Details of the Target

General Information of Target

Target ID LDTP08296
Target Name Cullin-associated NEDD8-dissociated protein 1 (CAND1)
Gene Name CAND1
Gene ID 55832
Synonyms
KIAA0829; TIP120; TIP120A; Cullin-associated NEDD8-dissociated protein 1; Cullin-associated and neddylation-dissociated protein 1; TBP-interacting protein of 120 kDa A; TBP-interacting protein 120A; p120 CAND1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASASYHISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKLLEDK
NGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPA
SSGSALAANVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCL
LPQLTSPRLAVRKRTIIALGHLVMSCGNIVFVDLIEHLLSELSKNDSMSTTRTYIQCIAA
ISRQAGHRIGEYLEKIIPLVVKFCNVDDDELREYCIQAFESFVRRCPKEVYPHVSTIINI
CLKYLTYDPNYNYDDEDEDENAMDADGGDDDDQGSDDEYSDDDDMSWKVRRAAAKCLDAV
VSTRHEMLPEFYKTVSPALISRFKEREENVKADVFHAYLSLLKQTRPVQSWLCDPDAMEQ
GETPLTMLQSQVPNIVKALHKQMKEKSVKTRQCCFNMLTELVNVLPGALTQHIPVLVPGI
IFSLNDKSSSSNLKIDALSCLYVILCNHSPQVFHPHVQALVPPVVACVGDPFYKITSEAL
LVTQQLVKVIRPLDQPSSFDATPYIKDLFTCTIKRLKAADIDQEVKERAISCMGQIICNL
GDNLGSDLPNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLRPVLGEGVPILASFLR
KNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQMAISFLTTLA
KVYPSSLSKISGSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNNLGYMDLLRMLT
GPVYSQSTALTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVKNSRSTDSIRLLALL
SLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPEYLPFVLQEIT
SQPKRQYLLLHSLKEIISSASVVGLKPYVENIWALLLKHCECAEEGTRNVVAECLGKLTL
IDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPIDPLLKNCIGDFLKTLEDPDL
NVRRVALVTFNSAAHNKPSLIRDLLDTVLPHLYNETKVRKELIREVEMGPFKHTVDDGLD
IRKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLVRLSTLCPSAVLQ
RLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAALLTIPEAEKSPLMSEFQS
QISSNPELAAIFESIQKDSSSTNLESMDTS
Target Bioclass
Enzyme
Family
CAND family
Subcellular location
Cytoplasm
Function
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
Uniprot ID
Q86VP6
Ensemble ID
ENST00000545606.6
HGNC ID
HGNC:30688

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.K826N DBIA    Probe Info 
AN3CA SNV: p.T363I DBIA    Probe Info 
HT115 SNV: p.R551C; p.A665V DBIA    Probe Info 
IGR1 SNV: p.S744L DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.G750EfsTer7 DBIA    Probe Info 
KYSE30 SNV: p.R1174Ter DBIA    Probe Info 
MFE319 Deletion: p.L604WfsTer16 DBIA    Probe Info 
MOLT4 Deletion: p.G750EfsTer7 IA-alkyne    Probe Info 
NALM6 SNV: p.R982Q DBIA    Probe Info 
NCIH1155 SNV: p.A468V DBIA    Probe Info 
NCIH23 SNV: p.Q583H DBIA    Probe Info 
SKN Deletion: p.S994LfsTer11 DBIA    Probe Info 
SNU1 SNV: p.Y980H DBIA    Probe Info 
SSP25 Substitution: p.S483P DBIA    Probe Info 
TE4 SNV: p.T112I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.93  LDD0402  [1]
A-EBA
 Probe Info  		3.18  LDD0215  [2]
CHEMBL5175495
 Probe Info  		7.05  LDD0196  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
TH211
 Probe Info  		Y797(20.00); Y398(10.81); Y784(10.54); Y372(8.91)  LDD0257  [5]
TH214
 Probe Info  		Y372(16.80); Y398(5.31)  LDD0258  [5]
TH216
 Probe Info  		Y564(20.00); Y797(18.20); Y784(17.18); Y372(11.54)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
STPyne
 Probe Info  		K1156(2.33); K1158(2.11); K51(9.17); K55(10.00)  LDD0277  [7]
Probe 1
 Probe Info  		Y564(35.66); Y723(38.04); Y784(14.62); Y796(74.41)  LDD3495  [8]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [9]
AHL-Pu-1
 Probe Info  		C356(2.82); C940(5.18); C413(4.16)  LDD0169  [10]
HHS-475
 Probe Info  		Y82(0.54)  LDD0264  [11]
HHS-465
 Probe Info  		Y291(2.82); Y372(10.00); Y797(1.59); Y82(9.75)  LDD2237  [12]
DBIA
 Probe Info  		C942(1.32); C802(0.87)  LDD0078  [13]
ATP probe
 Probe Info  		K577(0.00); K355(0.00); K1156(0.00); K1158(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C356(0.00); C71(0.00); C301(0.00); C275(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C92(0.00); C237(0.00); C954(0.00); C1007(0.00)  LDD0032  [16]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [17]
IPIAA_L
 Probe Info  		C264(0.00); C413(0.00); C1007(0.00); C92(0.00)  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C356(0.00); C71(0.00); C802(0.00); C571(0.00)  LDD0037  [15]
ATP probe
 Probe Info  		K971(0.00); K1057(0.00); K801(0.00)  LDD0035  [18]
BTD
 Probe Info  		N.A.  LDD0004  [19]
NAIA_4
 Probe Info  		N.A.  LDD2226  [20]
TFBX
 Probe Info  		C131(0.00); C1134(0.00); C802(0.00); C356(0.00)  LDD0027  [21]
WYneN
 Probe Info  		C1007(0.00); C954(0.00); C356(0.00); C802(0.00)  LDD0021  [19]
WYneO
 Probe Info  		C571(0.00); C954(0.00)  LDD0022  [19]
Compound 10
 Probe Info  		C237(0.00); C571(0.00)  LDD2216  [22]
ENE
 Probe Info  		C1007(0.00); C942(0.00)  LDD0006  [19]
IPM
 Probe Info  		N.A.  LDD0005  [19]
NHS
 Probe Info  		K577(0.00); K971(0.00); K630(0.00); K60(0.00)  LDD0010  [19]
NPM
 Probe Info  		C356(0.00); C71(0.00)  LDD0016  [19]
PF-06672131
 Probe Info  		C131(0.00); C571(0.00); C1007(0.00)  LDD0017  [23]
SF
 Probe Info  		K586(0.00); Y6(0.00); K14(0.00)  LDD0028  [24]
1c-yne
 Probe Info  		K812(0.00); K826(0.00); K14(0.00); K255(0.00)  LDD0228  [25]
Acrolein
 Probe Info  		H1051(0.00); C131(0.00); C954(0.00); C940(0.00)  LDD0217  [26]
Methacrolein
 Probe Info  		C237(0.00); C1134(0.00); C954(0.00); C571(0.00)  LDD0218  [26]
W1
 Probe Info  		C1134(0.00); C413(0.00); C954(0.00); C131(0.00)  LDD0236  [27]
NAIA_5
 Probe Info  		C356(0.00); C571(0.00); C301(0.00); C92(0.00)  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [28]
VE-P
 Probe Info  		N.A.  LDD0396  [29]
DA-2
 Probe Info  		N.A.  LDD0070  [30]
STS-1
