Details of the Target

General Information of Target

Target ID LDTP03769
Target Name Sterol O-acyltransferase 1 (SOAT1)
Gene Name SOAT1
Gene ID 6646
Synonyms
ACACT; ACACT1; ACAT; ACAT1; SOAT; STAT; Sterol O-acyltransferase 1; EC 2.3.1.26; Acyl-coenzyme A:cholesterol acyltransferase 1; ACAT-1; Cholesterol acyltransferase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEE
LKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGK
IFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGK
FPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPT
YVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYF
LFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSAR
VLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTW
NVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFM
FFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVR
PRSWTCRYVF
Target Bioclass
Enzyme
Family
Membrane-bound acyltransferase family, Sterol o-acyltransferase subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol . Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions.
Uniprot ID
P35610
Ensemble ID
ENST00000367619.8
HGNC ID
HGNC:11177
ChEMBL ID
CHEMBL2782

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.W438C .
HUH7 Insertion: p.R547PfsTer30 .
KYSE410 Deletion: p.S220FfsTer57 .
NCIH1155 SNV: p.M7I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.75  LDD0402  [1]
HDSF-alk
 Probe Info  		2.25  LDD0197  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
STPyne
 Probe Info  		K104(1.49); K120(10.00); K283(6.46); K353(3.80)  LDD0277  [4]
BTD
 Probe Info  		C528(1.64)  LDD1699  [5]
ONAyne
 Probe Info  		K283(10.00)  LDD0275  [4]
Dasatinib-CA-4PAP
 Probe Info  		4.17  LDD0270  [6]
P13
 Probe Info  		6.91  LDD0203  [7]
AHL-Pu-1
 Probe Info  		C92(2.01)  LDD0168  [8]
Acrolein
 Probe Info  		N.A.  LDD0221  [9]
DBIA
 Probe Info  		C92(1.14)  LDD0078  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [12]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
NAIA_5
 Probe Info  		N.A.  LDD2225  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
WYneN
 Probe Info  		N.A.  LDD0021  [15]
1d-yne
 Probe Info  		N.A.  LDD0356  [16]
Compound 10
 Probe Info  		N.A.  LDD2216  [17]
Compound 11
 Probe Info  		N.A.  LDD2213  [17]
IPM
 Probe Info  		N.A.  LDD0005  [15]
VSF
 Probe Info  		N.A.  LDD0007  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [9]
AOyne
 Probe Info  		12.00  LDD0443  [18]
PAL-AfBPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		5.78  LDD1714  [19]
C040
 Probe Info  		7.06  LDD1740  [19]
C094
 Probe Info  		26.35  LDD1785  [19]
C112
 Probe Info  		17.27  LDD1799  [19]
C140
 Probe Info  		7.73  LDD1822  [19]
C158
 Probe Info  		9.85  LDD1838  [19]
C164
 Probe Info  		4.99  LDD1844  [19]
C220
 Probe Info  		17.03  LDD1894  [19]
C228
 Probe Info  		18.90  LDD1901  [19]
C234
 Probe Info  		12.91  LDD1907  [19]
C266
 Probe Info  		9.85  LDD1937  [19]
C285
 Probe Info  		19.56  LDD1955  [19]
C289
 Probe Info  		25.63  LDD1959  [19]
C299
 Probe Info  		6.59  LDD1968  [19]
C326
 Probe Info  		7.52  LDD1990  [19]
C349
 Probe Info  		13.18  LDD2010  [19]
C350
 Probe Info  		26.17  LDD2011  [19]
C353
 Probe Info  		6.59  LDD2014  [19]
C362
 Probe Info  		27.47  LDD2023  [19]
C363
 Probe Info  		15.45  LDD2024  [19]
C409
 Probe Info  		5.35  LDD2066  [19]
C431
 Probe Info  		14.42  LDD2086  [19]
FFF probe11
 Probe Info  		12.05  LDD0471  [20]
FFF probe13
 Probe Info  		20.00  LDD0475  [20]
FFF probe14
 Probe Info  		20.00  LDD0477  [20]
FFF probe3
 Probe Info  		20.00  LDD0464  [20]
JN0003
 Probe Info  		14.79  LDD0469  [20]
STS-2
 Probe Info  		N.A.  LDD0138  [21]
AEA-DA
 Probe Info  		3.74  LDD0333  [22]
DA-2
 Probe Info  		N.A.  LDD0072  [23]
OEA-DA
 Probe Info  		20.00  LDD0046  [22]
STS-1
 Probe Info  		N.A.  LDD0069  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C528(1.09)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C528(1.33)  LDD2112  [5]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C528(0.61)  LDD2095  [5]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C528(0.72)  LDD2130  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C528(0.87)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C528(1.01)  LDD2152  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C528(0.94)  LDD2103  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C528(0.92)  LDD2132  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C528(0.56)  LDD2131  [5]
