Details of the Target

General Information of Target

Target ID LDTP04882
Target Name Ribose-phosphate pyrophosphokinase 1 (PRPS1)
Gene Name PRPS1
Gene ID 5631
Synonyms
Ribose-phosphate pyrophosphokinase 1; EC 2.7.6.1; PPRibP; Phosphoribosyl pyrophosphate synthase I; PRS-I
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGC
GEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAG
ADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTS
IADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG
ATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAI
RRTHNGESVSYLFSHVPL
Target Bioclass
Enzyme
Family
Ribose-phosphate pyrophosphokinase family
Function Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Uniprot ID
P60891
Ensemble ID
ENST00000372435.10
HGNC ID
HGNC:9462
ChEMBL ID
CHEMBL2638

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER SNV: p.A233T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		2.34  LDD0214  [1]
m-APA
 Probe Info  		10.22  LDD0402  [2]
AHL-Pu-1
 Probe Info  		C265(3.46)  LDD0168  [3]
HHS-465
 Probe Info  		Y94(1.79)  LDD2237  [4]
DBIA
 Probe Info  		C41(1.37); C265(0.94)  LDD0078  [5]
AMP probe
 Probe Info  		K176(0.00); K194(0.00)  LDD0200  [6]
ATP probe
 Probe Info  		K176(0.00); K194(0.00); K235(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C41(0.00); C265(0.00); C165(0.00); C91(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C165(0.00); C91(0.00)  LDD0032  [8]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [9]
IPIAA_L
 Probe Info  		C165(0.00); C226(0.00)  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		C41(0.00); C265(0.00); C165(0.00); C226(0.00)  LDD0037  [7]
ATP probe
 Probe Info  		N.A.  LDD0035  [10]
BTD
 Probe Info  		N.A.  LDD0004  [11]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
WYneO
 Probe Info  		C41(0.00); C165(0.00)  LDD0022  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
IPM
 Probe Info  		C41(0.00); C91(0.00)  LDD0005  [11]
PPMS
 Probe Info  		N.A.  LDD0008  [11]
SF
 Probe Info  		Y245(0.00); K194(0.00); K198(0.00); K197(0.00)  LDD0028  [14]
STPyne
 Probe Info  		N.A.  LDD0009  [11]
TFBX
 Probe Info  		C165(0.00); C91(0.00)  LDD0148  [15]
VSF
 Probe Info  		N.A.  LDD0007  [11]
Phosphinate-6
 Probe Info  		C265(0.00); C226(0.00)  LDD0018  [16]
Acrolein
 Probe Info  		C226(0.00); C41(0.00); C265(0.00); C91(0.00)  LDD0217  [17]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
Methacrolein
 Probe Info  		C41(0.00); C265(0.00); C165(0.00); C230(0.00)  LDD0218  [17]
W1
 Probe Info  		C91(0.00); C41(0.00)  LDD0236  [18]
AOyne
 Probe Info  		7.40  LDD0443  [19]
NAIA_5
 Probe Info  		C41(0.00); C265(0.00); C165(0.00); C230(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		6.78  LDD0138  [20]
VE-P
 Probe Info  		N.A.  LDD0396  [21]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [22]
Photonaproxen
 Probe Info  		N.A.  LDD0157  [23]
DA-2
 Probe Info  		N.A.  LDD0070  [24]
STS-1
 Probe Info  		N.A.  LDD0068  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C165(0.73)  LDD2095  [26]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C165(0.88)  LDD2130  [26]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C165(1.04)  LDD2117  [26]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C165(1.34)  LDD2152  [26]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C165(0.48); C265(0.61)  LDD2132  [26]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C165(0.52)  LDD2131  [26]
 LDCM0025  4SU-RNA HEK-293T C265(3.46)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C265(5.08)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C165(1.06); C226(0.99); C230(0.98); C265(0.96)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C41(1.13); C91(0.89)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C226(1.00); C230(1.00); C265(1.05); C41(0.81)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C226(1.37); C230(1.37); C265(1.00); C41(0.93)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C226(1.18); C230(1.18); C265(1.00); C41(0.94)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C226(1.39); C230(1.39); C265(1.14); C41(0.92)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C226(1.49); C230(1.49); C265(1.09); C41(0.83)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C226(1.03); C230(1.03); C265(1.18); C41(0.95)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C226(0.92); C230(0.92); C265(1.04); C41(0.83)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C226(0.97); C230(0.97); C265(1.11); C41(0.86)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C226(1.23); C230(1.23); C265(0.99); C41(0.89)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C226(0.99); C230(0.99); C265(0.96); C41(0.91)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C41(1.04); C91(0.85)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C226(1.04); C230(1.04); C265(0.94); C41(0.86)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C226(1.12); C230(1.12); C265(1.00); C41(0.89)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