 Probe Info  		N.A.  LDD0068  [31]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1153(0.88); C802(0.67); C571(0.90); C940(1.03)  LDD2142  [32]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1153(0.88); C571(0.88); C1007(0.83)  LDD2112  [32]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C1153(0.65); C356(0.63)  LDD2095  [32]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C1153(1.20); C356(0.80); C954(1.13); C802(0.93)  LDD2130  [32]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1153(0.61); C356(1.18); C237(0.06); C1134(1.40)  LDD2117  [32]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1153(1.05); C954(1.53)  LDD2152  [32]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1134(0.98)  LDD2103  [32]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1153(0.81); C237(0.42); C571(0.62); C1007(0.60)  LDD2132  [32]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C1153(0.89); C237(1.02); C571(0.74)  LDD2131  [32]
 LDCM0025  4SU-RNA DM93 C1134(2.19)  LDD0170  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C356(2.82); C940(5.18); C413(4.16)  LDD0169  [10]
 LDCM0214  AC1 HCT 116 C1088(0.70); C1096(0.64); C1007(1.08); C1134(1.07)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C1088(0.79); C1096(0.78); C1007(1.24); C1134(1.14)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C1007(0.96); C1134(1.32); C131(0.75); C237(0.90)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C1007(0.80); C1134(1.02); C131(0.67); C237(0.84)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C1007(0.81); C1134(1.06); C131(0.73); C237(0.75)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C1007(0.75); C1134(0.99); C131(0.63); C237(0.74)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C1007(0.78); C1134(1.25); C131(0.77); C237(0.78)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C1007(0.79); C1134(1.01); C131(0.63); C237(0.81)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C1007(0.87); C1134(1.04); C131(0.67); C237(0.81)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C1007(1.06); C1134(1.23); C131(0.74); C237(0.79)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C1007(0.90); C1134(1.24); C131(0.90); C237(0.92)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C1007(0.97); C1134(1.30); C131(1.00); C237(0.91)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C1088(0.75); C1096(0.70); C1007(1.11); C1134(1.09)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C1007(0.90); C1134(1.02); C131(0.78); C237(0.98)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C1007(0.89); C1134(1.04); C131(0.78); C237(0.92)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C1007(0.98); C1134(1.01); C131(0.65); C237(0.75)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C1088(0.53); C1096(0.53); C1007(1.00); C1134(1.03)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C1088(0.32); C1096(0.32); C1007(1.01); C1134(0.98)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C1088(0.35); C1096(0.35); C1007(1.03); C1134(1.06)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C1088(0.36); C1096(0.36); C1007(0.94); C1134(1.00)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C1088(0.35); C1096(0.35); C1007(0.99); C1134(1.02)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C1088(0.46); C1096(0.46); C1007(1.03); C1134(0.94)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C1088(0.43); C1096(0.43); C1007(0.94); C1134(0.86)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C1088(0.92); C1096(0.79); C1007(1.18); C1134(1.05)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C1088(0.46); C1096(0.46); C1007(0.92); C1134(0.91)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C1088(0.58); C1096(0.58); C1007(1.05); C1134(1.00)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C1088(0.45); C1096(0.45); C1007(0.97); C1134(1.03)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C1088(0.39); C1096(0.39); C1007(0.90); C1134(1.15)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C1088(0.40); C1096(0.40); C1007(1.09); C1134(1.12)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C1088(0.65); C1096(0.65); C1007(0.95); C1134(0.99)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C1088(0.41); C1096(0.41); C1007(1.04); C1134(1.06)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C1088(0.33); C1096(0.33); C1007(1.02); C1134(1.07)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C1088(0.91); C1096(0.72); C1007(1.45); C1134(1.47)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C1088(1.13); C1096(0.84); C1007(1.49); C1134(1.39)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C1088(0.94); C1096(0.61); C1007(1.26); C1134(1.15)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C1088(1.22); C1096(1.09); C1007(1.24); C1134(1.24)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C1088(0.94); C1096(0.90); C1007(1.32); C1134(1.27)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C1088(0.85); C1096(0.78); C1007(1.23); C1134(1.19)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C1088(0.90); C1096(0.63); C1007(1.21); C1134(1.17)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C1088(1.04); C1096(0.74); C1007(1.28); C1134(1.25)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C1088(0.92); C1096(0.78); C1007(1.19); C1134(1.18)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C1088(0.96); C1096(0.86); C1007(1.16); C1134(1.15)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C1088(1.00); C1096(0.69); C1007(1.23); C1134(1.06)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C1088(1.01); C1096(0.78); C1007(1.17); C1134(1.13)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