Details of the Target

General Information of Target

Target ID LDTP09725
Target Name HMG box transcription factor BBX (BBX)
Gene Name BBX
Gene ID 56987
Synonyms
HBP2; HMG box transcription factor BBX; Bobby sox homolog; HMG box-containing protein 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKGSNRNKDHSAEGEGVGKRPKRKCLQWHPLLAKKLLDFSEEEEEEDEEEDIDKVQLLGA
DGLEQDVGETEDDESPEQRARRPMNAFLLFCKRHRSLVRQEHPRLDNRGATKILADWWAV
LDPKEKQKYTDMAKEYKDAFMKANPGYKWCPTTNKPVKSPTPTVNPRKKLWAFPSDSSRD
LPSPKKAKTEEMPQLNFGMADPTQMGGLSMLLLAGEHALGTPEVSSGTCRPDVSESPELR
QKSPLFQFAEISSSTSHSDASTKQCQTSALFQFAEISSNTSQLGGAEPVKRCGKSALFQL
AEMCLASEGMKMEESKLIKAKESDGGRIKELEKGKEEKEIKMEKTDETRLQKEAEFEKSA
KENLRDSKELRNFEALQIDDIMAIKMEDPKEIRKEELEEDHKCSHFPDFSYSASSKIIIS
DVPSRKDHMCHPHGIMIIEDPAALNKPEKLKKKKKKSKMDRHGNDKSTPKKTCKKRQSSE
SDIESVIYTIEAVAKGDWGIEKLGDTPRKKVRTSSSGKGSILDAKPPKKKVKSREKKMSK
EKSSDTTKESRPPDFISISASKNISGETPEGIKAEPLTPMEDALPPSLSGQAKPEDSDCH
RKIETCGSRKSERSCKGALYKTLVSEGMLTSLRANVDRGKRSSGKGNSSDHEGCWNEESW
TFSQSGTSGSKKFKKTKPKEDCLLGSAKLDEEFEKKFNSLPQYSPVTFDRKCVPVPRKKK
KTGNVSSEPTKTSKGPFQSQKKNLFHKIVSKYKHKKEKPNVPEKGSGDKWSNKQLFLDAI
HPTEAIFSEDRNTMEPVHKVKNIPSIFNTPEPTTTQEPLVGSQKRKARKTKITHLVRTAD
GRVSPAGGTLDDKPKEQLQRSLPKATETDCNDKCSHNTEVGETRSSTPEMPAVSAFFSLA
ALAEVAAMENVHRGQRSTPLTHDGQPKEMPQAPVLISCADQ
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Transcription factor that is necessary for cell cycle progression from G1 to S phase.
Uniprot ID
Q8WY36
Ensemble ID
ENST00000325805.13
HGNC ID
HGNC:14422

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCSW1 SNV: p.H798Q DBIA    Probe Info 
CMK Deletion: p.S457AfsTer44 .
HEP3B217 SNV: p.Q56K .
HGC27 SNV: p.K124N DBIA    Probe Info 
HT115 SNV: p.A286V .
HUCCT1 SNV: p.R710Q DBIA    Probe Info 
NCIH1155 SNV: p.L195F DBIA    Probe Info 
NCIH2052 SNV: p.Q194R .
