Details of the Target

General Information of Target

Target ID LDTP10023
Target Name Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2)
Gene Name L3MBTL2
Gene ID 83746
Synonyms
Lethal(3)malignant brain tumor-like protein 2; H-l(3)mbt-like protein 2; L(3)mbt-like protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKAAAPSRGGGCGGRSRGLSSLFTVVPCLSCHTAAPGMSASTSGSGPEPKPQPQPVPEP
ERGPLSEQVSEAVSEAVPRSEPVSETTSEPEPGAGQPSELLQGSRPGSESSSGVGAGPFT
KAASEPLSRAVGSATFLRPESGSLPALKPLPLLRPGQAKTPLGVPMSGTGTTSSAPLALL
PLDSFEGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQGEMAHTCRGTINLSTAHIDTEDS
CGILLTSGARSYHLKASSEVDRQQWITALELAKAKAVRVMNTHSDDSGDDDEATTPADKS
ELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSLTELDGLKIPSESGEKLKVVNERATLF
RITSNAMINACRDFLELAEIHSRKWQRALQYEQEQRVHLEETIEQLAKQHNSLERAFHSA
PGRPANPSKSFIEGSLLTPKGEDSEEDEDTEYFDAMEDSTSFITVITEAKEDSRKAEGST
GTSSVDWSSADNVLDGASLVPKGSSKVKRRVRIPNKPNYSLNLWSIMKNCIGRELSRIPM
PVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFN
PMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITISSKFRGKYISI
MPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPY
SYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTL
SAKLLWKKYPLPENAENMYYFSELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTE
KQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGY
WEAKEKQDWHMCPNIF
Target Bioclass
Other
Subcellular location
Nucleus
Function
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.
Uniprot ID
Q969R5
Ensemble ID
ENST00000216237.10
HGNC ID
HGNC:18594

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.D578N DBIA    Probe Info 
HCT116 SNV: p.G387C DBIA    Probe Info 
HCT15 SNV: p.V267I DBIA    Probe Info 
HEC1 SNV: p.R354W DBIA    Probe Info 
HEC1B SNV: p.R354W .
LNCaP clone FGC SNV: p.G426S DBIA    Probe Info 
LS123 SNV: p.A398D DBIA    Probe Info 
MDAMB453 SNV: p.E50K; p.I588M DBIA    Probe Info 
MELHO Deletion: p.S304DfsTer19 .
MFE319 Deletion: p.S468PfsTer73 DBIA    Probe Info 
MOLT4 SNV: p.E50D IA-alkyne    Probe Info 
OVK18 SNV: p.R419Ter .
RL SNV: p.T306S .
SKMEL24 SNV: p.P654S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C554(0.79)  LDD2109  [1]
IPM
 Probe Info  		C554(8.99)  LDD1701  [1]
DBIA
 Probe Info  		C90(1.92); C93(1.92); C408(1.44)  LDD0080  [2]
IA-alkyne
 Probe Info  		C197(0.00); C368(0.00)  LDD0165  [3]
Lodoacetamide azide
 Probe Info  		C368(0.00); C531(0.00)  LDD0037  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
AOyne
 Probe Info  		9.80  LDD0443  [6]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C149
 Probe Info  		5.35  LDD1830  [7]
C170
 Probe Info  		8.94  LDD1850  [7]
C208
 Probe Info  		16.80  LDD1883  [7]
C237
 Probe Info  		12.38  LDD1910  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C110(0.89); C114(1.20); C197(0.78); C408(0.82)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C110(0.92); C114(0.90); C197(0.92); C408(0.67)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C110(0.84); C114(0.89); C197(0.69); C531(0.96)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C110(0.81); C114(0.87); C197(0.67); C531(1.01)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C110(0.95); C114(0.88); C197(0.70); C531(1.00)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C110(0.86); C114(0.97); C197(0.63); C531(0.93)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C110(1.00); C114(1.00); C197(0.65); C531(0.88)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C110(1.08); C114(1.00); C197(0.62); C531(0.89)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C110(1.06); C114(1.03); C197(0.63); C531(0.91)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C110(0.97); C114(1.11); C197(0.63); C531(0.93)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C110(0.98); C114(0.87); C197(0.72); C531(0.93)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C110(0.76); C114(0.79); C197(0.72); C531(0.90)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C110(1.38); C114(1.39); C197(0.96); C408(0.49)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C110(0.93); C114(0.88); C197(0.67); C531(0.95)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C110(1.06); C114(0.96); C197(0.71); C531(0.93)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C110(0.76); C114(0.85); C197(0.61); C531(1.03)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C110(0.86); C114(1.11); C197(1.07); C90(1.03)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C110(1.00); C114(0.94); C197(1.00); C90(1.15)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C110(0.95); C114(1.00); C197(0.89); C90(1.10)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C110(0.96); C114(1.00); C197(0.85); C90(1.00)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C110(0.83); C114(0.80); C197(0.92); C90(1.23)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C110(0.89); C114(0.92); C197(0.97); C90(1.11)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C110(0.84); C114(1.01); C197(0.94); C90(1.12)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C110(1.30); C114(1.40); C197(1.11); C408(0.56)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C110(0.88); C114(0.93); C197(1.00); C90(0.88)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C110(0.89); C114(0.89); C197(1.07); C90(1.13)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C110(0.92); C114(0.93); C197(0.88); C90(1.16)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C110(0.99); C114(0.85); C197(1.06); C90(0.99)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C110(0.85); C114(1.01); C197(1.01); C90(1.15)