C1088(0.73); C1096(0.69); C1007(0.87); C1134(1.11)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C1088(0.87); C1096(0.74); C1007(1.28); C1134(1.14)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C1088(0.86); C1096(0.76); C1007(1.20); C1134(1.18)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C1088(0.89); C1096(0.86); C1007(1.23); C1134(1.19)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C1088(0.38); C1007(1.05); C1134(0.73); C131(0.82)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C1088(0.19); C237(0.65); C131(0.67); C940(0.67)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C1088(0.33); C954(0.66); C237(0.70); C1134(0.75)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C1088(0.26); C71(0.53); C237(0.57); C940(0.62)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C1088(0.24); C940(0.63); C131(0.63); C237(0.66)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C1088(0.21); C71(0.42); C131(0.53); C237(0.55)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C1088(0.25); C71(0.49); C940(0.53); C131(0.54)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C940(0.69); C264(0.77); C1096(0.79); C237(0.82)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C1088(0.37); C1134(0.72); C954(0.72); C237(0.77)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C1088(0.29); C954(0.53); C940(0.77); C237(0.78)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C1088(0.18); C71(0.50); C954(0.55); C940(0.56)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C1088(0.18); C71(0.35); C131(0.51); C237(0.51)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C1088(0.27); C1007(1.05); C1134(0.65); C131(0.69)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C1088(0.22); C1007(1.06); C1134(0.65); C131(0.64)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C1088(0.26); C1007(1.16); C1134(0.86); C131(0.95)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C1088(0.28); C1007(1.36); C1134(0.66); C131(1.19)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C942(0.90); C71(0.91); C237(0.94); C940(0.95)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C71(0.42); C1096(0.55); C1088(0.63); C237(0.71)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C71(0.76); C942(0.80); C1088(0.86); C940(0.87)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C264(0.71); C1096(0.80); C940(0.82); C1088(0.85)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C264(0.82); C942(0.86); C237(0.86); C1088(0.87)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C264(0.71); C1088(0.73); C71(0.73); C942(0.76)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C264(0.83); C1096(0.92); C942(0.92); C237(0.93)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C264(0.76); C1088(0.82); C1096(0.86); C237(0.93)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C264(0.88); C1007(0.90); C71(0.94); C1088(1.09)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C1088(0.71); C1096(0.71); C356(0.81); C940(0.87)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C1088(0.54); C1096(0.54); C356(0.75); C940(0.76)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C1088(0.56); C1096(0.56); C940(0.70); C571(0.72)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C1088(0.56); C1096(0.56); C237(0.76); C71(0.78)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C1088(0.64); C1096(0.64); C940(0.68); C71(0.69)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C264(0.66); C131(0.78); C1096(0.80); C940(0.87)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C1088(0.64); C1096(0.64); C940(0.67); C131(0.72)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C1088(0.46); C1096(0.46); C71(0.70); C237(0.70)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C1088(0.44); C1096(0.44); C71(0.57); C356(0.60)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C1088(0.48); C1096(0.48); C940(0.60); C71(0.64)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C1088(0.51); C1096(0.51); C71(0.58); C940(0.59)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C571(0.91); C1007(0.99); C942(1.04); C1134(1.09)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C571(0.82); C1134(0.85); C802(0.90); C1007(0.90)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C1134(0.89); C1007(0.96); C802(0.97); C237(0.99)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C571(0.89); C802(0.90); C1134(0.91); C954(0.91)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C802(0.88); C237(0.93); C571(0.93); C954(0.93)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C264(0.63); C1096(0.67); C1088(0.75); C237(0.79)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C1134(0.87); C356(0.93); C571(0.93); C237(0.93)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C802(0.81); C571(0.87); C237(0.88); C131(0.89)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C802(0.79); C1134(0.86); C571(0.88); C954(0.89)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C942(0.77); C940(0.79); C131(0.83); C237(0.84)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C942(0.89); C1134(0.91); C940(0.93); C802(0.99)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C942(0.85); C802(0.89); C131(0.90); C940(0.91)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C940(0.88); C1088(0.88); C1096(0.88); C571(0.90)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C1088(0.81); C1096(0.81); C264(0.92); C131(0.97)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C413(0.64); C1088(0.70); C1096(0.70); C275(0.73)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C71(0.71); C275(0.78); C131(0.80); C1088(0.84)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