Details of the Target

General Information of Target

Target ID LDTP00576
Target Name NF-kappa-B-repressing factor (NKRF)
Gene Name NKRF
Gene ID 55922
Synonyms
ITBA4; NRF; NF-kappa-B-repressing factor; NFkB-repressing factor; NRF; Protein ITBA4
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEKILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLSTCDGQNPPKKQAGSKFHARPRFEPV
HFVASSSKDERQEDPYGPQTKEVNEQTHFASMPRDIYQDYTQDSFSIQDGNSQYCDSSGF
ILTKDQPVTANMYFDSGNPAPSTTSQQANSQSTPEPSPSQTFPESVVAEKQYFIEKLTAT
IWKNLSNPEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGY
ACEVRCQNIYLTTGYAGSKNGSRDRATELAVKLLQKRIEVRVVRRKFKHTFGEDLVVCQI
GMSSYEFPPALKPPEDLVVLGKDASGQPIFNASAKHWTNFVITENANDAIGILNNSASFN
KMSIEYKYEMMPNRTWRCRVFLQDHCLAEGYGTKKTSKHAAADEALKILQKTQPTYPSVK
SSQCHTGSSPRGSGKKKDIKDLVVYENSSNPVCTLNDTAQFNRMTVEYVYERMTGLRWKC
KVILESEVIAEAVGVKKTVKYEAAGEAVKTLKKTQPTVINNLKKGAVEDVISRNEIQGRS
AEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEGIREPISVKEQHKREGLGLDVERVNK
IAKRDIEQIIRNYARSESHTDLTFSRELTNDERKQIHQIAQKYGLKSKSHGVGHDRYLVV
GRKRRKEDLLDQLKQEGQVGHYELVMPQAN
Target Bioclass
Transcription factor
Subcellular location
Nucleus, nucleolus
Function
Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes.
Uniprot ID
O15226
Ensemble ID
ENST00000304449.8
HGNC ID
HGNC:19374
ChEMBL ID
CHEMBL3163

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y391(8.20)  LDD0257  [2]
Probe 1
 Probe Info  		Y76(7.81); Y416(18.59); Y545(41.67); Y657(9.75)  LDD3495  [3]
BTD
 Probe Info  		C424(0.50)  LDD2089  [4]
AHL-Pu-1
 Probe Info  		C424(2.27); C37(3.70); C115(2.10)  LDD0171  [5]
Alkyne-RA190
 Probe Info  		2.33  LDD0300  [6]
DBIA
 Probe Info  		C37(14.31); C424(15.78)  LDD0204  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C246(0.00); C242(0.00); C37(0.00); C424(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C246(0.00); C37(0.00)  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		C246(0.00); C453(0.00); C37(0.00); C242(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		C424(0.00); C453(0.00)  LDD2226  [11]
TFBX
 Probe Info  		C242(0.00); C246(0.00)  LDD0027  [12]
WYneN
 Probe Info  		C37(0.00); C424(0.00)  LDD0021  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
ENE
 Probe Info  		C424(0.00); C37(0.00)  LDD0006  [13]
IPM
 Probe Info  		N.A.  LDD0005  [13]
SF
 Probe Info  		N.A.  LDD0028  [15]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Phosphinate-6
 Probe Info  		C424(0.00); C37(0.00)  LDD0018  [16]
1c-yne
 Probe Info  		K411(0.00); K25(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		C242(0.00); C386(0.00)  LDD0217  [18]
Crotonaldehyde
 Probe Info  		C424(0.00); C242(0.00); C386(0.00)  LDD0219  [18]
Methacrolein
 Probe Info  		C386(0.00); C424(0.00); C37(0.00); C242(0.00)  LDD0218  [18]
W1
 Probe Info  		N.A.  LDD0236  [19]
AOyne
 Probe Info  		13.40  LDD0443  [20]
NAIA_5
 Probe Info  		C246(0.00); C37(0.00); C424(0.00); C386(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		15.03  LDD1865  [21]
FFF probe2