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C110(0.91); C114(0.99); C197(0.98); C90(0.98)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C110(0.92); C114(0.99); C197(1.02); C90(1.27)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C110(0.89); C114(0.94); C197(0.91); C90(1.06)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C110(0.44); C114(0.62); C197(1.41); C90(0.91)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C110(0.36); C114(0.59); C197(1.65); C90(0.47)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C110(0.35); C114(0.72); C197(1.12); C90(0.61)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C110(0.41); C114(0.55); C197(1.03); C90(0.52)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C110(0.48); C114(0.80); C197(1.18); C90(0.63)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C110(0.39); C114(0.68); C197(1.07); C90(0.91)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C110(0.47); C114(0.79); C197(1.15); C90(0.76)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C110(0.55); C114(0.76); C197(1.22); C90(0.77)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C110(0.44); C114(0.66); C197(1.26); C90(0.76)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C110(0.42); C114(0.71); C197(1.01); C90(0.76)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C110(0.44); C114(0.70); C197(1.07); C90(0.77)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C110(0.53); C114(0.75); C197(1.17); C90(0.75)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C110(0.81); C114(0.71); C197(0.99); C408(0.78)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C110(0.48); C114(0.79); C197(1.16); C90(0.82)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C110(0.48); C114(0.72); C197(1.16); C90(0.79)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C110(0.45); C114(0.68); C197(1.09); C90(0.76)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C197(0.85); C90(0.92); C93(0.92); C114(1.03)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C197(0.69); C408(0.79); C114(1.27); C110(1.37)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C197(0.80); C408(0.84); C90(1.07); C93(1.10)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C197(0.69); C90(1.07); C408(1.12); C114(1.16)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C197(0.79); C408(0.82); C93(1.06); C90(1.14)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C197(0.78); C408(1.07); C90(1.21); C93(1.27)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C197(0.69); C408(1.04); C90(1.14); C93(1.26)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C90(0.71); C93(0.71); C531(0.90); C197(0.95)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C197(0.79); C408(1.01); C93(1.05); C90(1.08)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C197(0.78); C408(1.01); C114(1.09); C90(1.13)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C197(0.71); C408(0.95); C114(1.30); C93(1.41)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C197(0.74); C408(1.12); C90(1.49); C93(1.69)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C110(1.65); C114(1.26); C197(0.82); C408(1.04)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C110(1.55); C114(1.45); C197(0.73); C408(1.07)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C110(1.36); C114(1.22); C197(0.83); C408(1.12)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C110(1.64); C114(1.12); C197(0.83); C408(0.93)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C408(0.79); C110(1.00); C197(1.44)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C408(0.81); C110(0.84); C197(1.34)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C408(0.83); C110(1.06); C197(1.19)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C408(0.80); C110(0.86); C197(0.88); C114(1.22)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C110(0.91); C197(1.17); C408(1.20)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C110(0.89); C408(0.94); C197(1.31)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C110(0.84); C408(0.88); C197(1.25)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C110(0.77); C408(0.84); C197(1.32)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C110(0.86); C408(1.10); C197(1.44)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C531(0.82); C110(0.86); C114(0.86); C90(0.89)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C197(0.86); C531(0.91); C408(1.08); C110(1.09)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C197(0.75); C531(0.96); C110(1.09); C114(1.09)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C197(0.81); C90(0.89); C93(0.89); C531(0.96)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C197(0.76); C531(0.90); C110(0.90); C114(0.90)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C408(0.70); C197(0.94); C110(0.96); C114(1.41)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C197(0.73); C531(0.87); C110(0.92); C114(0.92)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C197(0.71); C531(0.84); C90(1.08); C93(1.08)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C197(0.71); C531(1.03); C90(1.08); C93(1.08)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C197(0.75); C90(0.94); C93(0.94); C110(0.96)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C197(0.74); C90(1.00); C93(1.00); C110(1.00)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C110(0.92); C114(0.92); C531(0.94); C197(0.95)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C531(0.85); C197(0.94); C110(1.01); C114(1.01)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C531(0.91); C197(0.97); C90(1.09); C93(1.09)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C197(0.97); C110(1.06); C114(1.06); C531(1.07)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C531(1.01); C197(1.02); C110(1.07); C114(1.07)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C408(0.74); C110(0.85); C197(0.89); C114(1.21)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C531(0.97); C197(1.05); C110(1.08); C114(1.08)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C531(0.92); C197(1.05); C90(1.11); C93(1.11)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C197(0.99); C531(1.00); C90(1.13); C93(1.13)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C197(0.85); C531(0.86); C90(1.21); C93(1.21)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C531(0.87); C197(1.03); C110(1.10); C114(1.10)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C531(0.88); C197(0.96); C110(1.11); C114(1.11)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C197(0.90); C408(0.93); C110(1.08); C114(1.08)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C197(0.95); C408(0.97); C110(1.20); C114(1.20)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C408(0.80); C197(0.94); C110(0.99); C114(0.99)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C408(0.92); C197(0.97); C110(1.02); C114(1.02)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C408(0.80); C110(0.87); C197(0.95); C114(1.25)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C197(0.99); C110(1.10); C114(1.10); C408(1.43)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C110(0.99); C114(0.99); C197(1.20); C408(1.26)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C197(0.92); C110(0.99); C114(0.99); C408(1.09)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C197(0.87); C110(1.13); C114(1.13); C408(1.54)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C110(0.95); C114(0.95); C197(0.97); C408(1.14)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C197(0.92); C408(1.09); C110(1.25); C114(1.25)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C110(0.90); C114(0.90); C197(1.09); C408(1.29)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C197(0.84); C408(0.99); C90(1.07); C93(1.07)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C90(0.86); C93(0.86); C197(0.90); C114(1.01)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C197(0.78); C110(0.86); C90(0.96); C93(0.96)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C197(0.85); C90(0.86); C93(0.86); C531(0.92)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C197(0.75); C110(0.82); C90(1.11); C93(1.11)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C110(0.80); C90(0.84); C93(0.84); C197(0.90)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C110(0.74); C90(0.80); C93(0.80); C197(0.84)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C197(0.74); C90(0.86); C93(0.86); C110(0.99)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C110(0.71); C197(0.79); C90(1.03); C93(1.03)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C197(0.91); C408(0.98); C90(1.03); C93(1.03)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C110(0.75); C197(0.84); C114(0.98); C408(0.99)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C197(0.68); C110(0.75); C114(0.78); C408(0.89)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C110(0.73); C114(0.99); C197(1.03); C90(1.42)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C110(0.77); C197(0.98); C114(1.20); C90(1.62)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C90(0.80); C93(0.80); C110(0.82); C114(0.83)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C197(0.90); C90(1.22); C93(1.22); C114(1.49)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C110(0.97); C197(1.08); C114(1.15); C90(1.37)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C197(1.01); C110(1.31); C114(1.33); C90(1.36)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C197(0.97); C114(1.38); C110(1.40); C90(1.47)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C110(1.05); C197(1.15); C114(1.46); C90(1.50)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C197(1.14); C110(1.38); C114(1.53); C90(1.57)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C197(0.99); C90(1.35); C93(1.35); C110(1.37)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C110(0.74); C197(0.92); C114(1.33); C90(1.47)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C110(0.77); C197(0.91); C114(1.12); C90(1.29)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C197(1.03); C110(1.15); C114(1.36); C90(1.45)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C90(0.76); C93(0.76); C197(0.86); C531(0.87)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C197(1.00); C110(1.03); C114(1.27); C90(1.91)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C110(1.15); C197(1.21); C90(1.24); C93(1.24)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C197(1.19); C110(1.34); C114(1.46); C90(1.69)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C197(0.82); C531(0.98); C90(1.00); C93(1.00)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C197(0.84); C90(0.85); C93(0.85); C531(1.01)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C197(0.83); C90(0.89); C93(0.89); C531(0.93)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C197(0.91); C531(0.97); C90(1.06); C93(1.06)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C531(0.93); C90(0.97); C93(0.97); C197(1.01)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C197(0.87); C110(0.90); C90(0.98); C93(0.98)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