Details of the Target

General Information of Target

Target ID LDTP06154
Target Name Desmocollin-3 (DSC3)
Gene Name DSC3
Gene ID 1825
Synonyms
CDHF3; DSC4; Desmocollin-3; Cadherin family member 3; Desmocollin-4; HT-CP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRS
ADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVS
KTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDK
EPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNH
PVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPS
TGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAY
EAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVV
KPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRI
KENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETP
KNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPD
EPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAA
TKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKG
KRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIE
MMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNE
DRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEACTKR
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Uniprot ID
Q14574
Ensemble ID
ENST00000360428.9
HGNC ID
HGNC:3037

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.V73D .
HT SNV: p.P151H .
IPC298 SNV: p.G193E .
LOXIMVI SNV: p.E400K .
MDST8 SNV: p.E361K .
MFE319 Insertion: p.D210Ter .
NCIH196 SNV: p.D464Y .
NCIH1993 Substitution: p.V10W .
NCIH2286 SNV: p.D841Y .
SG231 SNV: p.M782V .
SKMEL5 SNV: p.H799Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K381(1.61); K662(1.83); K180(1.97); K281(1.99)  LDD3494  [1]
IMP-1710
 Probe Info  		2.41  LDD0040  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
IPM
 Probe Info  		C814(0.00); C677(0.00); C792(0.00)  LDD2156  [4]
AOyne
 Probe Info  		14.10  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C073
 Probe Info  		5.03  LDD1769  [6]
C115
 Probe Info  		4.99  LDD1802  [6]
C149
 Probe Info  		7.06  LDD1830  [6]
C159
 Probe Info  		7.84  LDD1839  [6]
C170
 Probe Info  		23.75  LDD1850  [6]
C171
 Probe Info  		5.17  LDD1851  [6]
C197
 Probe Info  		7.46  LDD1873  [6]
C237
 Probe Info  		7.73  LDD1910  [6]
C281
 Probe Info  		9.32  LDD1951  [6]
C310
 Probe Info  		12.21  LDD1977  [6]
C344
 Probe Info  		5.31  LDD2006  [6]
C355
 Probe Info  		48.50  LDD2016  [6]
C405
 Probe Info  		5.13  LDD2063  [6]
C407
 Probe Info  		11.55  LDD2064  [6]
C423
 Probe Info  		17.03  LDD2078  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0001  Panyain_cp1 HEK-293T 2.41  LDD0040  [2]

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Correction to "Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity". J Am Chem Soc. 2020 Sep 2;142(35):15199. doi: 10.1021/jacs.0c08385. Epub 2020 Aug 19.
Mass spectrometry data entry: PXD015825
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587