Details of the Target

General Information of Target

Target ID LDTP06684
Target Name Sister chromatid cohesion protein PDS5 homolog A (PDS5A)
Gene Name PDS5A
Gene ID 23244
Synonyms
KIAA0648; PDS5; Sister chromatid cohesion protein PDS5 homolog A; Cell proliferation-inducing gene 54 protein; Sister chromatid cohesion protein 112; SCC-112
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDFTAQPKPATALCGVVSADGKIAYPPGVKEITDKITTDEMIKRLKMVVKTFMDMDQDSE
DEKQQYLPLALHLASEFFLRNPNKDVRLLVACCLADIFRIYAPEAPYTSHDKLKDIFLFI
TRQLKGLEDTKSPQFNRYFYLLENLAWVKSYNICFELEDCNEIFIQLFRTLFSVINNSHN
KKVQMHMLDLMSSIIMEGDGVTQELLDSILINLIPAHKNLNKQSFDLAKVLLKRTVQTIE
ACIANFFNQVLVLGRSSVSDLSEHVFDLIQELFAIDPHLLLSVMPQLEFKLKSNDGEERL
AVVRLLAKLFGSKDSDLATQNRPLWQCFLGRFNDIHVPVRLESVKFASHCLMNHPDLAKD
LTEYLKVRSHDPEEAIRHDVIVTIITAAKRDLALVNDQLLGFVRERTLDKRWRVRKEAMM
GLAQLYKKYCLHGEAGKEAAEKVSWIKDKLLHIYYQNSIDDKLLVEKIFAQYLVPHNLET
EERMKCLYYLYASLDPNAVKALNEMWKCQNMLRSHVRELLDLHKQPTSEANCSAMFGKLM
TIAKNLPDPGKAQDFVKKFNQVLGDDEKLRSQLELLISPTCSCKQADICVREIARKLANP
KQPTNPFLEMVKFLLERIAPVHIDSEAISALVKLMNKSIEGTADDEEEGVSPDTAIRSGL
ELLKVLSFTHPTSFHSAETYESLLQCLRMEDDKVAEAAIQIFRNTGHKIETDLPQIRSTL
IPILHQKAKRGTPHQAKQAVHCIHAIFTNKEVQLAQIFEPLSRSLNADVPEQLITPLVSL
GHISMLAPDQFASPMKSVVANFIVKDLLMNDRSTGEKNGKLWSPDEEVSPEVLAKVQAIK
LLVRWLLGMKNNQSKSANSTLRLLSAMLVSEGDLTEQKRISKSDMSRLRLAAGSAIMKLA
QEPCYHEIITPEQFQLCALVINDECYQVRQIFAQKLHKALVKLLLPLEYMAIFALCAKDP
VKERRAHARQCLLKNISIRREYIKQNPMATEKLLSLLPEYVVPYMIHLLAHDPDFTRSQD
VDQLRDIKECLWFMLEVLMTKNENNSHAFMKKMAENIKLTRDAQSPDESKTNEKLYTVCD
VALCVINSKSALCNADSPKDPVLPMKFFTQPEKDFCNDKSYISEETRVLLLTGKPKPAGV
LGAVNKPLSATGRKPYVRSTGTETGSNINVNSELNPSTGNRSREQSSEAAETGVSENEEN
PVRIISVTPVKNIDPVKNKEINSDQATQGNISSDRGKKRTVTAAGAENIQQKTDEKVDES
GPPAPSKPRRGRRPKSESQGNATKNDDLNKPINKGRKRAAVGQESPGGLEAGNAKAPKLQ
DLAKKAAPAERQIDLQR
Target Bioclass
Other
Family
PDS5 family
Subcellular location
Nucleus
Function
Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Uniprot ID
Q29RF7
Ensemble ID
ENST00000303538.13
HGNC ID
HGNC:29088

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.R80W DBIA    Probe Info 
GB2 SNV: p.E481Q DBIA    Probe Info 
HEC1 SNV: p.R377C DBIA    Probe Info 
K562 SNV: p.D923N FFF probe13    Probe Info 
LS180 SNV: p.R889Ter DBIA    Probe Info 
MEWO SNV: p.P606S DBIA    Probe Info 
MOLT4 SNV: p.R979C IA-alkyne    Probe Info 
NCIH358 SNV: p.Q553Ter DBIA    Probe Info 
RKO Insertion: p.T1253NfsTer3
SNV: p.A989V		 DBIA    Probe Info 
SF295 SNV: p.D20N DBIA    Probe Info 
TOV21G SNV: p.E609Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.38  LDD0402  [1]
A-EBA
 Probe Info  		3.36  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y472(20.00); Y1121(8.10); Y680(7.57); Y107(5.86)  LDD0257  [4]
TH216
 Probe Info  		Y472(17.23); Y429(15.65); Y1121(7.40)  LDD0259  [4]
STPyne
 Probe Info  		K229(10.00); K308(10.00); K557(2.30); K558(4.94)  LDD0277  [5]
ONAyne
 Probe Info  		K962(5.00)  LDD0275  [5]
Probe 1
 Probe Info  		Y1121(26.73)  LDD3495  [6]
JZ128-DTB
 Probe Info  		C581(0.00); C532(0.00)  LDD0462  [7]
BTD
 Probe Info  		C1093(1.21)  LDD1700  [8]
AHL-Pu-1
 Probe Info  		C532(2.13); C327(2.48)  LDD0168  [9]
Alkyne-RA190
 Probe Info  		2.61  LDD0300  [10]
EA-probe
 Probe Info  		N.A.  LDD0440  [11]
DBIA
 Probe Info  		C532(1.23); C430(0.86)  LDD0078  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C327(0.00); C532(0.00); C350(0.00); C1116(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C1116(0.00); C350(0.00); C532(0.00); C92(0.00)  LDD0032  [14]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [15]
IPIAA_L
 Probe Info  		C327(0.00); C686(0.00)  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C486(0.00); C327(0.00); C532(0.00); C350(0.00)  LDD0037  [13]
NAIA_4
 Probe Info  		C327(0.00); C532(0.00)  LDD2226  [16]
TFBX
 Probe Info  		C583(0.00); C581(0.00)  LDD0027  [17]
WYneN
 Probe Info  		N.A.  LDD0021  [18]
Compound 10
 Probe Info  		C14(0.00); C327(0.00); C532(0.00)  LDD2216  [19]
Compound 11
 Probe Info  		C14(0.00); C327(0.00); C532(0.00)  LDD2213  [19]
ENE
 Probe Info  		N.A.  LDD0006  [18]
IPM
 Probe Info  		C532(0.00); C327(0.00); C430(0.00); C583(0.00)  LDD0005  [18]
NHS
 Probe Info  		K558(0.00); K366(0.00)  LDD0010  [18]
PF-06672131
 Probe Info  		N.A.  LDD0152  [20]
VSF
 Probe Info  		N.A.  LDD0007  [18]
Acrolein
 Probe Info  		C14(0.00); H336(0.00); H622(0.00); C430(0.00)  LDD0217  [21]
Methacrolein
 Probe Info  		C430(0.00); C14(0.00)  LDD0218  [21]
W1
 Probe Info  		C327(0.00); C581(0.00); C583(0.00); C1093(0.00)  LDD0236  [22]
AOyne
 Probe Info  		13.80  LDD0443  [23]
NAIA_5
 Probe Info  		C486(0.00); C327(0.00); C350(0.00); C1116(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C193
 Probe Info  		5.54  LDD1869  [24]
C380
 Probe Info  		4.99  LDD2039  [24]
C420
 Probe Info  		12.38  LDD2075  [24]
FFF probe11
 Probe Info  		20.00  LDD0471  [25]
FFF probe13
 Probe Info  		20.00  LDD0475  [25]
FFF probe3
 Probe Info  		20.00  LDD0465  [25]
FFF probe9
 Probe Info  		7.14  LDD0470  [25]
STS-2
 Probe Info  		N.A.  LDD0138  [26]
VE-P
 Probe Info  		N.A.  LDD0396  [27]
OEA-DA