C197(0.81); C531(0.86); C90(0.91); C93(0.91)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C531(0.90); C197(0.96); C114(1.11); C90(1.19)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C197(0.81); C110(0.87); C531(0.94); C114(1.09)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C197(0.79); C531(0.92); C90(1.07); C93(1.07)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C90(0.84); C93(0.84); C531(0.92); C197(0.93)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C90(0.84); C93(0.84); C531(0.85); C197(0.93)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C197(0.86); C531(0.86); C90(0.94); C93(0.94)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C197(0.85); C110(0.91); C90(0.93); C93(0.93)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C197(0.83); C531(0.92); C90(1.06); C93(1.06)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C197(0.61); C531(0.92); C90(1.06); C93(1.06)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C90(0.68); C93(0.68); C197(0.70); C110(0.85)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C110(1.12); C114(1.30); C197(0.91); C408(0.56)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C408(0.65); C90(0.86); C93(0.86); C197(0.86)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C90(0.72); C93(0.72); C408(0.93); C197(0.96)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C90(1.09); C93(1.09)  LDD2171  [2]
 LDCM0367  CL1 HCT 116 C90(0.90); C93(0.90); C197(0.92); C408(1.18)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C408(0.50); C197(0.77); C90(0.87); C93(0.87)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C197(0.86); C408(0.86); C110(1.02); C114(1.42)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C531(0.79); C90(0.82); C93(0.82); C197(0.88)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C90(0.58); C93(0.58); C408(0.60); C114(0.66)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C408(0.53); C90(0.72); C93(0.72); C531(0.91)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C90(0.72); C93(0.72); C408(0.73); C531(0.79)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C110(0.75); C408(0.75); C197(1.08)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C408(0.68); C110(0.77); C197(1.29)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C408(0.72); C110(0.94); C197(1.42)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C408(0.69); C110(0.78); C197(1.14)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C408(0.87); C110(0.89); C197(0.98)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C408(0.57); C197(0.85); C90(1.04); C93(1.04)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C110(0.65); C408(0.82); C197(1.10)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C408(0.87); C197(1.07); C110(1.12)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C197(0.80); C110(0.90); C114(0.90); C408(1.01)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C197(0.78); C110(0.82); C114(0.82); C531(0.91)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C110(0.73); C114(0.73); C197(0.78); C531(0.87)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C197(0.73); C90(0.87); C93(0.87); C110(0.93)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C197(0.79); C531(0.88); C110(0.89); C114(0.89)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C531(0.86); C197(1.03); C110(1.07); C114(1.07)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C531(0.91); C197(0.97); C90(1.01); C93(1.01)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C197(0.93); C531(0.96); C90(1.09); C93(1.09)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C408(0.45); C197(0.81); C90(1.17); C93(1.17)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C531(0.94); C197(0.98); C110(1.08); C114(1.08)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C197(0.84); C110(0.99); C114(0.99); C408(1.08)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C110(0.88); C114(0.88); C197(0.93); C408(1.13)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C110(0.81); C114(0.81); C197(0.93); C408(0.94)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C197(0.88); C110(1.01); C114(1.01); C408(1.02)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C90(0.73); C93(0.73); C408(0.81); C197(0.82)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C110(0.60); C90(0.77); C93(0.77); C197(0.79)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C110(0.75); C408(0.86); C197(0.94); C90(1.00)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C197(0.81); C90(0.92); C93(0.92); C114(1.04)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C197(0.80); C408(0.86); C90(0.87); C93(0.87)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C197(0.83); C90(0.94); C93(0.94); C408(1.07)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C408(0.78); C197(0.81); C90(1.07); C93(1.07)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C197(0.68); C90(1.04); C93(1.04); C110(1.08)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C110(0.67); C197(0.69); C114(0.80); C408(0.86)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C197(0.67); C408(0.86); C114(1.09); C110(1.12)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C197(0.77); C408(0.93); C114(0.94); C110(1.01)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C197(0.94); C90(1.11); C93(1.11); C408(1.48)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C197(0.68); C408(0.90); C114(0.90); C110(1.22)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C197(0.74); C114(0.78); C110(0.91); C408(1.13)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