Details of the Target

General Information of Target

Target ID LDTP05831
Target Name Receptor-type tyrosine-protein phosphatase S (PTPRS)
Gene Name PTPRS
Gene ID 5802
Synonyms
Receptor-type tyrosine-protein phosphatase S; R-PTP-S; EC 3.1.3.48; Receptor-type tyrosine-protein phosphatase sigma; R-PTP-sigma
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
NGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV
RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL
TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV
SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR
TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV
DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS
ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ
GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP
LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP
SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA
DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV
QQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGAT
YVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNG
AIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGP
FSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGR
TTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMV
YLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSR
QLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAAS
PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR
TKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAE
HTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG
IMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIK
CDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV
PEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGH
VTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGM
ELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF
IDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA
RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI
GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRP
AMVQTEDEYQFCYQAALEYLGSFDHYAT
Target Type
Successful
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Receptor class 2A subfamily
Subcellular location
Cell membrane
Function
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as a tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.
TTD ID
T10147
Uniprot ID
Q13332
DrugMap ID
TTCWXFA
Ensemble ID
ENST00000262963.11
HGNC ID
HGNC:9681
ChEMBL ID
CHEMBL2396508

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.V1621A; p.N1705S .
CAL33 SNV: p.G960V .
CORL23 SNV: p.R597H .
EFO27 Deletion: p.V1025SfsTer18
SNV: p.R612C		 .
HCT116 Deletion: p.V1025SfsTer18 .
HCT15 SNV: p.P642L; p.G1239D .
HGC27 SNV: p.A1328T .
IM95 SNV: p.R241C .
Ishikawa (Heraklio) 02 ER SNV: p.T1596I .
JURKAT SNV: p.R241C; p.V630M .
KYSE180 SNV: p.A28V .
LNCaP clone FGC SNV: p.T797S .
LS180 SNV: p.G390S .
MDAMB453 SNV: p.S189Ter DBIA    Probe Info 
MOLT4 Deletion: p.V1025SfsTer18 .
NALM6 SNV: p.V488M DBIA    Probe Info 
NCIH1792 SNV: p.K170R .
OVISE Deletion: p.T153_A158del .
PC3 SNV: p.A974S .
RKO SNV: p.S330Y .
SNU1196 SNV: p.R1901W .
SW1783 SNV: p.E1797K .
SW948 SNV: p.F1169V .
TOV21G SNV: p.W1480L; p.W1505G DBIA    Probe Info 
U118MG SNV: p.G1454C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1706(3.45)  LDD0277  [1]
OPA-S-S-alkyne
 Probe Info  		K144(1.57); K897(2.19); K379(2.21); K370(2.37)  LDD3494  [2]
BTD
 Probe Info  		C1723(0.93); C1704(0.81)  LDD2099  [3]
IPM
 Probe Info  		C1723(3.10); C1704(2.88)  LDD1702  [3]
DBIA
 Probe Info  		C1501(1.34)  LDD0080  [4]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [5]
Lodoacetamide azide
 Probe Info  		C1651(0.00); C1723(0.00)  LDD0037  [5]
TFBX
 Probe Info  		C1723(0.00); C1704(0.00); C1577(0.00)  LDD0148  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
Methacrolein
 Probe Info  		C1723(0.00); C1704(0.00)  LDD0218  [7]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C223
 Probe Info  		5.46  LDD1897  [8]
STS-1
 Probe Info  		N.A.  LDD0137  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1501(0.65); C1704(0.57)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C1704(0.84)  LDD0532  [4]
 LDCM0216  AC100 HEK-293T C1501(0.98)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C1501(1.31)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C1501(1.98)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C1501(0.93)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C1501(0.87)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C1501(1.12)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C1501(1.65)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C1501(1.14)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C1501(0.80)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C1501(1.35)  LDD0823  [4]
 LDCM0226  AC11 HCT 116 C1704(0.86)  LDD0543  [4]
 LDCM0227  AC110 HEK-293T C1501(1.96)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C1501(1.60)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C1501(1.14)  LDD0827  [4]
 LDCM0230  AC113 HCT 116 C1704(1.22)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C1704(1.02)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C1704(1.01)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C1704(1.09)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C1704(1.30)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C1704(1.12)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C1704(1.21)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C1704(0.92)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C1704(1.01)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C1704(1.53)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C1704(1.07)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C1704(1.86)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C1704(1.21)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C1704(0.90)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C1704(0.99)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C1704(1.03)  LDD0562  [4]
 LDCM0246  AC128 HEK-293T C1323(1.34); C1501(0.92)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C1323(1.57); C1501(0.87)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C1323(1.12); C1501(0.88)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C1323(1.06); C1501(0.82)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C1323(1.37); C1501(0.92)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C1323(1.24); C1501(0.92)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C1323(1.11); C1501(0.98)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C1323(1.33); C1501(0.80)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C1323(1.28); C1501(0.96)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C1323(1.27); C1501(1.02)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C1323(1.15); C1501(1.37)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C1323(1.28); C1501(1.14)  LDD0856  [4]
 LDCM0259  AC14 HCT 116 C1704(0.99)  LDD0576  [4]
 LDCM0260  AC140 HEK-293T C1323(1.16); C1501(0.99)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C1323(1.39); C1501(1.23)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C1323(1.25); C1501(0.99)  LDD0860  [4]
 LDCM0263  AC143 HEK-293T C1501(0.86)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C1501(0.92)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C1501(0.96)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C1501(0.91)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C1501(1.11)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C1501(0.73)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C1501(0.77)  LDD0867  [4]
 LDCM0270  AC15 HCT 116 C1704(0.90)  LDD0587  [4]
 LDCM0271  AC150 HEK-293T C1501(0.95)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C1501(1.13)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C1501(1.10)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C1501(1.15)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C1501(0.90)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C1501(1.00)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C1501(1.01)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C1501(0.81)  LDD2165  [4]