C226(1.11); C230(1.11); C265(1.03); C41(1.06)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C226(1.11); C230(1.11); C265(0.89); C41(1.19)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C226(1.19); C230(1.19); C265(1.38); C41(1.11)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C226(1.13); C230(1.13); C265(1.68); C41(1.11)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C226(1.29); C230(1.29); C265(1.20); C41(1.17)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C226(1.36); C230(1.36); C265(1.23); C41(1.21)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C226(1.15); C230(1.15); C265(1.17); C41(1.16)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C226(1.24); C230(1.24); C265(0.99); C41(1.41)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C41(1.02); C91(1.05)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C226(1.14); C230(1.14); C265(0.94); C41(1.00)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C226(1.10); C230(1.10); C265(1.07); C41(0.91)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C226(1.23); C230(1.23); C265(1.05); C41(1.07)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C226(1.14); C230(1.14); C265(1.01); C41(0.94)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C226(1.53); C230(1.53); C265(1.04); C41(1.14)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C226(1.29); C230(1.29); C265(1.15); C41(1.10)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C226(1.37); C230(1.37); C265(1.31); C41(0.99)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C226(1.21); C230(1.21); C265(1.18); C41(1.03)  LDD0562  [5]
 LDCM0246  AC128 HEK-293T C165(0.86); C265(0.90); C41(1.32); C91(0.89)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C165(0.84); C265(0.71); C41(1.46); C91(0.77)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C165(0.75); C265(0.67); C41(1.48); C91(1.06)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C165(0.85); C265(0.66); C41(0.95); C91(0.87)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C165(0.82); C265(0.96); C41(1.61); C91(0.84)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C165(0.80); C265(0.69); C41(1.10); C91(1.05)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C165(0.98); C265(0.67); C41(1.44); C91(0.87)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C165(0.88); C265(0.80); C41(0.93); C91(1.02)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C165(1.08); C265(0.62); C41(1.35); C91(0.99)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C165(1.05); C265(0.78); C41(1.51); C91(1.03)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C165(1.07); C265(0.55); C41(1.58); C91(1.03)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C165(0.99); C265(0.62); C41(1.31); C91(0.94)  LDD0856  [5]
 LDCM0259  AC14 HCT 116 C41(1.14); C91(0.92)  LDD0576  [5]
 LDCM0260  AC140 HEK-293T C165(0.81); C265(0.62); C41(1.49); C91(0.83)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C165(0.95); C265(0.65); C41(1.26); C91(0.83)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C165(0.77); C265(0.67); C41(1.31); C91(0.73)  LDD0860  [5]
 LDCM0263  AC143 HCT 116 C265(1.05); C41(1.17)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C265(0.85); C41(1.27)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C265(0.89); C41(1.25)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C265(0.95); C41(1.20)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C265(1.05); C41(1.09)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C265(0.96); C41(2.03)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C265(0.89); C41(1.57)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C91(1.03); C41(1.04)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C265(0.98); C41(1.11)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C265(1.10); C41(1.45)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C265(0.88); C41(1.14)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C265(0.60); C41(2.23)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C265(0.87); C41(1.16)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C265(0.99); C41(1.29)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C265(0.84); C41(1.03)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C265(0.90); C41(1.60)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C226(0.82); C230(0.82); C165(1.06); C265(1.10)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C226(0.90); C230(0.90); C41(1.11); C165(1.12)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C226(1.03); C230(1.03); C41(1.03); C265(1.14)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C230(0.96); C265(1.00); C226(1.06); C91(1.08)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C165(0.73); C226(0.79); C230(0.79); C41(0.96)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C226(0.78); C230(0.78); C165(0.80); C41(0.96)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C226(0.82); C230(0.82); C165(1.01); C41(1.03)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