C1096(0.67); C264(0.70); C131(0.72); C1088(0.75)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C1088(0.70); C1096(0.70); C71(0.73); C275(0.78)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C413(0.72); C264(0.97); C940(0.99); C275(0.99)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C413(0.79); C954(0.90); C1088(0.93); C1096(0.93)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C1088(0.74); C1096(0.74); C71(0.76); C275(0.85)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C1088(0.81); C1096(0.81); C71(0.88); C131(0.89)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C1088(0.68); C1096(0.68); C71(0.69); C264(0.77)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C71(0.61); C275(0.64); C1088(0.77); C1096(0.77)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C356(0.39); C1088(0.46); C1096(0.46); C942(0.60)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C356(0.34); C71(0.54); C942(0.59); C940(0.59)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C356(0.40); C71(0.52); C940(0.61); C942(0.63)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C1096(0.67); C940(0.71); C71(0.71); C264(0.71)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C356(0.29); C1088(0.39); C1096(0.39); C71(0.46)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C356(0.26); C1088(0.40); C1096(0.40); C942(0.56)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C356(0.42); C71(0.47); C1088(0.55); C1096(0.55)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C356(0.31); C1088(0.44); C1096(0.44); C71(0.45)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C356(0.34); C71(0.45); C1088(0.48); C1096(0.48)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C356(0.31); C71(0.51); C940(0.62); C942(0.63)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C356(0.28); C1088(0.58); C1096(0.58); C71(0.63)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C356(0.22); C71(0.39); C1088(0.49); C1096(0.49)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C71(0.58); C1088(0.58); C1096(0.58); C356(0.66)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C71(0.49); C356(0.54); C1088(0.58); C1096(0.58)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C264(0.72); C237(0.83); C940(0.83); C71(0.87)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C71(0.40); C356(0.51); C1088(0.60); C1096(0.60)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C1088(0.59); C1096(0.59); C356(0.68); C71(0.79)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C1088(0.58); C1096(0.58); C71(0.66); C356(0.67)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C71(0.37); C1088(0.54); C1096(0.54); C356(0.60)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C71(0.32); C1088(0.47); C1096(0.47); C356(0.50)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C71(0.33); C356(0.54); C1088(0.58); C1096(0.58)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C71(0.58); C1088(0.68); C1096(0.68); C356(0.78)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C1088(0.46); C1096(0.46); C71(0.54); C356(0.72)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C1088(0.47); C1096(0.47); C356(0.56); C71(0.68)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C1088(0.59); C1096(0.59); C71(0.70); C356(0.78)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C940(0.74); C1096(0.74); C71(0.75); C264(0.76)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C71(0.61); C1088(0.63); C1096(0.63); C356(0.76)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C1088(0.52); C1096(0.52); C356(0.68); C264(0.85)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C71(0.30); C356(0.54); C1088(0.56); C1096(0.56)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C1088(0.61); C1096(0.61); C802(0.67); C237(0.69)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C802(0.55); C1088(0.57); C1096(0.57); C131(0.65)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C1088(0.60); C1096(0.60); C802(0.67); C237(0.70)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C802(0.76); C954(0.82); C264(0.84); C940(0.88)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C802(0.76); C237(0.85); C356(0.86); C1088(0.87)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C264(0.73); C356(0.92); C275(0.93); C571(0.95)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C802(0.62); C954(0.70); C131(0.75); C356(0.77)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C264(0.81); C802(0.91); C571(0.98); C275(1.00)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C1088(0.67); C1096(0.67); C802(0.70); C237(0.71)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C802(0.69); C1088(0.71); C1096(0.71); C131(0.78)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C264(0.72); C802(0.73); C942(0.74); C131(0.82)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C802(0.62); C1088(0.88); C1096(0.88); C131(0.91)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C1088(0.48); C1096(0.48); C802(0.69); C356(0.71)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C1088(0.62); C1096(0.62); C802(0.73); C237(0.76)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C802(0.66); C356(0.74); C237(0.77); C1088(0.79)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C356(0.51); C131(0.52); C942(0.61); C71(0.65)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C942(0.66); C356(0.70); C131(0.78); C275(0.81)  LDD0683  [13]
 LDCM0545  Acetamide MDA-MB-231 C1153(0.25); C802(0.96)  LDD2138  [32]
 LDCM0520  AKOS000195272 MDA-MB-231 C1153(0.79); C954(0.87); C940(0.96)  LDD2113  [32]
