Details of the Probe

General Information of Probe

Probe ID
LDPC0470
Probe Name
C237
Synonyms
Z4282860624
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 290.4
Lipid-water partition coefficient (xlogp) 1.9
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C16H26N4O
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-1-[(3S,5R)-4-ethyl-3,5-dimethylpiperazin-1-yl]propan-1-one
Canonical SMILES
CCN1C(CN(CC1C)C(=O)CCC2(N=N2)CCC#C)C
InChI
InChI=1S/C16H26N4O/c1-5-7-9-16(17-18-16)10-8-15(21)19-11-13(3)20(6-2)14(4)12-19/h1,13-14H,6-12H2,2-4H3/t13-,14+
InChIKey
SWRLMSHQKWGLSO-OKILXGFUSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

68 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
5'-3' exonuclease PLD3 (PLD3) LDTP08476 5.82  LDD1910 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 5.82  LDD1910 
Acid ceramidase (ASAH1) LDTP05905 6.41  LDD1910 
Acid ceramidase (ASAH1) LDTP05905 6.41  LDD1910 
Alpha-galactosidase A (GLA) LDTP02141 10.70  LDD1910 
Alpha-galactosidase A (GLA) LDTP02141 10.70  LDD1910 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 5.78  LDD1910 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 5.78  LDD1910 
Beta-1,4-glucuronyltransferase 1 (B4GAT1) LDTP00783 5.06  LDD1910 
Beta-1,4-glucuronyltransferase 1 (B4GAT1) LDTP00783 5.06  LDD1910 
Beta-galactosidase (GLB1) LDTP02837 4.92  LDD1910 
Beta-galactosidase (GLB1) LDTP02837 4.92  LDD1910 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 7.89  LDD1910 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 7.89  LDD1910 
Bifunctional epoxide hydrolase 2 (EPHX2) LDTP03692 11.00  LDD1910 
Bifunctional epoxide hydrolase 2 (EPHX2) LDTP03692 11.00  LDD1910 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 8.40  LDD1910 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 8.40  LDD1910 
Carboxypeptidase D (CPD) LDTP01372 10.34  LDD1910 
Carboxypeptidase D (CPD) LDTP01372 10.34  LDD1910 
Dipeptidyl peptidase 1 (CTSC) LDTP04572 6.54  LDD1910 
Dipeptidyl peptidase 1 (CTSC) LDTP04572 6.54  LDD1910 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 10.70  LDD1910 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 10.70  LDD1910 
Ephrin type-A receptor 7 (EPHA7) LDTP06370 8.63  LDD1910 
Ephrin type-A receptor 7 (EPHA7) LDTP06370 8.63  LDD1910 
Gamma-glutamyl hydrolase (GGH) LDTP09886 6.96  LDD1910 
Gamma-glutamyl hydrolase (GGH) LDTP09886 6.96  LDD1910 
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) LDTP01333 6.82  LDD1910 
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) LDTP01333 6.82  LDD1910 
Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) LDTP04211 5.70  LDD1910 
Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) LDTP04211 5.70  LDD1910 
Legumain (LGMN) LDTP10888 9.25  LDD1910 
Legumain (LGMN) LDTP10888 9.25  LDD1910 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 13.74  LDD1910 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 13.74  LDD1910 
Lysosomal acid phosphatase (ACP2) LDTP02539 8.34  LDD1910 
Lysosomal acid phosphatase (ACP2) LDTP02539 8.34  LDD1910 
Lysosomal alpha-glucosidase (GAA) LDTP02486 10.85  LDD1910 
Lysosomal alpha-glucosidase (GAA) LDTP02486 10.85  LDD1910 
Lysosomal alpha-mannosidase (MAN2B1) LDTP00338 6.63  LDD1910 
Lysosomal alpha-mannosidase (MAN2B1) LDTP00338 6.63  LDD1910 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 6.63  LDD1910 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 6.63  LDD1910 
Lysosomal protective protein (CTSA) LDTP02505 6.19  LDD1910 