 Probe Info  		3.26  LDD0046  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C430(0.79); C14(0.75)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C430(1.22); C14(0.67)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C430(0.79); C14(0.64)  LDD2095  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C430(1.67); C589(1.00)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C430(1.61); C589(1.42); C350(0.88)  LDD2152  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C14(0.82)  LDD2103  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C430(0.83); C14(0.50)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C14(0.75)  LDD2131  [8]
 LDCM0025  4SU-RNA HEK-293T C532(2.13); C327(2.48)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C532(2.05); C327(2.79); C1093(2.01)  LDD0169  [9]
 LDCM0214  AC1 HCT 116 C327(0.86); C1079(0.78); C1084(0.78); C1093(1.28)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C327(1.01); C1079(0.95); C1084(0.95); C1093(1.12)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C327(1.06); C1079(0.62); C1084(0.62); C1093(1.13)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C327(1.05); C1079(0.67); C1084(0.67); C1093(1.02)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C327(0.86); C1079(0.72); C1084(0.72); C1093(0.98)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C327(1.11); C1079(0.80); C1084(0.80); C1093(1.24)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C327(1.18); C1079(0.82); C1084(0.82); C1093(1.14)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C327(1.05); C1079(0.72); C1084(0.72); C1093(1.14)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C327(1.13); C1079(0.71); C1084(0.71); C1093(1.12)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C327(1.16); C1079(0.80); C1084(0.80); C1093(1.19)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C327(1.23); C1079(0.63); C1084(0.63); C1093(1.28)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C327(0.90); C1079(0.65); C1084(0.65); C1093(1.21)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C327(1.02); C1079(0.87); C1084(0.87); C1093(1.13)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C327(0.99); C1079(0.68); C1084(0.68); C1093(1.15)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C327(1.11); C1079(0.62); C1084(0.62); C1093(1.12)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C327(1.03); C1079(0.71); C1084(0.71); C1093(1.02)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C327(0.92); C1079(1.11); C1084(1.11); C1093(0.99)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C327(0.91); C1079(1.04); C1084(1.04); C1093(1.02)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C327(0.89); C1079(1.20); C1084(1.20); C1093(1.13)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C327(0.90); C1079(1.15); C1084(1.15); C1093(1.40)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C327(1.06); C1079(1.08); C1084(1.08); C1093(1.17)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C327(0.89); C1079(1.05); C1084(1.05); C1093(1.13)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C327(0.82); C1079(1.08); C1084(1.08); C1093(1.06)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C327(1.00); C1079(1.01); C1084(1.01); C1093(1.02)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C327(0.85); C1079(1.26); C1084(1.26); C1093(1.04)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C327(0.81); C1079(0.94); C1084(0.94); C1093(0.93)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C327(0.93); C1079(1.04); C1084(1.04); C1093(1.02)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C327(0.88); C1079(1.05); C1084(1.05); C1093(0.88)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C327(0.85); C1079(1.00); C1084(1.00); C1093(0.96)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C327(1.22); C1079(0.96); C1084(0.96); C1093(1.03)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C327(0.87); C1079(1.33); C1084(1.33); C1093(1.04)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C327(1.05); C1079(1.07); C1084(1.07); C1093(1.21)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C327(1.28); C1079(1.40); C1084(1.40); C1093(1.05)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C327(1.27); C1079(0.84); C1084(0.84); C1093(0.95)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C327(1.28); C1079(1.06); C1084(1.06); C1093(1.23)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C327(1.19); C1079(0.97); C1084(0.97); C1093(1.05)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C327(1.50); C1079(0.83); C1084(0.83); C1093(1.09)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C327(1.36); C1079(0.94); C1084(0.94); C1093(1.07)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C327(1.11); C1079(0.98); C1084(0.98); C1093(1.16)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C327(1.24); C1079(0.99); C1084(0.99); C1093(1.23)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C327(1.11); C1079(0.91); C1084(0.91); C1093(1.09)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C327(1.41); C1079(0.82); C1084(0.82); C1093(0.99)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C327(1.87); C1079(0.89); C1084(0.89); C1093(1.14)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C327(1.44); C1079(0.81); C1084(0.81); C1093(1.41)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C327(1.02); C1079(0.99); C1084(0.99); C1093(0.99)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