 LDCM0025  4SU-RNA HEK-293T C92(2.01)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C92(2.05)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C92(1.07)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C92(1.23)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C92(1.08)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C92(1.29)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C92(1.15)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C92(1.32)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C92(1.08)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C92(1.38)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C92(1.40)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C92(1.25)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C92(1.03)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C92(0.98)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C92(1.44)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C92(1.21)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C92(1.28)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C92(1.19)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C92(0.93)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C92(0.97)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C92(0.86)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C92(0.99)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C92(0.94)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C92(0.99)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C92(0.99)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C92(1.00)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C92(1.13)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C92(0.89)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C92(0.96)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C92(0.95)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C92(0.92)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C92(0.98)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C92(1.02)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C92(0.92)  LDD0562  [10]
 LDCM0246  AC128 PaTu 8988t C92(1.38)  LDD1125  [10]
 LDCM0247  AC129 PaTu 8988t C92(1.57)  LDD1126  [10]
 LDCM0249  AC130 PaTu 8988t C92(1.43)  LDD1128  [10]
 LDCM0250  AC131 PaTu 8988t C92(1.27)  LDD1129  [10]
 LDCM0251  AC132 PaTu 8988t C92(1.18)  LDD1130  [10]
 LDCM0252  AC133 PaTu 8988t C92(1.96)  LDD1131  [10]
 LDCM0253  AC134 PaTu 8988t C92(1.76)  LDD1132  [10]
 LDCM0254  AC135 PaTu 8988t C92(2.04)  LDD1133  [10]
 LDCM0255  AC136 PaTu 8988t C92(1.51)  LDD1134  [10]
 LDCM0256  AC137 PaTu 8988t C92(1.79)  LDD1135  [10]
 LDCM0257  AC138 PaTu 8988t C92(1.55)  LDD1136  [10]
 LDCM0258  AC139 PaTu 8988t C92(1.74)  LDD1137  [10]
 LDCM0259  AC14 HCT 116 C92(1.42)  LDD0576  [10]
 LDCM0260  AC140 PaTu 8988t C92(1.42)  LDD1139  [10]
 LDCM0261  AC141 PaTu 8988t C92(1.40)  LDD1140  [10]
 LDCM0262  AC142 PaTu 8988t C92(1.48)  LDD1141  [10]
 LDCM0263  AC143 HCT 116 C92(0.98)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C92(0.82)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C92(0.97)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C92(1.02)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C92(1.18)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C92(0.90)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C92(1.29)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C92(1.38)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C92(0.83)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C92(1.08)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C92(1.28)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C92(0.84)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C92(0.89)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C92(0.80)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C92(1.02)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C92(0.97)  LDD2161  [10]
 LDCM0276  AC17 HEK-293T C92(0.97)  LDD1515  [25]
 LDCM0277  AC18 HEK-293T C92(1.03)  LDD1516  [25]
 LDCM0278  AC19 HEK-293T C92(0.98)  LDD1517  [25]
 LDCM0279  AC2 HCT 116 C92(1.16)  LDD0596  [10]
 LDCM0280  AC20 HEK-293T C92(0.94)  LDD1519  [25]
 LDCM0281  AC21 HEK-293T C92(1.04)  LDD1520  [25]
 LDCM0282  AC22 HEK-293T C92(0.93)  LDD1521  [25]
 LDCM0283  AC23 HEK-293T C92(0.94)  LDD1522  [25]
 LDCM0284  AC24 HEK-293T C92(0.96)  LDD1523  [25]
 LDCM0285  AC25 HEK-293T C92(1.04)  LDD1524  [25]
 LDCM0286  AC26 HEK-293T C92(0.97)  LDD1525  [25]
 LDCM0287  AC27 HEK-293T C92(0.97)  LDD1526  [25]
 LDCM0288  AC28 HEK-293T C92(1.02)  LDD1527  [25]
 LDCM0289  AC29 HEK-293T C92(1.33)  LDD1528  [25]
 LDCM0290  AC3 HCT 116 C92(1.04)  LDD0607  [10]
 LDCM0291  AC30 HEK-293T C92(1.00)  LDD1530  [25]
 LDCM0292  AC31 HEK-293T C92(0.98)  LDD1531  [25]
 LDCM0293  AC32 HEK-293T C92(0.98)  LDD1532  [25]
 LDCM0294  AC33 HEK-293T C92(1.06)  LDD1533  [25]
 LDCM0295  AC34 HEK-293T C92(1.00)  LDD1534  [25]
 LDCM0296  AC35 HEK-293T C92(1.00)  LDD1535  [25]
 LDCM0297  AC36 HEK-293T C92(0.97)  LDD1536  [25]
 LDCM0298  AC37 HEK-293T C92(1.03)  LDD1537  [25]
 LDCM0299  AC38 HEK-293T C92(0.95)  LDD1538  [25]
 LDCM0300  AC39 HEK-293T C92(1.00)  LDD1539  [25]
 LDCM0301  AC4 HCT 116 C92(1.27)  LDD0618  [10]
 LDCM0302  AC40 HEK-293T C92(0.92)  LDD1541  [25]
 LDCM0303  AC41 HEK-293T C92(1.00)  LDD1542  [25]
 LDCM0304  AC42 HEK-293T C92(1.01)  LDD1543  [25]
 LDCM0305  AC43 HEK-293T C92(1.06)  LDD1544  [25]
 LDCM0306  AC44 HEK-293T C92(0.96)  LDD1545  [25]
 LDCM0307  AC45 HEK-293T C92(1.05)  LDD1546  [25]