 Probe Info  		6.11  LDD0463  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C424(0.83)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C424(0.76)  LDD2117  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C424(1.19)  LDD2103  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C424(0.60)  LDD2132  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C424(2.27); C37(3.70); C115(2.10)  LDD0171  [5]
 LDCM0214  AC1 HEK-293T C37(1.07); C246(1.07); C242(0.95); C386(1.03)  LDD1507  [23]
 LDCM0215  AC10 HEK-293T C37(1.00); C246(1.07); C242(1.05); C386(0.98)  LDD1508  [23]
 LDCM0226  AC11 HEK-293T C37(0.98); C246(1.05); C242(0.94); C386(0.98)  LDD1509  [23]
 LDCM0237  AC12 HEK-293T C37(1.06); C246(1.03); C242(1.08); C386(1.06)  LDD1510  [23]
 LDCM0259  AC14 HEK-293T C37(0.91); C246(0.93); C242(1.06); C386(0.93)  LDD1512  [23]
 LDCM0270  AC15 HEK-293T C37(0.97); C246(1.08); C242(0.94); C386(0.94)  LDD1513  [23]
 LDCM0276  AC17 HEK-293T C37(1.10); C246(1.05); C242(0.86); C386(1.02)  LDD1515  [23]
 LDCM0277  AC18 HEK-293T C37(1.08); C246(1.00); C242(0.88); C386(0.95)  LDD1516  [23]
 LDCM0278  AC19 HEK-293T C37(1.16); C246(1.07); C242(0.86); C386(0.87)  LDD1517  [23]
 LDCM0279  AC2 HEK-293T C37(0.98); C246(1.03); C242(0.97); C386(1.18)  LDD1518  [23]
 LDCM0280  AC20 HEK-293T C37(1.15); C246(1.02); C242(0.98); C386(1.01)  LDD1519  [23]
 LDCM0281  AC21 HEK-293T C37(1.02); C246(1.01); C242(1.06); C386(0.99)  LDD1520  [23]
 LDCM0282  AC22 HEK-293T C37(0.95); C246(1.02); C242(1.03); C386(1.04)  LDD1521  [23]
 LDCM0283  AC23 HEK-293T C37(0.97); C246(1.07); C242(0.98); C386(0.88)  LDD1522  [23]
 LDCM0284  AC24 HEK-293T C37(0.96); C246(1.05); C242(0.96); C386(0.98)  LDD1523  [23]
 LDCM0285  AC25 HEK-293T C37(1.00); C246(1.06); C242(0.85); C386(0.90)  LDD1524  [23]
 LDCM0286  AC26 HEK-293T C37(1.03); C246(1.05); C242(0.97); C386(1.01)  LDD1525  [23]
 LDCM0287  AC27 HEK-293T C37(0.96); C246(1.10); C242(0.95); C386(0.99)  LDD1526  [23]
 LDCM0288  AC28 HEK-293T C37(1.12); C246(1.03); C242(1.01); C386(1.01)  LDD1527  [23]
 LDCM0289  AC29 HEK-293T C37(0.99); C246(1.03); C242(1.02); C386(0.99)  LDD1528  [23]
 LDCM0290  AC3 HEK-293T C37(0.96); C246(0.94); C242(0.94); C386(0.97)  LDD1529  [23]
 LDCM0291  AC30 HEK-293T C37(1.04); C246(0.96); C242(0.96); C386(1.01)  LDD1530  [23]
 LDCM0292  AC31 HEK-293T C37(1.02); C246(1.07); C242(1.08); C386(0.92)  LDD1531  [23]
 LDCM0293  AC32 HEK-293T C37(1.04); C246(1.13); C242(1.12); C386(1.05)  LDD1532  [23]
 LDCM0294  AC33 HEK-293T C37(1.00); C246(1.07); C242(0.84); C386(1.00)  LDD1533  [23]
 LDCM0295  AC34 HEK-293T C37(0.99); C246(1.12); C242(1.13); C386(1.01)  LDD1534  [23]
 LDCM0296  AC35 HEK-293T C37(0.96); C246(1.06); C242(1.03); C386(0.97)  LDD1535  [23]
 LDCM0297  AC36 HEK-293T C37(1.08); C246(0.97); C242(1.00); C386(0.98)  LDD1536  [23]
 LDCM0298  AC37 HEK-293T C37(0.99); C246(1.14); C242(1.05); C386(1.08)  LDD1537  [23]
 LDCM0299  AC38 HEK-293T C37(0.92); C246(1.03); C242(0.97); C386(0.99)  LDD1538  [23]
 LDCM0300  AC39 HEK-293T C37(1.00); C246(1.06); C242(0.97); C386(1.02)  LDD1539  [23]
 LDCM0301  AC4 HEK-293T C37(1.14); C246(1.01); C242(1.00); C386(1.04)  LDD1540  [23]
 LDCM0302  AC40 HEK-293T C37(0.99); C246(1.12); C242(0.94); C386(1.01)  LDD1541  [23]
