Details of the Target

General Information of Target

Target ID LDTP11463
Target Name Hyccin (HYCC1)
Gene Name HYCC1
Gene ID 84668
Synonyms
DRCTNNB1A; FAM126A; Hyccin; Down-regulated by CTNNB1 protein A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIVDKLLDDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASPPAAAPGACDASCSVLGPSAP
GSPGSDSSDFSSASSVSSCGAVESRSRGGARAERQPVEPHMGVGRQQRGPFQGVRVKNSV
KELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVSYSGKRKGPDSLSDGPACKRP
ALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNIINIKNECSPVSLNTVQVSWL
NPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQMIDQASLYQYSPQNQHVEQQP
HYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSLVSLLGDQRESENIANPMQTS
SSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLPFSNMGNPMNTTQLGKSLFQW
QVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNG
QSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSN
QFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQ
MGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQ
YRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY
Target Bioclass
Other
Family
Hyccin family
Subcellular location
Cytoplasm, cytosol
Function
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta-catenin/Lef signaling pathway (Probable).
Uniprot ID
Q9BYI3
Ensemble ID
ENST00000409923.5
HGNC ID
HGNC:24587

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1806 SNV: p.P25S DBIA    Probe Info 
HT1080 SNV: p.Y272H DBIA    Probe Info 
IGROV1 SNV: p.G289D DBIA    Probe Info 
SKMEL24 SNV: p.R217Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C371(4.93)  LDD0171  [2]
DBIA
 Probe Info  		C211(0.93); C213(0.93)  LDD0078  [3]
IA-alkyne
 Probe Info  		C300(0.00); C57(0.00)  LDD0165  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C223
 Probe Info  		6.02  LDD1897  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C371(4.93)  LDD0171  [2]
 LDCM0214  AC1 HEK-293T C211(1.26); C213(1.25)  LDD0812  [3]
 LDCM0215  AC10 HCT 116 C211(1.07); C213(1.07)  LDD0532  [3]
 LDCM0216  AC100 HEK-293T C211(1.12); C213(1.12)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C211(1.11); C213(1.11)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C211(1.12); C213(1.12)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C211(1.30); C213(1.30)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C211(1.11); C213(1.11)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C211(1.26); C213(1.26)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C211(1.12); C213(1.12)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C211(1.10); C213(1.10)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C211(1.20); C213(1.20)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C211(1.12); C213(1.12)  LDD0823  [3]
 LDCM0226  AC11 HCT 116 C211(0.92); C213(0.92)  LDD0543  [3]
 LDCM0227  AC110 HEK-293T C211(1.18); C213(1.18)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C211(1.02); C213(1.02)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C211(0.98); C213(0.98)  LDD0827  [3]
 LDCM0230  AC113 HCT 116 C211(1.06); C213(1.06)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C211(1.01); C213(1.12)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C211(1.09); C213(1.03)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C211(1.10); C213(1.09)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C211(0.97); C213(1.06)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C211(1.19); C213(1.22)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C211(1.10); C213(1.14)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C211(1.14); C213(1.14)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C211(1.02); C213(0.99)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C211(0.99); C213(0.97)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C211(1.03); C213(1.04)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C211(0.93); C213(1.12)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C211(1.09); C213(1.15)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C211(0.98); C213(0.99)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C211(1.10); C213(1.12)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C211(1.03); C213(1.22)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C211(0.93); C213(0.93)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C211(1.16); C213(1.16)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C211(1.24); C213(1.24)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C211(1.04); C213(1.04)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C211(1.18); C213(1.18)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C211(1.17); C213(1.17)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C211(1.12); C213(1.12)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C211(1.01); C213(1.01)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C211(1.02); C213(1.02)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C211(1.15); C213(1.15)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C211(1.11); C213(1.11)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C211(1.05); C213(1.05)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C211(0.90); C213(0.90)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C211(1.35); C213(1.35)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C211(1.33); C213(1.33)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C211(1.14); C213(1.14)  LDD0579  [3]
 LDCM0263  AC143 HEK-293T C211(0.92); C213(0.79)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C211(0.94); C213(0.88)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C211(0.89); C213(0.98)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C211(0.96); C213(0.94)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C211(1.06); C213(0.85)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C211(0.98); C213(0.88)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C211(1.26); C213(1.15)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C211(1.00); C213(1.00)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C211(1.08); C213(0.89)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C211(0.99); C213(0.89)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C211(1.05); C213(1.07)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C211(1.21); C213(1.26)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C211(1.21); C213(1.22)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C211(1.04); C213(1.09)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