Details of the Target

General Information of Target

Target ID LDTP02386
Target Name Fructose-bisphosphate aldolase C (ALDOC)
Gene Name ALDOC
Gene ID 230
Synonyms
ALDC; Fructose-bisphosphate aldolase C; EC 4.1.2.13; Brain-type aldolase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPHSYPALSAEQKKELSDIALRIVAPGKGILAADESVGSMAKRLSQIGVENTEENRRLYR
QVLFSADDRVKKCIGGVIFFHETLYQKDDNGVPFVRTIQDKGIVVGIKVDKGVVPLAGTD
GETTTQGLDGLSERCAQYKKDGADFAKWRCVLKISERTPSALAILENANVLARYASICQQ
NGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHAC
PIKYTPEEIAMATVTALRRTVPPAVPGVTFLSGGQSEEEASFNLNAINRCPLPRPWALTF
SYGRALQASALNAWRGQRDNAGAATEEFIKRAEVNGLAAQGKYEGSGEDGGAAAQSLYIA
NHAY
Target Bioclass
Enzyme
Family
Class I fructose-bisphosphate aldolase family
Uniprot ID
P09972
Ensemble ID
ENST00000226253.9
HGNC ID
HGNC:418
ChEMBL ID
CHEMBL4295709

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		16.00  LDD0385  [1]
Alkylaryl probe 2
 Probe Info  		14.00  LDD0389  [1]
A-EBA
 Probe Info  		4.10  LDD0215  [2]
TG42
 Probe Info  		4.57  LDD0326  [3]
OPA-S-S-alkyne
 Probe Info  		K111(6.08)  LDD3494  [4]
DBIA
 Probe Info  		C256(2.27)  LDD3310  [5]
BTD
 Probe Info  		C135(0.39)  LDD2116  [6]
AHL-Pu-1
 Probe Info  		C202(3.45); C178(4.28)  LDD0170  [7]
HHS-475
 Probe Info  		Y204(1.02); Y138(1.22)  LDD0264  [8]
HHS-465
 Probe Info  		Y138(10.00); Y204(10.00)  LDD2237  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
ATP probe
 Probe Info  		K111(0.00); K42(0.00)  LDD0199  [11]
m-APA
 Probe Info  		H81(0.00); H362(0.00)  LDD2231  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C240(0.00); C73(0.00); C290(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C178(0.00); C202(0.00)  LDD0032  [13]
IPIAA_H
 Probe Info  		C178(0.00); C240(0.00); C202(0.00)  LDD0030  [14]
IPIAA_L
 Probe Info  		C73(0.00); C202(0.00); C178(0.00); C135(0.00)  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C240(0.00); C73(0.00); C290(0.00)  LDD0037  [12]
ATP probe
 Probe Info  		K140(0.00); K42(0.00); K147(0.00)  LDD0035  [15]
NHS
 Probe Info  		N.A.  LDD0010  [16]
SF
 Probe Info  		Y214(0.00); K140(0.00); K13(0.00); K111(0.00)  LDD0028  [17]
STPyne
 Probe Info  		N.A.  LDD0009  [16]
Acrolein
 Probe Info  		C178(0.00); C202(0.00); H197(0.00)  LDD0217  [18]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [18]
Methacrolein
 Probe Info  		C178(0.00); C202(0.00)  LDD0218  [18]
MPP-AC
 Probe Info  		N.A.  LDD0428  [19]
NAIA_5
 Probe Info  		C240(0.00); C73(0.00); C290(0.00)  LDD2223  [20]
TER-AC
 Probe Info  		N.A.  LDD0426  [19]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [21]
VE-P
 Probe Info  		N.A.  LDD0396  [22]
DA-2
