Details of the Target

General Information of Target

Target ID LDTP06431
Target Name Thyroid receptor-interacting protein 11 (TRIP11)
Gene Name TRIP11
Gene ID 9321
Synonyms
CEV14; Thyroid receptor-interacting protein 11; TR-interacting protein 11; TRIP-11; Clonal evolution-related gene on chromosome 14 protein; Golgi-associated microtubule-binding protein 210; GMAP-210; Trip230
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSWLGGLGSGLGQSLGQVGGSLASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAI
HAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQ
LLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNE
VSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQ
NAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIE
KVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKL
QPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKL
KMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKE
QELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEK
KRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNV
SIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSE
LEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGE
IEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKK
NIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRK
NEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQ
LNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLE
KDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETER
LVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSH
TQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDEN
KKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVN
SNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNN
SKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSAS
LLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAAT
SELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELL
RQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFEC
HSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMEN
TALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKL
VSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVL
EHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQL
DVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRH
EVLRLMGSILGVRREEMEQLFHDDQGGVTRWMTGWLGGGSKSVPNTPLRPNQQSVVNSSF
SELFVKFLETESHPSIPPPKLSVHDMKPLDSPGRRKRDTNAPESFKDTAESRSGRRTDVN
PFLAPRSAAVPLINPAGLGPGGPGHLLLKPISDVLPTFTPLPALPDNSAGVVLKDLLKQ
Target Bioclass
Other
Subcellular location
Golgi apparatus, cis-Golgi network membrane
Function
Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function. It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex. Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription.
Uniprot ID
Q15643
Ensemble ID
ENST00000267622.8
HGNC ID
HGNC:12305

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.Q803Ter DBIA    Probe Info 
CALU1 SNV: p.M422V .
CORL88 SNV: p.E1639Ter DBIA    Probe Info 
HCC15 SNV: p.E257K DBIA    Probe Info 
HCT116 Deletion: p.K541RfsTer17 .
HCT15 SNV: p.T305I .
HEC1B SNV: p.R1494Ter .
HGC27 SNV: p.S1333N DBIA    Probe Info 
HT115 SNV: p.N224H; p.N587H .
Ishikawa (Heraklio) 02 ER SNV: p.S405R DBIA    Probe Info 
KASUMI1 Substitution: p.G136S .
KP4 SNV: p.E1148G DBIA    Probe Info 
MCC13 SNV: p.Q591E DBIA    Probe Info 
MFE319 SNV: p.L644F DBIA    Probe Info 
NB1 Substitution: p.Q805K .
SNGM Deletion: p.K1619SfsTer2 DBIA    Probe Info 
SUIT2 SNV: p.L1143F DBIA    Probe Info 
SW756 SNV: p.D1212Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K1038(10.00); K1100(0.64); K1108(1.43); K1116(0.74)  LDD0277  [2]
Probe 1
 Probe Info  		Y1479(12.70)  LDD3495  [3]
BTD
 Probe Info  		C75(1.71)  LDD2107  [4]
IMP-1710
 Probe Info  		3.09  LDD0040  [5]
AHL-Pu-1
 Probe Info  		C1722(2.54); C1329(2.15)  LDD0168  [6]
DBIA
 Probe Info  		C212(1.06); C726(1.02)  LDD0078  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
CY4
 Probe Info  		D466(0.00); E734(0.00); E735(0.00)  LDD0247  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
ENE
 Probe Info  		N.A.  LDD0006  [11]
IPM
 Probe Info  		C1329(0.00); C212(0.00); C1722(0.00)  LDD0147  [12]
TFBX
 Probe Info  		C686(0.00); C696(0.00); C1722(0.00)  LDD0148  [12]
VSF
 Probe Info  		C212(0.00); C1329(0.00)  LDD0007  [11]
YN-1
 Probe Info  		N.A.  LDD0447  [13]
Acrolein
 Probe Info  		C686(0.00); C212(0.00); H510(0.00)  LDD0217  [14]
Methacrolein
 Probe Info  		C212(0.00); C686(0.00)  LDD0218  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		11.31  LDD1779  [16]
C106
 Probe Info  		16.45  LDD1793  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C1722(2.54); C1329(2.15)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1722(2.12)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C212(1.05); C726(1.60)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C212(1.53)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C726(0.81)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C726(0.74)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C726(0.79)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C726(0.92)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C726(0.71)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C726(0.70)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C726(1.05)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C726(0.77)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C726(0.71)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C726(0.63)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C212(1.71)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C726(0.81)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C726(0.80)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C726(0.76)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C212(0.88); C726(1.03)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C212(0.93); C726(1.22)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C212(1.22); C726(1.25)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C212(1.08); C726(1.39)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C212(1.13); C726(1.13)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C212(0.93); C726(1.04)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C212(1.09); C726(1.27)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C212(1.23)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C212(0.89); C726(0.94)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C212(1.30); C726(0.93)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C212(1.00); C726(0.95)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C212(1.05); C726(0.82)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C212(1.06); C726(1.01)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C212(0.83); C726(1.02)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C212(0.94); C726(1.19)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C212(1.02); C726(1.18)  LDD0562  [7]