C41(0.88); C265(0.89); C226(1.00); C230(1.00)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C41(0.97); C265(1.02); C226(1.06); C230(1.06)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C91(0.99); C41(1.02); C265(1.13)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C91(1.02); C41(1.15); C265(1.21)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C91(1.07); C41(1.20); C265(1.44)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C91(1.01); C265(1.13); C41(1.16)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C91(0.93); C41(1.09); C265(1.22)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C230(0.96); C226(0.98); C265(1.04); C41(1.14)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C91(0.75); C41(1.15); C265(1.34)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C91(1.01); C41(1.23); C265(1.39)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C91(1.12); C41(1.12); C265(1.40)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C91(0.94); C41(1.19); C265(1.36)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C91(0.92); C41(1.05); C265(1.34)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C91(0.65); C226(0.73); C230(0.73); C265(0.85)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C91(0.62); C226(0.66); C230(0.66); C265(0.86)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C91(0.67); C226(0.75); C230(0.75); C41(0.86)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C226(0.75); C230(0.75); C91(0.78); C265(0.92)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C91(0.70); C226(0.72); C230(0.72); C265(1.01)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C230(0.98); C226(1.01); C265(1.06); C41(1.22)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C91(0.60); C226(0.64); C230(0.64); C41(0.87)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C91(0.69); C226(0.73); C230(0.73); C41(0.94)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C226(0.83); C230(0.83); C91(0.84); C265(1.03)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C91(0.77); C226(0.79); C230(0.79); C41(1.03)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C91(0.69); C226(0.80); C230(0.80); C41(0.81)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C91(0.68); C226(0.87); C230(0.87); C41(0.92)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C165(0.85); C265(0.91); C226(1.03); C230(1.03)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C165(0.89); C265(0.92); C226(1.19); C230(1.19)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C265(0.79); C165(0.90); C226(1.06); C230(1.06)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C165(0.94); C265(0.95); C41(0.95); C226(1.01)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C265(1.12); C41(1.17); C226(1.19); C230(1.24)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C165(0.97); C226(0.99); C230(0.99); C265(1.05)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C165(0.90); C265(0.90); C226(0.98); C230(0.98)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C165(0.67); C265(0.95); C41(1.12); C226(1.19)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C165(0.88); C265(0.98); C41(0.99); C226(1.15)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C165(0.72); C226(1.03); C230(1.03); C265(1.06)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C165(0.69); C265(0.90); C41(0.97); C226(1.15)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C165(0.68); C265(0.78); C41(0.94); C226(1.18)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C91(0.96); C265(1.02); C226(1.15); C230(1.15)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C226(0.77); C230(0.77); C91(0.87); C265(1.03)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C226(0.82); C230(0.82); C91(0.98); C265(1.00)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C91(0.83); C41(1.09)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C91(0.92); C265(0.97); C41(1.31); C226(1.32)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C265(1.09); C91(1.13); C226(1.18); C230(1.18)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C265(1.01); C91(1.05); C41(1.18); C226(1.19)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C91(0.71); C265(0.87); C226(1.02); C230(1.02)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C265(0.86); C91(0.88); C41(1.26); C226(1.30)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C91(1.07); C265(1.11); C226(1.12); C230(1.12)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C91(0.86); C226(0.90); C230(0.90); C265(1.11)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C91(0.96); C265(1.04); C41(1.18); C226(1.27)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C41(0.97); C226(1.04); C230(1.04); C91(1.09)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C226(0.93); C230(0.93); C41(0.94); C91(1.00)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C91(0.90); C41(1.02)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C91(0.78); C41(0.89); C265(0.97); C226(1.04)