 LDCM0248  AKOS034007472 HCT 116 C1088(1.34); C1096(0.94); C1007(1.11); C1134(1.06)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C571(0.74); C940(0.74); C1096(0.76); C264(0.76)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C940(0.61); C71(0.63); C237(0.65); C264(0.69)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0405  [1]
 LDCM0020  ARS-1620 HCC44 C942(1.32); C802(0.87)  LDD0078  [13]
 LDCM0104  BDHI 13 Jurkat C942(13.26)  LDD0206  [33]
 LDCM0498  BS-3668 MDA-MB-231 C954(0.84); C237(0.61); C571(0.94)  LDD2091  [32]
 LDCM0108  Chloroacetamide HeLa C131(0.00); C237(0.00); C954(0.00); C1007(0.00)  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C1134(20.00); C1007(20.00); C413(20.00); C131(20.00)  LDD2227  [20]
 LDCM0367  CL1 HCT 116 C413(0.72); C275(0.77); C571(0.79); C954(0.80)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C71(0.50); C356(0.62); C1096(0.63); C1088(0.73)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C264(0.66); C131(0.74); C237(0.75); C1096(0.78)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C571(0.65); C264(0.67); C940(0.71); C942(0.76)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C264(0.68); C571(0.77); C1096(0.86); C237(0.88)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C571(0.74); C1096(0.80); C264(0.83); C1088(0.87)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C571(0.74); C1096(0.75); C264(0.80); C940(0.82)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C71(0.60); C264(0.72); C237(0.77); C942(0.81)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C71(0.29); C1088(0.48); C1096(0.59); C264(0.65)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C71(0.51); C1088(0.59); C942(0.74); C1096(0.75)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C71(0.36); C264(0.71); C942(0.78); C1088(0.80)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C71(0.62); C1088(0.67); C264(0.72); C942(0.72)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C71(0.42); C1096(0.64); C356(0.67); C1088(0.72)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C71(0.49); C1088(0.66); C264(0.71); C1096(0.72)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C71(0.67); C1096(0.70); C1088(0.71); C264(0.74)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C954(0.78); C802(0.80); C264(0.82); C1088(0.85)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C1088(0.45); C1096(0.45); C71(0.61); C940(0.63)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C1088(0.60); C1096(0.60); C940(0.66); C131(0.73)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C1088(0.56); C1096(0.56); C940(0.60); C571(0.66)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C1088(0.62); C1096(0.62); C356(0.68); C571(0.69)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C71(0.80); C356(0.87); C954(0.90); C571(0.90)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C802(0.80); C571(0.83); C954(0.86); C237(0.88)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C802(0.89); C356(0.90); C237(0.93); C942(0.94)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C71(0.51); C1096(0.80); C131(0.85); C1088(0.88)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C802(0.80); C571(0.87); C942(0.91); C954(0.95)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C71(0.67); C571(0.78); C942(0.79); C954(0.94)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C1088(0.73); C1096(0.73); C275(0.79); C131(0.82)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C275(0.74); C1088(0.74); C1096(0.74); C71(0.80)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C275(0.71); C1088(0.75); C1096(0.75); C71(0.79)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C356(0.81); C942(0.82); C940(0.82); C1088(0.85)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C356(0.63); C1088(0.68); C1096(0.68); C954(0.71)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C356(0.63); C275(0.63); C954(0.65); C940(0.71)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C356(0.55); C942(0.66); C1088(0.66); C1096(0.66)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C71(0.48); C356(0.60); C1096(0.69); C131(0.71)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C954(0.83); C264(0.85); C413(0.86); C1096(0.88)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C71(0.65); C356(0.68); C1088(0.74); C1096(0.80)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C571(0.67); C71(0.74); C940(0.82); C942(0.83)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C571(0.60); C275(0.67); C1088(0.70); C1096(0.75)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C571(0.37); C1088(0.46); C1096(0.47); C275(0.50)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C571(0.54); C1088(0.64); C1096(0.64); C275(0.71)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C954(0.80); C413(0.83); C1134(0.85); C940(0.87)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C571(0.57); C71(0.61); C1088(0.62); C1096(0.65)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C275(0.48); C571(0.50); C1088(0.60); C1096(0.61)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C275(0.48); C71(0.53); C571(0.61); C1088(0.73)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C571(0.62); C71(0.65); C940(0.72); C264(0.74)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C71(0.55); C275(0.56); C571(0.64); C1096(0.67)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C1088(0.70); C1096(0.70); C1007(0.87); C1134(0.87)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C1088(0.69); C1096(0.76); C1007(0.89); C1134(0.81)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C1088(0.71); C1096(0.75); C1007(0.89); C1134(1.00)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C1088(0.70); C1096(0.75); C1007(0.85); C1134(0.94)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C1088(0.66); C1096(0.70); C1007(0.90); C1134(1.02)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C1088(1.03); C1096(0.96); C1007(1.12); C1134(0.99)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C1088(0.82); C1096(0.83); C1007(0.93); C1134(1.08)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C1088(0.78); C1096(0.61); C1007(1.20); C1134(1.09)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C1088(0.54); C1096(0.35); C1007(1.15); C1134(1.00)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C1088(0.53); C1096(0.35); C1007(1.00); C1134(0.96)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C1088(0.74); C1096(0.46); C1007(0.95); C1134(1.18)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C1088(0.80); C1096(0.60); C1007(1.00); C1134(0.97)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C1088(0.73); C1096(0.48); C1007(1.00); C1134(1.09)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C1088(0.68); C1096(0.46); C1007(1.09); C1134(1.10)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C1088(0.61); C1096(0.52); C1007(1.22); C1134(1.16)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C1088(1.18); C1096(1.35); C1007(1.01); C1134(0.83)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C1088(0.66); C1096(0.49); C1007(1.09); C1134(1.05)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C1088(0.65); C1096(0.49); C1007(0.84); C1134(1.08)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C1088(0.78); C1096(0.51); C1007(0.99); C1134(1.09)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C1088(0.70); C1096(0.50); C1007(1.12); C1134(1.18)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C1088(0.66); C1096(0.46); C1007(1.00); C1134(1.06)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C1088(0.65); C1096(0.46); C1007(1.06); C1134(1.09)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C1088(2.09); C1096(2.09); C1007(0.91); C1134(0.84)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C1088(2.00); C1096(2.00); C1007(0.91); C1134(0.74)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C1088(1.80); C1096(1.80); C1007(1.00); C1134(0.93)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C1088(1.59); C1096(1.59); C1007(1.04); C1134(1.11)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C1088(0.98); C1096(0.99); C1007(1.06); C1134(1.05)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C1088(1.57); C1096(1.57); C1007(0.99); C1134(0.97)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C1088(1.68); C1096(1.68); C1007(1.04); C1134(1.05)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C1088(1.63); C1096(1.63); C1007(0.95); C1134(1.03)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C1088(1.74); C1096(1.74); C1007(0.84); C1134(0.72)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C1088(1.57); C1096(1.57); C1007(0.96); C1134(0.80)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C1088(2.09); C1096(2.09); C1007(1.06); C1134(0.93)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C1088(1.41); C1096(1.41); C1007(0.99); C1134(0.94)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C1088(1.52); C1096(1.52); C1007(0.86); C1134(0.84)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C1088(1.94); C1096(1.94); C1007(0.89); C1134(1.03)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C1088(1.37); C1096(1.37); C1007(1.01); C1134(0.97)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C1088(0.63); C1096(0.58); C1007(0.88); C1134(0.99)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C1088(1.78); C1096(1.78); C1007(0.92); C1134(0.89)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C1088(0.80); C1096(0.84); C1007(0.99); C1134(0.89)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C1088(0.78); C1096(0.78); C1007(0.95); C1134(0.96)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C1088(0.63); C1096(0.65); C1007(0.87); C1134(0.78)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C1088(0.57); C1096(0.58); C1007(0.79); C1134(0.84)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C1088(0.79); C1096(0.81); C1007(0.99); C1134(1.06)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C1088(0.61); C1096(0.59); C1007(0.86); C1134(1.05)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C1088(0.61); C1096(0.59); C1007(0.78); C1134(0.89)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C1088(0.54); C1096(0.53); C1007(0.81); C1134(0.88)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C1088(0.54); C1096(0.54); C1007(0.73); C1134(0.90)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C1088(0.79); C1096(0.75); C1007(1.08); C1134(1.06)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C1088(0.54); C1096(0.54); C1007(0.83); C1134(1.18)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C1088(0.66); C1096(0.69); C1007(0.96); C1134(1.08)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C1088(0.74); C1096(0.73); C1007(0.91); C1134(0.90)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C1088(1.23); C1096(1.26); C1007(0.83); C1134(1.00)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C1088(0.83); C1096(0.81); C1007(0.86); C1134(1.08)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C1088(0.59); C1096(0.51); C1007(1.13); C1134(1.05)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C1088(2.91); C1096(3.14); C1007(1.08); C1134(1.02)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C1088(0.81); C1096(0.81); C1007(1.12); C1134(1.10)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C1088(0.63); C1096(0.57); C1007(1.16); C1134(1.03)