 LDCM0308  AC46 HCT 116 C92(1.01)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C92(0.96)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C92(0.94)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C92(1.26)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C92(1.29)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C92(1.31)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C92(0.86)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C92(0.98)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C92(1.23)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C92(1.13)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C92(1.33)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C92(1.51)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C92(1.54)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C92(1.95)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C92(1.46)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C92(1.27)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C92(1.60)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C92(1.48)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C92(1.94)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C92(1.69)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C92(1.78)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C92(1.40)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C92(1.41)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C92(1.61)  LDD0648  [10]
 LDCM0334  AC7 HCT 116 C92(1.19)  LDD0651  [10]
 LDCM0345  AC8 HCT 116 C92(1.28)  LDD0662  [10]
 LDCM0349  AC83 HCT 116 C92(1.45)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C92(1.44)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C92(1.26)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C92(1.15)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C92(1.05)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C92(1.17)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C92(1.34)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C92(0.99)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C92(1.65)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C92(1.64)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C92(1.17)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C92(1.26)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C92(1.14)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C92(1.34)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C92(1.39)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C92(1.56)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C92(1.07)  LDD0683  [10]
 LDCM0545  Acetamide MDA-MB-231 C528(0.28)  LDD2138  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C528(0.67)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C92(1.09)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C92(1.21)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C92(1.73)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 12.34  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C92(1.14)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C528(0.34); C92(0.71)  LDD2091  [5]
 LDCM0088  C45 HEK-293T 6.91  LDD0203  [7]
 LDCM0630  CCW28-3 231MFP C92(0.91)  LDD2214  [26]
 LDCM0632  CL-Sc Hep-G2 C92(1.01)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C92(1.13)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C92(1.02)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C92(1.18)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C92(1.45)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C92(1.50)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C92(1.25)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C92(1.36)  LDD0690  [10]
 LDCM0374  CL105 HEK-293T C92(1.02)  LDD1578  [25]
 LDCM0375  CL106 HEK-293T C92(0.93)  LDD1579  [25]
 LDCM0376  CL107 HEK-293T C92(0.93)  LDD1580  [25]
 LDCM0377  CL108 HEK-293T C92(1.02)  LDD1581  [25]
 LDCM0378  CL109 HEK-293T C92(0.98)  LDD1582  [25]
 LDCM0379  CL11 HCT 116 C92(1.11)  LDD0696  [10]
 LDCM0380  CL110 HEK-293T C92(1.09)  LDD1584  [25]
 LDCM0381  CL111 HEK-293T C92(1.04)  LDD1585  [25]
 LDCM0382  CL112 HEK-293T C92(0.99)  LDD1586  [25]
 LDCM0383  CL113 HEK-293T C92(1.06)  LDD1587  [25]
 LDCM0384  CL114 HEK-293T C92(0.96)  LDD1588  [25]
 LDCM0385  CL115 HEK-293T C92(0.82)  LDD1589  [25]
 LDCM0386  CL116 HEK-293T C92(0.96)  LDD1590  [25]
 LDCM0387  CL117 HEK-293T C92(0.97)  LDD1591  [25]
 LDCM0388  CL118 HEK-293T C92(0.85)  LDD1592  [25]
 LDCM0389  CL119 HEK-293T C92(0.90)  LDD1593  [25]
 LDCM0390  CL12 HCT 116 C92(1.06)  LDD0707  [10]
 LDCM0391  CL120 HEK-293T C92(1.04)  LDD1595  [25]
 LDCM0392  CL121 HCT 116 C92(0.84)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C92(1.07)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C92(1.92)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C92(1.30)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C92(1.00)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C92(1.15)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C92(1.20)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C92(1.45)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C92(1.03)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C92(1.13)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C92(1.16)  LDD0719  [10]
