Details of the Target

General Information of Target

Target ID LDTP05218
Target Name Low-density lipoprotein receptor-related protein 2 (LRP2)
Gene Name LRP2
Gene ID 4036
Synonyms
Low-density lipoprotein receptor-related protein 2; LRP-2; Glycoprotein 330; gp330; Megalin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDRGPAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEI
GCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQC
IPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCT
EICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWV
CDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENN
TSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQ
KCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVES
QNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNK
IYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLER
AFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSL
IPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYAT
NPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIR
GIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAA
NRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYL
FFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFD
GLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHL
KSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNE
PPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECI
PAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDE
KNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKC
IGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGS
DEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCL
GHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFL
LANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLV
ASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDR
RVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALD
PRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLD
YMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVM
YNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC
LRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGE
IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTL
IANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEH
LECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQY
EVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGL
FSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHV
DVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLY
FTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFL
DCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTP
YGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAE
VNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRS
LHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTV
IASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGY
LYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTL
TGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGI
NTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERC
GASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRC
DYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDR
TCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQH
WYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKR
HQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTC
GYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDG
SDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSIS
GCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAP
GYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKR
LYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLN
GGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVII
STKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTI
YWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLC
LIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSD
GSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQ
CANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDC
GDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCH
PVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDH
YNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGA
YCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSH
EVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDEL
GCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQH
CRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQD
EEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKY
VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF
WTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYD
GTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRI
FHQLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPP
CRCMHGGNCYFDETDLPKCKCPSGYTGKYCEMAFSKGISPGTTAVAVLLTILLIVVIGAL
AIAGFFHYRRTGSLLPALPKLPSLSSLVKPSENGNGVTFRSGADLNMDIGVSGFGPETAI
DRSMAMSEDFVMEMGKQPIIFENPMYSARDSAVKVVQPIQVTVSENVDNKNYGSPINPSE
IVPETNPTSPAADGTQVTKWNLFKRKSKQTTNFENPIYAQMENEQKESVAATPPPSPSLP
AKPKPPSRRDPTPTYSATEDTFKDTANLVKEDSEV
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
LDLR family
Subcellular location
Apical cell membrane
Function
Multiligand endocytic receptor. Acts together with CUBN to mediate endocytosis of high-density lipoproteins. Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B. In the kidney, mediates the tubular uptake and clearance of leptin. Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium. Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight. Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells. Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP. Mediates renal uptake of metallothionein-bound heavy metals. Together with CUBN, mediates renal reabsorption of myoglobin. Mediates renal uptake and subsequent lysosomal degradation of APOM. Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1. Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney. Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1. Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH. Also mediates ShhN transcytosis. In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon. Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH. During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure. In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed. In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid. Involved in neurite branching. During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells. Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent. Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG. Mediates endocytosis of angiotensin-2. Also mediates endocytosis of angiotensis 1-7. Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation. Required for embryonic heart development. Required for normal hearing, possibly through interaction with estrogen in the inner ear.
