Details of the Target

General Information of Target

Target ID LDTP07227
Target Name Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1)
Gene Name CDKAL1
Gene ID 54901
Synonyms
Threonylcarbamoyladenosine tRNA methylthiotransferase; EC 2.8.4.5; CDK5 regulatory subunit-associated protein 1-like 1; tRNA-t(6)A37 methylthiotransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTI
PGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFR
NSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVD
RAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILE
HLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDL
SRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIY
ESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSHTSAASQCDS
ASSRMVLPMPRLHQDCALRMSVGLALLGLLFAFFVKVYN
Target Bioclass
Enzyme
Family
Methylthiotransferase family, CDKAL1 subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Uniprot ID
Q5VV42
Ensemble ID
ENST00000274695.8
HGNC ID
HGNC:21050

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.D361N DBIA    Probe Info 
CCK81 SNV: p.H225R .
FUOV1 SNV: p.I208T DBIA    Probe Info 
HCT15 SNV: p.G213R DBIA    Probe Info 
MFE319 SNV: p.P468S .
TC71 SNV: p.K150E DBIA    Probe Info 
TF1 SNV: p.H425P DBIA    Probe Info 
U87MG SNV: p.A115G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.64  LDD0402  [1]
HDSF-alk
 Probe Info  		1.73  LDD0197  [2]
DA-P2
 Probe Info  		30.03  LDD0348  [3]
HRP
 Probe Info  		27.81  LDD0347  [3]
CHEMBL5175495
 Probe Info  		25.68  LDD0196  [4]
STPyne
 Probe Info  		K488(8.13)  LDD0277  [5]
Dasatinib-CA-4PAP
 Probe Info  		4.15  LDD0270  [6]
P12
 Probe Info  		20.00  LDD0202  [7]
BTD
 Probe Info  		C138(0.52)  LDD2099  [8]
Johansson_61
 Probe Info  		_(4.35)  LDD1487  [9]
IMP-1710
 Probe Info  		2.38  LDD0040  [10]
AHL-Pu-1
 Probe Info  		C109(4.17)  LDD0170  [11]
Alkyne-RA190
 Probe Info  		2.85  LDD0299  [12]
DBIA
 Probe Info  		C338(0.91)  LDD0078  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C109(0.00); C138(0.00); C6(0.00); C338(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C138(0.00); C6(0.00); C73(0.00); C338(0.00)  LDD0036  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C138(0.00); C6(0.00); C338(0.00)  LDD0037  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [16]
NAIA_4
 Probe Info  		C6(0.00); C138(0.00); C538(0.00)  LDD2226  [17]
TFBX
 Probe Info  		C138(0.00); C538(0.00)  LDD0027  [16]
DA-P3
 Probe Info  		N.A.  LDD0178  [3]
Compound 10
 Probe Info  		C138(0.00); C538(0.00)  LDD2216  [18]
Compound 11
 Probe Info  		C138(0.00); C538(0.00)  LDD2213  [18]
ENE
 Probe Info  		N.A.  LDD0006  [19]
IPM
 Probe Info  		C538(0.00); C556(0.00); C138(0.00)  LDD0005  [19]
VSF
 Probe Info  		N.A.  LDD0007  [19]
Phosphinate-6
 Probe Info  		C6(0.00); C138(0.00)  LDD0018  [20]
W1
 Probe Info  		N.A.  LDD0236  [21]
AOyne
 Probe Info  		6.90  LDD0443  [22]
NAIA_5
 Probe Info  		N.A.  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		7.78  LDD1740  [23]
C091
 Probe Info  		18.13  LDD1782  [23]
C092
 Probe Info  		29.86  LDD1783  [23]
C094
 Probe Info  		31.78  LDD1785  [23]
C112
 Probe Info  		20.11  LDD1799  [23]
C134
 Probe Info  		29.24  LDD1816  [23]
C201
 Probe Info  		32.00  LDD1877  [23]
C206
 Probe Info  		17.03  LDD1881  [23]
C210
 Probe Info  		46.21  LDD1884  [23]
C218
 Probe Info  		12.13  LDD1892  [23]
C231
 Probe Info  		19.56  LDD1904  [23]
C235
 Probe Info  		30.70  LDD1908  [23]
C238
 Probe Info  		11.96  LDD1911  [23]
C285
 Probe Info  		31.56  LDD1955  [23]
C287
 Probe Info  		12.47  LDD1957  [23]
C288
 Probe Info  		7.78  LDD1958  [23]
C289
 Probe Info  		47.84  LDD1959  [23]
C343
 Probe Info  		13.45  LDD2005  [23]
C349
 Probe Info  		9.51  LDD2010  [23]
C350
 Probe Info  		23.75  LDD2011  [23]
C362
 Probe Info  		29.04  LDD2023  [23]
C366
 Probe Info  		5.24  LDD2027  [23]
FFF probe11
 Probe Info  		20.00  LDD0471  [24]
FFF probe13
 Probe Info  		20.00  LDD0475  [24]
FFF probe14
 Probe Info  		20.00  LDD0477  [24]
FFF probe2
 Probe Info  		20.00  LDD0463  [24]
FFF probe3
 Probe Info  		11.66  LDD0465  [24]
OEA-DA
 Probe Info  		4.57  LDD0046  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C109(4.17)  LDD0170  [11]
 LDCM0026  4SU-RNA+native RNA DM93 C556(5.15); C538(3.51)  LDD0171  [11]
 LDCM0214  AC1 HCT 116 C138(0.86)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C109(0.91); C138(0.97); C556(1.24)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C109(1.50); C138(1.11); C556(0.76)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C109(1.29); C138(1.08); C556(0.81)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C109(1.79); C138(1.10); C556(0.76)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C109(1.46); C138(1.20); C556(0.91)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C109(1.46); C138(1.08); C556(0.78)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C109(1.12); C138(1.20); C556(0.75)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C109(1.33); C138(1.23); C556(0.86)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C109(1.42); C138(1.14); C556(0.66)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C109(1.46); C138(1.19); C556(0.57)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C109(1.73); C138(1.05); C556(0.72)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C109(1.15); C138(1.15); C556(1.14)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C109(1.69); C138(1.17); C556(0.70)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C109(1.64); C138(1.15); C556(0.66)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C109(1.37); C138(1.36); C556(0.75)  LDD0546  [13]