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C265(0.89); C91(1.01); C41(1.01); C226(1.20)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C91(0.87); C226(0.94); C230(0.94); C41(1.01)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C41(0.89); C91(0.90); C265(0.99); C226(1.09)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C91(0.88); C41(0.89); C265(1.03); C226(1.08)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C265(0.84); C91(0.89); C226(0.97); C230(0.97)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C226(0.84); C230(0.84); C91(0.90); C41(0.97)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C91(0.95); C41(0.97); C226(1.12); C230(1.12)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C91(0.93); C41(1.09); C226(1.22); C230(1.22)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C265(1.05); C41(1.07); C91(1.11); C226(1.26)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C91(0.92); C41(1.14)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C91(0.79); C41(1.13); C226(1.31); C230(1.31)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C91(0.80); C41(0.94); C265(1.00); C226(1.23)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C265(0.53); C41(0.82); C91(1.07); C226(1.25)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C91(0.84); C226(1.03); C230(1.03); C41(1.05)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C91(0.77); C226(0.80); C230(0.80); C265(1.00)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C91(0.79); C226(0.82); C230(0.82); C265(0.96)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C226(0.75); C230(0.75); C91(0.80); C41(1.08)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C226(0.80); C230(0.80); C265(0.96); C91(0.97)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C226(0.88); C230(0.88); C91(0.96); C265(1.02)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C91(0.86); C226(0.89); C230(0.89); C41(1.14)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C226(0.95); C230(0.95); C265(1.00); C41(1.02)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C91(0.62); C226(0.70); C230(0.70); C41(1.09)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C91(0.72); C226(0.87); C230(0.87); C41(1.17)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C91(0.78); C226(0.93); C230(0.93); C265(1.00)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C91(0.70); C226(0.82); C230(0.82); C265(0.98)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C91(0.69); C226(0.77); C230(0.77); C265(0.87)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C91(0.75); C226(0.82); C230(0.82); C265(1.12)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C91(0.73); C226(0.81); C230(0.81); C265(1.10)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C265(0.75); C41(0.91); C226(1.41); C230(1.41)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C226(0.79); C230(0.79); C41(0.87); C265(0.96)  LDD0683  [5]
 LDCM0545  Acetamide MDA-MB-231 C165(0.87)  LDD2138  [26]
 LDCM0520  AKOS000195272 MDA-MB-231 C165(0.76)  LDD2113  [26]
 LDCM0248  AKOS034007472 HCT 116 C41(1.17); C91(0.80)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C91(0.77); C41(1.09)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C91(0.99); C41(1.26)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 12.60  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C41(1.37); C265(0.94)  LDD0078  [5]
 LDCM0498  BS-3668 MDA-MB-231 C165(0.84)  LDD2091  [26]
 LDCM0630  CCW28-3 231MFP C91(0.59)  LDD2214  [27]
 LDCM0108  Chloroacetamide HeLa C41(0.00); C226(0.00); C265(0.00); C91(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C165(20.00); C41(2.15); C91(0.87); C226(0.51)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C265(0.79); C226(1.00); C230(1.00); C41(1.00)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C265(0.87); C41(0.98); C226(1.87); C230(1.87)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C230(0.95); C265(0.97); C226(1.00); C91(1.07)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C91(0.92); C41(1.15)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C91(0.65); C41(1.07)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C41(1.05); C91(1.07)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C91(0.91); C41(1.18)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C226(0.78); C230(0.78); C165(0.92); C265(1.06)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C165(0.86); C41(0.93); C226(0.96); C230(0.96)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C226(1.05); C230(1.05); C41(1.08); C165(1.13)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C226(0.97); C230(0.97); C165(1.01); C41(1.06)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C265(1.05); C165(1.09); C226(1.17); C230(1.17)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C265(0.87); C41(1.13); C226(1.20); C230(1.20)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C41(1.03); C265(1.06); C226(1.19); C230(1.19)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C265(1.04); C226(