General Information of Experiment

Probe Name IMP-1710  Probe Info 
Probe concentration 20 nM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
TMT
Competitor Name Panyain_cp1  Competitor Info 
Competitor Concentration 1 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03133  Fibroblast growth factor receptor 2 (FGFR2) 7.6
 LDTP02383  Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) 4.9
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 2.6
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 2.4
 LDTP02783  Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCHL3) 2.1
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06994  ER membrane protein complex subunit 4 (EMC4) 4.4
Other
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07136  Keratinocyte proline-rich protein (KPRP) 11.3
 LDTP06431  Thyroid receptor-interacting protein 11 (TRIP11) 3.1
 LDTP06403  Corneodesmosin (CDSN) 2.9
 LDTP02031  Keratin, type II cytoskeletal 1 (KRT1) 2.6
 LDTP06154  Desmocollin-3 (DSC3) 2.4
 LDTP12937  Calmodulin-like protein 5 (CALML5) 2.4
 LDTP05567  Desmocollin-1 (DSC1) 2.1

References

1 Correction to "Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity". J Am Chem Soc. 2020 Sep 2;142(35):15199. doi: 10.1021/jacs.0c08385. Epub 2020 Aug 19.
Mass spectrometry data entry: PXD015825