C197(0.75); C114(0.89); C110(0.97); C408(1.49)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C197(0.77); C408(0.78); C114(1.16); C110(1.20)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C197(0.74); C408(0.98); C110(1.06); C114(1.19)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C110(1.19); C114(1.17); C197(0.62); C408(0.89)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C110(0.98); C114(1.23); C197(0.72); C408(0.85)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C110(1.01); C114(1.12); C197(0.77); C408(0.92)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C110(0.97); C114(1.12); C197(0.68); C408(0.93)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C110(1.20); C114(1.26); C197(0.70); C408(1.02)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C197(0.95); C408(0.88); C90(1.07); C93(1.07)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C110(1.09); C114(1.10); C197(0.81); C408(1.26)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C197(0.98); C408(1.13); C531(0.99)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C110(1.09); C114(1.25); C197(0.83); C408(1.11)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C110(0.87); C114(0.75); C197(0.90); C408(1.18)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C110(1.06); C114(1.04); C197(0.78); C408(1.33)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C110(1.33); C114(1.56); C197(0.84); C408(1.29)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C110(0.97); C114(0.91); C197(0.84); C408(1.25)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C110(1.17); C114(1.14); C197(0.98); C408(1.33)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C110(1.15); C114(1.27); C197(0.97); C408(1.29)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C197(0.88); C408(0.88); C90(0.95); C93(0.95)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C110(1.18); C114(1.23); C197(0.78); C408(1.30)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C110(0.97); C114(0.99); C197(0.80); C408(1.22)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C110(1.15); C114(1.08); C197(0.96); C408(1.33)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C110(1.16); C114(1.22); C197(0.95); C408(1.39)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C110(1.22); C114(1.15); C197(0.84); C408(1.43)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C110(1.24); C114(1.34); C197(0.88); C408(1.46)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C110(0.96); C114(0.95); C197(0.90); C408(0.85)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C110(1.00); C114(0.98); C197(0.92); C408(0.92)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C110(1.16); C114(1.00); C197(0.96); C408(0.90)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C110(1.00); C114(1.16); C197(1.09); C408(0.94)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C197(0.91); C408(0.97); C90(1.11); C93(1.11)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C110(0.88); C114(0.83); C197(1.18); C408(0.79)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C110(0.88); C114(1.12); C197(1.10); C408(0.83)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C110(0.74); C114(0.84); C197(0.92); C408(0.87)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C110(0.79); C114(0.76); C197(0.84); C408(1.34)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C110(0.70); C114(0.92); C197(0.95); C408(0.91)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C110(0.78); C114(1.14); C197(1.06); C408(0.99)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C110(0.73); C114(1.06); C197(0.97); C408(1.03)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C110(0.70); C114(1.03); C197(0.97); C408(1.13)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C110(0.80); C114(0.98); C197(0.98); C408(0.97)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C110(0.66); C114(0.94); C197(1.10); C408(0.93)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C197(0.76); C408(0.90); C90(0.90); C93(0.90)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C110(0.70); C114(0.87); C197(1.02); C408(0.87)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C110(1.09); C114(1.24); C197(0.86)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C110(1.07); C114(1.13); C197(0.84)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C110(1.34); C114(1.04); C197(0.75)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C110(1.31); C114(1.20); C197(0.81)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C110(0.97); C114(1.03); C197(0.92)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C110(1.18); C114(1.11); C197(0.72)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C110(1.18); C114(1.13); C197(0.81)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C110(0.96); C114(0.92); C197(0.68)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C110(1.04); C114(1.07); C197(0.64)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C197(0.85); C408(0.51); C90(0.99); C93(0.99)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C110(1.10); C114(1.03); C197(0.73)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C110(1.01); C114(0.96); C197(0.75)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C110(1.01); C114(1.07); C197(0.72)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C110(0.97); C114(0.97); C197(0.72)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C110(1.82); C114(1.09); C197(0.74)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C110(1.06); C114(1.06); C197(0.80); C408(1.28)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