C327(1.50); C1079(0.88); C1084(0.88); C1093(1.19)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C327(1.72); C1079(0.80); C1084(0.80); C1093(1.21)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C327(1.18); C1079(0.76); C1084(0.76); C1093(1.04)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C327(0.95); C1079(0.88); C1084(0.88); C581(0.88)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C430(0.71); C583(0.85); C581(0.85); C742(0.93)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C430(0.87); C1079(0.89); C1084(0.89); C583(0.93)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C583(0.83); C581(0.85); C430(0.90); C1079(0.95)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C583(0.93); C430(0.97); C581(0.97); C14(1.01)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C742(0.97); C583(1.02); C581(1.04); C589(1.17)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C581(0.84); C583(0.84); C589(1.03); C742(1.06)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C742(0.79); C581(0.88); C430(0.88); C583(0.93)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C1079(0.84); C1084(0.84); C583(0.89); C581(0.90)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C583(0.84); C581(0.85); C742(0.93); C589(0.97)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C742(0.89); C583(0.97); C430(0.98); C581(0.98)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C742(0.94); C583(0.97); C581(0.99); C589(1.11)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C327(1.13); C1079(1.01); C1084(1.01); C1093(1.05)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C327(1.10); C1079(1.08); C1084(1.08); C1093(1.10)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C327(0.99); C1079(0.96); C1084(0.96); C1093(1.08)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C327(1.05); C1079(1.08); C1084(1.08); C1093(0.92)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C904(0.79); C917(0.79); C925(0.79); C430(0.80)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C904(0.73); C917(0.73); C925(0.73); C1079(0.84)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C430(0.81); C583(0.91); C1079(0.96); C1084(0.96)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C327(0.78); C1079(0.80); C1084(0.80); C904(0.84)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C430(0.78); C1079(0.84); C1084(0.84); C583(1.08)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C904(0.69); C917(0.69); C925(0.69); C430(0.81)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C904(0.72); C917(0.72); C925(0.72); C430(0.83)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C430(0.78); C904(0.79); C917(0.79); C925(0.79)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C430(0.77); C904(0.98); C917(0.98); C925(0.98)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C327(0.73); C14(0.86); C583(0.94); C581(0.94)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C742(0.71); C581(0.82); C589(0.87); C583(0.88)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C581(0.78); C742(0.83); C589(0.83); C327(0.86)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C742(0.57); C581(0.82); C583(0.88); C589(0.97)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C327(0.74); C742(0.76); C581(0.76); C583(0.88)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C327(0.73); C486(0.91); C1079(0.91); C1084(0.91)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C581(0.78); C742(0.78); C583(0.83); C589(0.89)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C742(0.68); C581(0.76); C583(0.86); C327(0.88)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C742(0.67); C581(0.78); C589(0.87); C583(0.90)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C581(0.75); C583(0.79); C327(0.86); C589(0.89)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C581(0.82); C14(0.87); C327(0.88); C583(0.95)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C532(0.92); C581(0.96); C1093(0.97); C14(1.03)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C581(0.86); C532(0.93); C430(0.97); C583(0.99)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C581(0.85); C532(0.90); C14(0.94); C583(0.95)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C430(0.89); C532(0.94); C581(0.96); C1093(0.99)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C327(0.77); C14(0.96); C1079(1.03); C1084(1.03)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C904(0.73); C917(0.73); C925(0.73); C1079(0.87)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C581(0.92); C327(0.93); C430(0.98); C14(1.00)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C581(0.85); C1079(0.94); C1084(0.94); C583(0.95)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C581(0.93); C589(0.95); C583(0.98); C430(0.98)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C581(0.88); C583(0.93); C589(0.97); C430(1.00)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C583(0.97); C581(0.98); C532(1.00); C430(1.03)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C581(0.88); C583(0.92); C14(1.00); C430(1.13)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C589(0.88); C1079(0.90); C1084(0.90); C583(0.95)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C327(0.79); C589(0.92); C486(0.92); C583(0.95)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C486(0.73); C1079(0.81); C1084(0.81); C583(0.97)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C589(0.89); C581(1.09); C583(1.13); C486(1.27)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C1079(0.77); C1084(0.77); C904(0.77); C917(0.77)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C589(0.96); C581(1.02); C583(1.08); C327(1.12)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C1079(0.89); C1084(0.89); C486(0.93); C589(0.94)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C589(0.85); C583(0.90); C581(0.93); C486(0.96)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C327(0.79); C581(0.95); C583(0.98); C589(0.99)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C581(0.98); C583(1.00); C589(1.08); C486(1.12)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C327(0.79); C589(1.05); C430(1.10); C486(1.17)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C589(1.02); C581(1.26); C583(1.29); C430(1.40)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C486(0.70); C14(0.90); C581(0.92); C742(0.96)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C486(0.81); C581(0.85); C583(0.89); C589(0.94)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C486(0.65); C581(0.92); C589(0.93); C583(0.94)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C742(0.81); C430(0.85); C581(0.91); C1079(0.92)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C486(0.58); C589(0.90); C581(0.94); C742(0.95)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C486(0.58); C742(0.84); C14(0.89); C589(0.90)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C486(0.83); C430(0.97); C742(0.98); C589(1.04)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C486(0.66); C581(0.98); C583(1.01); C14(1.01)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C486(0.74); C742(1.02); C14(1.04); C589(1.08)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C486(0.51); C589(0.87); C14(0.91); C742(0.93)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C486(0.58); C742(0.86); C589(0.88); C581(0.88)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C486(0.63); C589(0.93); C14(0.93); C581(0.99)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C1079(0.85); C1084(0.85); C1093(0.96); C327(0.99)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C742(1.07); C1093(1.09); C327(1.14); C430(1.15)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C742(0.73); C904(0.84); C917(0.84); C925(0.84)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C1079(0.61); C1084(0.61); C430(0.92); C742(1.11)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C1079(0.68); C1084(0.68); C1093(0.93); C327(1.04)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C430(0.95); C581(0.95); C1079(1.02); C1084(1.02)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C589(1.03); C742(1.13); C581(1.28); C1093(1.28)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C1093(0.97); C742(1.13); C589(1.14); C581(1.25)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C589(1.02); C1093(1.09); C742(1.16); C581(1.27)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C1079(0.83); C1084(0.83); C1093(1.09); C430(1.11)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C589(0.93); C430(1.03); C1093(1.08); C1079(1.09)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C1079(0.62); C1084(0.62); C327(0.95); C589(0.97)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C1079(0.95); C1084(0.95); C581(0.99); C430(1.02)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C742(0.73); C581(0.91); C327(0.93); C583(0.94)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C589(1.01); C1093(1.03); C430(1.04); C581(1.06)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C1079(0.65); C1084(0.65); C589(1.00); C327(1.03)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C1093(1.04); C589(1.08); C742(1.13); C581(1.44)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C742(0.70); C327(0.83); C589(0.90); C581(0.93)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C742(0.74); C327(0.87); C430(0.97); C581(1.02)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C742(0.66); C327(0.69); C430(0.84); C581(0.91)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C486(0.72); C742(0.73); C327(0.78); C430(0.86)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C327(0.65); C742(0.77); C430(0.90); C486(0.90)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C742(0.74); C430(0.87); C327(0.89); C581(0.91)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C742(0.70); C327(0.75); C430(0.86); C589(0.93)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C742(0.68); C486(0.80); C583(0.87); C430(0.88)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C742(0.62); C486(0.89); C327(0.92); C581(0.99)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C742(0.69); C581(0.90); C430(0.95); C583(1.00)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C327(0.80); C742(0.81); C581(0.85); C486(0.88)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C742(0.69); C904(0.90); C917(0.90); C925(0.90)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C742(0.73); C904(0.90); C917(0.90); C925(0.90)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C742(0.75); C486(0.96); C583(1.00); C1079(1.10)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C742(0.71); C581(0.88); C589(1.02); C583(1.03)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C486(0.57); C581(0.68); C742(0.74); C583(0.87)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C486(0.57); C742(0.62); C1079(0.67); C1084(0.67)  LDD0683  [12]