1.09); C230(1.09); C41(1.13)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C91(0.83); C41(1.02); C265(1.05)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C91(0.90); C41(1.03); C265(1.41)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C91(0.81); C41(0.92); C265(1.15)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C91(0.92); C41(1.01); C265(1.18)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C91(0.90); C41(1.18); C265(1.23)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C226(0.57); C230(0.57); C91(0.59); C41(0.89)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C91(0.81); C41(0.87); C226(0.95); C230(0.95)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C91(0.72); C226(0.90); C230(0.90); C41(1.06)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C265(0.77); C41(1.23); C226(1.76); C230(1.76)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C91(0.83); C226(0.97); C230(0.97); C265(1.01)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C165(0.66); C226(1.05); C230(1.05); C41(1.21)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C165(0.64); C265(0.88); C226(0.93); C230(0.93)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C165(0.55); C265(0.90); C41(0.96); C226(0.96)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C165(0.64); C265(0.89); C41(0.99); C226(1.08)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C265(0.89); C91(0.99); C41(1.13); C226(1.18)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C265(1.09); C91(1.33); C226(1.35); C230(1.35)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C226(0.96); C230(0.96); C91(1.00); C265(1.06)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C265(1.07); C91(1.11); C41(1.13); C226(1.16)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C265(0.96); C41(1.12); C226(1.13); C230(1.13)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C265(0.71); C41(0.98); C226(1.29); C230(1.29)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C265(0.68); C41(0.94); C226(1.01); C230(1.01)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C41(1.19); C91(1.34)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C91(0.73); C226(0.95); C230(0.95); C41(1.06)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C91(0.91); C226(0.92); C230(0.92); C41(1.05)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C91(0.77); C226(0.83); C230(0.83); C41(0.95)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C265(0.85); C41(0.93); C226(0.95); C230(0.95)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C91(0.69); C226(0.86); C230(0.86); C41(1.23)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C91(0.72); C226(0.79); C230(0.79); C41(0.90)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C226(1.00); C230(1.00); C91(1.08); C41(1.14)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C41(0.94); C91(0.98); C226(1.10); C230(1.10)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C226(0.87); C230(0.87); C41(1.19); C91(0.87)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C226(0.99); C230(0.99); C41(0.95); C91(0.86)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C226(0.92); C230(0.92); C41(1.21); C91(0.97)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C226(0.96); C230(0.96); C41(1.21); C91(0.88)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C226(0.97); C230(0.97); C41(1.14); C91(0.84)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C226(1.02); C230(1.02); C41(1.12); C91(0.97)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C226(1.04); C230(1.04); C265(0.76); C41(1.01)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C226(1.11); C230(1.11); C41(1.14); C91(0.90)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C165(0.77); C226(1.12); C230(1.12); C265(0.87)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C165(0.70); C265(0.93); C41(1.10); C91(0.89)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C165(0.68); C265(0.96); C41(0.88); C91(0.96)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C165(0.59); C265(0.97); C41(0.79); C91(1.35)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C165(0.61); C265(1.37); C41(0.96); C91(1.08)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C165(0.76); C265(1.23); C41(0.83); C91(1.07)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C165(0.76); C265(1.25); C41(1.01); C91(1.09)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C165(0.71); C265(1.04); C41(0.97); C91(1.16)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C226(0.86); C230(0.86); C265(0.71); C41(0.97)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C165(0.76); C265(1.22); C41(0.91); C91(1.02)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C165(0.83); C265(1.12); C41(0.84); C91(0.99)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C165(0.39); C265(0.98); C41(0.91); C91(1.25)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C165(0.62); C265(1.07); C41(0.94); C91(1.23)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C165(0.58); C265(0.88); C41(