 LDCM0303  AC41 HEK-293T C37(1.04); C246(1.08); C242(1.00); C386(0.97)  LDD1542  [23]
 LDCM0304  AC42 HEK-293T C37(1.03); C246(1.06); C242(1.13); C386(0.99)  LDD1543  [23]
 LDCM0305  AC43 HEK-293T C37(0.98); C246(1.14); C242(0.97); C386(0.99)  LDD1544  [23]
 LDCM0306  AC44 HEK-293T C37(1.07); C246(0.96); C242(0.98); C386(0.96)  LDD1545  [23]
 LDCM0307  AC45 HEK-293T C37(1.01); C246(1.02); C242(1.03); C386(1.01)  LDD1546  [23]
 LDCM0308  AC46 HEK-293T C37(0.92); C246(0.95); C242(1.06); C386(1.01)  LDD1547  [23]
 LDCM0309  AC47 HEK-293T C37(1.00); C246(1.06); C242(1.05); C386(1.01)  LDD1548  [23]
 LDCM0310  AC48 HEK-293T C37(1.07); C246(1.16); C242(0.94); C386(1.00)  LDD1549  [23]
 LDCM0311  AC49 HEK-293T C37(1.06); C246(1.05); C242(0.91); C386(1.03)  LDD1550  [23]
 LDCM0312  AC5 HEK-293T C37(1.00); C246(1.02); C242(1.11); C386(0.95)  LDD1551  [23]
 LDCM0313  AC50 HEK-293T C37(1.00); C246(1.04); C242(0.99); C386(1.10)  LDD1552  [23]
 LDCM0314  AC51 HEK-293T C37(0.96); C246(0.98); C242(1.05); C386(0.92)  LDD1553  [23]
 LDCM0315  AC52 HEK-293T C37(1.05); C246(1.04); C242(1.04); C386(0.92)  LDD1554  [23]
 LDCM0316  AC53 HEK-293T C37(1.00); C246(1.14); C242(1.13); C386(1.00)  LDD1555  [23]
 LDCM0317  AC54 HEK-293T C37(0.87); C246(0.92); C242(1.02); C386(0.98)  LDD1556  [23]
 LDCM0318  AC55 HEK-293T C37(0.94); C246(1.15); C242(0.97); C386(0.94)  LDD1557  [23]
 LDCM0319  AC56 HEK-293T C37(1.03); C246(1.11); C242(1.05); C386(1.02)  LDD1558  [23]
 LDCM0320  AC57 HEK-293T C37(0.97); C246(1.04); C242(0.86); C386(0.97)  LDD1559  [23]
 LDCM0321  AC58 HEK-293T C37(1.03); C246(1.04); C242(1.11); C386(1.05)  LDD1560  [23]
 LDCM0322  AC59 HEK-293T C37(0.94); C246(0.97); C242(0.89); C386(0.97)  LDD1561  [23]
 LDCM0323  AC6 HEK-293T C37(0.98); C246(0.90); C242(0.97); C386(0.98)  LDD1562  [23]
 LDCM0324  AC60 HEK-293T C37(1.17); C246(0.98); C242(1.08); C386(0.95)  LDD1563  [23]
 LDCM0325  AC61 HEK-293T C37(1.04); C246(1.04); C242(1.12); C386(0.98)  LDD1564  [23]
 LDCM0326  AC62 HEK-293T C37(0.87); C246(0.97); C242(0.96); C386(0.91)  LDD1565  [23]
 LDCM0327  AC63 HEK-293T C37(0.95); C246(1.04); C242(0.94); C386(0.87)  LDD1566  [23]
 LDCM0328  AC64 HEK-293T C37(1.14); C246(1.06); C242(1.06); C386(0.95)  LDD1567  [23]
 LDCM0334  AC7 HEK-293T C37(0.94); C246(1.03); C242(1.04); C386(0.97)  LDD1568  [23]
 LDCM0345  AC8 HEK-293T C37(1.13); C246(1.15); C242(0.84); C386(1.05)  LDD1569  [23]
 LDCM0545  Acetamide MDA-MB-231 C424(0.56)  LDD2138  [4]
 LDCM0248  AKOS034007472 HEK-293T C37(0.96); C246(1.14); C242(1.14); C386(1.02)  LDD1511  [23]
 LDCM0356  AKOS034007680 HEK-293T C37(1.04); C246(1.04); C242(0.98); C386(1.08)  LDD1570  [23]
 LDCM0275  AKOS034007705 HEK-293T C37(1.08); C246(1.10); C242(0.93); C386(1.11)  LDD1514  [23]
 LDCM0102  BDHI 8 Jurkat C37(14.31); C424(15.78)  LDD0204  [7]
 LDCM0498  BS-3668 MDA-MB-231 C424(0.36)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C386(0.00); C424(0.00); C242(0.00)  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C246(20.00); C37(3.73); C424(1.03); C37(0.99)  LDD2227  [11]
 LDCM0367  CL1 HEK-293T C37(1.02); C242(0.99); C386(1.04); C115(1.01)  LDD1571  [23]
