [7]
C056
 Probe Info  		18.25  LDD1753  [7]
C060
 Probe Info  		35.26  LDD1757  [7]
C063
 Probe Info  		43.71  LDD1760  [7]
C065
 Probe Info  		6.41  LDD1762  [7]
C070
 Probe Info  		8.88  LDD1766  [7]
C071
 Probe Info  		8.51  LDD1767  [7]
C072
 Probe Info  		13.55  LDD1768  [7]
C084
 Probe Info  		7.89  LDD1776  [7]
C085
 Probe Info  		6.11  LDD1777  [7]
C087
 Probe Info  		12.64  LDD1779  [7]
C091
 Probe Info  		10.70  LDD1782  [7]
C092
 Probe Info  		25.11  LDD1783  [7]
C100
 Probe Info  		11.96  LDD1789  [7]
C106
 Probe Info  		16.45  LDD1793  [7]
C107
 Probe Info  		5.98  LDD1794  [7]
C108
 Probe Info  		8.06  LDD1795  [7]
C109
 Probe Info  		17.88  LDD1796  [7]
C112
 Probe Info  		44.32  LDD1799  [7]
C132
 Probe Info  		17.63  LDD1814  [7]
C139
 Probe Info  		73.52  LDD1821  [7]
C140
 Probe Info  		52.71  LDD1822  [7]
C141
 Probe Info  		15.56  LDD1823  [7]
C142
 Probe Info  		10.27  LDD1824  [7]
C143
 Probe Info  		32.22  LDD1825  [7]
C153
 Probe Info  		14.62  LDD1834  [7]
C157
 Probe Info  		26.17  LDD1837  [7]
C158
 Probe Info  		10.27  LDD1838  [7]
C159
 Probe Info  		17.27  LDD1839  [7]
C161
 Probe Info  		16.22  LDD1841  [7]
C165
 Probe Info  		28.25  LDD1845  [7]
C166
 Probe Info  		11.63  LDD1846  [7]
C167
 Probe Info  		19.43  LDD1847  [7]
C169
 Probe Info  		20.68  LDD1849  [7]
C176
 Probe Info  		5.43  LDD1855  [7]
C177
 Probe Info  		10.70  LDD1856  [7]
C178
 Probe Info  		17.51  LDD1857  [7]
C183
 Probe Info  		5.03  LDD1861  [7]
C185
 Probe Info  		13.45  LDD1863  [7]
C186
 Probe Info  		29.65  LDD1864  [7]
C187
 Probe Info  		22.47  LDD1865  [7]
C191
 Probe Info  		37.79  LDD1868  [7]
C193
 Probe Info  		9.32  LDD1869  [7]
C196
 Probe Info  		12.47  LDD1872  [7]
C197
 Probe Info  		9.51  LDD1873  [7]
C198
 Probe Info  		17.51  LDD1874  [7]
C201
 Probe Info  		99.73  LDD1877  [7]
C203
 Probe Info  		44.02  LDD1878  [7]
C206
 Probe Info  		17.39  LDD1881  [7]
C210
 Probe Info  		99.73  LDD1884  [7]
C211
 Probe Info  		31.12  LDD1885  [7]
C212
 Probe Info  		8.34  LDD1886  [7]
C213
 Probe Info  		29.45  LDD1887  [7]
C214
 Probe Info  		76.11  LDD1888  [7]
C218
 Probe Info  		13.18  LDD1892  [7]
C219
 Probe Info  		20.39  LDD1893  [7]
C220
 Probe Info  		36.00  LDD1894  [7]
C225
 Probe Info  		32.22  LDD1898  [7]
C227
 Probe Info  		18.00  LDD1900  [7]
C228
 Probe Info  		41.93  LDD1901  [7]
C230
 Probe Info  		7.94  LDD1903  [7]
C231
 Probe Info  		21.26  LDD1904  [7]
C232
 Probe Info  		60.13  LDD1905  [7]
C233
 Probe Info  		67.18  LDD1906  [7]
C239
 Probe Info  		5.78  LDD1912  [7]
C240
 Probe Info  		28.05  LDD1913  [7]
C244
 Probe Info  		32.22  LDD1917  [7]
C246
 Probe Info  		21.86  LDD1919  [7]
C254
 Probe Info  		42.52  LDD1927  [7]
C261
 Probe Info  		7.78  LDD1933  [7]
C264
 Probe Info  		19.16  LDD1935  [7]
C265
 Probe Info  		35.75  LDD1936  [7]
C270
 Probe Info  		9.06  LDD1940  [7]
C273
 Probe Info  		4.99  LDD1943  [7]
C276
 Probe Info  		13.18  LDD1946  [7]
C277
 Probe Info  		18.51  LDD1947  [7]
C279
 Probe Info  		79.34  LDD1949  [7]
C280
 Probe Info  		23.10  LDD1950  [7]
C282
 Probe Info  		14.83  LDD1952  [7]
C286
 Probe Info  		11.16  LDD1956  [7]
C290
 Probe Info  		8.22  LDD1960  [7]
C292
 Probe Info  		25.63  LDD1962  [7]
C293
 Probe Info  		16.68  LDD1963  [7]
C299
 Probe Info  		5.82  LDD1968  [7]
C303
 Probe Info  		5.39  LDD1972  [7]
C305
 Probe Info  		11.47  LDD1974  [7]
C307
 Probe Info  		8.51  LDD1975  [7]
C313
 Probe Info  		17.51  LDD1980  [7]
C317
 Probe Info  		10.48  LDD1983  [7]
C319
 Probe Info  		10.20  LDD1985  [7]
C333
 Probe Info  		5.28  LDD1996  [7]
C335
 Probe Info  		8.06  LDD1998  [7]
C337
 Probe Info  		6.50  LDD2000  [7]
C338
 Probe Info  		17.63  LDD2001  [7]
C339
 Probe Info  		5.74  LDD2002  [7]
C342
 Probe Info  		20.68  LDD2004  [7]
C343
 Probe Info  		18.51  LDD2005  [7]
C346
 Probe Info  		39.12  LDD2007  [7]
C348
 Probe Info  		42.81  LDD2009  [7]
C349
 Probe Info  		62.68  LDD2010  [7]
C352
 Probe Info  		9.13  LDD2013  [7]
C353
 Probe Info  		13.36  LDD2014  [7]
C355
 Probe Info  		22.94  LDD2016  [7]
C356
 Probe Info  		19.43  LDD2017  [7]
C359
 Probe Info  		26.35  LDD2020  [7]
C360
 Probe Info  		15.67  LDD2021  [7]
C361
 Probe Info  		17.27  LDD2022  [7]
C362
 Probe Info  		26.54  LDD2023  [7]
C364
 Probe Info  		25.11  LDD2025  [7]
C365
 Probe Info  		14.42  LDD2026  [7]
C374
 Probe Info  		5.58  LDD2034  [7]
C376
 Probe Info  		25.99  LDD2036  [7]
C378
 Probe Info  		5.86  LDD2037  [7]
C380
 Probe Info  		22.63  LDD2039  [7]
C381
 Probe Info  		7.16  LDD2040  [7]
C385
 Probe Info  		13.00  LDD2044  [7]
C386
 Probe Info  		7.11  LDD2045  [7]
C391
 Probe Info  		55.72  LDD2050  [7]
C395
 Probe Info  		8.22  LDD2054  [7]
C400
 Probe Info  		11.63  LDD2059  [7]
C403
 Probe Info  		15.67  LDD2061  [7]
C407
 Probe Info  		18.00  LDD2064  [7]
C408
 Probe Info  		14.42  LDD2065  [7]
C409
 Probe Info  		12.82  LDD2066  [7]
C413
 Probe Info  		44.94  LDD2069  [7]
C420
 Probe Info  		14.12  LDD2075  [7]
C424
 Probe Info  		7.67  LDD2079  [7]
C425
 Probe Info  		11.08  LDD2080  [7]
C426
 Probe Info  		98.36  LDD2081  [7]
C428
 Probe Info  		7.62  LDD2083  [7]
C429
 Probe Info  		19.56  LDD2084  [7]
C431
 Probe Info  		19.03  LDD2086  [7]
C432
 Probe Info  		5.58  LDD2087  [7]
C433
 Probe Info  		9.32  LDD2088  [7]
FFF probe11
 Probe Info  		20.00  LDD0471  [8]
FFF probe14
 Probe Info  		20.00  LDD0477  [8]
FFF probe15
 Probe Info  		20.00  LDD0478  [8]
FFF probe4
 Probe Info  		20.00  LDD0466  [8]
FFF probe7
 Probe Info  		20.00  LDD0483  [8]
JN0003
 Probe Info  		20.00  LDD0469  [8]
VE-P
 Probe Info  		N.A.  LDD0396  [9]