 LDCM0545  Acetamide MDA-MB-231 C430(0.79)  LDD2138  [8]
 LDCM0248  AKOS034007472 HCT 116 C327(0.96); C1079(0.87); C1084(0.87); C1093(0.87)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C742(0.75); C581(0.91); C430(0.92); C583(0.94)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C742(0.77); C581(0.97); C430(0.99); C589(1.00)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C532(1.23); C430(0.86)  LDD0078  [12]
 LDCM0104  BDHI 13 Jurkat 5.15  LDD0206  [29]
 LDCM0498  BS-3668 MDA-MB-231 C430(0.93)  LDD2091  [8]
 LDCM0108  Chloroacetamide HeLa C686(0.00); C14(0.00); H622(0.00); C1093(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C1116(20.00); C14(20.00); C1093(1.81); C430(1.68)  LDD2227  [16]
 LDCM0367  CL1 HCT 116 C589(0.78); C1093(0.95); C583(0.98); C581(0.99)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C589(0.96); C583(0.99); C581(1.00); C14(1.05)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C904(0.82); C917(0.82); C925(0.82); C1079(0.87)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C742(0.72); C904(0.81); C917(0.81); C925(0.81)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C430(0.75); C581(0.80); C742(0.81); C904(0.82)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C742(0.77); C430(0.82); C581(0.84); C583(0.89)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C742(0.70); C430(0.79); C581(0.88); C327(0.94)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C430(0.81); C904(0.86); C917(0.86); C925(0.86)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C430(0.89); C589(1.03); C904(1.03); C917(1.03)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C430(0.88); C1079(0.95); C1084(0.95); C904(0.98)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C430(0.85); C904(0.87); C917(0.87); C925(0.87)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C430(0.65); C583(0.88); C581(0.96); C589(0.97)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C14(0.81); C589(0.89); C581(1.06); C583(1.07)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C430(0.67); C486(0.88); C589(0.98); C583(1.00)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C430(0.81); C1079(0.88); C1084(0.88); C327(0.94)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C327(0.80); C742(0.92); C14(0.96); C1093(0.96)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C581(0.79); C583(0.85); C327(0.86); C589(0.86)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C581(0.71); C327(0.74); C583(0.83); C589(0.84)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C581(0.75); C327(0.81); C583(0.86); C589(0.92)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C327(0.83); C581(0.85); C1079(0.89); C1084(0.89)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C14(0.99); C589(1.05); C581(1.18); C430(1.26)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C581(0.95); C583(0.96); C532(1.01); C430(1.06)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C581(0.92); C589(0.94); C327(0.95); C583(0.99)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C589(0.92); C14(0.95); C581(1.04); C583(1.17)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C581(0.84); C583(0.91); C1079(0.98); C1084(0.98)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C486(0.76); C430(0.77); C327(0.84); C532(0.91)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C1079(0.92); C1084(0.92); C486(0.97); C581(0.97)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C327(0.76); C581(0.89); C583(0.93); C589(0.98)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C589(0.90); C581(0.99); C583(1.04); C327(1.06)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C486(0.54); C430(0.91); C581(0.95); C583(0.95)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C486(0.64); C430(0.74); C589(0.82); C742(0.89)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C486(0.66); C430(0.77); C742(0.81); C14(0.82)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C486(0.64); C581(0.93); C583(0.94); C430(0.96)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C14(0.84); C589(1.02); C581(1.02); C1079(1.04)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C581(0.89); C583(0.90); C589(0.91); C1079(0.97)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C14(0.74); C589(0.83); C581(0.94); C583(1.01)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C581(0.76); C583(0.85); C430(0.96); C589(0.96)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C581(0.83); C14(0.86); C583(0.90); C430(0.94)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C581(0.89); C583(0.92); C430(0.95); C14(0.96)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C581(0.87); C14(0.88); C583(0.89); C327(0.94)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C327(0.92); C589(0.93); C1093(0.95); C583(0.97)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