 LDCM0368  CL10 HEK-293T C37(1.15); C246(1.07); C242(1.03); C386(0.85)  LDD1572  [23]
 LDCM0369  CL100 HEK-293T C37(1.08); C246(0.98); C242(0.92); C386(1.00)  LDD1573  [23]
 LDCM0370  CL101 HEK-293T C37(1.05); C242(1.04); C386(0.99); C115(1.08)  LDD1574  [23]
 LDCM0371  CL102 HEK-293T C37(1.00); C246(1.17); C242(1.00); C386(1.02)  LDD1575  [23]
 LDCM0372  CL103 HEK-293T C37(0.89); C246(0.98); C242(0.97); C386(0.90)  LDD1576  [23]
 LDCM0373  CL104 HEK-293T C37(1.02); C246(1.08); C242(1.08); C386(1.09)  LDD1577  [23]
 LDCM0374  CL105 HEK-293T C37(0.96); C242(1.07); C386(0.90); C115(1.12)  LDD1578  [23]
 LDCM0375  CL106 HEK-293T C37(1.05); C246(1.10); C242(1.00); C386(0.98)  LDD1579  [23]
 LDCM0376  CL107 HEK-293T C37(0.90); C246(0.96); C242(0.97); C386(0.97)  LDD1580  [23]
 LDCM0377  CL108 HEK-293T C37(1.06); C246(0.98); C242(0.98); C386(1.05)  LDD1581  [23]
 LDCM0378  CL109 HEK-293T C37(1.00); C242(1.05); C386(0.90); C115(1.00)  LDD1582  [23]
 LDCM0379  CL11 HEK-293T C37(1.00); C246(1.11); C242(0.99); C386(0.97)  LDD1583  [23]
 LDCM0380  CL110 HEK-293T C37(0.97); C246(1.21); C242(0.91); C386(0.98)  LDD1584  [23]
 LDCM0381  CL111 HEK-293T C37(0.97); C246(0.96); C242(0.71); C386(0.95)  LDD1585  [23]
 LDCM0382  CL112 HEK-293T C37(1.14); C246(1.04); C242(0.99); C386(0.98)  LDD1586  [23]
 LDCM0383  CL113 HEK-293T C37(0.99); C242(1.05); C386(1.04); C115(0.97)  LDD1587  [23]
 LDCM0384  CL114 HEK-293T C37(0.99); C246(1.10); C242(0.91); C386(0.98)  LDD1588  [23]
 LDCM0385  CL115 HEK-293T C37(0.92); C246(0.90); C242(0.97); C386(0.87)  LDD1589  [23]
 LDCM0386  CL116 HEK-293T C37(1.03); C246(0.96); C242(0.99); C386(1.00)  LDD1590  [23]
 LDCM0387  CL117 HEK-293T C37(0.98); C242(0.95); C386(1.10); C115(1.13)  LDD1591  [23]
 LDCM0388  CL118 HEK-293T C37(1.03); C246(1.09); C242(0.88); C386(1.15)  LDD1592  [23]
 LDCM0389  CL119 HEK-293T C37(0.91); C246(0.90); C242(1.07); C386(0.96)  LDD1593  [23]
 LDCM0390  CL12 HEK-293T C37(1.01); C246(1.17); C242(0.99); C386(1.12)  LDD1594  [23]
 LDCM0391  CL120 HEK-293T C37(1.25); C246(1.02); C242(0.99); C386(0.99)  LDD1595  [23]
 LDCM0392  CL121 HEK-293T C37(1.11); C242(0.89); C386(0.96); C115(1.02)  LDD1596  [23]
 LDCM0393  CL122 HEK-293T C37(1.01); C246(1.15); C242(1.03); C386(1.13)  LDD1597  [23]
 LDCM0394  CL123 HEK-293T C37(0.85); C246(0.98); C242(1.03); C386(0.87)  LDD1598  [23]
 LDCM0395  CL124 HEK-293T C37(1.06); C246(1.17); C242(1.01); C386(0.99)  LDD1599  [23]
 LDCM0396  CL125 HEK-293T C37(1.06); C242(0.90); C386(1.02); C115(1.04)  LDD1600  [23]
 LDCM0397  CL126 HEK-293T C37(1.03); C246(0.92); C242(1.03); C386(1.03)  LDD1601  [23]
 LDCM0398  CL127 HEK-293T C37(0.94); C246(0.89); C242(1.09); C386(0.91)  LDD1602  [23]
 LDCM0399  CL128 HEK-293T C37(0.96); C246(0.92); C242(0.97); C386(1.03)  LDD1603  [23]
 LDCM0400  CL13 HEK-293T C37(1.06); C242(1.05); C386(1.02); C115(1.13)  LDD1604  [23]
 LDCM0401  CL14 HEK-293T C37(0.95); C246(1.06); C242(1.07); C386(1.12)  LDD1605  [23]
 LDCM0402  CL15 HEK-293T C37(0.88); C246(1.00); C242(1.05); C386(0.86)  LDD1606  [23]
 LDCM0403  CL16 HEK-293T C37(1.26); C246(1.02); C242(0.93); C386(1.11)  LDD1607  [23]
