Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Dasatinib-CA-4PAP  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Dasatinib  Competitor Info 
Competitor Concentration 20 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Chronic myeloid leukemia [ICD-11:2A20]
Model Name Human chronic myeloid leukemia cell lysate (K562)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 17 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02232  Tyrosine-protein kinase Lyn (LYN) 27.7
 LDTP03989  Tyrosine-protein kinase Tec (TEC) 21.5
 LDTP06547  Mitogen-activated protein kinase 14 (MAPK14) 17.1
 LDTP03944  Tyrosine-protein kinase CSK (CSK) 16.1
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 15.0
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 10.6
 LDTP04689  Adenosine kinase (ADK) 9.8
 LDTP10930  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) 9.3
 LDTP04353  Protoporphyrinogen oxidase (PPOX) 7.3
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 7.0
 LDTP11247  Oxidoreductase HTATIP2 (HTATIP2) 6.6
 LDTP05480  Amidophosphoribosyltransferase (PPAT) 6.0
 LDTP12180  Retinol dehydrogenase 14 (RDH14) 5.4
 LDTP04183  Lanosterol synthase (LSS) 5.4
 LDTP12048  Complex I assembly factor ACAD9, mitochondrial (ACAD9) 4.4
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1) 4.2
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 4.2
Transporter and channel
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06144  Equilibrative nucleoside transporter 2 (SLC29A2) 9.3
 LDTP02122  Integrin beta-1 (ITGB1) 7.4
Other
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP17214  Protein odr-4 homolog (ODR4) 4.0

References

1 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.