 LDCM0276  AC17 HCT 116 C1704(0.98); C1723(1.12)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C1704(0.96); C1723(0.97)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C1723(0.87); C1704(0.89)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C1704(0.66); C1501(0.83)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C1723(0.84); C1704(0.96)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C1723(0.83); C1704(0.92)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C1723(0.88); C1704(0.91)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C1704(0.89); C1723(0.90)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C1704(0.92); C1723(0.93)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C1723(0.68)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C1723(1.06)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C1723(0.79)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C1723(0.84)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C1723(0.89)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C1704(0.70); C1501(1.02)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C1723(0.98)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C1723(0.90)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C1723(0.84)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C1723(0.75)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C1723(0.83)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C1501(0.63); C1704(1.02)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C1704(0.97); C1501(0.98)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C1501(0.98); C1704(1.21)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C1501(0.84); C1704(0.85)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C1501(0.84); C1704(0.96)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C1704(0.64); C1501(0.76)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C1501(0.63); C1704(1.09)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C1704(1.05); C1501(1.54)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C1704(0.93); C1501(1.18)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C1704(0.92); C1501(1.03)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C1501(0.76); C1704(1.16)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C1501(0.90); C1704(1.24)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C1704(0.84); C1723(1.04)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C1704(0.86); C1723(1.39)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C1704(0.94); C1723(1.16)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C1704(0.66); C1723(1.30)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C1704(0.65); C1501(0.80)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C1704(0.62); C1723(0.97)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C1704(0.96); C1723(1.02)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C1704(0.81); C1723(0.96)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C1704(0.65); C1723(0.89)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C1704(0.70); C1723(0.71)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C1704(0.68); C1723(1.03)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C1704(0.77); C1723(1.00)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C1501(1.29)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C1501(1.22)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C1501(1.09)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C1704(0.86)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C1501(1.55)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C1501(1.12)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C1501(1.22)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C1501(1.13)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C1501(1.13)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C1501(2.05)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C1501(1.48)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C1501(1.63)  LDD0648  [4]
 LDCM0334  AC7 HCT 116 C1704(0.92)  LDD0651  [4]
 LDCM0345  AC8 HCT 116 C1704(0.84)  LDD0662  [4]
 LDCM0349  AC83 HCT 116 C1704(0.58); C1501(0.99)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C1704(0.58); C1501(1.42)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C1704(0.82); C1501(1.89)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C1704(0.82); C1501(1.26)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C1704(1.00); C1501(1.15)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C1704(0.88); C1501(1.11)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C1704(0.64); C1501(1.31)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C1704(1.06); C1501(1.33)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C1704(0.50); C1501(1.34)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C1704(0.51); C1501(1.23)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C1704(0.80); C1501(1.92)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C1704(0.96); C1501(1.33)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C1704(1.11); C1501(1.63)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C1704(0.69); C1501(1.53)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C1704(0.61); C1501(1.34)  LDD0681  [4]
 LDCM0365  AC98 HEK-293T C1501(1.07)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C1501(0.77)  LDD0964  [4]
 LDCM0248  AKOS034007472 HCT 116 C1704(0.95)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C1704(0.89)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C1704(0.76)  LDD0592  [4]
 LDCM0367  CL1 HCT 116 C1704(1.40)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C1704(1.12)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C1704(0.59); C1501(0.62)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C1704(0.85)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C1704(0.95)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C1704(0.83)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C1704(0.92)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C1704(0.98); C1723(1.02)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C1704(0.94); C1723(1.16)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C1704(0.98); C1723(1.12)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C1704(0.88); C1723(1.15)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C1723(0.79); C1704(0.98)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C1704(0.87)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C1704(0.99); C1723(1.07)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C1723(0.89); C1704(1.01)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C1723(0.81)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C1723(0.74)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C1723(0.86)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C1723(0.66)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C1723(0.73)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C1704(0.88); C1501(1.39)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C1501(0.62); C1704(1.03)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C1501(0.69); C1704(1.05)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C1704(0.91)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C1501(0.70); C1704(1.06)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C1704(0.43); C1723(0.83)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C1704(0.94); C1723(1.00)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C1723(0.63); C1704(0.79)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C1704(0.67); C1723(0.90)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C1501(1.26)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C1501(0.89)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C1501(0.94)