Kambe_8
 Probe Info  		3.78  LDD0124  [10]
OEA-DA
 Probe Info  		20.00  LDD0046  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C55(3.01)  LDD0170  [1]
 LDCM0214  AC1 HCT 116 C198(1.19); C204(1.19)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C198(0.90); C204(0.90)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C198(0.89); C204(0.89)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C198(1.86); C204(1.86)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C198(1.82); C204(1.82)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C198(1.14); C204(1.14)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C198(1.08); C204(1.08)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C198(0.83); C204(0.83)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C198(0.84); C204(0.84)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C198(0.86); C204(0.86)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C198(0.82); C204(0.82)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C198(2.13); C204(2.13)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C198(0.81); C204(0.81)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C198(0.81); C204(0.81)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C198(0.75); C204(0.75)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C198(0.74); C204(0.74)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C198(2.12); C204(2.12)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C198(1.28); C204(1.23)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C198(0.87); C204(0.82)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C198(0.95); C204(1.02)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C198(1.18); C204(1.16)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C198(1.27); C204(1.31)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C198(1.05); C204(1.07)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C198(0.91); C204(0.91)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C198(0.91); C204(0.94)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C198(1.16); C204(1.13)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C198(0.95); C204(0.92)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C198(1.36); C204(1.20)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C198(1.26); C204(1.29)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C198(1.02); C204(1.03)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C198(1.53); C204(1.49)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C198(1.31); C204(1.40)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C198(0.68); C204(0.68)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C198(1.21); C204(1.21)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C198(1.58); C204(1.58)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C198(1.36); C204(1.36)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C198(1.34); C204(1.34)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C198(0.92); C204(0.92)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C198(1.48); C204(1.48)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C198(0.92); C204(0.92)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C198(0.85); C204(0.85)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C198(0.99); C204(0.99)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C198(1.92); C204(1.92)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C198(1.24); C204(1.24)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C198(0.77); C204(0.77)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C198(0.89); C204(0.89)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C198(0.90); C204(0.90)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C198(1.07); C204(1.07)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C198(0.93); C204(0.93)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C198(0.88); C204(0.88)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C198(1.65); C204(1.65)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C198(0.72); C204(0.72)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C198(0.75); C204(0.75)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C198(0.75); C204(0.75)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C198(0.65); C204(0.65)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C198(1.09); C204(1.09)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C198(0.93); C204(0.93)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C198(0.88); C204(0.88)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C198(0.74); C204(0.74)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C198(0.95); C204(0.95)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C198(0.86); C204(0.86)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C198(0.87); C204(0.87)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C198(1.09); C204(1.09)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C198(1.15); C204(1.15)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C198(1.49); C204(1.49)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C198(1.00); C204(1.00)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C198(0.89); C204(0.89)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C198(1.20); C204(1.20)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C198(1.17); C204(1.17)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C198(1.05); C204(1.05)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C198(0.98); C204(0.98)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C198(1.01); C204(1.01)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