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C1088(0.74); C1096(0.68); C1007(0.98); C1134(0.81)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C1088(0.58); C1096(0.50); C1007(1.25); C1134(1.13)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C1088(0.65); C1096(0.56); C1007(1.26); C1134(1.25)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C1088(0.57); C1096(0.50); C1007(1.22); C1134(1.41)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C1088(0.57); C1096(0.51); C1007(1.23); C1134(1.21)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C1088(0.68); C1096(0.58); C1007(1.09); C1134(0.99)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C1088(0.69); C1096(0.60); C1007(1.11); C1134(1.01)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C1088(0.84); C1096(0.77); C1007(1.12); C1134(1.14)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C1088(0.69); C1096(0.66); C1007(1.26); C1134(1.14)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C1088(0.64); C1096(0.59); C1007(1.32); C1134(1.19)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C1088(0.59); C1096(0.55); C1007(1.26); C1134(1.33)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C1088(0.91); C1096(0.82); C1007(0.98); C1134(0.85)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C1088(1.15); C1096(1.08); C1007(1.13); C1134(1.22)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C1088(0.73); C1096(0.68); C1007(1.04); C1134(0.93)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C1088(0.79); C1096(0.73); C1007(1.26); C1134(0.92)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C1088(0.95); C1096(0.83); C1007(1.31); C1134(1.19)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C1088(0.78); C1096(0.69); C1007(0.95); C1134(0.96)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C1088(0.70); C1096(0.65); C1007(1.12); C1134(1.01)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C1088(0.83); C1096(0.75); C1007(1.18); C1134(0.97)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C1088(0.86); C1096(0.84); C1007(1.13); C1134(0.92)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C1088(0.76); C1096(0.70); C1007(1.08); C1134(0.98)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C1088(0.85); C1096(0.76); C1007(1.20); C1134(0.96)  LDD0811  [13]
 LDCM0634  CY-0357 Hep-G2 C356(2.23); C954(0.42)  LDD2228  [20]
 LDCM0495  E2913 HEK-293T C802(0.91); C356(0.91); C264(1.07); C954(0.85)  LDD1698  [34]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1134(4.56); C1153(1.64); C356(1.32); C1007(1.27)  LDD1702  [32]
 LDCM0625  F8 Ramos C802(1.34); C1007(0.82); C356(0.77); C1134(0.78)  LDD2187  [35]
 LDCM0572  Fragment10 Ramos C802(0.59); C1007(0.65); C356(0.53); C1134(0.43)  LDD2189  [35]
 LDCM0573  Fragment11 Ramos C802(0.51); C1007(0.84); C356(0.75); C1134(0.08)  LDD2190  [35]
 LDCM0574  Fragment12 Ramos C802(0.69); C1007(0.64); C356(0.44); C1134(0.56)  LDD2191  [35]
 LDCM0575  Fragment13 Ramos C802(1.22); C1007(0.90); C356(1.28); C1134(1.11)  LDD2192  [35]
 LDCM0576  Fragment14 Ramos C802(1.40); C1007(1.33); C356(0.47); C1134(0.78)  LDD2193  [35]
 LDCM0579  Fragment20 Ramos C802(0.92); C1007(0.61); C356(0.74); C1134(0.44)  LDD2194  [35]
 LDCM0580  Fragment21 Ramos C802(0.72); C1007(0.89); C356(0.73); C1134(0.60)  LDD2195  [35]
 LDCM0582  Fragment23 Ramos C802(0.48); C1007(0.56); C356(0.53); C1134(0.21)  LDD2196  [35]
 LDCM0578  Fragment27 Ramos C802(1.00); C1007(0.88); C356(1.25); C1134(0.87)  LDD2197  [35]
 LDCM0586  Fragment28 Ramos C802(0.90); C1007(0.93); C356(0.92); C1134(1.91)  LDD2198  [35]
 LDCM0588  Fragment30 Ramos C802(1.24); C1007(0.93); C356(1.53); C1134(1.10)  LDD2199  [35]
 LDCM0589  Fragment31 Ramos C802(1.10); C1007(1.10); C356(1.26); C1134(0.95)  LDD2200  [35]
 LDCM0590  Fragment32 Ramos C802(0.54); C1007(0.72); C356(0.50); C1134(0.54)  LDD2201  [35]
 LDCM0468  Fragment33 HCT 116 C1088(0.73); C1096(0.75); C1007(0.77); C1134(0.85)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C802(1.36); C1007(0.85); C356(1.39); C1134(1.24)  LDD2203  [35]
 LDCM0566  Fragment4 Ramos C802(1.04); C1007(0.96); C356(0.55); C1134(0.99)  LDD2184  [35]
 LDCM0427  Fragment51 HCT 116 C1088(0.74); C1096(0.52); C1007(1.04); C1134(1.17)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C802(2.35); C1007(0.86); C356(1.89); C1134(1.39)  LDD2204  [35]
 LDCM0614  Fragment56 Ramos C802(1.65); C1007(0.83); C356(1.48); C1134(1.24)  LDD2205  [35]
 LDCM0569  Fragment7 Ramos C802(0.80); C1007(0.75); C356(0.64); C1134(0.54)  LDD2186  [35]
 LDCM0571  Fragment9 Ramos C802(0.48); C1007(0.44); C356(0.35); C1134(0.42)  LDD2188  [35]
 LDCM0116  HHS-0101 DM93 Y82(0.54)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y82(0.88)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y82(0.97)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y82(1.24)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y82(1.21)  LDD0268  [11]
 LDCM0015  HNE MDA-MB-231 C1134(0.95)  LDD0346  [35]
 LDCM0107  IAA HeLa C275(0.00); C237(0.00); H365(0.00); H7(0.00)  LDD0221  [26]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [9]
 LDCM0022  KB02 HCT 116 C237(1.34); C356(1.07); C1007(1.33); C942(1.28)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C237(2.10); C356(2.25); C1007(1.93); C942(1.36)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C237(3.01); C356(2.25); C1007(1.56); C942(1.41)  LDD0082  [13]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1134(0.84)  LDD2102  [32]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C1153(0.34); C802(1.05); C571(0.95)  LDD2121  [32]
