Details of the Target

General Information of Target

Target ID LDTP17158
Target Name Putative endoplasmin-like protein (HSP90B2P)
Gene Name HSP90B2P
Synonyms
GRP94B; GRP94P1; TRAP1; Putative endoplasmin-like protein; Putative heat shock protein 90 kDa beta member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASASARGNQDKDAHFPPPSKQSLLFCPKSKLHIHRAEISKIMRECQEESFWKRALPFSL
VSMLVTQGLVYQGYLAANSRFGSLPKVALAGLLGFGLGKVSYIGVCQSKFHFFEDQLRGA
GFGPQHNRHCLLTCEECKIKHGLSEKGDSQPSAS
Target Bioclass
Other
Family
Heat shock protein 90 family
Function Putative molecular chaperone.
Uniprot ID
Q58FF3
HGNC ID
HGNC:12099

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y58(0.86); Y306(0.88)  LDD0264  [1]
HHS-465
 Probe Info  		Y306(8.37); Y58(10.00)  LDD2237  [2]
Acrolein
 Probe Info  		H157(0.00); H111(0.00)  LDD0217  [3]
Crotonaldehyde
 Probe Info  		H157(0.00); H111(0.00)  LDD0219  [3]
Methacrolein
 Probe Info  		H157(0.00); H111(0.00)  LDD0218  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0069  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0116  HHS-0101 DM93 Y58(0.86); Y306(0.88)  LDD0264  [1]
 LDCM0117  HHS-0201 DM93 Y306(0.67); Y58(0.68)  LDD0265  [1]
 LDCM0118  HHS-0301 DM93 Y306(0.76); Y58(0.81)  LDD0266  [1]
 LDCM0119  HHS-0401 DM93 Y58(0.63); Y306(0.75)  LDD0267  [1]
 LDCM0120  HHS-0701 DM93 Y306(0.34); Y58(0.40)  LDD0268  [1]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0109  NEM HeLa H157(0.00); H111(0.00)  LDD0223  [3]

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
2 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.