C198(1.09); C204(1.09)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C198(1.36); C204(1.36)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C198(0.83); C204(0.83)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C198(1.23); C204(1.23)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C198(2.08); C204(2.08)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C198(0.67); C204(0.67)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C198(1.34); C204(1.34)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C198(0.72); C204(0.72)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C198(1.22); C204(1.22)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C198(0.75); C204(0.75)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C198(1.02); C204(1.02)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C198(0.87); C204(0.87)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C198(2.29); C204(2.29)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C198(1.16); C204(1.16)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C198(2.28); C204(2.28)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C198(2.04); C204(2.04)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C198(0.98); C204(0.98)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C198(1.45); C204(1.45)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C198(2.16); C204(2.16)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C198(1.09); C204(1.09)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C198(1.20); C204(1.20)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C198(1.14); C204(1.14)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C198(1.23); C204(1.23)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C198(1.26); C204(1.26)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C198(1.13); C204(1.13)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C198(1.28); C204(1.28)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C198(1.64); C204(1.64)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C198(0.89); C204(0.89)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C198(1.56); C204(1.56)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C198(0.73); C204(0.73)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C198(1.67); C204(1.67)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C198(1.18); C204(1.18)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C198(0.91); C204(0.91)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C198(0.92); C204(0.92)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C198(1.06); C204(1.06)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C198(0.68); C204(0.68)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C198(0.59); C204(0.59)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C198(0.60); C204(0.60)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C198(0.65); C204(0.65)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C198(1.02); C204(1.02)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C198(0.97); C204(0.97)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C198(0.56); C204(0.56)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C198(0.54); C204(0.54)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C198(1.21); C204(1.21)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C198(0.47); C204(0.47)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C198(1.02); C204(1.02)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C198(1.40); C204(1.40)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C198(0.77); C204(0.77)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C198(1.23); C204(1.23)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C198(0.61); C204(0.61)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C198(0.97); C204(0.97)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C198(0.75); C204(0.75)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C198(1.31); C204(1.31)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C198(0.79); C204(0.79)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C198(0.61); C204(0.61)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C198(1.77); C204(1.77)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C198(0.36); C204(0.36)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C198(0.73); C204(0.73)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C198(1.11); C204(1.11)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C198(0.68); C204(0.68)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C198(0.87); C204(0.87)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C198(0.92); C204(0.92)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C198(0.71); C204(0.71)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C198(1.26); C204(1.26)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C198(0.37); C204(0.37)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C198(0.77); C204(0.77)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C198(0.81); C204(0.81)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C198(1.85); C204(1.85)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C198(1.91); C204(1.91)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C198(0.98); C204(0.98)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C198(1.02); C204(1.02)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C198(0.86); C204(0.86)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C198(1.36); C204(1.36)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C198(0.67); C204(0.67)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C198(0.89); C204(0.89)