General Information of Experiment

Probe Name STS-1  Probe Info 
Probe concentration 10 uM
Criteria Other data
In Vivo Experiment Model Model Type Living cell
Derived Tissue Liver
Disease Model Hepatoblastoma [ICD-11:DB91]
Model Name Human hepatoblastoma cells (Hep-G2)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 90 Protein Related to This Bioclass
Target ID Target Name
 LDTP04499  6-phosphogluconate dehydrogenase, decarboxylating (PGD)
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1)
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)
 LDTP05073  Actin, alpha skeletal muscle (ACTA1)
 LDTP04876  Actin, cytoplasmic 1 (ACTB)
 LDTP06905  Acylglycerol kinase, mitochondrial (AGK)
 LDTP04689  Adenosine kinase (ADK)
 LDTP03242  Adenosylhomocysteinase (AHCY)
 LDTP04636  Adenylate kinase 2, mitochondrial (AK2)
 LDTP00776  Aflatoxin B1 aldehyde reductase member 2 (AKR7A2)
 LDTP02159  Alpha-enolase (ENO1)
 LDTP15993  Aminopeptidase B (RNPEP)
 LDTP01783  Aspartate aminotransferase, mitochondrial (GOT2)
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B)
 LDTP04561  ATP-citrate synthase (ACLY)
 LDTP02925  ATP-dependent 6-phosphofructokinase, liver type (PFKL)
 LDTP02261  ATP-dependent 6-phosphofructokinase, muscle type (PFKM)
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP)
 LDTP00314  ATP-dependent RNA helicase DDX3X (DDX3X)
 LDTP02700  Beta-enolase (ENO3)
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)
 LDTP02909  cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
 LDTP03591  Carbamoyl-phosphate synthase [ammonia], mitochondrial (CPS1)
 LDTP01205  Citrate synthase, mitochondrial (CS)
 LDTP02616  Creatine kinase B-type (CKB)
 LDTP08296  Cullin-associated NEDD8-dissociated protein 1 (CAND1)
 LDTP03610  Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1)
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH)
 LDTP06644  Discoidin domain-containing receptor 2 (DDR2)
 LDTP04286  DNA replication licensing factor MCM2 (MCM2)
 LDTP03681  DNA replication licensing factor MCM5 (MCM5)
 LDTP03682  DNA replication licensing factor MCM7 (MCM7)
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC)
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1)
 LDTP02672  Elongation factor 2 (EEF2)
 LDTP04878  Eukaryotic initiation factor 4A-I (EIF4A1)
 LDTP04243  Fatty acid synthase (FASN)
 LDTP02008  Fructose-bisphosphate aldolase A (ALDOA)
 LDTP02386  Fructose-bisphosphate aldolase C (ALDOC)
 LDTP02235  Fumarate hydratase, mitochondrial (FH)
 LDTP02569  Glucose-6-phosphate 1-dehydrogenase (G6PD)
 LDTP02162  Glucose-6-phosphate isomerase (GPI)
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
 LDTP05007  GTP-binding nuclear protein Ran (RAN)
 LDTP02541  Heat shock cognate 71 kDa protein (HSPA8)
 LDTP02225  Heat shock protein HSP 90-alpha (HSP90AA1)
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)
 LDTP03003  Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)
 LDTP06615  Kynureninase (KYNU)
 LDTP01766  L-lactate dehydrogenase A chain (LDHA)
 LDTP11509  L-lactate dehydrogenase A-like 6B (LDHAL6B)
 LDTP02179  L-lactate dehydrogenase B chain (LDHB)
 LDTP06294  Lysine--tRNA ligase (KARS1)
 LDTP03908  Malate dehydrogenase, mitochondrial (MDH2)
 LDTP02796  Nucleoside diphosphate kinase A (NME1)
 LDTP12610  Obg-like ATPase 1 (OLA1)
 LDTP05028  Peptidyl-prolyl cis-trans isomerase A (PPIA)
 LDTP05503  Peroxiredoxin-1 (PRDX1)
 LDTP03626  Peroxiredoxin-2 (PRDX2)
 LDTP03510  Peroxiredoxin-6 (PRDX6)
 LDTP01787  Phosphoglycerate kinase 1 (PGK1)
 LDTP13750  Proliferation-associated protein 2G4 (PA2G4)
 LDTP03333  Proteasome subunit alpha type-4 (PSMA4)
 LDTP03419  Proteasome subunit beta type-5 (PSMB5)
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1)
 LDTP02188  Protein disulfide-isomerase (P4HB)
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6)
 LDTP02891  Protein kinase C alpha type (PRKCA)
 LDTP18413  Putative tubulin-like protein alpha-4B (TUBA4B)
 LDTP00343  Pyridoxal kinase (PDXK)
 LDTP02733  Pyruvate kinase PKM (PKM)
 LDTP03259  Ribonucleoside-diphosphate reductase large subunit (RRM1)
 LDTP04882  Ribose-phosphate pyrophosphokinase 1 (PRPS1)
 LDTP02592  Ribose-phosphate pyrophosphokinase 2 (PRPS2)
 LDTP03577  S-adenosylmethionine synthase isoform type-2 (MAT2A)
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2)
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1)
 LDTP03819  Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC)
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3)
