Details of the Target

General Information of Target

Target ID LDTP00590
Target Name Protein RER1 (RER1)
Gene Name RER1
Gene ID 11079
Synonyms
Protein RER1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEGDSVGESVHGKPSVVYRFFTRLGQIYQSWLDKSTPYTAVRWVVTLGLSFVYMIRVYL
LQGWYIVTYALGIYHLNLFIAFLSPKVDPSLMEDSDDGPSLPTKQNEEFRPFIRRLPEFK
FWHAATKGILVAMVCTFFDAFNVPVFWPILVMYFIMLFCITMKRQIKHMIKYRYIPFTHG
KRRYRGKEDAGKAFAS
Target Bioclass
Transporter and channel
Family
RER1 family
Subcellular location
Golgi apparatus membrane
Function Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
Uniprot ID
O15258
Ensemble ID
ENST00000488353.2
HGNC ID
HGNC:30309

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		1.71  LDD0197  [1]
CHEMBL5175495
 Probe Info  		5.69  LDD0196  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
TH211
 Probe Info  		Y174(10.08); Y29(9.41)  LDD0260  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
OPA-S-S-alkyne
 Probe Info  		K181(7.46)  LDD3494  [6]
HPAP
 Probe Info  		3.60  LDD0064  [7]
Alkyne-RA190
 Probe Info  		3.95  LDD0300  [8]
Acrolein
 Probe Info  		N.A.  LDD0227  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
NHS
 Probe Info  		N.A.  LDD0010  [11]
STPyne
 Probe Info  		N.A.  LDD0009  [11]
AOyne
 Probe Info  		14.40  LDD0443  [12]
PAL-AfBPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		9.65  LDD1740  [13]
C091
 Probe Info  		12.82  LDD1782  [13]
C092
 Probe Info  		24.93  LDD1783  [13]
C094
 Probe Info  		43.41  LDD1785  [13]
C112
 Probe Info  		17.39  LDD1799  [13]
C161
 Probe Info  		10.56  LDD1841  [13]
C201
 Probe Info  		25.46  LDD1877  [13]
C218
 Probe Info  		14.83  LDD1892  [13]
C219
 Probe Info  		5.35  LDD1893  [13]
C220
 Probe Info  		17.51  LDD1894  [13]
C228
 Probe Info  		19.84  LDD1901  [13]
C231
 Probe Info  		19.70  LDD1904  [13]
C235
 Probe Info  		32.22  LDD1908  [13]
C285
 Probe Info  		28.25  LDD1955  [13]
C289
 Probe Info  		33.13  LDD1959  [13]
C293
 Probe Info  		16.00  LDD1963  [13]
C349
 Probe Info  		11.00  LDD2010  [13]
C350
 Probe Info  		31.56  LDD2011  [13]
C362
 Probe Info  		30.70  LDD2023  [13]
C388
 Probe Info  		36.25  LDD2047  [13]
C407
 Probe Info  		11.31  LDD2064  [13]
FFF probe14
 Probe Info  		20.00  LDD0477  [14]
FFF probe2
 Probe Info  		20.00  LDD0463  [14]
FFF probe3
 Probe Info  		20.00  LDD0464  [14]
STS-1
 Probe Info  		N.A.  LDD0137  [15]
STS-2
 Probe Info  		N.A.  LDD0138  [15]
OEA-DA
 Probe Info  		9.74  LDD0046  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0227  [9]
 LDCM0014  Panhematin hPBMC 3.60  LDD0064  [7]
 LDCM0131  RA190 MM1.R 3.95  LDD0300  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Synaptotagmin-16 (SYT16) Synaptotagmin family Q17RD7
SCAN domain-containing protein 1 (SCAND1) . P57086

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
8 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
16 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570