 LDCM0404  CL17 HEK-293T C37(0.93); C246(1.32); C242(0.95); C386(0.91)  LDD1608  [23]
 LDCM0405  CL18 HEK-293T C37(0.94); C246(1.15); C242(1.04); C386(1.09)  LDD1609  [23]
 LDCM0406  CL19 HEK-293T C37(1.05); C246(1.13); C242(0.97); C386(0.94)  LDD1610  [23]
 LDCM0407  CL2 HEK-293T C37(0.95); C246(0.98); C242(0.98); C386(1.10)  LDD1611  [23]
 LDCM0408  CL20 HEK-293T C37(1.04); C246(1.09); C242(1.11); C386(1.12)  LDD1612  [23]
 LDCM0409  CL21 HEK-293T C37(0.96); C246(1.23); C242(1.11); C386(0.94)  LDD1613  [23]
 LDCM0410  CL22 HEK-293T C37(1.07); C246(0.99); C242(0.98); C386(1.11)  LDD1614  [23]
 LDCM0411  CL23 HEK-293T C37(1.05); C246(1.25); C242(0.95); C386(0.91)  LDD1615  [23]
 LDCM0412  CL24 HEK-293T C37(1.05); C246(1.04); C242(0.98); C386(1.13)  LDD1616  [23]
 LDCM0413  CL25 HEK-293T C37(1.06); C242(0.84); C386(0.94); C115(0.99)  LDD1617  [23]
 LDCM0414  CL26 HEK-293T C37(1.06); C246(1.09); C242(0.89); C386(1.10)  LDD1618  [23]
 LDCM0415  CL27 HEK-293T C37(0.97); C246(0.94); C242(1.04); C386(1.04)  LDD1619  [23]
 LDCM0416  CL28 HEK-293T C37(1.11); C246(1.11); C242(0.99); C386(1.02)  LDD1620  [23]
 LDCM0417  CL29 HEK-293T C37(0.97); C246(1.18); C242(0.94); C386(1.09)  LDD1621  [23]
 LDCM0418  CL3 HEK-293T C37(0.89); C246(0.92); C242(1.17); C386(1.02)  LDD1622  [23]
 LDCM0419  CL30 HEK-293T C37(0.92); C246(1.17); C242(1.17); C386(1.04)  LDD1623  [23]
 LDCM0420  CL31 HEK-293T C37(1.06); C246(1.04); C242(0.80); C386(1.00)  LDD1624  [23]
 LDCM0421  CL32 HEK-293T C37(1.04); C246(1.14); C242(1.03); C386(0.86)  LDD1625  [23]
 LDCM0422  CL33 HEK-293T C37(0.98); C246(1.25); C242(1.24); C386(0.82)  LDD1626  [23]
 LDCM0423  CL34 HEK-293T C37(1.08); C246(0.97); C242(1.10); C386(1.02)  LDD1627  [23]
 LDCM0424  CL35 HEK-293T C37(1.12); C246(1.17); C242(1.09); C386(1.00)  LDD1628  [23]
 LDCM0425  CL36 HEK-293T C37(0.99); C246(1.08); C242(1.16); C386(1.07)  LDD1629  [23]
 LDCM0426  CL37 HEK-293T C37(0.99); C242(0.96); C386(1.04); C115(0.93)  LDD1630  [23]
 LDCM0428  CL39 HEK-293T C37(0.89); C246(1.10); C242(1.05); C386(0.92)  LDD1632  [23]
 LDCM0429  CL4 HEK-293T C37(1.05); C246(1.02); C242(0.83); C386(1.04)  LDD1633  [23]
 LDCM0430  CL40 HEK-293T C37(1.14); C246(1.03); C242(0.99); C386(1.09)  LDD1634  [23]
 LDCM0431  CL41 HEK-293T C37(1.02); C246(1.11); C242(0.98); C386(1.01)  LDD1635  [23]
 LDCM0432  CL42 HEK-293T C37(0.96); C246(1.04); C242(0.94); C386(1.03)  LDD1636  [23]
 LDCM0433  CL43 HEK-293T C37(1.01); C246(1.16); C242(0.95); C386(1.00)  LDD1637  [23]
 LDCM0434  CL44 HEK-293T C37(1.07); C246(1.00); C242(1.09); C386(1.06)  LDD1638  [23]
 LDCM0435  CL45 HEK-293T C37(1.10); C246(1.07); C242(0.99); C386(0.91)  LDD1639  [23]
 LDCM0436  CL46 HEK-293T C37(1.11); C246(0.98); C242(1.14); C386(1.03)  LDD1640  [23]
 LDCM0437  CL47 HEK-293T C37(1.15); C246(0.98); C242(0.99); C386(0.86)  LDD1641  [23]
 LDCM0438  CL48 HEK-293T C37(1.06); C246(1.13); C242(0.88); C386(1.03)  LDD1642  [23]
 LDCM0439  CL49 HEK-293T C37(1.03); C242(0.99); C386(1.05); C115(0.91)  LDD1643  [23]
 LDCM0440  CL5 HEK-293T C37(0.97); C246(1.10); C242(0.81); C386(1.07)  LDD1644  [23]
 LDCM0441  CL50 HEK-293T C37(0.96); C246(1.02); C242(1.16); C386(1.11)  LDD1645  [23]