Lysosomal protective protein (CTSA) LDTP02505 6.19  LDD1910 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 12.55  LDD1910 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 12.55  LDD1910 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 13.18  LDD1910 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 13.18  LDD1910 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 8.00  LDD1910 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 8.00  LDD1910 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 6.63  LDD1910 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 6.63  LDD1910 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 10.20  LDD1910 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 10.20  LDD1910 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 13.45  LDD1910 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 13.45  LDD1910 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 18.64  LDD1910 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 18.64  LDD1910 
Ribonuclease T2 (RNASET2) LDTP00316 12.21  LDD1910 
Ribonuclease T2 (RNASET2) LDTP00316 12.21  LDD1910 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 6.06  LDD1910 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 6.06  LDD1910 
Tissue alpha-L-fucosidase (FUCA1) LDTP02006 7.16  LDD1910 
Tissue alpha-L-fucosidase (FUCA1) LDTP02006 7.16  LDD1910 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 16.00  LDD1910 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 16.00  LDD1910 
------------------------------------------------------------------------------------
⏷ Show the Full List of 68 Enzyme
50 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Amyloid-beta precursor protein (APP) LDTP02071 12.21  LDD1910 
Amyloid-beta precursor protein (APP) LDTP02071 12.21  LDD1910 
Cation-independent mannose-6-phosphate receptor (IGF2R) LDTP02586 12.91  LDD1910 
Cation-independent mannose-6-phosphate receptor (IGF2R) LDTP02586 12.91  LDD1910 
Desmocollin-2 (DSC2) LDTP05356 6.45  LDD1910 
Desmocollin-2 (DSC2) LDTP05356 6.45  LDD1910 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 5.90  LDD1910 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 5.90  LDD1910 
Integrin alpha-V (ITGAV) LDTP02166 5.39  LDD1910 
Integrin alpha-V (ITGAV) LDTP02166 5.39  LDD1910 
Low-density lipoprotein receptor (LDLR) LDTP01829 9.78  LDD1910 
Low-density lipoprotein receptor (LDLR) LDTP01829 9.78  LDD1910 
Low-density lipoprotein receptor-related protein 2 (LRP2) LDTP05218 5.98  LDD1910 
Low-density lipoprotein receptor-related protein 2 (LRP2) LDTP05218 5.98  LDD1910 
Lysosome membrane protein 2 (SCARB2) LDTP06034 7.84  LDD1910 
Lysosome membrane protein 2 (SCARB2) LDTP06034 7.84  LDD1910 
Lysosome-associated membrane glycoprotein 1 (LAMP1) LDTP02562 6.63  LDD1910 
Lysosome-associated membrane glycoprotein 1 (LAMP1) LDTP02562 6.63  LDD1910 
Lysosome-associated membrane glycoprotein 2 (LAMP2) LDTP02655 5.78  LDD1910 
Lysosome-associated membrane glycoprotein 2 (LAMP2) LDTP02655 5.78  LDD1910 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 9.25  LDD1910 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 9.25  LDD1910 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 5.35  LDD1910 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 5.35  LDD1910 
NPC intracellular cholesterol transporter 2 (NPC2) LDTP04940 9.92  LDD1910 
NPC intracellular cholesterol transporter 2 (NPC2) LDTP04940 9.92  LDD1910 
Podocalyxin (PODXL) LDTP00321 9.85  LDD1910 
Podocalyxin (PODXL) LDTP00321 9.85  LDD1910 
Prolow-density lipoprotein receptor-related protein 1 (LRP1) LDTP05538 10.70  LDD1910 
Prolow-density lipoprotein receptor-related protein 1 (LRP1) LDTP05538 10.70  LDD1910 
Prosaposin (PSAP) LDTP02215 15.45  LDD1910 
Prosaposin (PSAP) LDTP02215 15.45  LDD1910 
Protein tweety homolog 3 (TTYH3) LDTP11615 6.92  LDD1910 
Protein tweety homolog 3 (TTYH3) LDTP11615 6.92  LDD1910 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 7.36  LDD1910 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 7.36  LDD1910 