0.91); C91(1.15)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C165(0.50); C265(0.98); C41(0.94); C91(1.47)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C265(0.98); C41(1.24); C91(0.96)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C265(0.87); C41(1.07); C91(1.05)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C265(0.96); C41(1.24); C91(1.09)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C265(1.17); C41(1.24); C91(1.12)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C226(0.96); C230(0.96); C265(0.79); C41(0.95)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C265(0.94); C41(0.99); C91(0.97)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C265(0.96); C41(1.07); C91(0.92)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C265(1.07); C41(1.14); C91(0.74)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C265(0.97); C41(1.07); C91(0.74)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C265(1.02); C41(1.08); C91(0.83)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C265(0.94); C41(1.11); C91(0.92)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C265(0.89); C41(1.08); C91(1.02)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C265(0.92); C41(1.02); C91(1.00)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C265(0.98); C41(1.18); C91(0.78)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C265(0.98); C41(1.10); C91(0.95)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C226(0.96); C230(0.96); C265(0.79); C41(1.09)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C265(1.00); C41(1.16); C91(1.07)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C265(1.14); C41(1.43)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C265(1.04); C41(1.43)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C265(1.20); C41(1.21)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C265(1.20); C41(1.15)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C265(1.07); C41(1.07)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C265(1.32); C41(1.14)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C265(1.13); C41(1.34)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C265(1.24); C41(1.19)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C265(1.03); C41(1.38)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C226(1.45); C230(1.45); C265(0.78); C41(1.05)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C265(1.14); C41(1.44)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C265(1.10); C41(0.93)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C265(1.09); C41(0.98)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C265(1.23); C41(1.54)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C265(1.20); C41(0.91)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C265(1.02); C41(1.06); C91(1.17)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C265(0.81); C41(0.74); C91(1.04)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C265(0.94); C41(1.04); C91(1.03)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C265(1.01); C41(1.00); C91(1.14)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C226(0.89); C230(0.89); C265(0.89); C41(1.39)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C265(0.97); C41(1.13); C91(1.12)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C265(1.06); C41(0.96); C91(1.13)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C265(1.04); C41(0.98); C91(1.25)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C265(0.91); C41(1.14); C91(1.05)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C265(0.96); C41(1.06); C91(1.09)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C265(1.07); C41(0.99); C91(1.03)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C265(1.14); C41(1.12); C91(1.05)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C265(1.13); C41(1.21); C91(1.08)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C265(1.16); C41(0.98); C91(1.00)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C265(1.05); C41(1.09); C91(1.17)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C226(1.50); C230(1.50); C265(0.88); C41(0.90)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C265(0.94); C41(0.86); C91(0.98)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C165(0.92); C226(0.76); C230(0.73); C265(0.98)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C165(0.80); C226(0.62); C230(0.47); C265(0.97)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C165(0.93); C226(0.78); C230(0.70); C265(0.90)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C165(1.26); C226(0.98); C230(0.75); C265(1.03)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C165(1.19); C226(0.92); C230(0.87); C265(0.98)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C165(1.31); C226(0.90); C230(0.77); C265(1.08)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C165(1.33); C226(0.99); C230(0.88); C265(1.07)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C165(1.02); C226(0.93); C230(0.95); C265(1.11)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C165(1.33); C226(0.87); C230(0.74); C265(1.05)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C165(1.12); C41(1.10); C265(0.97); C91(0.99)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C230(1.60); C91(1.31); C165(1.00)  LDD1702  [26]
