Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Alkyne-RA190  Probe Info 
Probe concentration 30 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name RA190  Competitor Info 
Competitor Concentration 10 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Plasma cell myeloma [ICD-11:2A83]
Model Name Human plasma cell myeloma cells (MM1.R)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 51 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10201  Atypical kinase COQ8B, mitochondrial (COQ8B) 32.3
 LDTP07967  Lysophosphatidylcholine acyltransferase 2 (LPCAT2) 19.6
 LDTP02812  Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) 11.8
 LDTP03458  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) 11.6
 LDTP07362  Atlastin-3 (ATL3) 10.9
 LDTP19892  DGAT1/2-independent enzyme synthesizing storage lipids (TMEM68) 9.7
 LDTP15154  Dehydrogenase/reductase SDR family member 13 (DHRS13) 8.8
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) 8.7
 LDTP00294  26S proteasome non-ATPase regulatory subunit 14 (PSMD14) 7.8
 LDTP11127  ADP-dependent glucokinase (ADPGK) 6.5
 LDTP10888  Legumain (LGMN) 6.3
 LDTP10038  Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1) 5.9
 LDTP04690  Double-stranded RNA-specific adenosine deaminase (ADAR) 5.6
 LDTP04310  E3 SUMO-protein ligase RanBP2 (RANBP2) 4.8
 LDTP12105  L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) 4.7
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 4.4
 LDTP04519  Kinesin-like protein KIF11 (KIF11) 4.3
 LDTP10399  Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5) 4.1
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 3.9
 LDTP13004  Serine/threonine-protein kinase pim-2 (PIM2) 3.8
 LDTP07290  Lysophospholipid acyltransferase LPCAT4 (LPCAT4) 3.8
 LDTP03985  Caspase-2 (CASP2) 3.7
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 3.7
 LDTP06104  Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) 3.7
 LDTP11558  ER degradation-enhancing alpha-mannosidase-like protein 3 (EDEM3) 3.6
 LDTP14074  Ribosomal biogenesis protein LAS1L (LAS1L) 3.6
 LDTP03540  Heme oxygenase 2 (HMOX2) 3.5
 LDTP10432  ATP synthase membrane subunit K, mitochondrial (ATP5MK) 3.4
 LDTP05795  Nucleoside diphosphate kinase 3 (NME3) 3.4
 LDTP09895  Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) 3.3
 LDTP04889  Signal peptidase complex subunit 3 (SPCS3) 3.3
 LDTP07511  Long-chain fatty acid transport protein 4 (SLC27A4) 3.1
 LDTP01514  NADH dehydrogenase 1 beta subcomplex subunit 4 (NDUFB4) 2.9
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) 2.8
 LDTP08799  Lysophosphatidylserine lipase ABHD12 (ABHD12) 2.8
 LDTP10077  Patatin-like phospholipase domain-containing protein 2 (PNPLA2) 2.8
 LDTP08156  Schlafen family member 11 (SLFN11) 2.7
 LDTP11642  DNA-directed RNA polymerase I subunit RPA49 (POLR1E) 2.6
 LDTP09061  Retinol dehydrogenase 13 (RDH13) 2.6
 LDTP05312  Exosome complex component 10 (EXOSC10) 2.4
 LDTP03145  Catechol O-methyltransferase (COMT) 2.4
 LDTP05091  Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8) 2.4
 LDTP06455  Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) 2.3
 LDTP02223  Cathepsin B (CTSB) 2.3
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 2.3
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) 2.2
 LDTP13675  COP9 signalosome complex subunit 3 (COPS3) 2.2
 LDTP10471  Protein disulfide-isomerase TMX3 (TMX3) 2.2