C211(1.09); C213(1.11)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C211(1.24); C213(1.04)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C211(1.34)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C211(1.11)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C211(1.16)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C211(1.16); C213(0.94)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C211(1.50)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C211(1.13)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C211(1.49)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C211(1.71)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C211(1.17)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C211(1.26); C213(1.10)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C211(0.96); C213(0.87)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C211(0.98); C213(0.79)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C211(0.83); C213(0.82)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C211(1.06); C213(0.86)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C211(1.22); C213(1.35)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C211(1.00); C213(0.83)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C211(1.04); C213(0.89)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C211(0.98); C213(0.82)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C211(1.08); C213(0.86)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C211(1.06); C213(0.82)  LDD0893  [3]
 LDCM0296  AC35 HCT 116 C211(1.01); C213(1.01)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C211(0.82); C213(0.82)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C211(0.96); C213(0.96)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C211(0.88); C213(0.88)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C211(0.83); C213(0.83)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C211(1.17); C213(1.24)  LDD0899  [3]
 LDCM0302  AC40 HCT 116 C211(0.95); C213(0.95)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C211(0.86); C213(0.86)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C211(0.93); C213(0.93)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C211(1.04); C213(1.04)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C211(0.99); C213(0.99)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C211(1.02); C213(1.02)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C211(1.06); C213(1.07)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C211(1.08); C213(0.94)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C211(1.11); C213(0.80)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C211(1.23); C213(1.21)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C211(1.17); C213(1.13)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C211(1.08); C213(0.93)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C211(1.28); C213(1.00)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C211(1.27); C213(0.95)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C211(1.09); C213(1.22)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C211(1.16); C213(0.90)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C211(1.13); C213(1.01)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C211(1.28); C213(1.25)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C211(1.05); C213(1.05)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C211(0.78); C213(0.78)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C211(0.95); C213(0.95)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C211(0.88); C213(0.88)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C211(0.90); C213(0.90)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C211(0.88); C213(0.88)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C211(0.89); C213(0.89)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C211(1.02); C213(1.02)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C211(1.01); C213(1.01)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C211(1.01); C213(1.01)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C211(0.90); C213(0.90)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C211(0.91); C213(0.91)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C211(1.06); C213(1.06)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C211(0.95); C213(0.95)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C211(0.98); C213(0.98)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C211(1.31); C213(1.31)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C211(1.17); C213(1.17)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C211(1.14); C213(1.14)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C211(1.11); C213(1.11)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C211(1.15); C213(1.15)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C211(1.28); C213(1.28)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C211(1.11); C213(1.11)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C211(1.01); C213(1.01)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C211(0.91); C213(0.91)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C211(1.20); C213(1.20)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C211(1.00); C213(1.00)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C211(0.96); C213(0.96)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C211(0.90); C213(0.90)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C211(1.29); C213(1.29)  LDD0665  [3]
 LDCM0349  AC83 HEK-293T C211(0.95); C213(0.86)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C211(1.00); C213(0.72)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C211(1.00); C213(0.82)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C211(1.13); C213(0.96)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C211(1.00); C213(0.82)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C211(1.14); C213(1.02)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C211(1.20); C213(0.94)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C211(1.08); C213(0.92)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C211(1.05); C213(0.87)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C211(0.97); C213(0.88)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C211(0.99); C213(1.01)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C211(1.18); C213(0.94)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C211(1.20); C213(1.04)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C211(1.13); C213(0.84)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C211(1.63); C213(0.99)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C211(1.16); C213(1.16)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C211(0.98); C213(0.98)  LDD0964  [3]