 LDCM0403  CL16 HEK-293T C92(0.97)  LDD1607  [25]
 LDCM0404  CL17 HEK-293T C92(1.11)  LDD1608  [25]
 LDCM0405  CL18 HEK-293T C92(1.00)  LDD1609  [25]
 LDCM0406  CL19 HEK-293T C92(0.97)  LDD1610  [25]
 LDCM0407  CL2 HCT 116 C92(1.10)  LDD0724  [10]
 LDCM0408  CL20 HEK-293T C92(0.91)  LDD1612  [25]
 LDCM0409  CL21 HEK-293T C92(1.12)  LDD1613  [25]
 LDCM0410  CL22 HEK-293T C92(0.94)  LDD1614  [25]
 LDCM0411  CL23 HEK-293T C92(0.98)  LDD1615  [25]
 LDCM0412  CL24 HEK-293T C92(0.92)  LDD1616  [25]
 LDCM0413  CL25 HEK-293T C92(0.90)  LDD1617  [25]
 LDCM0414  CL26 HEK-293T C92(0.98)  LDD1618  [25]
 LDCM0415  CL27 HEK-293T C92(0.91)  LDD1619  [25]
 LDCM0416  CL28 HEK-293T C92(1.00)  LDD1620  [25]
 LDCM0417  CL29 HEK-293T C92(0.90)  LDD1621  [25]
 LDCM0418  CL3 HCT 116 C92(1.03)  LDD0735  [10]
 LDCM0419  CL30 HEK-293T C92(0.93)  LDD1623  [25]
 LDCM0420  CL31 HEK-293T C92(0.93)  LDD1624  [25]
 LDCM0421  CL32 HEK-293T C92(0.94)  LDD1625  [25]
 LDCM0422  CL33 HEK-293T C92(1.09)  LDD1626  [25]
 LDCM0423  CL34 HEK-293T C92(0.95)  LDD1627  [25]
 LDCM0424  CL35 HEK-293T C92(0.95)  LDD1628  [25]
 LDCM0425  CL36 HEK-293T C92(0.97)  LDD1629  [25]
 LDCM0426  CL37 HEK-293T C92(0.98)  LDD1630  [25]
 LDCM0428  CL39 HEK-293T C92(0.94)  LDD1632  [25]
 LDCM0429  CL4 HCT 116 C92(1.82)  LDD0746  [10]
 LDCM0430  CL40 HEK-293T C92(0.97)  LDD1634  [25]
 LDCM0431  CL41 HEK-293T C92(0.92)  LDD1635  [25]
 LDCM0432  CL42 HEK-293T C92(1.06)  LDD1636  [25]
 LDCM0433  CL43 HEK-293T C92(0.93)  LDD1637  [25]
 LDCM0434  CL44 HEK-293T C92(0.94)  LDD1638  [25]
 LDCM0435  CL45 HEK-293T C92(1.21)  LDD1639  [25]
 LDCM0436  CL46 PaTu 8988t C92(1.40)  LDD1315  [10]
 LDCM0437  CL47 PaTu 8988t C92(1.00)  LDD1316  [10]
 LDCM0438  CL48 PaTu 8988t C92(1.44)  LDD1317  [10]
 LDCM0439  CL49 PaTu 8988t C92(1.19)  LDD1318  [10]
 LDCM0440  CL5 HCT 116 C92(0.91)  LDD0757  [10]
 LDCM0441  CL50 PaTu 8988t C92(1.36)  LDD1320  [10]
 LDCM0442  CL51 PaTu 8988t C92(1.51)  LDD1321  [10]
 LDCM0443  CL52 PaTu 8988t C92(1.46)  LDD1322  [10]
 LDCM0444  CL53 PaTu 8988t C92(1.25)  LDD1323  [10]
 LDCM0445  CL54 PaTu 8988t C92(1.26)  LDD1324  [10]
 LDCM0446  CL55 PaTu 8988t C92(1.30)  LDD1325  [10]
 LDCM0447  CL56 PaTu 8988t C92(1.20)  LDD1326  [10]
 LDCM0448  CL57 PaTu 8988t C92(1.67)  LDD1327  [10]
 LDCM0449  CL58 PaTu 8988t C92(1.25)  LDD1328  [10]
 LDCM0450  CL59 PaTu 8988t C92(1.26)  LDD1329  [10]
 LDCM0451  CL6 HCT 116 C92(1.07)  LDD0768  [10]
 LDCM0452  CL60 PaTu 8988t C92(1.20)  LDD1331  [10]
 LDCM0453  CL61 HCT 116 C92(0.93)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C92(1.13)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C92(1.09)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C92(1.66)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C92(1.00)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C92(1.74)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C92(1.45)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C92(1.36)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C92(1.59)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C92(0.86)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C92(1.13)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C92(1.15)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C92(0.87)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C92(1.91)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C92(1.39)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C92(1.08)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C92(2.08)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C92(1.26)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C92(1.42)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C92(1.47)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C92(1.46)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C92(1.16)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C92(1.86)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C92(1.61)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C92(2.16)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C92(1.24)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C92(1.05)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C92(1.16)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C92(1.48)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C92(2.14)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C92(1.09)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C92(1.42)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C92(1.04)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C92(1.34)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C92(1.19)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C92(1.37)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C92(1.43)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C92(1.21)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C92(1.12)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C92(1.05)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C92(1.01)  LDD0811  [10]
 LDCM0097  Dasatinib K562 4.17  LDD0270  [6]
 LDCM0495  E2913 HEK-293T C92(0.98)  LDD1698  [25]