 LDCM0230  AC113 HEK-293T C338(0.75); C556(1.08)  LDD0828  [13]
 LDCM0231  AC114 HEK-293T C338(1.37); C556(1.02)  LDD0829  [13]
 LDCM0232  AC115 HEK-293T C338(1.28); C556(2.43)  LDD0830  [13]
 LDCM0233  AC116 HEK-293T C338(1.11); C556(1.32)  LDD0831  [13]
 LDCM0234  AC117 HEK-293T C338(1.22); C556(0.95)  LDD0832  [13]
 LDCM0235  AC118 HEK-293T C338(1.06); C556(1.09)  LDD0833  [13]
 LDCM0236  AC119 HEK-293T C338(1.24); C556(1.30)  LDD0834  [13]
 LDCM0237  AC12 HCT 116 C109(1.01); C138(1.08); C556(1.06)  LDD0554  [13]
 LDCM0238  AC120 HEK-293T C338(1.19); C556(1.57)  LDD0836  [13]
 LDCM0239  AC121 HEK-293T C338(1.02); C556(1.59)  LDD0837  [13]
 LDCM0240  AC122 HEK-293T C338(1.00); C556(1.88)  LDD0838  [13]
 LDCM0241  AC123 HEK-293T C338(1.17); C556(1.94)  LDD0839  [13]
 LDCM0242  AC124 HEK-293T C338(1.48); C556(1.85)  LDD0840  [13]
 LDCM0243  AC125 HEK-293T C338(1.07); C556(2.11)  LDD0841  [13]
 LDCM0244  AC126 HEK-293T C338(1.31); C556(2.26)  LDD0842  [13]
 LDCM0245  AC127 HEK-293T C338(1.69); C556(2.15)  LDD0843  [13]
 LDCM0246  AC128 HCT 116 C138(1.02)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C138(0.98)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C138(1.22)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C138(0.86)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C138(1.20)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C138(1.10)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C138(1.36)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C138(1.09)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C138(1.07)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C138(1.01)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C138(1.30)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C138(1.39)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C109(0.87); C138(0.99); C556(1.01)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C138(1.33)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C138(1.20)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C138(1.12)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C556(1.16)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C556(1.53)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C556(1.20)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C556(1.46)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C556(1.46)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C556(2.03)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C556(1.89)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C138(1.05); C109(1.05); C556(1.22)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C556(1.26)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C556(1.06)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C556(1.67)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C556(2.24)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C556(1.50)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C556(1.43)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C556(1.12)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C556(1.03)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C556(0.93); C109(0.94); C138(1.07)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C109(1.00); C556(1.11); C138(1.27)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C109(0.88); C556(1.03); C138(1.04)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C138(0.89)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C109(0.94); C138(0.98); C556(1.13)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C109(0.91); C138(1.01); C556(1.05)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C109(0.70); C556(1.04); C138(1.08)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C109(0.86); C138(1.04); C556(1.48)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C109(0.82); C556(0.84); C138(1.04)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C138(1.00)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C138(1.08)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C138(1.14)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C138(1.11)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C138(1.17)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C138(0.81)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C138(1.08)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C138(1.11)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C138(1.18)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C138(1.22)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C138(1.33)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C138(1.05)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C138(1.17)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C138(1.29)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C138(1.25)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C138(1.07)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C138(0.85)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C138(1.46)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C138(1.23)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C138(1.23)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C138(1.47)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C138(1.40)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C138(1.73)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C109(0.75)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C109(0.80)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C109(0.67)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C109(0.89)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C138(0.85)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C109(0.80)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C109(0.70)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C109(0.67)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C109(0.73)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C109(0.69)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C109(0.74)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C109(0.46)  LDD0636  [13]