 LDCM0246  AC128 HEK-293T C1329(0.88); C726(1.07)  LDD0844  [7]
 LDCM0247  AC129 HEK-293T C1329(1.35); C726(1.27)  LDD0845  [7]
 LDCM0249  AC130 HEK-293T C1329(0.82); C726(1.16)  LDD0847  [7]
 LDCM0250  AC131 HEK-293T C1329(1.38); C726(1.26)  LDD0848  [7]
 LDCM0251  AC132 HEK-293T C1329(1.23); C726(1.30)  LDD0849  [7]
 LDCM0252  AC133 HEK-293T C1329(1.06); C726(1.39)  LDD0850  [7]
 LDCM0253  AC134 HEK-293T C1329(1.28); C726(1.27)  LDD0851  [7]
 LDCM0254  AC135 HEK-293T C1329(1.48); C726(1.31)  LDD0852  [7]
 LDCM0255  AC136 HEK-293T C1329(0.91); C726(1.15)  LDD0853  [7]
 LDCM0256  AC137 HEK-293T C1329(1.03); C726(1.19)  LDD0854  [7]
 LDCM0257  AC138 HEK-293T C1329(1.47); C726(1.15)  LDD0855  [7]
 LDCM0258  AC139 HEK-293T C1329(1.61); C726(1.30)  LDD0856  [7]
 LDCM0259  AC14 HCT 116 C212(1.29)  LDD0576  [7]
 LDCM0260  AC140 HEK-293T C1329(0.92); C726(1.18)  LDD0858  [7]
 LDCM0261  AC141 HEK-293T C1329(1.48); C726(1.31)  LDD0859  [7]
 LDCM0262  AC142 HEK-293T C1329(0.97); C726(1.40)  LDD0860  [7]
 LDCM0263  AC143 HEK-293T C1329(1.13); C212(1.21)  LDD0861  [7]
 LDCM0264  AC144 HEK-293T C1329(1.00); C212(1.30)  LDD0862  [7]
 LDCM0265  AC145 HEK-293T C1329(1.13); C212(1.32)  LDD0863  [7]
 LDCM0266  AC146 HEK-293T C1329(0.92); C212(1.40)  LDD0864  [7]
 LDCM0267  AC147 HEK-293T C1329(1.33); C212(1.28)  LDD0865  [7]
 LDCM0268  AC148 HEK-293T C1329(0.80); C212(1.25)  LDD0866  [7]
 LDCM0269  AC149 HEK-293T C1329(0.98); C212(0.98)  LDD0867  [7]
 LDCM0270  AC15 HCT 116 C212(1.61)  LDD0587  [7]
 LDCM0271  AC150 HEK-293T C1329(1.07); C212(1.13)  LDD0869  [7]
 LDCM0272  AC151 HEK-293T C1329(0.89); C212(1.17)  LDD0870  [7]
 LDCM0273  AC152 HEK-293T C1329(0.74); C212(1.00)  LDD0871  [7]
 LDCM0274  AC153 HEK-293T C1329(0.91); C212(1.17)  LDD0872  [7]
 LDCM0621  AC154 HEK-293T C1329(0.96); C212(0.95)  LDD2162  [7]
 LDCM0622  AC155 HEK-293T C1329(1.49); C212(1.20)  LDD2163  [7]
 LDCM0623  AC156 HEK-293T C1329(1.07); C212(1.21)  LDD2164  [7]
 LDCM0624  AC157 HEK-293T C1329(1.03); C212(1.53)  LDD2165  [7]
 LDCM0276  AC17 HCT 116 C726(1.11); C212(1.12)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C726(1.29); C212(1.41)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C726(1.06); C212(1.12)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C212(1.23); C726(1.58)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C726(1.09); C212(1.12)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C726(1.11); C212(1.22)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C726(0.95); C212(0.96)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C212(0.98); C726(0.98)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C726(0.97); C212(1.01)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C212(1.09); C726(1.10)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C212(1.34); C726(1.39)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C726(1.47); C212(1.60)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C212(1.43); C726(1.47)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C726(1.24); C212(1.57)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C212(1.00); C726(1.87)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C726(1.40); C212(1.73)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C726(1.23); C212(1.37)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C726(1.81); C212(1.95)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C726(1.65); C212(1.67)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C726(1.83); C212(1.97)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C726(0.83); C212(0.86)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C726(0.81); C212(0.87)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C726(0.80); C212(0.93)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C212(0.87); C726(0.91)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C212(1.09); C726(1.09)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C212(1.16); C726(1.67)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C726(1.17); C212(1.19)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C726(0.93); C212(1.08)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C212(1.06); C726(1.08)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C726(1.11); C212(1.14)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C726(1.14); C212(1.15)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C726(1.24); C212(1.29)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C212(1.23); C726(1.58)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C212(1.12); C726(1.33)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C212(1.25); C726(1.47)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C212(1.70); C726(1.72)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C212(1.22); C726(1.94)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C212(1.66); C726(1.78)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C212(1.00); C726(1.65)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C212(1.28); C726(1.44)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C726(1.27); C212(1.30)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C212(1.30); C726(1.49)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C726(1.05); C212(1.93)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C726(1.41); C212(2.94)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C212(0.92)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C212(1.28)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C212(0.92)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C212(1.47)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C212(0.85)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C212(0.96)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C212(0.89)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C212(0.70)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C212(0.74)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C212(1.07)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C212(1.06)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C212(0.93)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C212(1.09)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C212(1.14)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C212(1.34)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C212(1.23)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C212(1.07)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C212(1.24)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C212(1.73)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C212(1.56)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C212(2.31)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C212(1.29)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C212(1.38)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C212(1.11)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C212