 LDCM0248  AKOS034007472 HCT 116 C211(1.00); C213(1.00)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C211(0.81); C213(0.81)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C211(0.84); C213(0.84)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C211(0.93); C213(0.93)  LDD0078  [3]
 LDCM0632  CL-Sc Hep-G2 C371(20.00)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C211(1.01); C213(1.01)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C211(1.17); C213(1.17)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C211(1.44); C213(1.29)  LDD0967  [3]
 LDCM0370  CL101 HCT 116 C211(0.74); C213(0.74)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C211(0.77); C213(0.77)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C211(0.78); C213(0.78)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C211(0.87); C213(0.87)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C211(1.13)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C211(1.31)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C211(1.07)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C211(1.27)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C211(1.12)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C211(0.78); C213(0.78)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C211(1.14)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C211(0.98)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C211(0.99); C213(0.93)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C211(0.89); C213(1.16)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C211(1.26); C213(0.90)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C211(1.01); C213(0.80)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C211(1.10); C213(0.81)  LDD0984  [3]
 LDCM0387  CL117 HCT 116 C211(1.02); C213(1.02)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C211(0.85); C213(0.85)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C211(0.90); C213(0.90)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C211(1.05); C213(1.05)  LDD0988  [3]
 LDCM0391  CL120 HCT 116 C211(1.04); C213(1.04)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C211(1.04); C213(0.91)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C211(1.09); C213(0.96)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C211(1.14); C213(1.34)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C211(1.16); C213(1.24)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C211(0.91); C213(0.91)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C211(0.93); C213(0.93)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C211(1.08); C213(1.08)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C211(0.89); C213(0.89)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C211(0.97); C213(0.97)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C211(0.82); C213(0.82)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C211(1.04); C213(1.04)  LDD1000  [3]
 LDCM0403  CL16 HCT 116 C211(0.78); C213(0.78)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C211(0.68); C213(0.68)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C211(1.06); C213(1.06)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C211(1.19); C213(1.19)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C211(0.89); C213(0.89)  LDD1005  [3]
 LDCM0408  CL20 HCT 116 C211(0.79); C213(0.79)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C211(1.31); C213(1.31)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C211(1.16); C213(1.16)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C211(1.38); C213(1.38)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C211(1.10); C213(1.10)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C211(0.78); C213(0.78)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C211(0.72); C213(0.72)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C211(0.71); C213(0.71)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C211(0.87); C213(0.87)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C211(1.08); C213(1.08)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C211(1.01); C213(1.01)  LDD1016  [3]
 LDCM0419  CL30 HCT 116 C211(0.81); C213(0.81)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C401(0.95); C300(0.89); C57(0.97); C484(1.13)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C401(1.02); C300(0.90); C57(0.99); C472(1.02)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C401(0.98); C300(0.93); C57(0.57); C472(1.30)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C401(0.93); C300(0.98); C57(1.21); C472(1.03)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C401(1.06); C300(1.08); C57(0.81); C472(1.11)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C401(1.14); C300(1.12); C57(1.02); C472(0.82)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C401(0.94); C300(0.85); C57(0.84); C472(1.20)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C401(0.96); C300(0.91); C472(1.12); C484(0.94)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C211(0.93); C213(0.93)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C401(0.99); C300(1.18); C57(1.22); C484(1.05)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C401(0.90); C300(0.97); C57(0.94); C484(1.06)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C401(0.99); C300(0.98); C57(0.90); C472(1.20)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C401(0.99); C300(0.96); C57(0.96); C484(1.10)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C401(1.04); C300(0.94); C57(1.37); C472(1.24)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C401(1.09); C300(1.11); C57(0.87); C472(0.90)  LDD1639  [10]
 LDCM0436  CL46 HCT 116 C211(0.87); C213(0.87)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C211(0.90); C213(0.90)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C211(0.91); C213(0.91)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C211(1.12); C213(1.12)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C211(1.04); C213(1.04)  LDD1038  [3]