 Probe Info  		N.A.  LDD0070  [23]
STS-1
 Probe Info  		N.A.  LDD0069  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C202(3.45); C178(4.28)  LDD0170  [7]
 LDCM0214  AC1 HEK-293T C202(0.83); C178(0.90); C240(1.04)  LDD1507  [25]
 LDCM0215  AC10 HEK-293T C202(0.81); C178(1.09); C240(0.98)  LDD1508  [25]
 LDCM0226  AC11 HEK-293T C202(0.94); C178(1.15); C240(0.90)  LDD1509  [25]
 LDCM0237  AC12 HEK-293T C202(0.90); C178(1.02); C290(1.01)  LDD1510  [25]
 LDCM0259  AC14 HEK-293T C202(1.11); C178(1.05); C290(0.83)  LDD1512  [25]
 LDCM0270  AC15 HEK-293T C202(0.96); C178(0.84); C240(0.91); C290(0.97)  LDD1513  [25]
 LDCM0276  AC17 HEK-293T C202(0.84); C178(0.95); C240(0.89)  LDD1515  [25]
 LDCM0277  AC18 HEK-293T C202(0.83); C178(1.04); C240(1.03)  LDD1516  [25]
 LDCM0278  AC19 HEK-293T C202(0.79); C178(0.91); C240(0.82)  LDD1517  [25]
 LDCM0279  AC2 HEK-293T C202(0.80); C178(1.25); C240(1.09)  LDD1518  [25]
 LDCM0280  AC20 HEK-293T C202(0.98); C178(0.95); C290(1.26)  LDD1519  [25]
 LDCM0281  AC21 HEK-293T C202(1.03); C178(1.30)  LDD1520  [25]
 LDCM0282  AC22 HEK-293T C202(0.99); C178(1.12); C290(0.82)  LDD1521  [25]
 LDCM0283  AC23 HEK-293T C202(0.90); C178(0.87); C240(0.91); C290(0.77)  LDD1522  [25]
 LDCM0284  AC24 HEK-293T C202(0.88); C178(0.96); C290(1.31)  LDD1523  [25]
 LDCM0285  AC25 HEK-293T C202(0.88); C178(0.72); C240(0.78)  LDD1524  [25]
 LDCM0286  AC26 HEK-293T C202(1.11); C178(0.98); C240(0.97)  LDD1525  [25]
 LDCM0287  AC27 HEK-293T C202(0.94); C178(1.06); C240(0.95)  LDD1526  [25]
 LDCM0288  AC28 HEK-293T C202(0.94); C178(1.03); C290(1.01)  LDD1527  [25]
 LDCM0289  AC29 HEK-293T C202(1.19); C178(1.21)  LDD1528  [25]
 LDCM0290  AC3 HEK-293T C202(0.95); C178(1.21); C240(0.92)  LDD1529  [25]
 LDCM0291  AC30 HEK-293T C202(1.10); C178(1.20); C290(1.60)  LDD1530  [25]
 LDCM0292  AC31 HEK-293T C202(1.00); C178(1.02); C240(0.88); C290(0.98)  LDD1531  [25]
 LDCM0293  AC32 HEK-293T C202(0.94); C178(1.08); C290(1.08)  LDD1532  [25]
 LDCM0294  AC33 HEK-293T C202(0.79); C178(0.73); C240(0.86)  LDD1533  [25]
 LDCM0295  AC34 HEK-293T C202(0.72); C178(1.21); C240(1.05)  LDD1534  [25]
 LDCM0296  AC35 HEK-293T C202(0.88); C178(0.99); C240(0.92)  LDD1535  [25]
 LDCM0297  AC36 HEK-293T C202(0.88); C178(1.02); C290(0.99)  LDD1536  [25]
 LDCM0298  AC37 HEK-293T C202(1.08); C178(1.23)  LDD1537  [25]
 LDCM0299  AC38 HEK-293T C202(1.06); C178(1.17); C290(1.04)  LDD1538  [25]
 LDCM0300  AC39 HEK-293T C202(0.92); C178(1.00); C240(0.84); C290(0.90)  LDD1539  [25]
 LDCM0301  AC4 HEK-293T C202(0.92); C178(1.11); C290(1.31)  LDD1540  [25]
 LDCM0302  AC40 HEK-293T C202(0.88); C178(0.98); C290(0.99)  LDD1541  [25]