C110(1.05); C114(1.05); C197(0.83); C408(2.61)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C110(1.06); C114(1.06); C197(0.92); C408(1.20)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C110(0.83); C114(0.83); C197(0.80); C408(1.57)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C197(0.83); C408(1.80); C90(1.07); C93(1.07)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C110(1.22); C114(1.22); C197(0.79); C408(1.61)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C110(0.85); C114(0.85); C197(0.90); C408(1.22)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C110(0.82); C114(0.82); C197(0.84); C408(1.59)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C110(0.84); C114(0.84); C197(0.79); C408(1.64)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C110(1.05); C114(1.05); C197(0.83); C408(1.90)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C110(1.01); C114(1.01); C197(0.85); C408(1.17)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C110(1.09); C114(1.09); C197(0.92); C408(1.09)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C110(0.95); C114(0.95); C197(0.80); C408(1.35)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C110(1.05); C114(1.05); C197(0.78); C408(1.63)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C110(1.14); C114(1.14); C197(0.97); C408(1.70)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C197(0.81); C408(1.00); C90(1.05); C93(1.05)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C110(1.00); C114(1.00); C197(0.98); C408(0.87)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C110(0.88); C114(0.93); C197(0.92); C408(0.97)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C110(0.77); C114(0.84); C197(0.92); C408(1.07)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C110(0.87); C114(1.23); C197(0.91); C408(1.03)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C110(1.15); C114(1.37); C197(0.89); C408(1.10)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C110(1.10); C114(1.00); C197(0.82); C408(1.01)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C110(0.96); C114(0.97); C197(0.85); C408(0.78)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C110(0.77); C114(1.15); C197(0.81); C408(0.85)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C110(0.92); C114(1.28); C197(0.81); C408(0.72)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C110(0.87); C114(1.12); C197(0.82); C408(0.73)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C531(0.92); C408(1.04); C114(0.89)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C110(1.00); C114(1.01); C197(0.68)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C110(0.93); C114(1.00); C197(0.86); C408(1.69)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C90(1.92); C93(1.92); C408(1.44)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C90(1.80); C93(1.80); C408(1.44)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C90(1.80); C93(1.80); C408(1.29)  LDD0082  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C554(0.79)  LDD2109  [1]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C554(0.77)  LDD2125  [1]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C197(0.78)  LDD2137  [1]
 LDCM0021  THZ1 HCT 116 C90(1.09); C93(1.09)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone deacetylase 3 (HDAC3) Histone deacetylase family O15379
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) SAICAR synthetase family; AIR carboxylase family P22234
E3 ubiquitin-protein ligase TRIM50 (TRIM50) TRIM/RBCC family Q86XT4
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 4E transporter (EIF4ENIF1) 4E-T/EIF4E-T family Q9NRA8
Transcription factor
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G protein-coupled receptor associated sorting protein 3 (GPRASP3) GPRASP family Q6PI77
RB-associated KRAB zinc finger protein (RBAK) Krueppel C2H2-type zinc-finger protein family Q9NYW8
Telomere zinc finger-associated protein (ZBTB48) Krueppel C2H2-type zinc-finger protein family P10074
Zinc finger protein 467 (ZNF467) Krueppel C2H2-type zinc-finger protein family Q7Z7K2
Zinc finger protein 64 (ZFP64) Krueppel C2H2-type zinc-finger protein family Q9NTW7
Zinc finger Y-chromosomal protein (ZFY) Krueppel C2H2-type zinc-finger protein family P08048
Protein max (MAX) MAX family P61244
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Homeobox protein MOX-1 (MEOX1) . P50221
Zinc finger and BTB domain-containing protein 26 (ZBTB26) . Q9HCK0
Other
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiomotin-like protein 2 (AMOTL2) Angiomotin family Q9Y2J4
Basic immunoglobulin-like variable motif-containing protein (BIVM) BIVM family Q86UB2
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Chromatin modification-related protein MEAF6 (MEAF6) EAF6 family Q9HAF1
Protein FAM217B (FAM217B) FAM217 family Q9NTX9
G kinase-anchoring protein 1 (GKAP1) GKAP1 family Q5VSY0
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Signal transducing adapter molecule 2 (STAM2) STAM family O75886
Tektin-1 (TEKT1) Tektin family Q969V4
Troponin I, slow skeletal muscle (TNNI1) Troponin I family P19237
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Coiled-coil domain-containing protein 106 (CCDC106) . Q9BWC9
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
Heat shock factor 2-binding protein (HSF2BP) . O75031
PRKCA-binding protein (PICK1) . Q9NRD5
SH3 and cysteine-rich domain-containing protein 3 (STAC3) . Q96MF2
Tax1-binding protein 1 (TAX1BP1) . Q86VP1

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402