TTD ID
T75210
Uniprot ID
P98164
DrugMap ID
TTPH1AJ
Ensemble ID
ENST00000649046.1
HGNC ID
HGNC:6694

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C4401(2.51)  LDD3365  [1]
CY4
 Probe Info  		N.A.  LDD0247  [2]
NAIA_4
 Probe Info  		C1026(0.00); C1013(0.00)  LDD2226  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
YN-1
 Probe Info  		N.A.  LDD0447  [5]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		26.54  LDD1850  [6]
C171
 Probe Info  		8.82  LDD1851  [6]
C223
 Probe Info  		6.87  LDD1897  [6]
C237
 Probe Info  		5.98  LDD1910  [6]
C281
 Probe Info  		11.88  LDD1951  [6]
C310
 Probe Info  		13.36  LDD1977  [6]
C318
 Probe Info  		4.92  LDD1984  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1375(0.90)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C4047(1.17); C362(0.93); C256(1.21)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C4047(0.93); C1601(1.12); C1156(0.85); C1375(0.87)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C4047(0.96); C1305(1.02); C2822(0.93); C4401(0.99)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C4047(1.25); C2822(0.97); C3719(0.97); C2906(1.00)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C4047(0.97); C2822(1.08); C256(1.04); C234(1.11)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C1375(1.20)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C4047(1.18); C362(1.34); C256(0.80)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C4047(1.36); C1601(0.98); C1156(1.06); C1375(1.24)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C4047(1.23); C362(1.00); C256(1.00)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C4047(1.05); C1305(0.92); C2822(0.88); C4401(0.91)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C4047(0.96); C1305(1.01); C4401(1.17); C3719(0.99)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C4047(1.11); C2822(1.02); C3719(1.02); C2906(1.03)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C4047(1.12); C2822(0.96); C256(0.88); C234(1.35)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C4047(0.90); C2822(1.26); C2517(0.94); C1375(0.92)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C1375(0.99)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C4047(1.07); C362(1.32); C256(0.91)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C4047(0.94); C1601(0.96); C1156(1.39); C1375(1.09)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C4047(0.96); C1305(0.81); C2822(0.99); C4401(1.00)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C4047(0.86); C1305(1.22); C4401(1.20); C3719(0.98)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C4047(1.22); C1601(1.10); C1156(0.84); C1375(1.12)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C4047(1.12); C2822(0.99); C3719(1.08); C2906(1.11)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C4047(1.02); C2822(0.96); C256(0.99); C234(0.90)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C4047(0.85); C2822(1.23); C2517(1.05); C1375(0.98)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C1375(1.00)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C4047(1.09); C362(1.22); C256(1.19)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C4047(1.36); C1601(0.99); C1156(1.14); C1375(0.92)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C4047(0.99); C1305(0.99); C2822(0.97); C4401(0.96)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C4047(0.88); C1305(1.09); C4401(1.13); C3719(1.07)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C4047(1.31); C2822(0.98); C3719(0.96); C2906(1.03)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C4047(0.95); C2822(0.78); C256(1.11); C234(1.31)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C4047(1.12); C1305(1.14); C2822(0.96); C4401(0.85)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C4047(0.90); C2822(0.92); C2517(1.08); C1375(1.00)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C1375(1.05)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C4047(1.19); C362(1.20); C256(1.39)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C4047(1.16); C1601(1.00); C1156(0.92); C1375(1.05)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C4047(1.13); C1305(0.87); C2822(1.07); C4401(0.94)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C4047(0.97); C1305(1.09); C4401(1.07); C3719(1.01)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C4047(1.11); C2822(1.09); C3719(1.09); C2906(1.01)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C4047(0.99); C2822(1.06); C256(0.99); C234(1.25)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C4047(0.96); C2822(0.97); C2517(1.04); C1375(1.02)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C1375(0.86)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C4047(0.97); C1305(0.93); C4401(1.14); C3719(1.04)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C4047(1.20); C362(1.23); C256(1.05)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C4047(1.06); C1601(1.02); C1156(1.08); C1375(1.04)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C4047(1.16); C1305(1.16); C2822(0.92); C4401(0.99)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C4047(0.80); C1305(1.02); C4401(1.20); C3719(0.93)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C4047(1.29); C2822(1.03); C3719(1.02); C2906(1.03)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C4047(0.92); C2822(1.00); C256(0.94); C234(0.94)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C4047(0.73); C2822(1.04); C2517(1.00); C1375(1.07)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C1375(0.96)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C4047(1.12); C362(1.40); C256(1.01)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C4047(1.01); C1601(1.11); C1156(0.91); C1375(0.91)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C4047(1.23); C2822(1.19); C3719(0.95); C2906(0.94)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C4047(0.92); C1305(0.86); C2822(1.03); C4401(1.04)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C4047(1.08); C1305(1.17); C4401(1.09); C3719(1.08)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C4047(0.95); C2