 LDCM0303  AC41 HEK-293T C202(0.83); C178(1.01); C240(1.01)  LDD1542  [25]
 LDCM0304  AC42 HEK-293T C202(0.76); C178(1.24); C240(0.97)  LDD1543  [25]
 LDCM0305  AC43 HEK-293T C202(0.86); C178(1.13); C240(0.96)  LDD1544  [25]
 LDCM0306  AC44 HEK-293T C202(0.86); C178(0.95); C290(0.97)  LDD1545  [25]
 LDCM0307  AC45 HEK-293T C202(1.07); C178(1.11)  LDD1546  [25]
 LDCM0308  AC46 HEK-293T C202(1.02); C178(1.12); C290(0.90)  LDD1547  [25]
 LDCM0309  AC47 HEK-293T C202(0.92); C178(1.16); C240(0.91); C290(0.96)  LDD1548  [25]
 LDCM0310  AC48 HEK-293T C202(0.85); C178(0.94); C290(1.09)  LDD1549  [25]
 LDCM0311  AC49 HEK-293T C202(0.86); C178(0.99); C240(0.98)  LDD1550  [25]
 LDCM0312  AC5 HEK-293T C202(1.04); C178(1.13)  LDD1551  [25]
 LDCM0313  AC50 HEK-293T C202(0.79); C178(1.19); C240(1.16)  LDD1552  [25]
 LDCM0314  AC51 HEK-293T C202(0.93); C178(1.03); C240(0.96)  LDD1553  [25]
 LDCM0315  AC52 HEK-293T C202(0.86); C178(0.91); C290(1.06)  LDD1554  [25]
 LDCM0316  AC53 HEK-293T C202(0.98); C178(1.18)  LDD1555  [25]
 LDCM0317  AC54 HEK-293T C202(1.01); C178(1.16); C290(0.96)  LDD1556  [25]
 LDCM0318  AC55 HEK-293T C202(0.92); C178(0.98); C240(0.96); C290(1.15)  LDD1557  [25]
 LDCM0319  AC56 HEK-293T C202(0.94); C178(0.99); C290(1.15)  LDD1558  [25]
 LDCM0320  AC57 HEK-293T C202(0.76); C178(0.99); C240(0.87)  LDD1559  [25]
 LDCM0321  AC58 HEK-293T C202(0.73); C178(1.10); C240(1.06)  LDD1560  [25]
 LDCM0322  AC59 HEK-293T C202(0.88); C178(1.11); C240(0.96)  LDD1561  [25]
 LDCM0323  AC6 HEK-293T C202(0.94); C178(1.15); C290(0.85)  LDD1562  [25]
 LDCM0324  AC60 HEK-293T C202(0.76); C178(1.12); C290(1.41)  LDD1563  [25]
 LDCM0325  AC61 HEK-293T C202(0.91); C178(1.14)  LDD1564  [25]
 LDCM0326  AC62 HEK-293T C202(0.85); C178(1.08); C290(0.99)  LDD1565  [25]
 LDCM0327  AC63 HEK-293T C202(0.83); C178(0.96); C240(0.84); C290(0.98)  LDD1566  [25]
 LDCM0328  AC64 HEK-293T C202(0.88); C178(0.93); C290(1.26)  LDD1567  [25]
 LDCM0334  AC7 HEK-293T C202(0.98); C178(0.98); C240(1.07); C290(0.98)  LDD1568  [25]
 LDCM0345  AC8 HEK-293T C202(0.91); C178(1.09); C290(1.19)  LDD1569  [25]
 LDCM0248  AKOS034007472 HEK-293T C202(1.01); C178(1.11)  LDD1511  [25]
 LDCM0356  AKOS034007680 HEK-293T C202(0.88); C178(0.94); C240(0.92)  LDD1570  [25]
 LDCM0275  AKOS034007705 HEK-293T C202(0.91); C178(0.99); C290(1.19)  LDD1514  [25]
 LDCM0108  Chloroacetamide HeLa C178(0.00); C202(0.00)  LDD0222  [18]
 LDCM0367  CL1 HEK-293T C202(0.65); C178(0.96)  LDD1571  [25]
 LDCM0368  CL10 HEK-293T C202(0.82); C178(0.56); C290(0.40)  LDD1572  [25]
 LDCM0369  CL100 HEK-293T C202(0.85); C178(1.10); C240(0.94)  LDD1573  [25]