 LDCM0625  F8 Ramos C165(0.98); C91(0.80); C41(1.50); C265(1.29)  LDD2187  [29]
 LDCM0572  Fragment10 Ramos C165(0.54); C91(0.32); C41(0.37); C265(0.67)  LDD2189  [29]
 LDCM0573  Fragment11 Ramos C165(0.03); C41(1.12); C265(0.23); 5.63  LDD2190  [29]
 LDCM0574  Fragment12 Ramos C165(0.65); C91(0.43); C41(0.56); C265(2.30)  LDD2191  [29]
 LDCM0575  Fragment13 Ramos C165(0.94); C91(0.84)  LDD2192  [29]
 LDCM0576  Fragment14 Ramos C165(0.67); C91(0.43); C41(0.67); C265(0.94)  LDD2193  [29]
 LDCM0579  Fragment20 Ramos C165(0.48); C91(0.35); C41(0.49); C265(0.71)  LDD2194  [29]
 LDCM0580  Fragment21 Ramos C165(0.94); C91(0.65); C41(1.31)  LDD2195  [29]
 LDCM0582  Fragment23 Ramos C165(0.46); C91(0.46); C41(0.40); C265(0.72)  LDD2196  [29]
 LDCM0578  Fragment27 Ramos C165(1.01); C91(0.77); C265(4.72)  LDD2197  [29]
 LDCM0586  Fragment28 Ramos C165(0.54); C91(0.87); C41(1.51); 2.90  LDD2198  [29]
 LDCM0588  Fragment30 Ramos C165(1.09); C91(0.71); C41(0.72); C265(0.91)  LDD2199  [29]
 LDCM0589  Fragment31 Ramos C165(1.07); C91(0.99)  LDD2200  [29]
 LDCM0590  Fragment32 Ramos C165(0.47); C91(0.34); C41(0.46); C265(0.81)  LDD2201  [29]
 LDCM0468  Fragment33 HCT 116 C265(1.14); C41(1.08)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C165(0.92); C91(0.74); C41(0.85); C265(1.14)  LDD2203  [29]
 LDCM0566  Fragment4 Ramos C165(0.65); C91(0.64); C41(0.69); C265(0.75)  LDD2184  [29]
 LDCM0427  Fragment51 HCT 116 C165(0.54); C265(1.04); C41(0.80); C91(0.83)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C165(1.19); C91(0.89); C41(0.91)  LDD2204  [29]
 LDCM0614  Fragment56 Ramos C165(1.33); C91(0.89); C41(0.77); C265(0.66)  LDD2205  [29]
 LDCM0569  Fragment7 Ramos C165(0.54); C91(0.40); C41(0.51); C265(0.89)  LDD2186  [29]
 LDCM0571  Fragment9 Ramos C165(0.50); C91(0.38); C41(0.29); C265(1.11)  LDD2188  [29]
 LDCM0107  IAA HeLa C226(0.00); C41(0.00); H12(0.00); C265(0.00)  LDD0221  [17]
 LDCM0022  KB02 HCT 116 C41(0.97)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C41(1.18)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C41(1.16)  LDD0082  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C165(0.95)  LDD2121  [26]
 LDCM0109  NEM HeLa H12(0.00); H193(0.00); H250(0.00); H231(0.00)  LDD0223  [17]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C165(1.04)  LDD2089  [26]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C165(1.13)  LDD2093  [26]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C165(1.00)  LDD2099  [26]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C165(0.91); C284(1.41)  LDD2107  [26]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C284(1.01)  LDD2109  [26]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C165(1.00)  LDD2111  [26]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C165(1.25)  LDD2119  [26]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C165(0.89)  LDD2123  [26]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C165(0.83); C284(1.03)  LDD2125  [26]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C284(1.46)  LDD2127  [26]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C165(1.10); C284(1.16)  LDD2129  [26]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C165(0.58)  LDD2133  [26]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C284(1.09)  LDD2135  [26]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C165(1.13)  LDD2136  [26]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C284(0.92)  LDD2137  [26]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C165(0.80)  LDD2140  [26]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C165(1.80)  LDD2144  [26]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C165(0.87); C284(0.73)  LDD2146  [26]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C165(0.89)  LDD2150  [26]
 LDCM0131  RA190 MM1.R C165(1.26); C265(1.07); C41(1.05)  LDD0304  [30]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [22]
 LDCM0021  THZ1 HCT 116 C265(0.99)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
Eukaryotic translation initiation factor 3 subunit F (EIF3F) EIF-3 subunit F family O00303
DNA-directed RNA polymerase III subunit RPC6 (POLR3F) Eukaryotic RPC34/RPC39 RNA polymerase subunit family Q9H1D9
Fructose-1,6-bisphosphatase isozyme 2 (FBP2) FBPase class 1 family O00757
Glucose-fructose oxidoreductase domain-containing protein 1 (GFOD1) Gfo/Idh/MocA family Q9NXC2
Hexokinase-3 (HK3) Hexokinase family P52790
Peptidoglycan recognition protein 3 (PGLYRP3) N-acetylmuramoyl-L-alanine amidase 2 family Q96LB9
Phospholipid phosphatase-related protein type 1 (PLPPR1) PA-phosphatase related phosphoesterase family Q8TBJ4
Ubiquitin thioesterase OTUB1 (OTUB1) Peptidase C65 family Q96FW1