Slit homolog 2 protein (SLIT2) LDTP01427 5.06  LDD1910 
Slit homolog 2 protein (SLIT2) LDTP01427 5.06  LDD1910 
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) LDTP11826 4.96  LDD1910 
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) LDTP11826 4.96  LDD1910 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 7.46  LDD1910 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 7.46  LDD1910 
Sortilin (SORT1) LDTP10885 9.78  LDD1910 
Sortilin (SORT1) LDTP10885 9.78  LDD1910 
Transferrin receptor protein 1 (TFRC) LDTP01969 9.25  LDD1910 
Transferrin receptor protein 1 (TFRC) LDTP01969 9.25  LDD1910 
Transmembrane protein 87A (TMEM87A) LDTP15481 5.13  LDD1910 
Transmembrane protein 87A (TMEM87A) LDTP15481 5.13  LDD1910 
V-type proton ATPase subunit S1 (ATP6AP1) LDTP06499 5.74  LDD1910 
V-type proton ATPase subunit S1 (ATP6AP1) LDTP06499 5.74  LDD1910 
------------------------------------------------------------------------------------
⏷ Show the Full List of 50 Transporter and channel
4 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
IgG receptor FcRn large subunit p51 (FCGRT) LDTP04720 14.62  LDD1910 
IgG receptor FcRn large subunit p51 (FCGRT) LDTP04720 14.62  LDD1910 
Neogenin (NEO1) LDTP09907 11.88  LDD1910 
Neogenin (NEO1) LDTP09907 11.88  LDD1910 
------------------------------------------------------------------------------------
2 Cytokine and receptor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Interferon gamma receptor 1 (IFNGR1) LDTP02775 7.62  LDD1910 
Interferon gamma receptor 1 (IFNGR1) LDTP02775 7.62  LDD1910 
------------------------------------------------------------------------------------
28 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Amyloid beta precursor like protein 2 (APLP2) LDTP05491 11.71  LDD1910 
Amyloid beta precursor like protein 2 (APLP2) LDTP05491 11.71  LDD1910 
Collectin-12 (COLEC12) LDTP07031 6.87  LDD1910 
Collectin-12 (COLEC12) LDTP07031 6.87  LDD1910 
Desmocollin-3 (DSC3) LDTP06154 7.73  LDD1910 
Desmocollin-3 (DSC3) LDTP06154 7.73  LDD1910 
Ganglioside GM2 activator (GM2A) LDTP02927 7.26  LDD1910 
Ganglioside GM2 activator (GM2A) LDTP02927 7.26  LDD1910 
Golgi apparatus protein 1 (GLG1) LDTP09920 5.98  LDD1910 
Golgi apparatus protein 1 (GLG1) LDTP09920 5.98  LDD1910 
Golgi membrane protein 1 (GOLM1) LDTP09054 7.84  LDD1910 
Golgi membrane protein 1 (GOLM1) LDTP09054 7.84  LDD1910 
Hepatoma-derived growth factor-related protein 2 (HDGFL2) LDTP08081 7.16  LDD1910 
Hepatoma-derived growth factor-related protein 2 (HDGFL2) LDTP08081 7.16  LDD1910 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 11.96  LDD1910 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 11.96  LDD1910 
Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) LDTP10023 12.38  LDD1910 
Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) LDTP10023 12.38  LDD1910 
Neuferricin (CYB5D2) LDTP15623 7.78  LDD1910 
Neuferricin (CYB5D2) LDTP15623 7.78  LDD1910 
Seizure 6-like protein 2 (SEZ6L2) LDTP07703 16.22  LDD1910 
Seizure 6-like protein 2 (SEZ6L2) LDTP07703 16.22  LDD1910 
Synaptic vesicle glycoprotein 2A (SV2A) LDTP07934 6.87  LDD1910 
Synaptic vesicle glycoprotein 2A (SV2A) LDTP07934 6.87  LDD1910 
Tetraspanin-6 (TSPAN6) LDTP14458 5.54  LDD1910 
Tetraspanin-6 (TSPAN6) LDTP14458 5.54  LDD1910 
Trans-Golgi network integral membrane protein 2 (TGOLN2) LDTP00779 17.03  LDD1910 
Trans-Golgi network integral membrane protein 2 (TGOLN2) LDTP00779 17.03  LDD1910 
------------------------------------------------------------------------------------
⏷ Show the Full List of 28 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1910 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587