 LDCM0370  CL101 HEK-293T C202(0.81); C178(1.04)  LDD1574  [25]
 LDCM0371  CL102 HEK-293T C202(0.81); C178(1.09)  LDD1575  [25]
 LDCM0372  CL103 HEK-293T C202(0.87); C178(1.07); C240(0.85)  LDD1576  [25]
 LDCM0373  CL104 HEK-293T C202(0.95); C178(1.13); C240(0.97)  LDD1577  [25]
 LDCM0374  CL105 HEK-293T C202(0.87); C178(0.97)  LDD1578  [25]
 LDCM0375  CL106 HEK-293T C202(0.97); C178(1.02)  LDD1579  [25]
 LDCM0376  CL107 HEK-293T C202(1.04); C178(0.94); C240(0.94)  LDD1580  [25]
 LDCM0377  CL108 HEK-293T C202(0.96); C178(0.93); C240(0.83)  LDD1581  [25]
 LDCM0378  CL109 HEK-293T C202(0.95); C178(1.02)  LDD1582  [25]
 LDCM0379  CL11 HEK-293T C202(1.05); C178(0.81); C240(1.01); C290(0.31)  LDD1583  [25]
 LDCM0380  CL110 HEK-293T C202(0.85); C178(1.03)  LDD1584  [25]
 LDCM0381  CL111 HEK-293T C202(0.91); C178(0.85); C240(0.90)  LDD1585  [25]
 LDCM0382  CL112 HEK-293T C202(0.99); C178(1.17); C240(0.78)  LDD1586  [25]
 LDCM0383  CL113 HEK-293T C202(0.77); C178(1.05)  LDD1587  [25]
 LDCM0384  CL114 HEK-293T C202(0.71); C178(0.94)  LDD1588  [25]
 LDCM0385  CL115 HEK-293T C202(0.93); C178(0.95); C240(1.10)  LDD1589  [25]
 LDCM0386  CL116 HEK-293T C202(0.89); C178(1.16); C240(0.82)  LDD1590  [25]
 LDCM0387  CL117 HEK-293T C202(0.81); C178(0.91)  LDD1591  [25]
 LDCM0388  CL118 HEK-293T C202(0.83); C178(1.12)  LDD1592  [25]
 LDCM0389  CL119 HEK-293T C202(0.96); C178(1.04); C240(0.98)  LDD1593  [25]
 LDCM0390  CL12 HEK-293T C202(0.80); C178(0.80); C290(0.41)  LDD1594  [25]
 LDCM0391  CL120 HEK-293T C202(0.93); C178(1.07); C240(0.90)  LDD1595  [25]
 LDCM0392  CL121 HEK-293T C202(0.81); C178(0.97)  LDD1596  [25]
 LDCM0393  CL122 HEK-293T C202(0.82); C178(1.06)  LDD1597  [25]
 LDCM0394  CL123 HEK-293T C202(0.80); C178(0.82); C240(0.87)  LDD1598  [25]
 LDCM0395  CL124 HEK-293T C202(0.99); C178(1.15); C240(0.91)  LDD1599  [25]
 LDCM0396  CL125 HEK-293T C202(0.74); C178(0.97)  LDD1600  [25]
 LDCM0397  CL126 HEK-293T C202(0.72); C178(1.04)  LDD1601  [25]
 LDCM0398  CL127 HEK-293T C202(0.77); C178(1.09); C240(0.97)  LDD1602  [25]
 LDCM0399  CL128 HEK-293T C202(0.82); C178(1.17); C240(0.86)  LDD1603  [25]
 LDCM0400  CL13 HEK-293T C202(0.67); C178(0.85)  LDD1604  [25]
 LDCM0401  CL14 HEK-293T C202(0.74); C178(0.83)  LDD1605  [25]
 LDCM0402  CL15 HEK-293T C202(0.75); C178(0.94); C240(0.82)  LDD1606  [25]
 LDCM0403  CL16 HEK-293T C202(0.91); C178(1.06); C240(0.96)  LDD1607  [25]
 LDCM0404  CL17 HEK-293T C202(0.72); C178(0.89); C240(1.08)  LDD1608  [25]
 LDCM0405  CL18 HEK-293T C202(0.70); C178(0.91); C240(1.10)  LDD1609  [25]
 LDCM0406  CL19 HEK-293T C202(1.13); C178(0.92); C240(1.06)  LDD1610  [25]
 LDCM0407  CL2 HEK-293T C202(0.83); C178(0.94)  LDD1611  [25]
