Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name DBIA  Probe Info 
Probe concentration 50 mM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
TMT
Competitor Name BDHI 13  Competitor Info 
Competitor Concentration 50 mM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Bone marrow
Disease Model T acute lymphoblastic leukemia [ICD-11:2A90]
Model Name Human T acute lymphoblastic leukemia cell lysate (Jurkat)

Interaction Altas of This Experiment [1]

Enzyme
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Target ID Target Name Binding Sites Binding Ratio
 LDTP08296  Cullin-associated NEDD8-dissociated protein 1 (CAND1) C942 13.3
 LDTP07230  Deubiquitinase MYSM1 (MYSM1) C780 7.1
 LDTP04163  Prolyl endopeptidase (PREP) C255 5.3
Transporter and channel
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Target ID Target Name Binding Sites Binding Ratio
 LDTP02815  Desmoplakin (DSP) C1499 6.4
Transcription factor
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Target ID Target Name Binding Sites Binding Ratio
 LDTP09725  HMG box transcription factor BBX (BBX) C606 5.6
Other
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP15478  Late secretory pathway protein AVL9 homolog (AVL9) C409 8.7
 LDTP01363  Cell cycle checkpoint protein RAD17 (RAD17) C252 5.6
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) . 5.2

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.