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C198(0.92); C204(0.92)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C198(0.95); C204(0.95)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C198(0.87); C204(0.87)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C198(0.88); C204(0.88)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C198(0.88); C204(0.88)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C198(0.82); C204(0.82)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C198(1.11); C204(1.11)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C198(1.04); C204(1.04)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C198(0.93); C204(0.93)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C198(1.37); C204(1.37)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C198(0.85); C204(0.85)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C55(4.15)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C198(1.30); C204(1.30)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C198(0.60); C204(0.60)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C198(0.98); C204(0.98)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C198(0.87); C204(0.87)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C198(1.07); C204(1.07)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C198(0.93); C204(0.93)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C198(0.94); C204(0.94)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C198(0.98); C204(0.98)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C198(0.84); C204(0.84)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C198(0.86); C204(0.86)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C198(1.07); C204(1.07)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C198(0.94); C204(0.94)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C198(0.58); C204(0.58)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C198(1.06); C204(1.06)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C198(0.78); C204(0.78)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C198(0.95); C204(0.95)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C198(0.65); C204(0.65)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C198(0.64); C204(0.64)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C198(0.77); C204(0.77)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C198(0.93); C204(0.93)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C198(0.57); C204(0.57)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C198(1.06); C204(1.06)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C198(0.84); C204(0.84)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C198(0.60); C204(0.60)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C198(0.93); C204(0.93)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C198(1.39); C204(1.39)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C198(0.82); C204(0.82)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C198(0.80); C204(0.80)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C198(0.79); C204(0.79)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C198(1.22); C204(1.22)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C198(0.79); C204(0.79)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C198(0.87); C204(0.87)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C198(0.66); C204(0.66)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C198(0.61); C204(0.61)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C198(1.02); C204(1.02)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C198(0.64); C204(0.64)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C198(0.68); C204(0.68)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C198(0.86); C204(0.86)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C198(0.62); C204(0.62)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C198(0.84); C204(0.84)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C198(1.27); C204(1.27)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C198(0.77); C204(0.77)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C198(0.76); C204(0.76)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C198(0.54); C204(0.54)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C198(0.71); C204(0.71)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C198(0.60); C204(0.60)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C198(0.60); C204(0.60)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C198(0.66); C204(0.66)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C198(0.88); C204(0.88)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C198(0.68); C204(0.68)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C198(0.72); C204(0.72)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C198(1.28); C204(1.28)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C198(0.78); C204(0.78)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C198(1.41); C204(1.31)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C198(1.29); C204(1.10)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C198(1.28); C204(1.12)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C198(1.27); C204(1.06)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C198(1.39); C204(0.98)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C198(1.32); C204(1.26)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C198(1.35); C204(1.01)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C198(1.58); C204(1.21)  LDD1026  [2]