 LDCM0408  CL20 HEK-293T C202(1.04); C178(0.86); C290(0.55)  LDD1612  [25]
 LDCM0409  CL21 HEK-293T C202(0.89); C178(0.90)  LDD1613  [25]
 LDCM0410  CL22 HEK-293T C202(1.11); C178(0.79); C290(0.33)  LDD1614  [25]
 LDCM0411  CL23 HEK-293T C202(1.00); C178(0.80); C240(1.11); C290(0.28)  LDD1615  [25]
 LDCM0412  CL24 HEK-293T C202(0.97); C178(1.14); C290(0.54)  LDD1616  [25]
 LDCM0413  CL25 HEK-293T C202(0.72); C178(0.83)  LDD1617  [25]
 LDCM0414  CL26 HEK-293T C202(0.89); C178(0.90)  LDD1618  [25]
 LDCM0415  CL27 HEK-293T C202(0.97); C178(0.87); C240(0.88)  LDD1619  [25]
 LDCM0416  CL28 HEK-293T C202(0.93); C178(0.87); C240(0.85)  LDD1620  [25]
 LDCM0417  CL29 HEK-293T C202(0.99); C178(0.90); C240(1.16)  LDD1621  [25]
 LDCM0418  CL3 HEK-293T C202(0.87); C178(1.24); C240(0.98)  LDD1622  [25]
 LDCM0419  CL30 HEK-293T C202(0.97); C178(0.93); C240(1.06)  LDD1623  [25]
 LDCM0420  CL31 HEK-293T C202(1.06); C178(0.90); C240(0.98)  LDD1624  [25]
 LDCM0421  CL32 HEK-293T C202(1.09); C178(0.73); C290(0.73)  LDD1625  [25]
 LDCM0422  CL33 HEK-293T C202(0.94); C178(0.90)  LDD1626  [25]
 LDCM0423  CL34 HEK-293T C202(1.11); C178(0.78); C290(0.37)  LDD1627  [25]
 LDCM0424  CL35 HEK-293T C202(1.02); C178(0.73); C240(1.02); C290(0.28)  LDD1628  [25]
 LDCM0425  CL36 HEK-293T C202(0.98); C178(0.99); C290(0.42)  LDD1629  [25]
 LDCM0426  CL37 HEK-293T C202(0.73); C178(0.90)  LDD1630  [25]
 LDCM0428  CL39 HEK-293T C202(0.88); C178(0.86); C240(0.83)  LDD1632  [25]
 LDCM0429  CL4 HEK-293T C202(0.85); C178(1.01); C240(0.94)  LDD1633  [25]
 LDCM0430  CL40 HEK-293T C202(0.98); C178(1.01); C240(0.86)  LDD1634  [25]
 LDCM0431  CL41 HEK-293T C202(0.85); C178(0.98); C240(0.99)  LDD1635  [25]
 LDCM0432  CL42 HEK-293T C202(0.93); C178(0.93); C240(1.13)  LDD1636  [25]
 LDCM0433  CL43 HEK-293T C202(1.19); C178(0.95); C240(1.11)  LDD1637  [25]
 LDCM0434  CL44 HEK-293T C202(1.07); C178(0.83); C290(0.59)  LDD1638  [25]
 LDCM0435  CL45 HEK-293T C202(1.04); C178(0.90)  LDD1639  [25]
 LDCM0436  CL46 HEK-293T C202(1.07); C178(0.79); C290(0.35)  LDD1640  [25]
 LDCM0437  CL47 HEK-293T C202(1.03); C178(0.88); C240(1.12); C290(0.27)  LDD1641  [25]
 LDCM0438  CL48 HEK-293T C202(0.82); C178(0.91); C290(0.56)  LDD1642  [25]
 LDCM0439  CL49 HEK-293T C202(0.72); C178(0.98)  LDD1643  [25]
 LDCM0440  CL5 HEK-293T C202(0.95); C178(0.93); C240(1.07)  LDD1644  [25]
 LDCM0441  CL50 HEK-293T C202(0.69); C178(1.01)  LDD1645  [25]
 LDCM0443  CL52 HEK-293T C202(0.96); C178(1.06); C240(1.06)  LDD1646  [25]
 LDCM0444  CL53 HEK-293T C202(0.79); C178(0.75); C240(0.96)  LDD1647  [25]
 LDCM0445  CL54 HEK-293T C202(0.70); C178(1.24); C240(0.90)  LDD1648  [25]