 LDCM0443  CL52 HEK-293T C37(1.35); C246(1.15); C242(1.08); C386(1.02)  LDD1646  [23]
 LDCM0444  CL53 HEK-293T C37(1.01); C246(1.27); C242(1.14); C386(0.97)  LDD1647  [23]
 LDCM0445  CL54 HEK-293T C37(0.93); C246(1.12); C242(0.90); C386(0.92)  LDD1648  [23]
 LDCM0446  CL55 HEK-293T C37(1.09); C246(1.30); C242(1.10); C386(0.96)  LDD1649  [23]
 LDCM0447  CL56 HEK-293T C37(1.07); C246(0.97); C242(1.10); C386(1.06)  LDD1650  [23]
 LDCM0448  CL57 HEK-293T C37(1.09); C246(1.15); C242(0.99); C386(0.94)  LDD1651  [23]
 LDCM0449  CL58 HEK-293T C37(1.11); C246(1.16); C242(1.09); C386(1.02)  LDD1652  [23]
 LDCM0450  CL59 HEK-293T C37(1.04); C246(1.11); C242(0.94); C386(0.90)  LDD1653  [23]
 LDCM0451  CL6 HEK-293T C37(1.00); C246(1.20); C242(1.10); C386(0.96)  LDD1654  [23]
 LDCM0452  CL60 HEK-293T C37(1.14); C246(1.22); C242(1.05); C386(1.10)  LDD1655  [23]
 LDCM0453  CL61 HEK-293T C37(1.10); C242(0.94); C386(1.10); C115(1.05)  LDD1656  [23]
 LDCM0454  CL62 HEK-293T C37(0.97); C246(1.02); C242(0.95); C386(1.11)  LDD1657  [23]
 LDCM0455  CL63 HEK-293T C37(0.95); C246(0.97); C242(0.96); C386(0.89)  LDD1658  [23]
 LDCM0456  CL64 HEK-293T C37(1.17); C246(1.13); C242(1.08); C386(0.99)  LDD1659  [23]
 LDCM0457  CL65 HEK-293T C37(1.08); C246(1.12); C242(0.94); C386(1.01)  LDD1660  [23]
 LDCM0458  CL66 HEK-293T C37(1.01); C246(1.11); C242(1.04); C386(1.01)  LDD1661  [23]
 LDCM0459  CL67 HEK-293T C37(1.03); C246(1.22); C242(1.03); C386(0.98)  LDD1662  [23]
 LDCM0460  CL68 HEK-293T C37(1.14); C246(1.00); C242(1.13); C386(0.95)  LDD1663  [23]
 LDCM0461  CL69 HEK-293T C37(1.05); C246(1.21); C242(1.18); C386(0.98)  LDD1664  [23]
 LDCM0462  CL7 HEK-293T C37(1.01); C246(1.08); C242(1.03); C386(0.93)  LDD1665  [23]
 LDCM0463  CL70 HEK-293T C37(1.03); C246(1.01); C242(1.13); C386(1.03)  LDD1666  [23]
 LDCM0464  CL71 HEK-293T C37(1.06); C246(1.15); C242(1.04); C386(0.95)  LDD1667  [23]
 LDCM0465  CL72 HEK-293T C37(1.08); C246(1.17); C242(1.15); C386(1.00)  LDD1668  [23]
 LDCM0466  CL73 HEK-293T C37(1.17); C242(1.05); C386(0.93); C115(0.95)  LDD1669  [23]
 LDCM0467  CL74 HEK-293T C37(1.01); C246(1.04); C242(0.89); C386(1.05)  LDD1670  [23]
 LDCM0469  CL76 HEK-293T C37(1.15); C246(1.11); C242(1.09); C386(1.09)  LDD1672  [23]
 LDCM0470  CL77 HEK-293T C37(1.00); C246(1.19); C242(0.92); C386(1.00)  LDD1673  [23]
 LDCM0471  CL78 HEK-293T C37(0.94); C246(1.17); C242(1.02); C386(1.02)  LDD1674  [23]
 LDCM0472  CL79 HEK-293T C37(0.98); C246(1.20); C242(0.96); C386(1.05)  LDD1675  [23]
 LDCM0473  CL8 HEK-293T C37(1.05); C246(1.51); C242(1.08); C386(0.79)  LDD1676  [23]
 LDCM0474  CL80 HEK-293T C37(1.12); C246(1.00); C242(1.06); C386(1.04)  LDD1677  [23]
 LDCM0475  CL81 HEK-293T C37(0.94); C246(1.17); C242(1.07); C386(0.99)  LDD1678  [23]
 LDCM0476  CL82 HEK-293T C37(1.06); C246(1.11); C242(1.00); C386(1.04)  LDD1679  [23]
 LDCM0477  CL83 HEK-293T C37(1.10); C246(1.09); C242(1.05); C386(0.93)  LDD1680  [23]
 LDCM0478  CL84 HEK-293T C37(1.03); C246(1.22); C242(1.04); C386(1.00)  LDD1681  [23]
 LDCM0479  CL85 HEK-293T C37(1.09); C242(1.09); C386(1.05); C115(0.99)  LDD1682  [23]