(1.27)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C212(1.51)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C212(1.25)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C212(1.13)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C212(2.07)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C726(1.29); C212(1.60)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C726(1.24); C212(1.57)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C726(1.17); C212(1.37)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C726(1.27); C212(1.47)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C212(1.14); C726(1.24)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C212(1.31); C726(1.38)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C726(1.28); C212(1.54)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C212(1.12); C726(1.15)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C726(1.07); C212(1.69)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C726(1.17); C212(1.57)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C726(1.13); C212(1.27)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C726(1.01); C212(1.22)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C212(1.22); C726(1.47)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C726(0.98); C212(1.46)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C726(1.25); C212(1.55)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C726(0.97)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C726(0.65)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C212(1.13)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C212(1.42)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C212(2.72)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C212(1.06); C726(1.02)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa C212(0.00); H907(0.00); C686(0.00)  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C75(1.03); C1299(0.75); C1299(0.48)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C212(1.08)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C212(1.02)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C212(1.02); C726(1.77)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C212(1.47)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C212(1.20)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C212(0.99)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C212(1.17)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C726(1.23); C212(1.25)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C726(1.43); C212(1.65)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C726(1.53); C212(1.57)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C212(1.46); C726(1.69)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C212(1.10); C726(1.17)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C212(0.90)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C212(1.30); C726(1.40)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C212(1.19); C726(1.33)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C212(1.02); C726(1.18)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C726(1.57); C212(1.68)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C726(1.03); C212(1.27)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C726(1.31); C212(1.43)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C726(1.31); C212(1.51)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C212(1.88); C726(1.92)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C212(0.99); C726(1.10)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C212(1.08); C726(1.09)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C212(1.01)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C726(1.02); C212(1.05)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C212(1.13); C726(1.25)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C212(1.24); C726(1.33)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C726(1.19); C212(1.19)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C726(1.45); C212(1.63)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C212(1.28)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C212(1.12)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C212(1.01)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C212(0.95)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C212(0.91)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C212(0.90)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C212(0.96)  LDD0719  [7]
 LDCM0403  CL16 HEK-293T C212(1.00)  LDD1001  [7]
 LDCM0404  CL17 HCT 116 C212(1.05); C726(1.26)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C212(0.94); C726(1.10)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C726(1.01); C212(1.20)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C212(0.97)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C212(1.10); C726(1.13)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C212(1.10); C726(1.26)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C726(0.89); C212(1.01)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C212(0.99); C726(1.23)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C212(0.92); C726(1.04)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C212(0.84); C726(1.22)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C212(1.00); C726(1.06)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C212(1.16); C726(1.10)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C212(1.05); C726(1.28)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C212(0.96); C726(0.93)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C212(0.86)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C212(0.80); C726(0.98)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C212(0.91); C726(1.07)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C212(0.97); C726(1.06)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C212(1.00); C726(1.18)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C212(1.06); C726(1.06)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C212(1.09); C726(1.11)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C212(1.10); C726(1.26)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C212(1.03); C726(1.05)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C212(0.94); C726(1.02)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C212(0.98)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C212(1.01); C726(1.05)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C212(0.95); C726(1.01)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C212(0.95); C726(1.06)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C212(1.00); C726(1.02)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C212(0.96); C726(0.92)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C212(0.97); C726(1.00)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