 LDCM0320  AC57 HEK-293T C138(0.95); C221(0.99)  LDD0918  [13]
 LDCM0321  AC58 HEK-293T C138(1.04); C221(1.07)  LDD0919  [13]
 LDCM0322  AC59 HEK-293T C138(1.09); C221(1.12)  LDD0920  [13]
 LDCM0323  AC6 HCT 116 C138(1.00); C556(1.22); C109(1.29)  LDD0640  [13]
 LDCM0324  AC60 HEK-293T C138(1.09); C221(1.20)  LDD0922  [13]
 LDCM0325  AC61 HEK-293T C138(1.06); C221(1.07)  LDD0923  [13]
 LDCM0326  AC62 HEK-293T C138(1.15); C221(1.16)  LDD0924  [13]
 LDCM0327  AC63 HEK-293T C138(1.04); C221(1.36)  LDD0925  [13]
 LDCM0328  AC64 HEK-293T C138(1.21); C221(1.15)  LDD0926  [13]
 LDCM0329  AC65 HEK-293T C138(1.08); C221(1.27)  LDD0927  [13]
 LDCM0330  AC66 HEK-293T C138(1.09); C221(1.14)  LDD0928  [13]
 LDCM0331  AC67 HEK-293T C138(1.02); C221(1.21)  LDD0929  [13]
 LDCM0332  AC68 HEK-293T C556(1.05)  LDD0930  [13]
 LDCM0333  AC69 HEK-293T C556(1.05)  LDD0931  [13]
 LDCM0334  AC7 HCT 116 C138(1.17); C109(1.38); C556(1.71)  LDD0651  [13]
 LDCM0335  AC70 HEK-293T C556(1.18)  LDD0933  [13]
 LDCM0336  AC71 HEK-293T C556(1.14)  LDD0934  [13]
 LDCM0337  AC72 HEK-293T C556(1.25)  LDD0935  [13]
 LDCM0338  AC73 HEK-293T C556(1.27)  LDD0936  [13]
 LDCM0339  AC74 HEK-293T C556(1.25)  LDD0937  [13]
 LDCM0340  AC75 HEK-293T C556(1.18)  LDD0938  [13]
 LDCM0341  AC76 HEK-293T C556(1.06)  LDD0939  [13]
 LDCM0342  AC77 HEK-293T C556(1.14)  LDD0940  [13]
 LDCM0343  AC78 HEK-293T C556(1.06)  LDD0941  [13]
 LDCM0344  AC79 HEK-293T C556(1.00)  LDD0942  [13]
 LDCM0345  AC8 HCT 116 C109(1.14); C138(1.18); C556(1.21)  LDD0662  [13]
 LDCM0346  AC80 HEK-293T C556(1.24)  LDD0944  [13]
 LDCM0347  AC81 HEK-293T C556(1.28)  LDD0945  [13]
 LDCM0348  AC82 HEK-293T C556(1.42)  LDD0946  [13]
 LDCM0349  AC83 HCT 116 C138(1.56); C556(1.60)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C556(1.55); C138(1.65)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C138(1.19); C556(1.51)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C138(1.51); C556(1.60)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C556(1.08); C138(1.38)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C138(1.08); C556(1.17)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C138(1.04); C556(1.33)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C556(0.94); C138(1.04)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C556(1.55); C138(1.80)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C138(1.06); C556(1.49)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C138(0.92); C556(1.18)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C138(0.85); C556(1.34)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C138(1.06); C556(1.22)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C138(1.10); C556(1.27)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C138(1.48); C556(1.50)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C138(1.25); C109(1.26); C556(1.36)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C556(0.85); C138(1.17); C109(1.33)  LDD0683  [13]
 LDCM0248  AKOS034007472 HCT 116 C109(1.11); C138(1.02); C556(1.12)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C109(1.01); C138(1.15); C556(1.23)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C138(0.91); C109(1.31); C556(1.71)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 11.40  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C338(0.91)  LDD0078  [13]
 LDCM0088  C45 HEK-293T 20.00  LDD0202  [7]
 LDCM0087  Capsaicin HEK-293T 42.48  LDD0185  [3]
 LDCM0367  CL1 HCT 116 C138(1.05); C109(1.17); C556(1.24)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C138(0.85); C109(1.31); C556(1.32)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C138(0.88)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C138(0.84); C109(1.49); C556(1.70)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C138(0.84); C109(0.88); C556(1.48)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C109(0.92); C138(0.93); C556(3.67)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C109(0.86); C138(1.01); C556(1.66)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C109(0.95); C138(1.09); C556(1.53)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C109(1.15); C138(1.16); C556(1.40)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C109(0.88); C138(1.10); C556(1.15)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C556(0.93); C109(1.00); C138(1.19)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C109(0.91); C138(1.13); C556(1.55)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C138(0.90); C556(1.31); C109(1.72)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C109(1.04); C138(1.18); C556(1.66)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C109(1.00); C138(1.03); C556(1.40)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C138(0.92)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C138(1.06)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C138(1.09)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C138(1.14)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C138(1.13)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C138(1.39)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C138(1.06)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C138(1.05)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C138(0.96); C556(1.11); C109(1.52)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C138(1.11)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C109(0.80)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C109(0.62)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C109(0.59)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C109(0.57)  LDD0712  [13]