 LDTP05991  Spliceosome RNA helicase DDX39B (DDX39B)
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1)
 LDTP03365  Threonine--tRNA ligase 1, cytoplasmic (TARS1)
 LDTP03258  Thymidylate kinase (DTYMK)
 LDTP03847  Transaldolase (TALDO1)
 LDTP04665  Transitional endoplasmic reticulum ATPase (VCP)
 LDTP03487  Transketolase (TKT)
 LDTP04851  Triosephosphate isomerase (TPI1)
 LDTP07907  Tubulin alpha-1A chain (TUBA1A)
 LDTP11074  Tubulin alpha-1C chain (TUBA1C)
 LDTP03166  Ubiquitin-like modifier-activating enzyme 1 (UBA1)
Transporter and channel
Click to Show/Hide to Show 22 Protein Related to This Bioclass
Target ID Target Name
 LDTP04969  14-3-3 protein epsilon (YWHAE)
 LDTP04953  14-3-3 protein gamma (YWHAG)
 LDTP03385  14-3-3 protein theta (YWHAQ)
 LDTP05043  14-3-3 protein zeta/delta (YWHAZ)
 LDTP02087  ADP/ATP translocase 2 (SLC25A5)
 LDTP02199  Annexin A2 (ANXA2)
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A)
 LDTP05173  b(0,+)-type amino acid transporter 1 (SLC7A9)
 LDTP03405  Calnexin (CANX)
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1)
 LDTP05252  Clathrin heavy chain 1 (CLTC)
 LDTP03107  Filamin-A (FLNA)
 LDTP01197  Filamin-B (FLNB)
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1)
 LDTP06242  Importin subunit beta-1 (KPNB1)
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2)
 LDTP05273  Spectrin beta chain, non-erythrocytic 1 (SPTBN1)
 LDTP04391  T-complex protein 1 subunit delta (CCT4)
 LDTP01969  Transferrin receptor protein 1 (TFRC)
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1)
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2)
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3)
Other
Click to Show/Hide to Show 54 Protein Related to This Bioclass
Target ID Target Name
 LDTP00843  Alpha-actinin-4 (ACTN4)
 LDTP14951  Beta-actin-like protein 2 (ACTBL2)
 LDTP03367  Elongation factor 1-gamma (EEF1G)
 LDTP02734  Endoplasmin (HSP90B1)
 LDTP09938  Far upstream element-binding protein 2 (KHSRP)
 LDTP06598  Fascin (FSCN1)
 LDTP02434  Heat shock 70 kDa protein 1A (HSPA1A)
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4)
 LDTP02884  Heat shock 70 kDa protein 6 (HSPA6)
 LDTP05697  Heat shock protein 75 kDa, mitochondrial (TRAP1)
 LDTP06032  Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF)
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK)
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR)
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
 LDTP02227  Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)
 LDTP13036  Inhibitor of Bruton tyrosine kinase (IBTK)
 LDTP03755  Keratin, type I cytoskeletal 9 (KRT9)
 LDTP02031  Keratin, type II cytoskeletal 1 (KRT1)
 LDTP03792  Keratin, type II cytoskeletal 2 epidermal (KRT2)
 LDTP04919  Large ribosomal subunit protein eL15 (RPL15)
 LDTP05378  Large ribosomal subunit protein eL6 (RPL6)
 LDTP04106  Large ribosomal subunit protein uL18 (RPL5)
 LDTP05026  Large ribosomal subunit protein uL5 (RPL11)
 LDTP03997  Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC)
 LDTP03346  Moesin (MSN)
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1)
 LDTP06367  Poly(rC)-binding protein 2 (PCBP2)
 LDTP02595  Polyadenylate-binding protein 1 (PABPC1)
 LDTP02596  Proliferating cell nuclear antigen (PCNA)
 LDTP17158  Putative endoplasmin-like protein (HSP90B2P)
 LDTP14956  Putative heat shock protein HSP 90-beta 2 (HSP90AB2P)
 LDTP04355  Rab GDP dissociation inhibitor beta (GDI2)
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1)
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X)
 LDTP04964  Small ribosomal subunit protein eS8 (RPS8)
 LDTP02312  Small ribosomal subunit protein uS2 (RPSA)
 LDTP14323  Small ribosomal subunit protein uS2B (RPSA2)
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5)
 LDTP06376  Splicing factor 3B subunit 3 (SF3B3)
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9)
 LDTP02934  T-complex protein 1 subunit alpha (TCP1)
 LDTP05113  T-complex protein 1 subunit beta (CCT2)
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5)
 LDTP04249  T-complex protein 1 subunit gamma (CCT3)
 LDTP04390  T-complex protein 1 subunit theta (CCT8)
 LDTP03846  Transgelin-2 (TAGLN2)
 LDTP02205  Tubulin beta chain (TUBB)
 LDTP05904  Tubulin beta-3 chain (TUBB3)
 LDTP02037  Tubulin beta-4A chain (TUBB4A)
 LDTP05076  Tubulin beta-4B chain (TUBB4B)
 LDTP06809  Tubulin beta-8 chain (TUBB8)
 LDTP02946  Vinculin (VCL)

References

1 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.