 LDCM0480  CL86 HEK-293T C37(1.02); C246(1.08); C242(1.04); C386(1.05)  LDD1683  [23]
 LDCM0481  CL87 HEK-293T C37(1.00); C246(1.03); C242(0.96); C386(0.94)  LDD1684  [23]
 LDCM0482  CL88 HEK-293T C37(0.89); C246(1.08); C242(0.92); C386(1.06)  LDD1685  [23]
 LDCM0483  CL89 HEK-293T C37(0.94); C246(1.14); C242(0.87); C386(1.08)  LDD1686  [23]
 LDCM0484  CL9 HEK-293T C37(1.04); C246(1.19); C242(1.01); C386(1.08)  LDD1687  [23]
 LDCM0485  CL90 HEK-293T C37(1.02); C246(1.26); C242(0.97); C386(0.89)  LDD1688  [23]
 LDCM0486  CL91 HEK-293T C37(1.04); C246(1.33); C242(0.85); C386(0.99)  LDD1689  [23]
 LDCM0487  CL92 HEK-293T C37(1.16); C246(1.02); C242(1.11); C386(0.86)  LDD1690  [23]
 LDCM0488  CL93 HEK-293T C37(1.01); C246(1.20); C242(1.12); C386(0.94)  LDD1691  [23]
 LDCM0489  CL94 HEK-293T C37(1.00); C246(0.96); C242(0.95); C386(0.98)  LDD1692  [23]
 LDCM0490  CL95 HEK-293T C37(1.03); C246(1.16); C242(0.82); C386(0.71)  LDD1693  [23]
 LDCM0491  CL96 HEK-293T C37(1.52); C246(1.21); C242(1.04); C386(0.95)  LDD1694  [23]
 LDCM0492  CL97 HEK-293T C37(1.01); C242(1.02); C386(0.90); C115(0.99)  LDD1695  [23]
 LDCM0493  CL98 HEK-293T C37(0.98); C246(1.03); C242(1.06); C386(1.01)  LDD1696  [23]
 LDCM0494  CL99 HEK-293T C37(0.94); C246(0.89); C242(1.11); C386(0.88)  LDD1697  [23]
 LDCM0495  E2913 HEK-293T C37(0.93); C246(1.05); C242(1.04); C386(0.95)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C424(1.17); C37(1.02)  LDD1702  [4]
 LDCM0625  F8 Ramos C424(1.50); C37(1.61); C453(1.06)  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C424(1.34); C37(1.82); C453(0.95)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C424(12.26); C37(6.89); C453(5.29)  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C424(0.77); C37(0.90); C453(0.85)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C424(1.04); C37(0.90)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C424(0.62); C37(1.00); C453(1.05)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C424(0.97); C37(1.20)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C424(1.24); C37(0.82)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C424(0.91); C37(1.26); C453(0.97)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C424(1.52)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C424(0.50); C37(0.45)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C424(1.58); C37(0.97); C453(1.09)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C424(0.94); C37(0.62)  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C424(1.61); C37(2.22); C453(1.05)  LDD2201  [24]
 LDCM0468  Fragment33 HEK-293T C37(0.95); C246(0.91); C242(0.98); C386(0.90)  LDD1671  [23]
 LDCM0596  Fragment38 Ramos C424(1.04); C37(0.73)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C424(0.70); C37(0.91); C453(0.62)  LDD2184  [24]
 LDCM0427  Fragment51 HEK-293T C37(1.00); C246(1.09); C242(1.04); C386(1.03)  LDD1631  [23]
 LDCM0610  Fragment52 Ramos C424(2.11); C37(0.94)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C424(1.87); C37(1.04); C453(1.05)  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C424(0.82); C37(1.02)  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C424(1.07); C37(0.81); C453(0.85)  LDD2188  [24]