C581(0.78); C583(0.82); C589(0.84); C14(0.92)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C581(0.75); C583(0.84); C14(0.93); C589(0.99)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C14(0.89); C589(0.90); C581(1.03); C583(1.07)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C589(0.80); C430(0.85); C583(1.04); C14(1.07)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C589(0.89); C583(0.96); C581(0.97); C430(1.07)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C327(0.92); C1079(1.58); C1084(1.58); C1093(1.18)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C327(1.06); C1079(1.45); C1084(1.45); C1093(1.11)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C327(0.85); C1079(1.06); C1084(1.06); C1093(1.15)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C327(1.14); C1079(1.60); C1084(1.60); C1093(1.11)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C327(1.22); C1079(1.35); C1084(1.35); C1093(1.19)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C327(0.93); C1079(0.98); C1084(0.98); C1093(0.94)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C327(1.13); C1079(1.16); C1084(1.16); C1093(1.14)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C327(0.97); C1079(0.87); C1084(0.87); C1093(1.09)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C327(1.41); C1079(0.82); C1084(0.82); C1093(1.14)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C327(1.66); C1079(0.75); C1084(0.75); C1093(1.14)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C327(1.74); C1079(1.18); C1084(1.18); C1093(1.31)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C327(1.88); C1079(1.43); C1084(1.43); C1093(1.21)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C327(2.11); C1079(1.08); C1084(1.08); C1093(1.24)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C327(1.75); C1079(1.28); C1084(1.28); C1093(1.31)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C327(1.66); C1079(1.04); C1084(1.04); C1093(1.26)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C327(1.03); C1079(1.11); C1084(1.11); C1093(0.97)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C327(1.43); C1079(1.08); C1084(1.08); C1093(1.21)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C327(1.74); C1079(0.97); C1084(0.97); C1093(1.30)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C327(1.91); C1079(1.62); C1084(1.62); C1093(1.75)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C327(1.94); C1079(1.47); C1084(1.47); C1093(1.39)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C327(1.78); C1079(1.06); C1084(1.06); C1093(1.31)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C327(1.69); C1079(1.26); C1084(1.26); C1093(1.40)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C327(0.90); C1093(1.00); C14(1.18); C532(0.93)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C327(0.89); C1093(1.02); C14(1.21); C532(0.89)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C327(0.84); C1093(0.93); C14(1.06); C532(0.91)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C327(0.94); C1093(1.12); C14(0.99); C532(1.02)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C327(1.03); C1079(1.07); C1084(1.07); C1093(1.01)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C327(0.97); C1093(0.97); C14(0.94); C532(1.27)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C327(0.94); C1093(1.09); C14(1.01); C532(1.00)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C327(0.89); C1093(1.01); C14(1.18); C532(0.97)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C327(1.15); C1093(0.81); C14(0.98); C532(1.42)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C327(0.95); C1093(0.97); C14(0.92); C532(1.00)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C327(0.97); C1093(1.04); C14(0.95); C532(0.80)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C327(0.96); C1093(0.92); C14(0.83); C532(1.00)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C327(0.97); C1093(0.93); C14(0.91); C532(0.87)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C327(0.98); C1093(1.07); C14(0.98); C532(0.86)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C327(0.85); C1093(1.07); C14(0.90); C532(0.89)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C327(0.94); C1079(1.08); C1084(1.08); C1093(1.07)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C327(0.96); C1093(1.14); C14(0.98); C532(1.06)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C327(1.08); C1079(0.81); C1084(0.81); C1093(1.07)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C327(1.12); C1079(0.82); C1084(0.82); C1093(1.10)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C327(0.98); C1079(0.94); C1084(0.94); C1093(1.24)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C327(1.02); C1079(1.14); C1084(1.14); C1093(1.29)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C327(1.09); C1079(0.90); C1084(0.90); C1093(1.11)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C327(1.03); C1079(1.33); C1084(1.33); C1093(1.31)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C327(0.93); C1079(1.05); C1084(1.05); C1093(1.29)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C327(1.36); C1079(0.89); C1084(0.89); C1093(1.27)