 LDCM0396  CL125 HEK-293T C138(1.14); C221(1.07)  LDD0994  [13]
 LDCM0397  CL126 HEK-293T C138(0.85); C221(1.19)  LDD0995  [13]
 LDCM0398  CL127 HEK-293T C138(1.11); C221(1.27)  LDD0996  [13]
 LDCM0399  CL128 HEK-293T C138(1.16); C221(1.29)  LDD0997  [13]
 LDCM0400  CL13 HCT 116 C138(0.93); C556(1.09); C109(1.27)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C138(0.95); C556(1.13); C109(1.23)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C138(0.86); C556(1.10); C109(1.42)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C138(0.86); C109(0.98)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C109(0.90)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C109(1.05)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C109(0.82)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C138(0.88); C556(1.12); C109(1.15)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C109(0.96)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C109(1.09)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C109(1.33)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C109(1.03)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C109(1.20)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C109(1.28)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C109(1.01)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C109(1.08)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C109(0.90)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C109(1.07)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C109(0.98); C138(0.86); C556(1.26)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C109(1.01)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C109(0.77); C138(0.99); C556(3.05)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C109(1.00); C138(1.02); C556(1.02)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C109(1.05); C138(0.88); C556(2.46)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C109(1.08); C138(0.93); C556(2.45)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C109(0.93); C138(0.96); C556(1.03)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C109(1.08); C138(0.98); C556(2.34)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C109(0.94); C138(0.94); C556(1.23)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C109(0.95); C138(1.07); C556(1.37)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C109(1.00); C138(0.91); C556(1.31)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C109(0.85); C138(0.95); C556(1.98)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C109(1.20); C138(1.04); C556(1.37)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C109(1.06); C138(0.99); C556(1.79)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C109(1.33); C138(0.96); C556(1.17)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C109(0.99); C138(0.97); C556(1.37)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C109(1.05); C138(1.05); C556(2.35)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C109(0.93); C556(1.12)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C109(0.80); C556(1.00)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C109(0.93); C556(1.60)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C109(0.88); C556(1.31)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C109(1.04); C138(0.96); C556(0.97)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C109(0.92); C556(1.69)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C109(0.97); C556(2.08)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C109(0.88); C556(1.21)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C109(0.98); C556(1.41)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C109(1.05); C556(2.54)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C109(0.91); C556(0.88)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C109(0.95); C556(0.84)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C109(0.93); C556(1.42)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C109(0.95); C556(0.95)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C109(1.04); C556(1.04)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C109(1.22); C138(0.95); C556(1.46)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C109(1.07); C556(1.23)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C138(0.88)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C138(0.92)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C138(1.12)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C138(1.07)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C138(0.96)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C138(0.89)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C138(0.87)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C138(0.89)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C138(1.00)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C109(1.06); C138(1.06); C556(1.21)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