RKO SNV: p.R641Ter DBIA    Probe Info 
SNU1196 SNV: p.N760I DBIA    Probe Info 
TOV21G Deletion: p.K452RfsTer49 DBIA    Probe Info 
WM1552C SNV: p.A895T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.57  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C874(10.60); C150(2.71)  LDD0169  [2]
DBIA
 Probe Info  		C606(1.04)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
NAIA_4
 Probe Info  		C265(0.00); C304(0.00); C874(0.00)  LDD2226  [6]
TFBX
 Probe Info  		C712(0.00); C870(0.00); C874(0.00)  LDD0027  [7]
IPM
 Probe Info  		C150(0.00); C606(0.00)  LDD0005  [8]
VSF
 Probe Info  		C712(0.00); C874(0.00)  LDD0007  [8]
Phosphinate-6
 Probe Info  		C150(0.00); C874(0.00); C870(0.00); C615(0.00)  LDD0018  [9]
AOyne
 Probe Info  		13.80  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C304(9.22)  LDD0170  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C874(10.60); C150(2.71)  LDD0169  [2]
 LDCM0214  AC1 HCT 116 C150(0.72); C606(0.88)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C150(1.08)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C150(1.16)  LDD0543  [3]
 LDCM0230  AC113 PaTu 8988t C403(0.90)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C403(0.73)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C403(0.98)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C403(0.83)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C403(0.93)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C403(0.90)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C403(0.82)  LDD1115  [3]
 LDCM0237  AC12 HCT 116 C150(0.96)  LDD0554  [3]
 LDCM0238  AC120 PaTu 8988t C403(0.76)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C403(0.77)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C403(0.73)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C403(0.74)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C403(0.83)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C403(1.09)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C403(0.88)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C403(0.71)  LDD1124  [3]
 LDCM0246  AC128 HEK-293T C150(0.81); C403(0.77)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C150(0.67); C403(0.89)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C150(0.79); C403(1.04)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C150(0.90); C403(1.13)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C150(0.81); C403(0.89)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C150(0.75); C403(0.85)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C150(0.66); C403(0.97)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C150(0.78); C403(0.78)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C150(0.69); C403(0.92)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C150(0.94); C403(0.89)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C150(0.89); C403(0.93)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C150(0.76); C403(1.00)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C150(1.13)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C150(0.74); C403(0.97)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C150(0.77); C403(1.05)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C150(0.69); C403(1.03)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C150(1.04); C403(0.94)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C150(0.85); C403(0.80)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C150(0.94); C403(0.66)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C150(0.98); C403(0.88)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C150(0.99); C403(0.62)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C150(0.97); C403(0.59)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C150(1.01); C403(0.93)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C150(1.18)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C150(0.86); C403(0.66)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C150(0.88); C403(0.70)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C150(0.97); C403(0.89)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C150(0.86); C403(0.82)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C150(0.94); C403(1.06)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C150(0.91); C403(1.01)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C150(1.00); C403(0.54)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C150(1.11); C403(0.68)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C606(0.25)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C606(0.30)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C606(0.27)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C606(0.77); C150(0.79)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C606(0.25)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C606(0.32)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C606(0.28)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C606(0.32)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C606(0.24)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C150(0.82)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C150(0.86)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C150(0.93)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C150(0.80)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C150(0.91)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C150(0.69); C606(0.90)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C150(0.98)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C150(0.94)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C150(0.85)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C150(1.06)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C150(0.88)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C870(0.95); C150(1.02); C403(1.00); C682(0.97)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C870(0.93); C150(0.94); C403(1.01); C682(0.98)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C870(0.87); C150(1.04); C403(1.06); C682(1.01)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C870(1.06); C150(1.02); C403(1.01); C682(0.93)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C870(0.97); C606(1.03); C150(0.93); C403(1.09)  LDD1539  [11]