 LDTP13533  Long-chain-fatty-acid--CoA ligase 5 (ACSL5) 2.2
 LDTP03842  Squalene synthase (FDFT1) 2.1
 LDTP02055  Thymidylate synthase (TYMS) 2.1
Transporter and channel
Click to Show/Hide to Show 30 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15898  HIG1 domain family member 2A, mitochondrial (HIGD2A) 152.4
 LDTP01060  PRA1 family protein 2 (PRAF2) 39.0
 LDTP04407  Amiloride-sensitive sodium channel subunit beta (SCNN1B) 22.9
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 19.7
 LDTP15948  Transmembrane protein 126A (TMEM126A) 7.3
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 5.2
 LDTP18053  Probable mitochondrial glutathione transporter SLC25A40 (SLC25A40) 5.0
 LDTP02658  Cytochrome b-245 light chain (CYBA) 4.9
 LDTP09579  Nuclear pore complex protein Nup133 (NUP133) 4.7
 LDTP04227  Guided entry of tail-anchored proteins factor CAMLG (CAMLG) 4.3
 LDTP12210  Mitochondrial thiamine pyrophosphate carrier (SLC25A19) 4.0
 LDTP00590  Protein RER1 (RER1) 4.0
 LDTP09502  Nuclear pore membrane glycoprotein 210 (NUP210) 3.5
 LDTP05528  Apoptosis regulator BAX (BAX) 3.5
 LDTP10897  Nuclear pore complex protein Nup88 (NUP88) 3.5
 LDTP01556  Vesicle-associated membrane protein-associated protein B/C (VAPB) 3.3
 LDTP05780  Syntaxin-5 (STX5) 3.3
 LDTP02058  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (RPN2) 3.1
 LDTP04800  Nuclear pore complex protein Nup107 (NUP107) 3.0
 LDTP03810  ATP synthase subunit gamma, mitochondrial (ATP5F1C) 3.0
 LDTP05631  Bone marrow stromal antigen 2 (BST2) 2.9
 LDTP01748  Mitochondrial import receptor subunit TOM40 homolog (TOMM40) 2.8
 LDTP07477  Transmembrane protein 214 (TMEM214) 2.8
 LDTP09515  Importin-4 (IPO4) 2.6
 LDTP12142  Exportin-5 (XPO5) 2.6
 LDTP11213  Nucleoporin NDC1 (NDC1) 2.5
 LDTP15838  Translocation protein SEC62 (SEC62) 2.5
 LDTP03061  Cation-dependent mannose-6-phosphate receptor (M6PR) 2.4
 LDTP03952  Reduced folate transporter (SLC19A1) 2.3
 LDTP01969  Transferrin receptor protein 1 (TFRC) 2.3
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10756  Nucleus accumbens-associated protein 1 (NACC1) 3.4
 LDTP06354  Interferon regulatory factor 4 (IRF4) 3.3
 LDTP00576  NF-kappa-B-repressing factor (NKRF) 2.3
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12387  SLAM family member 7 (SLAMF7) 3.8
Cytokine and receptor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03659  CD70 antigen (CD70) 3.0
Other
Click to Show/Hide to Show 73 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14139  Origin recognition complex subunit 6 (ORC6) 120.8
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) 67.3
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 22.4
 LDTP13800  Proteasome maturation protein (POMP) 20.1
 LDTP15395  Cell cycle exit and neuronal differentiation protein 1 (CEND1) 14.8
 LDTP11324  RNA-binding protein 4 (RBM4) 11.9
 LDTP04038  Melanoma-associated antigen 1 (MAGEA1) 10.3
 LDTP07521  Enhancer of mRNA-decapping protein 4 (EDC4) 9.9
 LDTP07205  Telomere-associated protein RIF1 (RIF1) 7.8
 LDTP03527  G1/S-specific cyclin-D2 (CCND2) 7.2
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 6.8
 LDTP19831  Protein THEM6 (THEM6) 6.3
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 6.1
 LDTP16080  Protein FAM114A2 (FAM114A2) 5.9
 LDTP12506  DNA polymerase epsilon subunit 3 (POLE3) 5.7
 LDTP09787  Nicastrin (NCSTN) 5.4