C138(0.82)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C138(0.98)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C138(0.87)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C138(0.85)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C138(1.05)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C138(0.85)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C138(0.92)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C138(0.84)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C138(0.86)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C109(1.64); C138(0.91); C556(1.04)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C138(0.91)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C138(0.79)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C138(0.75)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C138(0.77)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C138(0.89)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C138(0.90)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C138(0.87)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C138(0.76)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C138(0.85)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C138(0.87)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C109(1.23); C138(0.97); C556(1.13)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C138(0.80)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C138(0.88)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C138(0.73)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C138(1.07)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C138(0.85)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C138(0.85)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C138(0.79)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C138(0.87)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C138(1.03)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C138(0.82)  LDD0811  [13]
 LDCM0097  Dasatinib K562 4.15  LDD0270  [6]
 LDCM0028  Dobutamine HEK-293T 7.73  LDD0180  [3]
 LDCM0027  Dopamine HEK-293T 10.02  LDD0179  [3]
 LDCM0495  E2913 HEK-293T C556(1.00); C138(0.82); C364(0.91); C221(1.15)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C138(1.85)  LDD1702  [8]
 LDCM0031  Epigallocatechin gallate HEK-293T 9.48  LDD0183  [3]
 LDCM0625  F8 Ramos C556(1.37); C138(0.71); C538(1.78)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C556(3.25); C538(2.15); C6(1.35)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C556(6.27); C138(1.15); C6(0.92)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C138(1.09); C538(0.97)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C556(1.53); C138(1.26); C538(0.79)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C138(0.98); C538(2.64); C6(1.22)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C138(1.31); C538(2.74)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C556(1.95); C138(1.19); C538(0.68); C6(0.16)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C556(0.65); C138(1.05); C538(0.59); C6(0.11)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C556(0.82); C138(1.02); C538(0.66)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C556(1.09); C138(0.76); C538(1.01)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C556(1.53); C138(1.09); C538(1.04)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C556(1.30); C138(1.13); C538(0.74)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C556(3.49); C538(1.74)  LDD2201  [27]
 LDCM0468  Fragment33 HCT 116 C138(0.89)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C556(2.71); C138(0.70); C538(0.97); C6(0.13)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C538(1.69)  LDD2184  [27]
 LDCM0427  Fragment51 HCT 116 C109(0.68); C138(0.97); C556(2.09)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C556(3.67); C138(1.67); C538(1.11)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C556(1.21); C138(1.21); C538(1.08); C6(1.06)  LDD2205  [27]
 LDCM0615  Fragment63-R Jurkat _(4.35)  LDD1487  [9]
 LDCM0617  Fragment63-S Jurkat _(5.32)  LDD1490  [9]
 LDCM0569  Fragment7 Ramos C138(1.13); C538(2.20)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C556(1.59); C138(2.11); C538(3.59); C6(0.16)  LDD2188  [27]
 LDCM0022  KB02 HEK-293T C338(1.01); C538(1.02)  LDD1492  [26]
 LDCM0023  KB03 Jurkat C556(50.51)  LDD0209  [28]
 LDCM0024  KB05 HMCB C68(3.11)  LDD3312  [29]
 LDCM0030  Luteolin HEK-293T 24.55  LDD0182  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C138(0.52)  LDD2099  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C338(0.95)  LDD2123  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C138(0.22)  LDD2137  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C138(1.10); C538(0.37)  LDD2206  [30]
 LDCM0628  OTUB2-COV-1 HEK-293T C538(0.82); C138(0.79)  LDD2207  [30]
 LDCM0001  Panyain_cp1 HEK-293T 2.38  LDD0040  [10]
 LDCM0029  Quercetin HEK-293T 18.99  LDD0181  [3]
 LDCM0131  RA190 MM1.R 2.85  LDD0299  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein kinase Lck (LCK) Tyr protein kinase family P06239
Ataxin-3 (ATXN3) . P54252
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
7 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
10 Correction to "Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity". J Am Chem Soc. 2020 Sep 2;142(35):15199. doi: 10.1021/jacs.0c08385. Epub 2020 Aug 19.
Mass spectrometry data entry: PXD015825
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD047840
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