822(0.99); C3719(0.98); C2906(0.95)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C4047(1.03); C2822(0.86); C256(0.94); C234(1.19)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C4047(0.89); C2822(1.30); C2517(1.09); C1375(1.03)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C4047(0.77); C2822(1.09); C256(0.95); C234(1.22)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C4047(0.88); C2822(1.20); C2517(1.03); C1375(1.01)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C4047(0.96); C1305(0.94); C4401(1.12); C3719(0.90)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C1375(1.22)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C4047(0.93); C2822(0.98); C2517(1.08); C1375(1.05)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C4047(0.89); C35(1.09)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C4047(1.75); C2822(0.92); C3719(0.95); C2906(1.24)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C4047(1.23); C362(1.00); C2822(1.02); C4401(1.14)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C4047(0.99); C35(1.08)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C4047(0.98)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C1305(1.05)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C4047(1.30); C362(1.13); C2822(0.98); C4401(1.04)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C4047(0.88); C35(0.95)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C4047(1.20)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C1305(1.03)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C4047(1.58); C362(1.18); C2822(1.02); C4401(1.21)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C4047(0.86); C35(0.99)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C4047(1.04); C2822(0.77); C256(1.00); C234(1.13)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C4047(1.03)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C1305(1.02)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C4047(1.10); C362(1.05); C2822(1.07); C4401(1.18)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C4047(0.95); C35(1.23)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C4047(1.11)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C1305(1.07)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C4047(1.36); C362(1.08); C2822(1.01); C4401(1.19)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C4047(1.09); C35(1.00)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C4047(1.17)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C1305(0.97)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C4047(0.94); C2822(1.04); C2517(1.07); C1375(0.88)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C4047(1.20); C362(1.20); C2822(1.09); C4401(1.24)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C4047(0.99); C35(1.05)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C4047(1.02)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C1305(1.01)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C4047(1.21); C362(1.28); C2822(0.99); C4401(1.20)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C4047(0.92); C35(1.06)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C4047(0.97)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C1305(1.05)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C4047(1.09); C362(1.12); C2822(1.01); C4401(1.19)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C4047(0.90); C35(1.19)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C4047(1.09)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C1305(1.04)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C4047(1.07); C362(1.06); C2822(1.07); C4401(1.17)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C1375(1.20)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C4047(1.10); C362(1.33); C256(1.15)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C4047(1.35); C1601(0.90); C1156(1.16); C1375(0.90)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C4047(1.20)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C4047(1.10); C1305(0.85); C2822(1.08); C4401(0.91)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C4047(0.86); C1305(1.05); C4401(1.22); C3719(0.93)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C4047(1.54); C2822(1.06); C3719(1.08); C2906(1.21)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C4047(1.00); C2822(1.11); C256(1.03); C234(1.32)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C4047(0.84); C2822(1.14); C2517(0.94); C1375(0.93)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C4047(0.94); C35(1.10)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C4047(0.76)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C1305(0.98)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C4047(1.40); C362(1.08); C2822(0.89); C4401(1.13)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C1375(0.87)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C1305(1.06)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C4047(1.18); C362(0.95); C256(1.01)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C4047(0.96); C1601(0.86); C1156(1.18); C1375(0.94)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C4047(0.96); C1305(1.24); C2822(1.02); C4401(0.99)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C4047(0.97); C1305(1.09); C4401(1.24); C3719(1.02)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C4047(1.29); C2822(0.99); C3719(0.89); C2906(1.22)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C4047(1.07); C2822(0.95); C256(1.02); C234(1.10)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C4047(0.98); C2822(1.14); C2517(1.05); C1375(0.92)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C4047(0.70); C35(0.89)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C1305(0.99)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C4047(1.25); C362(1.03); C2822(0.94); C4401(1.32)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C4047(1.30); C362(1.02); C2822(1.06); C4401(1.09)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C1375(1.22)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C4047(1.01); C362(1.48); C256(1.05)