 LDCM0446  CL55 HEK-293T C202(1.07); C178(0.86); C240(0.99)  LDD1649  [25]
 LDCM0447  CL56 HEK-293T C202(0.98); C178(0.73); C290(0.55)  LDD1650  [25]
 LDCM0448  CL57 HEK-293T C202(0.96); C178(0.81)  LDD1651  [25]
 LDCM0449  CL58 HEK-293T C202(1.05); C178(0.91); C290(0.43)  LDD1652  [25]
 LDCM0450  CL59 HEK-293T C202(0.99); C178(0.73); C240(1.04); C290(0.34)  LDD1653  [25]
 LDCM0451  CL6 HEK-293T C202(0.57); C178(0.96); C240(0.90)  LDD1654  [25]
 LDCM0452  CL60 HEK-293T C202(0.86); C178(0.89); C290(0.55)  LDD1655  [25]
 LDCM0453  CL61 HEK-293T C202(0.67); C178(1.00)  LDD1656  [25]
 LDCM0454  CL62 HEK-293T C202(0.73); C178(1.03)  LDD1657  [25]
 LDCM0455  CL63 HEK-293T C202(0.89); C178(1.07); C240(0.87)  LDD1658  [25]
 LDCM0456  CL64 HEK-293T C202(0.82); C178(0.93); C240(0.77)  LDD1659  [25]
 LDCM0457  CL65 HEK-293T C202(0.79); C178(0.86); C240(0.99)  LDD1660  [25]
 LDCM0458  CL66 HEK-293T C202(0.66); C178(0.96); C240(0.98)  LDD1661  [25]
 LDCM0459  CL67 HEK-293T C202(0.97); C178(0.97); C240(0.98)  LDD1662  [25]
 LDCM0460  CL68 HEK-293T C202(1.02); C178(0.73); C290(0.71)  LDD1663  [25]
 LDCM0461  CL69 HEK-293T C202(1.09); C178(1.06)  LDD1664  [25]
 LDCM0462  CL7 HEK-293T C202(1.06); C178(0.96); C240(0.94)  LDD1665  [25]
 LDCM0463  CL70 HEK-293T C202(0.98); C178(0.76); C290(0.45)  LDD1666  [25]
 LDCM0464  CL71 HEK-293T C202(0.98); C178(0.76); C240(1.09); C290(0.41)  LDD1667  [25]
 LDCM0465  CL72 HEK-293T C202(0.83); C178(0.90); C290(0.56)  LDD1668  [25]
 LDCM0466  CL73 HEK-293T C202(0.77); C178(1.29)  LDD1669  [25]
 LDCM0467  CL74 HEK-293T C202(0.83); C178(1.07)  LDD1670  [25]
 LDCM0469  CL76 HEK-293T C202(0.97); C178(1.23); C240(1.06)  LDD1672  [25]
 LDCM0470  CL77 HEK-293T C202(0.75); C178(0.74); C240(0.83)  LDD1673  [25]
 LDCM0471  CL78 HEK-293T C202(1.04); C178(1.00); C240(1.02)  LDD1674  [25]
 LDCM0472  CL79 HEK-293T C202(1.14); C178(1.21); C240(0.99)  LDD1675  [25]
 LDCM0473  CL8 HEK-293T C202(0.55); C178(0.57); C290(0.53)  LDD1676  [25]
 LDCM0474  CL80 HEK-293T C202(1.24); C178(1.04); C290(0.75)  LDD1677  [25]
 LDCM0475  CL81 HEK-293T C202(1.12); C178(1.07)  LDD1678  [25]
 LDCM0476  CL82 HEK-293T C202(1.19); C178(0.93); C290(0.44)  LDD1679  [25]
 LDCM0477  CL83 HEK-293T C202(1.02); C178(0.78); C240(1.07); C290(0.48)  LDD1680  [25]
 LDCM0478  CL84 HEK-293T C202(0.94); C178(1.04); C290(0.62)  LDD1681  [25]
 LDCM0479  CL85 HEK-293T C202(0.61); C178(0.80)  LDD1682  [25]
 LDCM0480  CL86 HEK-293T C202(0.63); C178(1.10)  LDD1683  [25]
 LDCM0481  CL87 HEK-293T C202(0.70); C178(1.21); C240(0.88)  LDD1684  [25]
 LDCM0482  CL88 HEK-293T C202(0.81); C178(1.04); C240(1.02)  LDD1685  [25]