 LDCM0109  NEM HeLa H365(0.00); H7(0.00); H1051(0.00); H996(0.00)  LDD0223  [26]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C1153(0.40); C356(1.14); C954(1.05); C802(1.56)  LDD2089  [32]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C1153(1.04); C954(1.04)  LDD2090  [32]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1153(1.07); C1134(1.03)  LDD2092  [32]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1153(0.71); C954(1.16)  LDD2093  [32]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1153(0.82)  LDD2094  [32]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C954(0.11); C940(1.12)  LDD2096  [32]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C1153(0.92); C954(0.99)  LDD2097  [32]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1153(0.75); C237(0.67); C1134(1.11)  LDD2098  [32]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1153(0.63); C356(1.20); C237(1.15); C131(1.10)  LDD2099  [32]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1153(0.73); C571(0.88); C1007(0.58); C940(1.53)  LDD2100  [32]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1153(1.25); C954(0.98); C940(0.89)  LDD2101  [32]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1153(0.78); C571(0.93); C1007(0.59); C940(1.03)  LDD2104  [32]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1153(1.04); C1134(1.59)  LDD2105  [32]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C571(0.73)  LDD2106  [32]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1153(0.66); C237(0.98); C131(0.97)  LDD2107  [32]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1153(0.67); C571(0.73)  LDD2108  [32]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1153(0.37); C356(0.69); C954(0.54); C802(1.09)  LDD2109  [32]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C571(1.61)  LDD2110  [32]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1153(0.65)  LDD2111  [32]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1153(1.09); C954(0.72); C802(0.55); C571(0.94)  LDD2114  [32]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C954(0.45)  LDD2115  [32]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1153(0.57); C940(1.33)  LDD2118  [32]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1153(2.64)  LDD2119  [32]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1153(1.00)  LDD2120  [32]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1153(0.60); C954(0.08); C940(1.19)  LDD2122  [32]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1153(0.55); C954(1.12); C802(0.97); C237(0.27)  LDD2123  [32]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1153(0.47); C356(0.03); C954(0.10); C940(0.95)  LDD2124  [32]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1153(0.50); C954(0.99); C237(0.75); C1134(0.86)  LDD2125  [32]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C1153(0.47); C356(0.02); C940(1.02)  LDD2126  [32]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1153(0.66); C954(1.09); C802(0.98); C237(1.21)  LDD2127  [32]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1153(0.98); C571(0.34)  LDD2128  [32]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1153(0.72); C954(1.05)  LDD2129  [32]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1153(0.59); C954(0.45)  LDD2133  [32]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1153(0.56); C954(0.58); C940(0.83)  LDD2134  [32]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1153(0.80); C954(1.58); C237(1.17); C131(1.38)  LDD2135  [32]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1153(0.81); C954(1.65); C802(1.97); C237(1.67)  LDD2136  [32]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1153(0.85); C954(1.02); C802(1.52)  LDD2137  [32]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C954(4.37); C1153(1.01)  LDD1700  [32]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1153(0.45); C356(1.15); C954(1.12); C131(0.92)  LDD2140  [32]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1153(0.66); C571(0.65); C1007(0.73); C940(1.08)  LDD2141  [32]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1153(1.50); C954(0.53)  LDD2143  [32]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1153(1.68)  LDD2144  [32]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C1007(4.18)  LDD2145  [32]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1153(0.56); C954(1.06); C237(0.50)  LDD2146  [32]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1153(0.52); C954(0.40); C940(0.61)  LDD2148  [32]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C1153(0.60); C940(1.54)  LDD2149  [32]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1153(0.42); C356(0.82); C237(0.90); C571(1.07)  LDD2150  [32]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C954(0.12)  LDD2151  [32]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C954(1.43); C1134(1.39)  LDD2153  [32]
 LDCM0131  RA190 MM1.R C1007(1.31); C942(1.04)  LDD0304  [36]
 LDCM0021  THZ1 HCT 116 C1007(1.22); C237(1.05); C802(1.22); C356(1.10)  LDD2173  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cullin-1 (CUL1) Cullin family Q13616
Cullin-2 (CUL2) Cullin family Q13617
Cullin-3 (CUL3) Cullin family Q13618
Cullin-4A (CUL4A) Cullin family Q13619
Cullin-4B (CUL4B) Cullin family Q13620
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large ribosomal subunit protein uL15 (RPL27A) Universal ribosomal protein uL15 family P46776

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD029500 , PXD031647
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD041264
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD036569
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD027578
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