Details of the Target

General Information of Target

Target ID LDTP09043
Target Name Lysine-specific histone demethylase 2 (KDM1B)
Gene Name KDM1B
Gene ID 221656
Synonyms
AOF1; C6orf193; LSD2; Lysine-specific histone demethylase 2; EC 1.14.99.66; Flavin-containing amine oxidase domain-containing protein 1; Lysine-specific histone demethylase 1B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATPRGRTKKKASFDHSPDSLPLRSSGRQAKKKATETTDEDEDGGSEKKYRKCEKAGCTA
TCPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYDKYTTWKKIWTSN
GKTEPSPKAFMADQQLPYWVQCTKPECRKWRQLTKEIQLTPQIAKTYRCGMKPNTAIKPE
TSDHCSLPEDLRVLEVSNHWWYSMLILPPLLKDSVAAPLLSAYYPDCVGMSPSCTSTNRA
AATGNASPGKLEHSKAALSVHVPGMNRYFQPFYQPNECGKALCVRPDVMELDELYEFPEY
SRDPTMYLALRNLILALWYTNCKEALTPQKCIPHIIVRGLVRIRCVQEVERILYFMTRKG
LINTGVLSVGADQYLLPKDYHNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGR
VWDDKSFKGVTVGRGAQIVNGCINNPVALMCEQLGISMHKFGERCDLIQEGGRITDPTID
KRMDFHFNALLDVVSEWRKDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQVLQFHL
SNLEYACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQC
IDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIE
KIALQFPYRFWDSKVQGADFFGHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVAS
VRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD
IIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Flavin monoamine oxidase family
Subcellular location
Nucleus
Function
Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes.
TTD ID
T24823
Uniprot ID
Q8NB78
DrugMap ID
TT8VP2T
Ensemble ID
ENST00000297792.9
HGNC ID
HGNC:21577
ChEMBL ID
CHEMBL1938208

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.Q469H; p.E739K .
KELLY SNV: p.Y295F .
LNCaP clone FGC SNV: p.Y107C .
MFE319 SNV: p.S231G DBIA    Probe Info 
OV56 SNV: p.P304S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 2
 Probe Info  		17.00  LDD0389  [1]
BTD
 Probe Info  		C345(0.92)  LDD2099  [2]
DBIA
 Probe Info  		C234(2.73); C278(1.76); C227(1.29)  LDD0080  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C465(0.00); C92(0.00); C95(0.00); C87(0.00)  LDD0037  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
IPM
 Probe Info  		N.A.  LDD0147  [5]
STPyne
 Probe Info  		N.A.  LDD0009  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
PAL-AfBPP Probe
Click To Hide/Show 62 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.77  LDD1714  [8]
C026
 Probe Info  		7.11  LDD1732  [8]
C060
 Probe Info  		6.36  LDD1757  [8]
C069
 Probe Info  		9.92  LDD1765  [8]
C089
 Probe Info  		11.00  LDD1781  [8]
C091
 Probe Info  		11.88  LDD1782  [8]
C107
 Probe Info  		5.86  LDD1794  [8]
C141
 Probe Info  		23.75  LDD1823  [8]
C153
 Probe Info  		28.05  LDD1834  [8]
C159
 Probe Info  		11.96  LDD1839  [8]
C160
 Probe Info  		8.40  LDD1840  [8]
C161
 Probe Info  		12.04  LDD1841  [8]
C163
 Probe Info  		7.84  LDD1843  [8]
C169
 Probe Info  		23.59  LDD1849  [8]
C170
 Probe Info  		18.13  LDD1850  [8]
C178
 Probe Info  		28.05  LDD1857  [8]
C180
 Probe Info  		8.11  LDD1859  [8]
C182
 Probe Info  		6.23  LDD1860  [8]
C186
 Probe Info  		11.71  LDD1864  [8]
C194
 Probe Info  		14.62  LDD1870  [8]
C195
 Probe Info  		5.46  LDD1871  [8]
C198
 Probe Info  		19.16  LDD1874  [8]
C206
 Probe Info  		16.56  LDD1881  [8]
C208
 Probe Info  		14.52  LDD1883  [8]
C219
 Probe Info  		20.97  LDD1893  [8]
C223
 Probe Info  		9.99  LDD1897  [8]
C225
 Probe Info  		5.98  LDD1898  [8]
C227
 Probe Info  		15.35  LDD1900  [8]
C233
 Probe Info  		13.93  LDD1906  [8]
C239
 Probe Info  		9.13  LDD1912  [8]
C254
 Probe Info  		9.38  LDD1927  [8]
C256
 Probe Info  		11.16  LDD1929  [8]
C271
 Probe Info  		9.32  LDD1941  [8]
C277
 Probe Info  		13.45  LDD1947  [8]
C282
 Probe Info  		16.00  LDD1952  [8]
C284
 Probe Info  		47.84  LDD1954  [8]
C287
 Probe Info  		9.45  LDD1957  [8]
C290
 Probe Info  		8.11  LDD1960  [8]
C305
 Probe Info  		10.70  LDD1974  [8]
C312
 Probe Info  		5.39  LDD1979  [8]
C326
 Probe Info  		25.63  LDD1990  [8]
C337
 Probe Info  		5.74  LDD2000  [8]
C338
 Probe Info  		11.08  LDD2001  [8]
C339
 Probe Info  		5.10  LDD2002  [8]
C343
 Probe Info  		13.93  LDD2005  [8]
C349
 Probe Info  		20.82  LDD2010  [8]
C351
 Probe Info  		6.77  LDD2012  [8]
C355
 Probe Info  		26.17  LDD2016  [8]
C356
 Probe Info  		8.11  LDD2017  [8]
C357
 Probe Info  		8.82  LDD2018  [8]
C364
 Probe Info  		17.39  LDD2025  [8]
C380
 Probe Info  		5.50  LDD2039  [8]
C385
 Probe Info  		22.78  LDD2044  [8]
C386
 Probe Info  		15.67  LDD2045  [8]
C393
 Probe Info  		5.31  LDD2052  [8]
C414
 Probe Info  		14.12  LDD2070  [8]
C419
 Probe Info  		9.00  LDD2074  [8]
C420
 Probe Info  		11.71  LDD2075  [8]
C422
 Probe Info  		13.09  LDD2077  [8]
C431
 Probe Info  		21.56  LDD2086  [8]
FFF probe13
 Probe Info  		20.00  LDD0475  [9]
OEA-DA
 Probe Info  		20.00  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C345(1.15)  LDD2117  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C278(2.28)  LDD0372  [11]