C212(0.99); C726(1.13)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C212(1.05); C726(1.22)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C212(0.98); C726(1.10)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C212(1.11); C726(1.09)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C212(0.92)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C212(0.98); C726(1.21)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C212(1.02); C726(1.26)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C212(1.32); C726(1.24)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C212(1.00); C726(1.02)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C212(0.99); C726(0.99)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C212(1.02); C726(1.14)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C212(0.92); C726(1.15)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C212(1.05); C726(0.94)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C212(1.07); C726(1.08)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C212(0.95); C726(1.02)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C212(0.96)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C212(1.02); C726(1.27)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C212(1.11); C726(1.08)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C212(1.01); C726(1.11)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C212(0.92); C726(1.02)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C212(1.01); C726(1.09)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C212(1.02); C726(1.01)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C212(1.01); C726(0.98)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C212(0.87); C726(0.87)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C212(0.94); C726(0.95)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C212(1.08); C726(0.95)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C212(0.87)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C212(0.98); C726(0.97)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C212(1.17); C726(1.02)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C212(1.38); C726(1.22)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C212(1.00); C726(0.94)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C212(1.11); C726(1.02)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C212(1.07); C726(1.34)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C212(1.12); C726(1.14)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C212(1.38); C726(1.43)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C212(1.08); C726(1.46)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C212(0.97)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C212(1.03); C726(1.06)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C212(1.09); C726(1.46)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C212(1.11); C726(1.98)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C212(1.10); C726(1.76)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C212(1.14); C726(1.62)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C212(1.14); C726(1.55)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C212(1.09); C726(1.29)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C212(1.08); C726(1.17)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C212(1.08); C726(1.63)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C212(1.16); C726(2.22)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C212(1.06)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C212(1.13); C726(0.92)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C212(1.20); C726(1.23)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C212(0.93); C726(1.38)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C212(0.90); C726(1.16)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C212(1.20); C726(2.81)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C212(1.05); C726(2.30)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C212(1.07); C726(1.98)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C212(1.08); C726(2.37)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C212(1.21); C726(2.61)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C212(1.18); C726(2.14)  LDD0811  [7]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C726(4.45)  LDD0513  [17]
 LDCM0495  E2913 HEK-293T C726(1.00); C1722(1.14); C1329(1.12); C686(0.88)  LDD1698  [18]
 LDCM0625  F8 Ramos C212(2.07)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C212(0.49)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C212(3.74)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C212(0.39)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C212(0.77)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C212(2.44)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C212(0.41)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C212(0.65)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C212(0.67)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C212(0.74)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C212(0.45)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C212(0.99)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C212(0.70)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C212(0.66)  LDD2201  [19]
 LDCM0468  Fragment33 HCT 116 C212(1.04); C726(0.98)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C212(0.36)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C212(0.57)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C212(1.27); C726(1.23)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C212(1.10)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C212(0.89)  LDD2205  [19]
 LDCM0571  Fragment9 Ramos C212(0.57)  LDD2188  [19]
 LDCM0107  IAA HeLa H510(0.00); H907(0.00)  LDD0221  [14]
 LDCM0022  KB02 HCT 116 C1329(1.69); C726(2.15); C212(1.77)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C1329(1.58); C726(1.37); C212(1.42)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C1329(1.92); C726(1.77); C212(1.51)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0224  [14]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C75(1.71)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C75(0.66)  LDD2109  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C75(0.14)  LDD2137  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C75(0.54)  LDD2144  [4]
 LDCM0001  Panyain_cp1 HEK-293T 3.09  LDD0040  [5]
 LDCM0021  THZ1 HCT 116 C212(1.20)  LDD2173  [7]

References

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2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Correction to "Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity". J Am Chem Soc. 2020 Sep 2;142(35):15199. doi: 10.1021/jacs.0c08385. Epub 2020 Aug 19.
Mass spectrometry data entry: PXD015825
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578