Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C227  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 25.1
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 19.4
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 18.0
 LDTP00575  Glutathione S-transferase A4 (GSTA4) 16.6
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 15.3
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 8.0
 LDTP13751  Exonuclease 1 (EXO1) 5.1
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 5.0
Transporter and channel
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 10.9
 LDTP20002  Transmembrane protein 160 (TMEM160) 6.0
Other
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13630  Neudesin (NENF) 7.7
 LDTP03520  Phosphatidylethanolamine-binding protein 1 (PEBP1) 6.9
 LDTP15623  Neuferricin (CYB5D2) 6.7

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587