 LDCM0214  AC1 HCT 116 C227(1.15); C234(1.15); C278(1.03); C465(0.94)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C142(0.71); C147(0.71); C278(0.88)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C142(0.44); C147(0.44); C227(1.04); C234(1.04)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C142(0.58); C147(0.58); C227(0.92); C234(0.92)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C142(0.79); C147(0.79); C227(1.21); C234(1.21)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C142(0.59); C147(0.59); C227(1.21); C234(1.21)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C142(0.80); C147(0.80); C227(1.20); C234(1.20)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C142(0.58); C147(0.58); C227(1.07); C234(1.07)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C142(0.50); C147(0.50); C227(1.20); C234(1.20)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C142(0.56); C147(0.56); C227(1.12); C234(1.12)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C142(0.50); C147(0.50); C227(1.19); C234(1.19)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C142(0.94); C147(0.94); C227(1.11); C234(1.11)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C142(0.60); C147(0.60); C278(0.95)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C142(0.52); C147(0.52); C227(1.12); C234(1.12)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C142(0.53); C147(0.53); C227(1.22); C234(1.22)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C142(0.54); C147(0.54); C227(1.12); C234(1.12)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C142(1.11); C147(1.11); C227(0.93); C234(0.93)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C142(0.89); C147(1.01); C227(1.02); C234(1.02)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C142(0.96); C147(1.04); C227(0.99); C234(0.99)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C142(1.14); C147(1.00); C227(1.03); C234(1.03)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C142(1.02); C147(0.94); C227(0.94); C234(0.94)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C142(1.16); C147(1.01); C227(0.94); C234(0.94)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C142(0.85); C147(0.93); C227(1.00); C234(1.00)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C142(0.62); C147(0.62); C278(0.85)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C142(1.00); C147(1.13); C227(1.76); C234(1.76)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C142(1.14); C147(1.04); C227(1.20); C234(1.20)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C142(1.10); C147(1.22); C227(0.97); C234(0.97)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C142(1.28); C147(1.07); C227(1.23); C234(1.23)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C142(1.16); C147(1.11); C227(1.12); C234(1.12)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C142(1.08); C147(1.10); C227(1.09); C234(1.09)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C142(1.14); C147(1.12); C227(1.08); C234(1.08)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C142(1.27); C147(1.15); C227(1.18); C234(1.18)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C142(0.56); C147(0.56); C227(1.27); C234(1.27)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C142(1.17); C147(1.17); C227(0.79); C234(0.79)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C142(0.92); C147(0.92); C227(0.73); C234(0.73)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C142(1.45); C147(1.45); C227(1.66); C234(1.66)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C142(1.85); C147(1.85); C227(0.79); C234(0.79)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C142(1.16); C147(1.16); C227(0.90); C234(0.90)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C142(1.10); C147(1.10); C227(1.28); C234(1.28)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C142(0.90); C147(0.90); C227(0.82); C234(0.82)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C142(1.18); C147(1.18); C227(0.88); C234(0.88)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C142(1.33); C147(1.33); C227(0.85); C234(0.85)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C142(1.03); C147(1.03); C227(1.18); C234(1.18)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C142(1.27); C147(1.27); C227(0.91); C234(0.91)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C142(0.58); C147(0.58); C278(1.01)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C142(0.92); C147(0.92); C227(1.04); C234(1.04)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C142(1.16); C147(1.16); C227(1.16); C234(1.16)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C142(1.70); C147(1.70); C227(0.86); C234(0.86)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C58(0.89); C65(0.89); C142(0.94); C147(0.94)