 LDCM0483  CL89 HEK-293T C202(0.80); C178(1.19); C240(0.96)  LDD1686  [25]
 LDCM0484  CL9 HEK-293T C202(1.19); C178(1.05)  LDD1687  [25]
 LDCM0485  CL90 HEK-293T C202(0.55); C178(0.97); C240(0.86)  LDD1688  [25]
 LDCM0486  CL91 HEK-293T C202(0.94); C178(1.07); C240(1.02)  LDD1689  [25]
 LDCM0487  CL92 HEK-293T C202(0.75); C178(0.82); C290(0.68)  LDD1690  [25]
 LDCM0488  CL93 HEK-293T C202(0.94); C178(0.91)  LDD1691  [25]
 LDCM0489  CL94 HEK-293T C202(0.90); C178(0.73); C290(0.69)  LDD1692  [25]
 LDCM0490  CL95 HEK-293T C202(0.70); C178(0.67); C240(0.86); C290(0.48)  LDD1693  [25]
 LDCM0491  CL96 HEK-293T C202(0.73); C178(0.90); C290(0.88)  LDD1694  [25]
 LDCM0492  CL97 HEK-293T C202(0.72); C178(0.84)  LDD1695  [25]
 LDCM0493  CL98 HEK-293T C202(0.84); C178(1.00)  LDD1696  [25]
 LDCM0494  CL99 HEK-293T C202(0.83); C178(1.02); C240(1.15)  LDD1697  [25]
 LDCM0495  E2913 HEK-293T C202(0.73); C178(0.99); C240(0.79)  LDD1698  [25]
 LDCM0625  F8 Ramos C290(0.76)  LDD2187  [26]
 LDCM0576  Fragment14 Ramos C290(0.69)  LDD2193  [26]
 LDCM0468  Fragment33 HEK-293T C202(0.96); C178(1.06); C240(0.95)  LDD1671  [25]
 LDCM0566  Fragment4 Ramos C290(0.87)  LDD2184  [26]
 LDCM0427  Fragment51 HEK-293T C202(0.81); C178(0.96)  LDD1631  [25]
 LDCM0569  Fragment7 Ramos C290(0.41)  LDD2186  [26]
 LDCM0116  HHS-0101 DM93 Y204(1.02); Y138(1.22)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y138(0.93); Y204(1.08)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y204(0.80); Y138(0.85)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y138(0.96); Y204(1.05)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y204(0.93); Y138(1.93)  LDD0268  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [18]
 LDCM0022  KB02 HEK-293T C202(1.00); C240(1.04)  LDD1492  [25]
 LDCM0023  KB03 Jurkat C240(9.43)  LDD0315  [13]
 LDCM0024  KB05 COLO792 C256(2.27)  LDD3310  [5]
 LDCM0109  NEM HeLa C178(0.00); H197(0.00)  LDD0223  [18]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C135(0.39)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C135(0.47)  LDD2118  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C135(0.24)  LDD2122  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C135(0.85)  LDD2126  [6]
 LDCM0099  Phenelzine HEK-293T 3.00  LDD0386  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fructose-bisphosphate aldolase A (ALDOA) Class I fructose-bisphosphate aldolase family P04075
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
22 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
23 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
24 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578