MPN domain-containing protein (MPND) Peptidase M67 family Q8N594
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) STE Ser/Thr protein kinase family Q99683
Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPSAP1) Ribose-phosphate pyrophosphokinase family Q14558
Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPSAP2) Ribose-phosphate pyrophosphokinase family O60256
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Ribose-phosphate pyrophosphokinase 2 (PRPS2) Ribose-phosphate pyrophosphokinase family P11908
Terminal nucleotidyltransferase 5B (TENT5B) TENT family Q96A09
Ubiquitin-conjugating enzyme E2 E3 (UBE2E3) Ubiquitin-conjugating enzyme family Q969T4
G/T mismatch-specific thymine DNA glycosylase (TDG) TDG/mug family Q13569
E3 ubiquitin-protein ligase RNF183 (RNF183) . Q96D59
Methyltransferase-like protein 27 (METTL27) . Q8N6F8
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Beclin-1 (BECN1) Beclin family Q14457
Voltage-dependent anion-selective channel protein 2 (VDAC2) Eukaryotic mitochondrial porin family P45880
Aquaporin-8 (AQP8) MIP/aquaporin (TC 1.A.8) family O94778
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Alpha-crystallin B chain (CRYAB) Small heat shock protein (HSP20) family P02511
Membrane protein MLC1 (MLC1) . Q15049
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Basic leucine zipper transcriptional factor ATF-like (BATF) BZIP family Q16520
Krueppel-like factor 3 (KLF3) Krueppel C2H2-type zinc-finger protein family P57682
Zinc finger and SCAN domain-containing protein 9 (ZSCAN9) Krueppel C2H2-type zinc-finger protein family O15535
Zinc finger protein 296 (ZNF296) Krueppel C2H2-type zinc-finger protein family Q8WUU4
Zinc finger protein 497 (ZNF497) Krueppel C2H2-type zinc-finger protein family Q6ZNH5
Zinc finger protein 57 (ZNF57) Krueppel C2H2-type zinc-finger protein family Q68EA5
Zinc finger protein with KRAB and SCAN domains 8 (ZKSCAN8) Krueppel C2H2-type zinc-finger protein family Q15776
Visual system homeobox 2 (VSX2) Paired homeobox family P58304
PHD finger-like domain-containing protein 5A (PHF5A) PHF5 family Q7RTV0
Zinc finger protein ZXDC (ZXDC) ZXD family Q2QGD7
Achaete-scute homolog 4 (ASCL4) . Q6XD76
Zinc finger protein 366 (ZNF366) . Q8N895
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 141 (CCDC141) . Q6ZP82
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytokine receptor-like factor 3 (CRLF3) Cytokine receptor-like factor 3 family Q8IUI8
Other
Click To Hide/Show 36 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A8 (ANXA8) Annexin family P13928
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (KCTD13) BACURD family Q8WZ19
Cbp/p300-interacting transactivator 2 (CITED2) CITED family Q99967
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Protein pelota homolog (PELO) Eukaryotic release factor 1 family Q9BRX2
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Cytosolic iron-sulfur assembly component 2B (CIAO2B) MIP18 family Q9Y3D0
Protein Mis18-alpha (MIS18A) Mis18 family Q9NYP9
Protein Mis18-beta (OIP5) Mis18 family O43482
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
MORF4 family-associated protein 1-like 1 (MRFAP1L1) MORF4 family-associated protein family Q96HT8
Protein sprouty homolog 4 (SPRY4) Sprouty family Q9C004
Signal transducing adapter molecule 2 (STAM2) STAM family O75886
Protein TASOR 2 (TASOR2) TASOR family Q5VWN6
CST complex subunit TEN1 (TEN1) TEN1 family Q86WV5
Vacuolar protein sorting-associated protein 37A (VPS37A) VPS37 family Q8NEZ2
WD repeat domain-containing protein 83 (WDR83) WD repeat MORG1 family Q9BRX9
Fasciculation and elongation protein zeta-2 (FEZ2) Zygin family Q9UHY8
ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) . Q9NP61
Fanconi anemia group G protein (FANCG) . O15287
IQ domain-containing protein F2 (IQCF2) . Q8IXL9
Kelch-like protein 20 (KLHL20) . Q9Y2M5
Leukocyte receptor cluster member 8 (LENG8) . Q96PV6
Methyl-CpG-binding protein 2 (MECP2) . P51608
Period circadian protein homolog 1 (PER1) . O15534
Protein FAM117B (FAM117B) . Q6P1L5
Retinoic acid-induced protein 2 (RAI2) . Q9Y5P3
Sperm-associated microtubule inner protein 4 (SPMIP4) . Q8N865
Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) . Q7Z698
Synaptonemal complex central element protein 3 (SYCE3) . A1L190
TAR DNA-binding protein 43 (TARDBP) . Q13148
Ubiquitin-associated domain-containing protein 1 (UBAC1) . Q9BSL1
Uncharacterized protein C8orf48 (C8orf48) . Q96LL4
Uncharacterized protein KIAA0408 (KIAA0408) . Q6ZU52

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
21 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
22 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
23 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
24 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
25 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
26 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
27 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
30 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.