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C142(0.64); C147(0.64); C58(1.21); C65(1.21)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C142(0.80); C147(0.80); C278(1.13); C58(1.40)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C142(0.59); C147(0.59); C58(1.02); C65(1.02)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C142(0.53); C147(0.53); C58(1.13); C65(1.13)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C142(0.34); C147(0.34); C58(0.85); C65(0.85)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C142(0.56); C147(0.56); C58(0.96); C65(0.96)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C142(0.60); C147(0.60); C278(0.93)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C142(0.98); C147(0.98); C62(1.11); C278(1.16)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C142(0.84); C147(0.84); C278(1.04); C62(1.07)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C142(0.51); C147(0.51); C62(1.05); C58(1.10)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C142(0.34); C147(0.34); C62(0.57); C58(1.12)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C142(0.72); C147(0.72); C278(1.34); C58(1.43)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C142(0.83); C147(0.83); C278(1.21); C58(1.08)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C142(0.83); C147(0.83); C278(1.00); C58(1.16)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C142(0.81); C147(0.81); C278(1.03); C58(1.04)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C234(0.69); C142(0.99); C147(0.99); C278(1.01)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C234(0.51); C142(0.75); C147(0.75); C278(1.34)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C234(1.00); C142(1.08); C147(1.08); C278(1.11)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C227(0.90); C234(0.90); C58(0.91); C62(0.91)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C234(0.94); C278(1.12); C142(1.36); C147(1.36)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C234(0.94); C278(1.01); C142(1.04); C147(1.04)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C234(0.58); C278(0.97); C142(1.03); C147(1.03)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C234(0.51); C278(1.05); C142(1.45); C147(1.45)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C234(0.74); C278(1.03); C142(1.25); C147(1.25)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C227(0.79); C234(0.79); C278(0.90); C465(0.99)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C142(0.72); C147(0.72); C465(0.82); C227(0.88)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C465(0.85); C142(0.94); C147(0.94); C278(0.97)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C142(0.78); C147(0.78); C227(0.78); C234(0.78)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C142(0.50); C147(0.50); C465(0.89); C278(1.02)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C227(0.77); C234(0.77); C58(0.81); C62(0.81)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C142(0.54); C147(0.54); C227(1.04); C234(1.04)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C142(0.79); C147(0.79); C227(0.97); C234(0.97)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C142(0.51); C147(0.51); C227(0.94); C234(0.94)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C142(0.85); C147(0.85); C465(0.87); C227(1.04)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C465(0.92); C142(1.04); C147(1.04); C278(1.24)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C58(0.66); C62(0.66); C65(0.66); C465(0.94)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C278(0.82); C465(0.85); C58(1.10); C62(1.10)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C278(0.77); C465(1.00); C142(1.10); C147(1.10)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C58(0.84); C62(0.84); C65(0.84); C278(0.88)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C142(0.72); C147(0.72); C278(0.96); C465(1.02)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C58(0.80); C62(0.80); C65(0.80); C227(0.86)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C142(0.69); C147(0.69); C465(0.90); C278(1.03)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C278(0.83); C465(0.88); C58(0.89); C62(0.89)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C142(0.94); C147(0.94); C465(0.96); C278(1.09)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C142(0.89); C147(0.89); C278(0.91); C465(0.93)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C142(0.87); C147(0.87); C278(0.93); C465(0.93)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C142(0.62); C147(0.62); C465(0.68); C278(0.92)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C142(1.01); C147(1.01); C278(1.03); C227(1.06)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C142(0.85); C147(0.85); C227(0.87); C234(0.87)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