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C327(0.94); C1079(0.93); C1084(0.93); C1093(1.16)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C327(1.08); C1079(1.09); C1084(1.09); C1093(1.20)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C327(1.00); C1079(0.85); C1084(0.85); C1093(1.51)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C327(1.01); C1079(0.91); C1084(0.91); C1093(1.25)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C327(0.98); C1079(0.95); C1084(0.95); C1093(1.12)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C327(1.03); C1079(0.89); C1084(0.89); C1093(1.16)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C327(0.92); C1079(0.92); C1084(0.92); C1093(1.14)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C327(1.25); C1093(1.11); C14(1.04); C430(0.94)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C327(4.84); C1093(0.98); C14(1.28); C430(0.84)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C327(1.21); C1093(1.10); C14(1.20); C430(0.89)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C327(1.42); C1093(1.28); C14(1.09); C430(0.98)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C327(1.35); C1079(1.42); C1084(1.42); C1093(1.33)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C327(1.32); C1093(0.98); C14(1.05); C430(0.99)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C327(1.30); C1093(1.13); C14(1.09); C430(0.91)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C327(1.52); C1093(1.51); C14(1.02); C430(1.18)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C327(1.68); C1093(1.48); C14(0.96); C430(1.18)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C327(2.24); C1093(1.72); C14(0.99); C430(1.30)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C327(1.16); C1093(1.23); C14(1.17); C430(0.99)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C327(1.08); C1093(1.04); C14(1.11); C430(0.99)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C327(1.14); C1093(1.29); C14(0.90); C430(0.99)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C327(1.69); C1093(1.38); C14(0.94); C430(1.16)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C327(1.67); C1093(2.02); C14(1.00); C430(1.53)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C327(1.25); C1079(1.08); C1084(1.08); C1093(1.10)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C327(1.06); C1093(0.91); C14(1.04); C430(0.97)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C327(0.72); C1079(0.88); C1084(0.88); C1093(1.18)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C327(0.83); C1079(0.93); C1084(0.93); C1093(1.12)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C327(1.07); C1079(0.94); C1084(0.94); C1093(1.19)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C327(1.02); C1079(0.89); C1084(0.89); C1093(1.31)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C327(0.85); C1079(0.90); C1084(0.90); C1093(1.23)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C327(0.84); C1079(0.94); C1084(0.94); C1093(1.31)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C327(0.93); C1079(0.85); C1084(0.85); C1093(1.36)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C327(0.85); C1079(0.84); C1084(0.84); C1093(1.19)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C327(0.72); C1079(0.92); C1084(0.92); C1093(1.26)  LDD0811  [12]
 LDCM0634  CY-0357 Hep-G2 C14(0.64)  LDD2228  [16]
 LDCM0495  E2913 HEK-293T C430(0.91); C1093(0.84); C532(0.87); C14(1.08)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C589(22.87); C327(19.40); C583(2.00)  LDD1702  [8]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [11]
 LDCM0204  EV-97 T cell C532(8.80)  LDD0524  [31]
 LDCM0625  F8 Ramos C1116(1.97); C350(3.69); 0.32; C430(2.00)  LDD2187  [32]
 LDCM0572  Fragment10 MDA-MB-231 C242(0.99)  LDD1389  [33]
 LDCM0573  Fragment11 MDA-MB-231 C242(1.41)  LDD1391  [33]
 LDCM0574  Fragment12 MDA-MB-231 C242(1.06)  LDD1393  [33]
 LDCM0575  Fragment13 Ramos C242(0.68)  LDD1396  [33]
 LDCM0576  Fragment14 MDA-MB-231 C242(1.63)  LDD1397  [33]
 LDCM0577  Fragment15 MDA-MB-231 C242(1.17)  LDD1399  [33]
 LDCM0579  Fragment20 MDA-MB-231 C242(1.04)  LDD1402  [33]
 LDCM0580  Fragment21 MDA-MB-231 C242(0.67)  LDD1404  [33]
 LDCM0581  Fragment22 Ramos C242(0.83)  LDD1407  [33]
 LDCM0582  Fragment23 Ramos C1116(0.58); C350(0.89); 2.15; C430(2.21)  LDD2196  [32]
 LDCM0584  Fragment25 MDA-MB-231 C242(1.41)  LDD1411  [33]
 LDCM0585  Fragment26 Ramos C242(1.11)  LDD1412  [33]
 LDCM0578  Fragment27 MDA-MB-231 C242(0.64)  LDD1401  [33]
 LDCM0586  Fragment28 MDA-MB-231 C242(0.76)  LDD1415  [33]
 LDCM0587  Fragment29 MDA-MB-231 C242(1.25)  LDD1417  [33]
 LDCM0588  Fragment30 Ramos C1116(0.50); C350(1.02); 1.29; C430(0.97)  LDD2199  [32]
 LDCM0589  Fragment31 MDA-MB-231 C242(1.18)  LDD1421  [33]
 LDCM0590  Fragment32 MDA-MB-231 C242(1.00)  LDD1423  [33]
 LDCM0468  Fragment33 HCT 116 C327(1.13); C1079(1.17); C1084(1.17); C1093(1.05)  LDD0785  [12]
 LDCM0594  Fragment36 MDA-MB-231 C242(1.56)  LDD1431  [33]
 LDCM0596  Fragment38 MDA-MB-231 C242(1.10)  LDD1433  [33]
 LDCM0566  Fragment4 MDA-MB-231 C242(0.92)  LDD1378  [33]
 LDCM0598  Fragment40 Ramos C242(1.42)  LDD1437  [33]
 LDCM0599  Fragment41 MDA-MB-231 C242(1.27)  LDD1438  [33]