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C4047(0.89); C1601(0.99); C1156(0.90); C1375(0.95)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C4047(1.23); C1305(1.15); C2822(1.14); C4401(0.95)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C4047(1.45); C1305(1.23); C4401(1.13); C3719(1.08)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C4047(1.47); C2822(1.08); C3719(1.04); C2906(1.22)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C4047(1.20); C2822(0.80); C256(0.95); C234(1.39)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C4047(1.02); C2822(0.97); C2517(0.86); C1375(0.98)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C4047(1.01); C35(1.03)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C1375(0.94)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C4047(1.05)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C4047(1.00); C362(1.03); C2822(1.16); C4401(1.14)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C1375(1.46)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C4047(1.08); C362(0.92); C256(1.32)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C4047(1.24); C1601(0.98); C1156(0.88); C1375(1.05)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C4047(1.17); C1305(0.70); C2822(1.01); C4401(0.93)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C4047(0.93); C1305(1.30); C4401(1.31); C3719(1.03)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C4047(1.17); C2822(1.15); C3719(1.04); C2906(1.50)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C4047(1.17); C2822(0.88); C256(1.06); C234(1.34)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C4047(1.00); C362(0.92); C256(0.94)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C4047(1.01); C2822(1.10); C2517(1.06); C1375(0.81)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C4047(0.96); C35(1.03)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C4047(1.05)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C1305(1.03)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C4047(1.38); C362(1.00); C2822(1.01); C4401(1.28)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C1375(0.89)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C4047(0.99); C362(1.01); C256(0.79)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C4047(1.07); C1601(0.96); C1156(1.06); C1375(1.00)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C4047(1.07); C1305(0.69); C2822(1.13); C4401(0.98)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C4047(0.89); C1305(1.10); C4401(1.05); C3719(1.06)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C4047(1.13); C1601(0.97); C1156(1.21); C1375(0.89)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C4047(1.55); C2822(1.09); C3719(1.09); C2906(1.23)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C4047(1.15); C2822(1.05); C256(1.06); C234(1.05)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C4047(0.81); C2822(1.00); C2517(0.98); C1375(0.94)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C4047(0.91); C35(1.01)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C4047(1.00)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C4047(1.20); C362(1.10); C2822(0.91); C4401(1.23)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C1375(1.11)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C4047(1.38); C362(1.87); C256(0.87)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C4047(1.06); C1601(0.93); C1156(1.31); C1375(0.87)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C4047(1.06); C1305(1.50); C2822(1.20); C4401(1.16)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C4047(0.99); C1305(1.34); C2822(0.97); C4401(0.91)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C4047(0.93); C1305(1.12); C4401(1.07); C3719(1.01)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C4047(1.26); C2822(0.99); C3719(1.06); C2906(1.39)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C4047(1.14); C2822(1.06); C256(0.98); C234(1.22)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C4047(0.97); C2822(1.33); C2517(1.21); C1375(1.24)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C4047(0.82); C35(0.90)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C4047(1.14)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C1305(0.93)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C4047(1.10); C362(1.12); C2822(1.10); C4401(1.14)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C1375(0.97)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C4047(0.95); C1305(0.95); C4401(1.15); C3719(0.93)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C4047(1.43); C362(1.22); C256(0.89)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C4047(1.09); C1601(0.90); C1156(0.98); C1375(1.06)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C4047(0.97); C1305(1.63); C2822(0.97); C4401(1.05)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C4047(0.88); C1305(1.23); C4401(1.24); C3719(0.93)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C4047(1.48); C2822(1.05); C3719(1.04); C2906(1.17)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C4047(1.20); C2822(1.09); C256(0.92); C234(1.18)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C4047(0.74); C2822(1.10); C2517(1.36); C1375(1.18)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C4047(0.88); C35(1.15)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C4047(0.96)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C1305(1.07)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C1305(1.06)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C1305(1.05)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C4047(0.96)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C256(0.99); C371(1.00)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C256(1.07); C371(1.02)  LDD1497  [7]
 LDCM0024  KB05 OVCAR-3 C4401(2.51)  LDD3365  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Insulin Human BiotechDrug DB00030
Urokinase BiotechDrug DB00013
Cyanocobalamin Small molecular drug DB00115
Gentamicin Small molecular drug DB00798

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402