C227(0.53); C234(0.53); C142(0.73); C147(0.73)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C142(0.43); C147(0.43); C227(0.85); C234(0.85)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C58(0.73); C62(0.73); C65(0.73); C227(0.80)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C142(0.47); C147(0.47); C278(1.12); C227(1.59)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C227(0.83); C234(0.83); C278(0.99); C142(1.37)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C278(0.91); C227(0.96); C234(0.96); C142(1.23)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C142(0.67); C147(0.67); C278(1.21); C227(1.22)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C142(0.65); C147(0.65); C227(0.93); C234(0.93)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C142(0.50); C147(0.50); C278(1.21); C227(1.27)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C142(0.51); C147(0.51); C227(1.26); C234(1.26)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C142(0.71); C147(0.71); C227(0.77); C234(0.77)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C142(0.52); C147(0.52); C227(1.02); C234(1.02)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C142(0.55); C147(0.55); C227(0.92); C234(0.92)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C142(0.67); C147(0.67); C278(1.12)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C142(0.75); C147(0.75); C227(1.10); C234(1.10)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C142(0.52); C147(0.52); C227(0.72); C234(0.72)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C142(0.40); C147(0.40); C227(0.63); C234(0.63)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C142(0.62); C147(0.62); C227(0.75); C234(0.75)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C142(0.48); C147(0.48); C227(0.81); C234(0.81)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C142(0.41); C147(0.41); C227(0.69); C234(0.69)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C142(0.48); C147(0.48); C227(0.73); C234(0.73)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C142(0.27); C147(0.27); C227(0.97); C234(0.97)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C142(0.65); C147(0.65); C227(0.70); C234(0.70)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C142(0.50); C147(0.50); C465(0.85); C58(0.95)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C142(0.85); C147(0.85); C278(1.03)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C142(0.38); C147(0.38); C227(0.61); C234(0.61)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C227(0.56); C234(0.56); C142(0.82); C147(0.82)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C142(0.69); C147(0.69); C465(0.95); C58(0.96)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C142(0.31); C147(0.31); C227(0.78); C234(0.78)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C142(0.38); C147(0.38); C227(0.64); C234(0.64)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C142(0.37); C147(0.37); C227(0.79); C234(0.79)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C142(0.47); C147(0.47); C227(0.70); C234(0.70)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C142(0.41); C147(0.41); C465(0.80); C227(0.95)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C142(0.64); C147(0.64); C465(0.78); C227(0.89)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C142(0.78); C147(0.78); C227(0.79); C234(0.79)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C142(0.83); C147(0.83); C278(1.10)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C142(0.55); C147(0.55); C227(0.86); C234(0.86)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C227(0.64); C234(0.64); C58(0.92); C62(0.92)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C142(0.37); C147(0.37); C227(0.52); C234(0.52)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C142(0.59); C147(0.59); C62(1.08); C58(1.12)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C142(0.59); C147(0.59); C62(0.86); C58(0.86)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C142(0.68); C147(0.68); C227(0.95); C234(0.95)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C142(0.94); C147(0.94); C278(1.06); C58(1.38)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C142(0.81); C147(0.81); C278(0.97); C227(1.14)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C227(0.96); C234(0.96); C278(1.03); C142(1.15)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C142(0.78); C147(0.78); C278(1.02); C62(1.23)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C227(0.76); C234(0.76); C278(0.84); C142(0.99)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C142(0.62); C147(0.62); C62(0.91); C58(0.93)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C142(0.75); C147(0.75); C227(0.85); C234(0.85)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C142(0.76); C147(0.76); C227(0.98); C234(0.98)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C142(0.80); C147(0.80); C227(0.86); C234(0.86)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C227(0.86); C234(0.86); C142(0.89); C147(0.89)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C142(0.66); C147(0.66); C227(0.97); C234(0.97)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C142(0.82); C147(0.82); C58(1.00); C65(1.00)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C142(0.45); C147(0.45); C227(1.01); C234(1.01)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C142(0.54); C147(0.54); C278(0.95); C227(1.20)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C142(0.76); C147(0.76); C278(0.96)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C142(0.75); C147(0.75); C278(1.00)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C142(0.26); C147(0.26); C278(1.04)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C227(1.02); C234(1.02)  LDD2171  [3]
 LDCM0367  CL1 HCT 116 C278(1.01); C142(1.43); C147(1.43)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C278(0.84); C142(1.12); C147(1.12)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C465(0.81); C227(0.85); C234(0.85); C58(0.97)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C142(0.61); C147(0.61); C278(1.10)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C142(0.86); C147(0.86); C278(1.13)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C278(0.88); C142(1.08); C147(1.08)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C142(0.72); C147(0.72); C278(1.08)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C234(0.61); C142(0.74); C147(0.74); C278(1.27)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C142(0.49); C147(0.49); C234(0.92); C278(1.36)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C142(0.57); C147(0.57); C234(0.69); C278(1.21)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C142(0.45); C147(0.45); C234(0.60); C278(1.43)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C234(1.00); C142(1.04); C147(1.04); C278(1.15)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C278(0.87); C142(1.20); C147(1.20)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C142(0.75); C147(0.75); C234(0.75); C278(1.34)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C234(1.02); C142(1.05); C147(1.05); C278(1.25)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C142(0.92); C147(0.92); C465(1.02); C227(1.06)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C142(0.53); C147(0.53); C465(0.85); C278(1.24)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C142(0.53); C147(0.53); C465(0.90); C278(1.17)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C142(0.63); C147(0.63); C465(0.98); C278(1.23)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C465(0.85); C142(0.93); C147(0.93); C278(1.00)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C142(0.48); C147(0.48); C58(0.74); C62(0.74)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C278(0.87); C142(0.96); C147(0.96); C58(1.42)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C142(0.79); C147(0.79); C465(0.90); C278(0.97)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C278(0.83); C142(1.39); C147(1.39)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C465(0.83); C278(0.90); C142(1.06); C147(1.06)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C278(1.04); C142(1.64); C147(1.64); C227(3.59)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C142(0.68); C147(0.68); C227(0.90); C234(0.90)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C142(0.54); C147(0.54); C278(1.20); C227(1.22)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C142(0.51); C147(0.51); C227(1.04); C234(1.04)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C227(0.85); C234(0.85); C142(1.08); C147(1.08)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C142(0.84); C147(0.84); C227(1.21); C234(1.21)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C227(0.83); C234(0.83); C142(0.90); C147(0.90)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C142(0.66); C147(0.66); C227(0.93); C234(0.93)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C278(0.89); C142(1.43); C147(1.43)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C278(0.90); C142(0.97); C147(0.97)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C278(0.95); C142(1.54); C147(1.54)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C227(0.86); C234(0.86); C278(1.00); C142(1.07)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C227(0.82); C234(0.82); C142(0.98); C147(0.98)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C142(0.57); C147(0.57); C227(2.02); C234(2.02)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C142(0.69); C147(0.69); C227(1.02); C234(1.02)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C278(0.94); C142(1.07); C147(1.07)