 LDCM0625  F8 Ramos C92(1.19)  LDD2187  [27]
 LDCM0574  Fragment12 Ramos C92(1.10)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C92(1.07)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C92(1.87)  LDD2193  [27]
 LDCM0580  Fragment21 Ramos C92(1.54)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C92(0.69)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C92(0.98)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C92(0.90)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C92(0.71)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C92(0.81)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C92(0.72)  LDD2201  [27]
 LDCM0468  Fragment33 HCT 116 C92(1.26)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C92(0.66)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C92(1.01)  LDD2184  [27]
 LDCM0427  Fragment51 HEK-293T C92(0.97)  LDD1631  [25]
 LDCM0610  Fragment52 Ramos C92(0.91)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C92(2.03)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C92(0.96)  LDD2186  [27]
 LDCM0107  IAA HeLa N.A.  LDD0221  [9]
 LDCM0022  KB02 HEK-293T C345(0.95); C92(0.96)  LDD1492  [25]
 LDCM0023  KB03 Jurkat C92(4.20)  LDD0315  [11]
 LDCM0024  KB05 COLO792 C528(4.46)  LDD3310  [28]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C528(0.98)  LDD2102  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C528(0.39)  LDD2121  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [9]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C528(0.53); C92(0.89)  LDD2089  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C528(0.79)  LDD2092  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C528(0.96)  LDD2093  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C528(0.93)  LDD2094  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C528(1.07)  LDD2097  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C528(1.09)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C528(0.75)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C528(2.34)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C528(0.84)  LDD2101  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C528(1.13)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C528(1.03)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C528(1.45)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C528(0.79)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C528(1.00)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C528(0.86)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C528(0.76)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C528(0.96)  LDD2114  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C528(1.07)  LDD2115  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C528(2.29)  LDD2119  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C528(0.91)  LDD2120  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C528(0.82)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C528(0.95)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C528(0.99)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C528(0.73)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C528(0.89)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C528(0.83)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C528(0.81)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C528(1.04)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C528(0.88)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C528(1.03)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C528(0.75)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C528(0.86)  LDD2141  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C528(2.12)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C528(0.95)  LDD2146  [5]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C528(1.86)  LDD2147  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C528(0.48); C92(0.63)  LDD2150  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C528(1.39)  LDD2153  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C92(0.84)  LDD2206  [29]
 LDCM0628  OTUB2-COV-1 HEK-293T C92(0.58)  LDD2207  [29]
 LDCM0131  RA190 MM1.R C92(1.91)  LDD0304  [30]
 LDCM0136  SR-4559 HEK-293T 3.74  LDD0333  [22]
 LDCM0170  Structure8 Ramos 4.00  LDD0433  [31]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) UbiA prenyltransferase family Q9Y5Z9
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 1 (TERF1) . P54274

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ezetimibe Small molecular drug DB00973
Omega-3-acid Ethyl Esters . DB09539
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Hesperetin Small molecular drug DB01094

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
7 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
22 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
23 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
24 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
29 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
30 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
31 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.