 LDCM0301  AC4 HCT 116 C150(0.64); C606(0.87)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C870(0.88); C150(0.91); C403(1.06); C682(0.93)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C870(1.07); C150(1.01); C403(1.13); C682(1.02)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C870(1.04); C606(1.04); C150(0.99); C403(1.13)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C870(0.95); C150(1.00); C403(1.06); C682(1.00)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C870(0.95); C150(1.01); C403(0.96); C682(1.04)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C870(0.94); C150(1.07); C403(1.03); C682(1.02)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C403(0.72)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C403(0.77)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C403(0.84)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C403(1.05)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C150(0.60); C606(0.89)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C403(0.93)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C403(1.25)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C403(0.95)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C403(0.95)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C403(1.09)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C403(1.25)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C403(0.73)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C150(1.47)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C150(1.52)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C150(1.51)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C150(1.18)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C150(1.62)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C150(1.65)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C150(1.99)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C150(1.56)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C150(1.65)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C150(1.04)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C150(1.14)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C150(1.39)  LDD0648  [3]
 LDCM0334  AC7 HCT 116 C150(0.93)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C150(1.12)  LDD0662  [3]
 LDCM0349  AC83 HEK-293T C403(1.16)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C403(1.13)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C403(0.97)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C403(1.25)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C403(1.09)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C403(1.13)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C403(1.27)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C403(1.12)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C403(1.38)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C403(1.34)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C403(1.19)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C403(1.19)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C403(1.29)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C403(1.40)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C403(1.05)  LDD0962  [3]
 LDCM0248  AKOS034007472 HCT 116 C150(1.02)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C150(1.32)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C150(1.09)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C606(1.04)  LDD0078  [3]
 LDCM0104  BDHI 13 Jurkat C606(5.60)  LDD0206  [12]
 LDCM0632  CL-Sc Hep-G2 C874(20.00)  LDD2227  [6]
 LDCM0367  CL1 PaTu 8988t C403(1.06)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C403(1.03)  LDD1247  [3]
 LDCM0369  CL100 HCT 116 C150(0.78); C606(0.89)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C150(1.16)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C150(0.90)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C150(0.99)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C150(1.34)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C606(0.34)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C606(0.41)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C606(0.34)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C606(0.27)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C606(0.26)  LDD0695  [3]
 LDCM0379  CL11 PaTu 8988t C403(0.89)  LDD1258  [3]
 LDCM0380  CL110 HCT 116 C606(0.20)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C606(0.29)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C150(0.86)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C150(0.92)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C150(0.83)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C150(1.05)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C150(0.89)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C870(1.19); C606(0.98); C150(0.98); C403(1.01)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C870(1.06); C150(0.96); C403(1.33); C682(1.05)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C870(1.00); C150(0.97); C403(1.11); C682(0.93)  LDD1593  [11]
 LDCM0390  CL12 PaTu 8988t C403(1.07)  LDD1269  [3]
 LDCM0391  CL120 HEK-293T C870(1.09); C150(1.04); C403(1.15); C682(0.96)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C403(0.90)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C403(1.03)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C403(0.81)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C403(0.70)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C150(1.20)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C150(1.14)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C150(1.18)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C150(1.52)  LDD0716  [3]
 LDCM0400  CL13 PaTu 8988t C403(1.11)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C403(1.05)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C403(1.11)  LDD1281  [3]
 LDCM0403  CL16 HCT 116 C606(0.94)  LDD0720  [3]
 LDCM0404  CL17 HEK-293T C870(1.03); C150(0.97); C403(1.13); C682(1.13)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C870(0.94); C606(1.00); C150(1.08); C403(0.99)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C870(0.96); C150(0.92); C403(1.01); C682(1.05)  LDD1610  [11]
 LDCM0407  CL2 PaTu 8988t C403(1.27)  LDD1286  [3]
 LDCM0408  CL20 HEK-293T C870(0.94); C150(1.08); C403(1.02); C682(1.02)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C870(1.11); C150(1.08); C403(0.99); C682(1.08)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C870(0.93); C150(1.08); C403(0.96); C682(1.05)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C870(0.92); C606(1.19); C150(1.15); C403(1.12)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C870(0.92); C150(0.84); C403(1.11); C682(0.99)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C870(1.06); C606(0.92); C150(0.88); C403(1.02)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C870(1.01); C150(1.07); C403(1.16); C682(0.92)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C870(0.94); C150(1.03); C403(1.09); C682(0.92)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C870(1.00); C150(1.02); C403(1.12); C682(0.92)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C870(0.99); C150(0.95); C403(1.07); C682(1.03)  LDD1621  [11]