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C142(0.54); C147(0.54); C227(2.47); C234(2.47)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C142(0.42); C147(0.42); C227(1.28); C234(1.28)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C142(0.35); C147(0.35); C227(1.40); C234(1.40)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C142(0.69); C147(0.69); C227(1.46); C234(1.46)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C142(0.40); C147(0.40); C227(1.90); C234(1.90)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C142(0.49); C147(0.49); C227(0.95); C234(0.95)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C142(0.70); C147(0.70); C227(1.21); C234(1.21)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C142(0.69); C147(0.69); C227(0.89); C234(0.89)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C142(0.63); C147(0.63); C227(2.17); C234(2.17)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C142(0.51); C147(0.51); C227(1.40); C234(1.40)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C142(1.08); C147(1.08); C278(0.82)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C142(0.88); C147(0.88); C227(1.30); C234(1.30)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C142(0.61); C147(0.61); C227(0.90); C234(0.90)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C142(0.51); C147(0.51); C278(1.07); C465(1.02)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C142(0.63); C147(0.63); C278(1.27); C465(1.01)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C142(0.39); C147(0.39); C278(1.05); C465(1.07)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C142(0.38); C147(0.38); C278(0.99); C465(1.00)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C142(0.42); C147(0.42); C278(1.10); C465(1.04)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C142(0.35); C147(0.35); C278(1.02); C465(1.03)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C142(0.35); C147(0.35); C278(1.04); C465(0.94)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C142(1.16); C147(1.16); C278(1.26)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C142(0.40); C147(0.40); C278(1.19); C465(0.96)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C142(0.42); C147(0.42); C278(1.16); C465(0.90)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C142(0.30); C147(0.30); C278(1.08); C465(0.98)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C142(0.33); C147(0.33); C278(1.02); C465(0.85)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C142(0.47); C147(0.47); C278(0.95); C465(0.95)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C142(0.36); C147(0.36); C278(1.01); C465(0.85)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C142(0.85); C147(0.85); C227(0.89); C234(0.89)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C142(0.67); C147(0.67); C227(0.91); C234(0.91)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C142(0.69); C147(0.69); C227(0.79); C234(0.79)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C142(0.77); C147(0.77); C227(0.87); C234(0.87)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C142(1.07); C147(1.07); C278(0.78)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C142(0.82); C147(0.82); C227(0.89); C234(0.89)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C142(0.96); C147(0.96); C227(0.74); C234(0.74)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C142(0.82); C147(0.82); C227(1.02); C234(1.02)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C142(0.78); C147(0.78); C227(2.39); C234(2.39)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C142(0.89); C147(0.89); C227(1.35); C234(1.35)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C142(0.94); C147(0.94); C227(1.01); C234(1.01)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C142(0.76); C147(0.76); C227(1.47); C234(1.47)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C142(0.99); C147(0.99); C227(1.25); C234(1.25)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C142(0.82); C147(0.82); C227(1.02); C234(1.02)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C142(0.83); C147(0.83); C227(1.02); C234(1.02)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C142(1.64); C147(1.64); C278(0.84)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C142(0.76); C147(0.76); C227(0.83); C234(0.83)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C227(0.84); C234(0.84); C278(1.12); C58(1.21)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C227(0.78); C234(0.78); C278(0.96); C58(1.01)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C227(1.11); C234(1.11); C278(1.10); C58(0.95)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C227(0.81); C234(0.81); C278(1.32); C58(1.19)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C227(0.98); C234(0.98); C278(1.02); C58(2.16)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