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C1501(1.06)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C1704(1.20)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C1704(1.34)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C1704(1.18)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C1501(0.81)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C1501(1.14)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C1501(1.14)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C1501(0.94)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C1704(1.35)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C1501(1.39)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C1501(1.14)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C1501(1.30)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C1501(0.94)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C1501(0.87)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C1501(1.01)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C1501(0.84)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C1501(1.27)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C1501(1.02)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C1501(0.98)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C1704(1.27)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C1501(0.84)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C1501(0.90); C1704(0.87)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C1501(0.87); C1704(0.93)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C1501(0.83); C1704(0.84)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C1501(1.06); C1704(0.74)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C1501(1.18); C1704(0.67)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C1501(1.18); C1704(0.69)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C1501(1.39); C1704(0.75)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C1501(0.99); C1704(0.77)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C1704(1.05)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C1501(1.03); C1704(0.66)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C1501(0.98); C1704(0.78)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C1501(1.08); C1704(0.74)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C1501(1.03); C1704(0.76)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C1501(0.99); C1704(0.86)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C1501(1.19); C1704(0.84)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C1790(1.10); C1501(1.23); C1323(1.00); C1723(1.03)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C1790(1.17); C1501(1.28); C1323(1.08); C1723(1.02)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C1790(1.17); C1501(1.13); C1323(0.97); C1723(0.98)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C1790(1.01); C1501(1.02); C1323(1.01); C1723(1.02)  LDD1643  [10]
 LDCM0440  CL5 HCT 116 C1704(1.22)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C1790(1.18); C1501(1.02); C1323(1.05); C1723(1.03)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C1790(1.01); C1501(1.01); C1323(0.98); C1723(0.98)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C1790(1.07); C1501(1.09); C1323(1.20); C1723(0.93)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C1790(1.15); C1501(1.02); C1323(1.52); C1723(0.99)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C1790(1.05); C1501(1.08); C1323(1.01); C1723(1.03)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C1790(1.12); C1501(1.11); C1323(1.05); C1723(1.02)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C1790(1.23); C1501(1.25); C1323(1.24); C1723(1.00)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C1790(1.03); C1501(1.23); C1323(1.17); C1723(0.97)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C1790(1.24); C1501(1.30); C1323(1.16); C1723(1.03)  LDD1653  [10]
 LDCM0451  CL6 HCT 116 C1704(1.06)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C1790(1.18); C1501(1.24); C1323(1.02); C1723(0.94)  LDD1655  [10]
 LDCM0453  CL61 HCT 116 C1723(1.37)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C1723(1.96)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C1723(1.41)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C1723(1.66)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C1723(1.48)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C1723(1.51)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C1723(0.94)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C1723(1.04)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C1723(1.25)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C1704(1.04)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C1723(1.34)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C1723(1.20)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C1723(1.02)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C1723(1.30)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C1723(1.31)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C1501(0.91)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C1501(0.75)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C1501(1.21)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C1501(0.99)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C1704(0.97)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C1501(1.08)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C1501(1.35)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C1501(1.12)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C1501(1.26)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C1501(1.39)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C1501(0.88)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C1501(1.06)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C1501(1.46)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C1501(0.85)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C1501(0.71)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C1704(1.15)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C1501(1.10)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C1501(0.95); C1704(0.88)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C1501(1.01); C1704(0.94)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C1501(1.11); C1704(0.94)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C1501(1.12); C1704(0.94)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C1501(0.92); C1704(0.94)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C1501(0.97); C1704(0.90)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C1501(0.72); C1704(0.58)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C1501(0.74); C1704(0.63)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C1501(0.68); C1704(0.55)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C1790(1.01); C1501(1.06); C1323(1.20); C1723(1.02)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1723(3.10); C1704(2.88)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C1723(1.83)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C1501(1.05); C1704(0.63)  LDD0744  [4]
 LDCM0022  KB02 HCT 116 C1501(1.34)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C1501(1.25)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C1501(1.37)  LDD0082  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1723(0.93); C1704(0.81)  LDD2099  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1723(0.99)  LDD2107  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1723(0.93)  LDD2123  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) Protein-tyrosine phosphatase family Q16849
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
General transcription factor 3C polypeptide 3 (GTF3C3) . Q9Y5Q9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alendronic Acid Small molecular drug DB00630
Etidronic Acid Small molecular drug D00NNC
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Orthovanadate Small molecular drug D0N4XG

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402