Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C223  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 43 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 37.5
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 30.3
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 22.0
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 21.9
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 21.0
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 19.8
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 18.6
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 18.1
 LDTP02141  Alpha-galactosidase A (GLA) 16.6
 LDTP00316  Ribonuclease T2 (RNASET2) 16.1
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 16.0
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 15.7
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 14.9
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 14.9
 LDTP00282  Beta-mannosidase (MANBA) 14.8
 LDTP02539  Lysosomal acid phosphatase (ACP2) 14.0
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 13.7
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 13.5
 LDTP02976  Peptidyl-glycine alpha-amidating monooxygenase (PAM) 13.5
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 11.3
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 11.2
 LDTP02260  Beta-glucuronidase (GUSB) 10.9
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 10.8
 LDTP01372  Carboxypeptidase D (CPD) 10.8
 LDTP02776  Arylsulfatase A (ARSA) 10.7
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 10.1
 LDTP02837  Beta-galactosidase (GLB1) 10.0
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 10.0
 LDTP02006  Tissue alpha-L-fucosidase (FUCA1) 9.9
 LDTP13147  Cathepsin Z (CTSZ) 9.8
 LDTP05905  Acid ceramidase (ASAH1) 9.6
 LDTP04452  N-sulphoglucosamine sulphohydrolase (SGSH) 9.4
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 9.3
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 8.7
 LDTP02505  Lysosomal protective protein (CTSA) 8.5
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 7.9
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 7.2
 LDTP03858  Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) 6.7
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 5.9
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 5.6
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 5.6
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 5.5
 LDTP05831  Receptor-type tyrosine-protein phosphatase S (PTPRS) 5.5
Transporter and channel
Click to Show/Hide to Show 30 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02655  Lysosome-associated membrane glycoprotein 2 (LAMP2) 23.8
 LDTP16813  Tetraspanin-3 (TSPAN3) 23.8
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 22.6
 LDTP02215  Prosaposin (PSAP) 22.6
 LDTP11615  Protein tweety homolog 3 (TTYH3) 20.8
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 17.8
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 16.2
 LDTP02071  Amyloid-beta precursor protein (APP) 13.6
 LDTP02562  Lysosome-associated membrane glycoprotein 1 (LAMP1) 10.8
 LDTP00321  Podocalyxin (PODXL) 10.3
 LDTP02586  Cation-independent mannose-6-phosphate receptor (IGF2R) 10.0
 LDTP12451  Integral membrane protein 2C (ITM2C) 9.5
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 9.4
 LDTP01829  Low-density lipoprotein receptor (LDLR) 9.1
 LDTP03380  Stomatin (STOM) 8.8
 LDTP15481  Transmembrane protein 87A (TMEM87A) 8.6
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 8.1
 LDTP05538  Prolow-density lipoprotein receptor-related protein 1 (LRP1) 7.6
 LDTP01969  Transferrin receptor protein 1 (TFRC) 7.1
 LDTP05218  Low-density lipoprotein receptor-related protein 2 (LRP2) 6.9
 LDTP06499  V-type proton ATPase subunit S1 (ATP6AP1) 6.6
 LDTP11406  Transmembrane protein 59 (TMEM59) 6.3
 LDTP07236  Protein GPR107 (GPR107) 5.9
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 5.8
 LDTP02068  Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1) 5.8
 LDTP00592  Surfeit locus protein 4 (SURF4) 5.7
 LDTP02166  Integrin alpha-V (ITGAV) 5.5
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.4
 LDTP10731  Sodium-coupled neutral amino acid symporter 2 (SLC38A2) 5.2
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 4.9
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12820  Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) 6.7
Immunoglobulin
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09907  Neogenin (NEO1) 18.5
 LDTP04720  IgG receptor FcRn large subunit p51 (FCGRT) 16.3
 LDTP02040  HLA class I histocompatibility antigen, A alpha chain (HLA-A) 5.4
 LDTP05572  Leukocyte surface antigen CD47 (CD47) 5.2
Other
Click to Show/Hide to Show 24 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 21.6
 LDTP07703  Seizure 6-like protein 2 (SEZ6L2) 17.4
 LDTP02927  Ganglioside GM2 activator (GM2A) 14.4
 LDTP14458  Tetraspanin-6 (TSPAN6) 13.1
 LDTP15115  Protein GOLM2 (GOLM2) 12.6
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 12.6
 LDTP07031  Collectin-12 (COLEC12) 10.6
 LDTP09787  Nicastrin (NCSTN) 9.3
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 9.0
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 7.9
 LDTP09920  Golgi apparatus protein 1 (GLG1) 7.4
 LDTP12352  CD320 antigen (CD320) 7.4
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 7.1
 LDTP05960  Trophoblast glycoprotein (TPBG) 7.0
 LDTP13114  C-type mannose receptor 2 (MRC2) 6.8
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 6.6
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 6.5
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 6.2
 LDTP00071  Vacuolar protein sorting-associated protein 37C (VPS37C) 6.2
 LDTP07760  CD109 antigen (CD109) 6.1
 LDTP11463  Hyccin (HYCC1) 6.0
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 5.9
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 5.6
 LDTP06097  Reticulocalbin-2 (RCN2) 4.9

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587