C227(0.91); C234(0.91); C278(1.35); C58(0.98)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C227(0.99); C234(0.99); C278(1.19); C58(1.59)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C227(2.92); C234(2.92); C278(1.26); C58(1.56)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C227(0.93); C234(0.93); C278(1.16); C58(1.03)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C142(1.19); C147(1.19); C278(0.71)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C227(1.10); C234(1.10); C278(1.11); C58(1.35)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C227(1.06); C234(1.06); C278(1.20); C58(1.29)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C227(1.25); C234(1.25); C278(1.26); C58(1.00)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C227(1.50); C234(1.50); C278(1.28); C58(1.36)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C227(1.47); C234(1.47); C278(1.22); C58(0.92)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C227(0.86); C234(0.86); C278(1.04)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C227(0.83); C234(0.83); C278(1.27)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C227(0.67); C234(0.67); C278(0.99)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C227(0.68); C234(0.68); C278(1.19)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C142(1.49); C147(1.49); C278(1.14)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C227(0.63); C234(0.63); C278(1.04)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C227(0.57); C234(0.57); C278(0.99)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C227(0.77); C234(0.77); C278(1.16)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C227(0.68); C234(0.68); C278(1.21)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C227(1.11); C234(1.11); C278(1.31)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C227(1.22); C234(1.22); C278(1.09)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C227(0.82); C234(0.82); C278(0.91)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C227(0.68); C234(0.68); C278(1.07)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C227(0.89); C234(0.89); C278(1.30)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C227(0.65); C234(0.65); C278(1.51)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C142(1.13); C147(1.13); C278(0.93)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C227(0.70); C234(0.70); C278(1.05)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C227(2.22); C234(2.22); C278(1.13); C465(1.17)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C227(2.53); C234(2.53); C278(1.08); C465(1.02)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C227(0.84); C234(0.84); C278(0.94); C465(0.82)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C227(1.06); C234(1.06); C278(1.23); C465(0.93)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C227(1.02); C234(1.02); C278(1.28); C465(1.14)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C227(1.68); C234(1.68); C278(1.13); C465(1.16)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C227(1.24); C234(1.24); C278(1.04); C465(1.05)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C227(1.06); C234(1.06); C278(1.18); C465(1.13)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C227(1.08); C234(1.08); C278(1.11); C465(1.04)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C600(1.20); C278(0.97)  LDD1698  [12]
 LDCM0468  Fragment33 HCT 116 C227(0.96); C234(0.96); C278(1.12); C58(1.14)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C142(0.30); C147(0.30); C278(1.41); C465(1.06)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C234(2.73); C278(1.76); C227(1.29)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C234(1.53); C278(1.09); C227(1.53)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C234(1.69); C278(1.67); C227(1.18)  LDD0082  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C345(0.92)  LDD2099  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C345(1.00)  LDD2107  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C345(0.83)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C345(1.20)  LDD2127  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C345(0.91)  LDD2135  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C345(0.75)  LDD2140  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C345(2.42)  LDD2144  [2]
 LDCM0021  THZ1 HCT 116 C227(1.02); C234(1.02)  LDD2173  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Patented
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid27019002-compound-46 Small molecular drug D0Z7HE
Pmid27019002-compound-47 Small molecular drug D0WO5W
Pmid27019002-compound-48 Small molecular drug D09OMM
Tarnylcypromine Derivative 2 Small molecular drug D04OHC
Tarnylcypromine Derivative 3 Small molecular drug D0O7IH

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402