 LDCM0600  Fragment42 Ramos C242(0.88)  LDD1440  [33]
 LDCM0601  Fragment43 MDA-MB-231 C242(1.07)  LDD1441  [33]
 LDCM0604  Fragment46 MDA-MB-231 C242(1.19)  LDD1445  [33]
 LDCM0605  Fragment47 MDA-MB-231 C242(1.17)  LDD1446  [33]
 LDCM0606  Fragment48 MDA-MB-231 C242(1.10)  LDD1447  [33]
 LDCM0607  Fragment49 MDA-MB-231 C242(5.03)  LDD1448  [33]
 LDCM0427  Fragment51 HCT 116 C327(1.69); C1079(1.74); C1084(1.74); C1093(1.64)  LDD0744  [12]
 LDCM0610  Fragment52 MDA-MB-231 C242(0.88)  LDD1452  [33]
 LDCM0611  Fragment53 MDA-MB-231 C242(0.86)  LDD1454  [33]
 LDCM0614  Fragment56 MDA-MB-231 C242(0.80)  LDD1458  [33]
 LDCM0568  Fragment6 MDA-MB-231 C242(0.88)  LDD1382  [33]
 LDCM0569  Fragment7 Ramos C1116(1.50); C430(1.47); C1093(2.46); C327(7.70)  LDD2186  [32]
 LDCM0570  Fragment8 MDA-MB-231 C242(0.86)  LDD1385  [33]
 LDCM0571  Fragment9 MDA-MB-231 C242(0.73)  LDD1387  [33]
 LDCM0107  IAA HeLa N.A.  LDD0221  [21]
 LDCM0179  JZ128 PC-3 C581(0.00); C532(0.00)  LDD0462  [7]
 LDCM0022  KB02 HCT 116 C532(16.71); C486(2.73); C1093(1.40); C430(1.40)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C532(2.07); C486(1.45); C1093(1.68); C430(0.91)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C532(17.10); C486(1.77); C1093(1.55); C430(1.55)  LDD0082  [12]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C14(0.88)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C14(0.58)  LDD2121  [8]
 LDCM0109  NEM HeLa H622(0.00); H725(0.00)  LDD0223  [21]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C430(1.03); C14(0.60)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C14(1.29)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C430(0.92); C14(0.94)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C430(1.25); C14(1.07); C589(1.04); C350(2.10)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C430(1.01); C14(0.75)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C532(0.80)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C430(1.05)  LDD2097  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C430(1.61); C14(1.19); C589(1.09)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C430(1.11); C14(0.91)  LDD2100  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C589(0.64)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C14(0.60)  LDD2105  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C14(0.68)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C350(1.54); C1093(0.91)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C430(1.09); C14(0.73)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C430(0.82); C350(1.05)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C589(1.16); C350(1.91); C1093(1.26)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C430(0.82); C14(0.85); C589(0.90)  LDD2114  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C430(1.99); C589(2.48)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C14(0.98)  LDD2120  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C430(1.38)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C589(0.89)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1093(1.17)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C430(1.04); C14(1.35); C589(1.11)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C430(0.96); C589(0.84)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C430(0.96)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C430(1.30); C14(0.99); C589(1.18); C350(1.49)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C430(2.15); C14(1.39); C532(1.72)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C430(1.04)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1093(1.21)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C430(0.98); C14(0.85)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C14(0.76)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C14(0.87)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C430(1.65); C14(0.90)  LDD2144  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C430(1.02); C589(1.04)  LDD2146  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C430(0.76); C14(0.74); C589(0.73); C350(0.72)  LDD2150  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C14(1.55)  LDD2153  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C350(0.79); C1093(0.56); C14(0.56); C532(0.36)  LDD2206  [34]
 LDCM0628  OTUB2-COV-1 HEK-293T C589(1.15); C1116(1.10); C14(0.63); C92(0.49)  LDD2207  [34]
 LDCM0131  RA190 MM1.R 2.61  LDD0300  [10]
 LDCM0021  THZ1 HCT 116 C532(1.09); C327(1.10); C1093(0.92)  LDD2173  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
mRNA export factor GLE1 (GLE1) GLE1 family Q53GS7
MyoD family inhibitor (MDFI) MDFI family Q99750
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Double-strand-break repair protein rad21 homolog (RAD21) Rad21 family O60216
Cohesin subunit SA-1 (STAG1) SCC3 family Q8WVM7
Cohesin subunit SA-2 (STAG2) SCC3 family Q8N3U4
Structural maintenance of chromosomes protein 3 (SMC3) SMC family Q9UQE7
Sororin (CDCA5) Sororin family Q96FF9
PRKCA-binding protein (PICK1) . Q9NRD5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
20 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD027578
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