 LDCM0429  CL4 HCT 116 C198(1.06); C204(1.06)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C198(1.33); C204(1.10)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C198(1.59); C204(1.14)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C198(1.75); C204(1.29)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C198(1.58); C204(1.26)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C198(1.95); C204(1.74)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C198(1.72); C204(1.41)  LDD1033  [2]
 LDCM0436  CL46 HCT 116 C198(0.95); C204(0.95)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C198(0.82); C204(0.82)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C198(0.95); C204(0.95)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C198(1.09); C204(1.09)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C198(0.89); C204(0.89)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C198(1.09); C204(1.09)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C198(1.19); C204(1.19)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C198(1.05); C204(1.05)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C198(1.05); C204(1.05)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C198(1.01); C204(1.01)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C198(1.03); C204(1.03)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C198(0.99); C204(0.99)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C198(0.96); C204(0.96)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C198(0.94); C204(0.94)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C198(1.01); C204(1.01)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C198(0.71); C204(0.71)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C198(0.93); C204(0.93)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C198(0.94); C204(0.94)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C198(0.80); C204(0.80)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C198(0.79); C204(0.79)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C198(0.71); C204(0.71)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C198(0.59); C204(0.59)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C198(0.48); C204(0.48)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C198(0.73); C204(0.73)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C198(0.76); C204(0.76)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C198(0.53); C204(0.53)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C198(0.72); C204(0.72)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C198(0.70); C204(0.70)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C198(0.69); C204(0.69)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C198(0.81); C204(0.81)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C198(0.81); C204(0.81)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C198(0.72); C204(0.72)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C198(0.83); C204(0.83)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C198(1.02); C204(1.02)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C198(0.93); C204(0.93)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C198(0.85); C204(0.85)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C198(0.55); C204(0.55)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C198(0.91); C204(0.91)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C198(1.06); C204(1.06)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C198(1.08); C204(1.08)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C198(1.06); C204(1.06)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C198(0.95); C204(0.95)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C198(0.91); C204(0.91)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C198(0.90); C204(0.90)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C198(0.95); C204(0.95)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C198(1.11); C204(1.11)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C198(1.08); C204(1.08)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C198(0.86); C204(0.86)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C198(1.07); C204(1.07)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C198(1.20); C204(1.20)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C198(0.83); C204(0.83)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C198(0.76); C204(0.76)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C198(0.96); C204(0.96)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C198(0.96); C204(0.96)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C198(1.05); C204(1.05)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C198(1.28); C204(1.28)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C198(1.63); C204(1.63)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C198(1.30); C204(1.30)  LDD0811  [2]
 LDCM0187  Compound 32 HEK-293T 19.23  LDD0507  [8]
 LDCM0188  Compound 33 HEK-293T 6.21  LDD0505  [8]
 LDCM0495  E2913 HEK-293T C55(1.13); C218(1.24)  LDD1698  [12]
 LDCM0468  Fragment33 HCT 116 C198(0.58); C204(0.58)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C198(1.42); C204(1.60)  LDD1025  [2]
 LDCM0073  Kambe_cp3 PC-3 3.78  LDD0124  [10]
 LDCM0075  kambe_cp62 PC-3 2.80  LDD0131  [10]
 LDCM0022  KB02 HEK-293T C218(1.01); C55(0.96)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C218(0.99); C55(1.06)  LDD1497  [12]
 LDCM0024  KB05 HMCB C55(1.50)  LDD3312  [13]
 LDCM0021  THZ1 HCT 116 C198(1.03); C204(1.03)  LDD2173  [2]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
9 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
10 Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.
11 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840