 LDCM0418  CL3 PaTu 8988t C403(1.14)  LDD1297  [3]
 LDCM0419  CL30 HEK-293T C870(1.02); C606(1.04); C150(1.05); C403(0.93)  LDD1623  [11]
 LDCM0420  CL31 HCT 116 C150(1.11)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C150(1.11); C606(0.97)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C150(1.05); C606(0.82)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C150(0.95); C606(1.10)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C150(1.27); C606(0.90)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C150(1.46); C606(0.77)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C150(1.29); C606(0.82)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C150(1.16); C606(0.89)  LDD0745  [3]
 LDCM0429  CL4 PaTu 8988t C403(1.20)  LDD1308  [3]
 LDCM0430  CL40 HCT 116 C150(1.74); C606(0.96)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C150(1.04); C606(0.85)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C150(1.24); C606(0.67)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C150(0.99); C606(0.89)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C150(1.14); C606(0.74)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C150(1.17); C606(0.92)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C150(1.18); C606(0.98)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C150(1.04); C606(0.90)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C150(0.94); C606(0.92)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C150(0.98); C606(0.91)  LDD0756  [3]
 LDCM0440  CL5 PaTu 8988t C403(1.32)  LDD1319  [3]
 LDCM0441  CL50 HCT 116 C150(0.98); C606(0.93)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C150(1.20); C606(0.85)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C150(1.04); C606(1.11)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C150(1.04); C606(0.98)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C150(1.02); C606(1.02)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C150(0.95); C606(0.85)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C150(1.03); C606(0.85)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C150(1.21); C606(0.85)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C150(0.98); C606(0.84)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C150(0.96); C606(0.88)  LDD0767  [3]
 LDCM0451  CL6 PaTu 8988t C403(1.35)  LDD1330  [3]
 LDCM0452  CL60 HCT 116 C150(0.95); C606(0.81)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C150(1.16); C606(0.77)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C150(1.38); C606(0.88)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C150(1.26); C606(0.73)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C150(1.65); C606(0.58)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C150(1.24); C606(0.53)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C150(1.63); C606(0.56)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C150(1.43); C606(0.50)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C150(1.72); C606(0.45)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C150(1.39); C606(0.58)  LDD0778  [3]
 LDCM0462  CL7 PaTu 8988t C403(1.46)  LDD1341  [3]
 LDCM0463  CL70 HCT 116 C150(1.45); C606(0.52)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C150(1.76); C606(0.55)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C150(1.48); C606(0.56)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C150(1.62); C606(0.51)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C150(1.40); C606(0.55)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C870(1.10); C150(0.98); C403(1.07); C682(0.93)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C870(0.93); C150(1.08); C403(1.11); C682(1.07)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C870(1.01); C606(1.01); C150(1.06); C403(0.90)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C870(0.99); C150(0.95); C403(1.10); C682(0.98)  LDD1675  [11]
 LDCM0473  CL8 PaTu 8988t C403(1.01)  LDD1352  [3]
 LDCM0474  CL80 HEK-293T C870(0.95); C150(1.03); C403(0.93); C682(1.02)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C870(0.99); C150(1.06); C403(1.05); C682(1.02)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C870(0.87); C150(1.02); C403(1.00); C682(0.99)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C870(0.88); C606(1.10); C150(1.16); C403(0.98)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C870(0.91); C150(0.92); C403(1.06); C682(1.04)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C870(1.12); C606(0.86); C150(0.87); C403(1.00)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C870(0.87); C150(0.96); C403(1.09); C682(0.90)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C870(0.92); C150(1.01); C403(1.04); C682(0.89)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C870(1.12); C150(1.00); C403(1.06); C682(0.91)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C870(1.00); C150(0.95); C403(0.96); C682(1.02)  LDD1686  [11]
 LDCM0484  CL9 PaTu 8988t C403(1.04)  LDD1363  [3]
 LDCM0485  CL90 HEK-293T C870(1.02); C606(0.99); C150(1.12); C403(0.99)  LDD1688  [11]
 LDCM0486  CL91 HCT 116 C150(1.01); C606(0.94)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C150(0.83); C606(0.89)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C150(0.71); C606(0.71)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C150(0.90); C606(0.85)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C150(0.96); C606(0.75)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C150(0.67); C606(0.90)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C150(0.69); C606(0.89)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C150(0.90); C606(0.85)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C150(0.87); C606(0.82)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C870(0.92); C150(1.13); C403(1.07); C682(1.03)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C150(3.27); C606(1.22); C712(0.73)  LDD1702  [13]
 LDCM0468  Fragment33 HCT 116 C150(1.79); C606(0.50)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C150(1.89); C606(0.81)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C870(1.40)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C870(1.12)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C870(1.21)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C606(0.97)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761