 LDTP12680  Fanconi anemia group I protein (FANCI) 5.4
 LDTP13338  Vacuolar protein sorting-associated protein 51 homolog (VPS51) 5.3
 LDTP15874  Mitochondrial import inner membrane translocase subunit Tim29 (TIMM29) 5.2
 LDTP09587  Protein BRICK1 (BRK1) 5.1
 LDTP10584  Junctional sarcoplasmic reticulum protein 1 (JSRP1) 5.1
 LDTP14122  U3 small nucleolar RNA-associated protein 18 homolog (UTP18) 5.1
 LDTP03886  Alpha-taxilin (TXLNA) 4.8
 LDTP01379  Ribosomal L1 domain-containing protein 1 (RSL1D1) 4.7
 LDTP05898  Sequestosome-1 (SQSTM1) 4.3
 LDTP13094  Tuftelin-interacting protein 11 (TFIP11) 4.2
 LDTP06412  Telomeric repeat-binding factor 2 (TERF2) 4.1
 LDTP06954  Nucleolar MIF4G domain-containing protein 1 (NOM1) 4.1
 LDTP06809  Tubulin beta-8 chain (TUBB8) 4.1
 LDTP04904  Alpha-centractin (ACTR1A) 4.0
 LDTP10091  Pre-B-cell leukemia transcription factor-interacting protein 1 (PBXIP1) 3.9
 LDTP13701  Serine/threonine-protein phosphatase 6 regulatory subunit 1 (PPP6R1) 3.8
 LDTP00517  U2 snRNP-associated SURP motif-containing protein (U2SURP) 3.7
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) 3.6
 LDTP06182  Ribosomal RNA processing protein 1 homolog B (RRP1B) 3.6
 LDTP01021  Perilipin-3 (PLIN3) 3.6
 LDTP04500  Heterogeneous nuclear ribonucleoprotein M (HNRNPM) 3.6
 LDTP00691  TELO2-interacting protein 1 homolog (TTI1) 3.5
 LDTP05922  Dynactin subunit 2 (DCTN2) 3.5
 LDTP08387  Dynein axonemal assembly factor 5 (DNAAF5) 3.5
 LDTP08418  RAS protein activator like-3 (RASAL3) 3.3
 LDTP13657  Melanoma-associated antigen D2 (MAGED2) 3.3
 LDTP10353  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) 3.2
 LDTP04729  Ribosomal RNA processing protein 1 homolog A (RRP1) 3.1
 LDTP06109  Guanine nucleotide-binding protein subunit alpha-13 (GNA13) 3.1
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 3.0
 LDTP15253  HEAT repeat-containing protein 3 (HEATR3) 3.0
 LDTP06915  Borealin (CDCA8) 2.9
 LDTP01522  Reticulon-3 (RTN3) 2.9
 LDTP02302  Small ribosomal subunit protein eS17 (RPS17) 2.9
 LDTP02306  Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3) 2.8
 LDTP05525  KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) 2.8
 LDTP04078  Proliferation marker protein Ki-67 (MKI67) 2.8
 LDTP09878  Symplekin (SYMPK) 2.8
 LDTP09545  Nucleolar complex protein 3 homolog (NOC3L) 2.8
 LDTP11766  Activating signal cointegrator 1 complex subunit 2 (ASCC2) 2.7
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) 2.7
 LDTP10700  KH domain-containing RNA-binding protein QKI (QKI) 2.7
 LDTP07781  Nesprin-3 (SYNE3) 2.6
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) 2.6
 LDTP10914  Translin-associated protein X (TSNAX) 2.5
 LDTP00078  CCR4-NOT transcription complex subunit 1 (CNOT1) 2.5
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) 2.5
 LDTP05867  Treacle protein (TCOF1) 2.5
 LDTP09820  La-related protein 4B (LARP4B) 2.4
 LDTP17603  Spermatogenesis-associated serine-rich protein 2 (SPATS2) 2.3
 LDTP07401  Ragulator complex protein LAMTOR1 (LAMTOR1) 2.3
 LDTP13913  Inner nuclear membrane protein Man1 (LEMD3) 2.2
 LDTP14980  RRP12-like protein (RRP12) 2.2
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 2.1
 LDTP01611  Formin-like protein 1 (FMNL1) 2.1
 LDTP18131  MOB kinase activator 3A (MOB3A) 2.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) 2.0

References

1 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.