 LDCM0441  CL50 HCT 116 C211(0.83); C213(0.83)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C211(1.06); C213(1.06)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C211(1.01); C213(1.01)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C211(0.97); C213(0.97)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C211(0.80); C213(0.80)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C211(0.97); C213(0.97)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C211(0.91); C213(0.91)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C211(1.00); C213(1.00)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C211(0.67); C213(0.67)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C211(0.79); C213(0.79)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C211(1.07); C213(1.07)  LDD1049  [3]
 LDCM0452  CL60 HCT 116 C211(0.82); C213(0.82)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C401(0.97); C300(1.02); C57(1.05); C472(0.74)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C401(0.87); C300(0.98); C57(1.24); C484(1.21)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C401(1.00); C300(0.95); C472(1.39); C484(1.03)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C401(1.02); C300(1.04); C57(1.12); C484(1.11)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C401(0.88); C300(0.95); C57(1.02); C484(1.12)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C401(0.98); C300(0.97); C57(0.91); C472(1.06)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C401(1.06); C300(0.94); C57(1.08); C484(1.04)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C401(1.02); C300(0.86); C57(1.00); C472(1.09)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C401(1.05); C300(0.95); C57(1.09); C472(1.06)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C211(1.05); C213(1.05)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C401(0.91); C300(1.00); C57(1.31); C472(0.87)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C401(1.11); C300(1.07); C57(0.98); C472(0.92)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C401(1.11); C300(1.14); C57(0.91); C472(1.37)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C401(0.97); C300(0.82); C57(0.86); C472(1.06)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C401(0.93); C300(0.93); C57(1.18); C484(0.89)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C211(1.03)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C211(1.05)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C211(0.84)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C211(0.94)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C211(1.05)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C211(0.94)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C211(1.02)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C211(1.06)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C211(1.17)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C211(0.90)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C211(0.94)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C211(0.82)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C211(0.91)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C211(0.96)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C211(0.92)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C211(1.10)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C211(1.00)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C211(1.00); C213(1.06)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C211(1.16); C213(1.35)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C211(1.10); C213(1.09)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C211(1.30); C213(1.10)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C211(1.16); C213(0.87)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C211(1.15); C213(1.10)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C211(1.05); C213(1.07)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C211(1.18); C213(1.14)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C211(1.17); C213(1.19)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C401(1.02); C300(0.96); C472(1.11); C484(1.05)  LDD1698  [10]
 LDCM0625  F8 Ramos C300(0.93); C371(1.97); C484(1.05); C401(1.33)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C300(1.15); C371(1.73); C484(1.61); C57(2.09)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C300(2.63); C371(0.45); C484(11.90); C401(4.64)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C300(1.41); C371(0.87); C484(0.93); C401(0.78)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C300(1.09); C371(1.75); C484(0.89); C401(0.83)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C300(1.16); C371(1.00); C484(1.02); C401(1.26)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C300(1.33); C371(1.19); C484(1.33); C401(0.88)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C300(0.83); C371(1.03); C484(1.65); C401(0.68)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C300(0.97); C371(1.26); C484(1.05); C401(1.67)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C300(0.85); C371(2.28); C484(0.99); C401(0.79)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C300(1.87); C371(0.80); C484(0.77); C401(0.59)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C300(1.26); C371(1.47); C484(1.22); C401(1.03)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C300(0.89); C371(1.04); C484(0.95); C401(0.92)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C300(1.27); C371(1.71); C484(1.41); C401(1.35)  LDD2201  [11]
 LDCM0468  Fragment33 HEK-293T C401(1.01); C300(1.00); C472(1.13); C484(0.99)  LDD1671  [10]
 LDCM0596  Fragment38 Ramos C300(1.01); C371(1.42); C484(0.95); C401(1.45)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C300(1.48); C371(0.94); C401(0.75); C472(1.09)  LDD2184  [11]
 LDCM0427  Fragment51 HEK-293T C401(1.03); C300(0.93); C57(0.99); C484(0.96)  LDD1631  [10]
 LDCM0610  Fragment52 Ramos C300(3.37); C371(1.57); C484(1.29); C401(0.95)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C300(1.51); C371(2.08); C484(1.50); C401(0.83)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C300(1.15); C371(1.11); C401(0.90); C472(3.06)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C300(1.41); C371(1.52); C401(0.66)  LDD2188  [11]
 LDCM0022  KB02 HCT 116 C401(3.13)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C401(1.25)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C401(3.09)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Four and a half LIM domains protein 3 (FHL3) . Q13643
Tetratricopeptide repeat protein 7B (TTC7B) . Q86TV6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578