 LDCM0107  IAA HeLa N.A.  LDD0221  [18]
 LDCM0022  KB02 HEK-293T C424(1.29); C37(1.01); C246(0.94); C453(1.12)  LDD1492  [23]
 LDCM0023  KB03 HEK-293T C424(0.71); C37(1.04); C246(1.05); C453(1.09)  LDD1497  [23]
 LDCM0024  KB05 G361 C261(3.50); C439(2.08); C401(1.31)  LDD3311  [25]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C424(0.39)  LDD2121  [4]
 LDCM0109  NEM HeLa N.A.  LDD0225  [18]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C424(0.50)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C424(1.36)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C424(1.03)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C424(0.90)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C424(1.05)  LDD2094  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C424(0.59)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C424(0.93)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C424(0.57)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C424(0.87)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C424(1.88)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C424(0.79)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C424(0.85)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C424(0.58)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C424(0.77)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C424(2.47)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C424(0.88)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C424(0.95); C386(0.55)  LDD2114  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C424(0.74)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C424(0.73)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C424(2.26)  LDD2119  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C424(0.89)  LDD2122  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C424(0.94)  LDD2124  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C424(0.68)  LDD2127  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C424(0.62)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C424(0.92)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C424(0.96)  LDD2137  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C424(0.42)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C424(0.57)  LDD2143  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C424(5.21)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C424(0.89)  LDD2146  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C424(0.30)  LDD2150  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C424(1.46)  LDD2153  [4]
 LDCM0131  RA190 MM1.R 2.33  LDD0300  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-dependent RNA helicase DHX15 (DHX15) DEAD box helicase family O43143
ATP-dependent RNA helicase DHX58 (DHX58) Helicase family Q96C10
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA) PRKRA family O75569
Double-stranded RNA-binding protein Staufen homolog 1 (STAU1) . O95793
Zinc finger protein 346 (ZNF346) . Q9UL40

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840