Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name HPAP  Probe Info 
Probe concentration 25 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
TMT
Competitor Name Panhematin  Competitor Info 
Competitor Concentration 100 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (hPBMC)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 58 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03540  Heme oxygenase 2 (HMOX2) 11.2
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 9.8
 LDTP09364  Retinol dehydrogenase 11 (RDH11) 6.1
 LDTP13203  STE20/SPS1-related proline-alanine-rich protein kinase (STK39) 5.7
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 5.3
 LDTP03500  2'-5'-oligoadenylate synthase 2 (OAS2) 5.0
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 4.8
 LDTP06905  Acylglycerol kinase, mitochondrial (AGK) 4.8
 LDTP02367  Cytochrome c oxidase subunit 6C (COX6C) 4.6
 LDTP04992  Ras-related protein Rab-11A (RAB11A) 4.6
 LDTP12293  Adipocyte plasma membrane-associated protein (APMAP) 4.4
 LDTP06294  Lysine--tRNA ligase (KARS1) 4.4
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 4.3
 LDTP12312  Ras-related protein Rab-18 (RAB18) 4.3
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 4.3
 LDTP03210  Prostaglandin G/H synthase 1 (PTGS1) 4.1
 LDTP13959  Dehydrogenase/reductase SDR family member 7 (DHRS7) 3.9
 LDTP11070  Vitamin K epoxide reductase complex subunit 1 (VKORC1) 3.9
 LDTP02380  Polyunsaturated fatty acid 5-lipoxygenase (ALOX5) 3.7
 LDTP03251  Diacylglycerol kinase alpha (DGKA) 3.7
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 3.7
 LDTP04901  Ras-related protein Rab-14 (RAB14) 3.7
 LDTP04403  Ras-related protein Rab-27A (RAB27A) 3.6
 LDTP02936  Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12) 3.6
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 3.6
 LDTP03400  Deoxycytidine kinase (DCK) 3.6
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 3.5
 LDTP03794  Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL) 3.4
 LDTP05408  Antigen peptide transporter 1 (TAP1) 3.4
 LDTP17014  Schlafen family member 5 (SLFN5) 3.4
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) 3.4
 LDTP04398  Ras-related protein Rab-5C (RAB5C) 3.4
 LDTP02493  Serine/threonine-protein kinase A-Raf (ARAF) 3.3
 LDTP02184  Glutathione peroxidase 1 (GPX1) 3.3
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) 3.3
 LDTP02852  Methylated-DNA--protein-cysteine methyltransferase (MGMT) 3.3
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 3.3
 LDTP15496  GTPase IMAP family member 8 (GIMAP8) 3.3
 LDTP01649  Phosphatidate cytidylyltransferase 2 (CDS2) 3.3
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 3.3
 LDTP12608  Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) 3.3
 LDTP10291  GTPase IMAP family member 5 (GIMAP5) 3.3
 LDTP00464  Glutathione S-transferase 3, mitochondrial (MGST3) 3.2
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) 3.2
 LDTP11247  Oxidoreductase HTATIP2 (HTATIP2) 3.2
 LDTP08858  Probable hydrolase PNKD (PNKD) 3.2
 LDTP05958  Ras-related protein Rab-32 (RAB32) 3.2
 LDTP10471  Protein disulfide-isomerase TMX3 (TMX3) 3.2
 LDTP08596  Mitochondrial Rho GTPase 2 (RHOT2) 3.1
 LDTP01465  Glutaminase kidney isoform, mitochondrial (GLS) 3.1
 LDTP13303  NADH-cytochrome b5 reductase 1 (CYB5R1) 3.1
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) 3.1
 LDTP00293  Cytochrome c oxidase subunit NDUFA4 (NDUFA4) 3.1
 LDTP00210  Ras-related protein Rab-27B (RAB27B) 3.1
 LDTP02356  2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) 3.1
 LDTP04895  Ras-related protein Rab-10 (RAB10) 3.0
 LDTP12810  Tubulin alpha-8 chain (TUBA8) 3.0
 LDTP00538  Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) 3.0
Transporter and channel
Click to Show/Hide to Show 24 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 8.2
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 6.4
 LDTP06633  Reticulon-1 (RTN1) 5.1
 LDTP15838  Translocation protein SEC62 (SEC62) 4.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 4.1
 LDTP03064  Cytochrome c oxidase subunit 5A, mitochondrial (COX5A) 4.0
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 3.9
 LDTP03061  Cation-dependent mannose-6-phosphate receptor (M6PR) 3.8
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 3.8
 LDTP03717  Prohibitin 1 (PHB1) 3.7
 LDTP00590  Protein RER1 (RER1) 3.6
 LDTP00411  Apoptotic protease-activating factor 1 (APAF1) 3.6
 LDTP02057  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) 3.6
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 3.5
 LDTP10081  Leucine-rich repeat-containing protein 59 (LRRC59) 3.5
 LDTP11281  Voltage-gated monoatomic cation channel TMEM109 (TMEM109) 3.4
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 3.3
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 3.3
 LDTP11916  Tubulin beta-1 chain (TUBB1) 3.2
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 3.2
 LDTP02122  Integrin beta-1 (ITGB1) 3.2
 LDTP02863  Platelet glycoprotein 4 (CD36) 3.1
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 3.0
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 3.0
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03804  Transcription factor 7 (TCF7) 4.0
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05572  Leukocyte surface antigen CD47 (CD47) 3.1
Other
Click to Show/Hide to Show 20 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08418  RAS protein activator like-3 (RASAL3) 6.7
 LDTP12412  Reticulon-4 (RTN4) 5.7
 LDTP01021  Perilipin-3 (PLIN3) 5.1
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) 4.6
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) 4.5
 LDTP18400  DENN domain-containing protein 2D (DENND2D) 4.4
 LDTP00555  BET1 homolog (BET1) 4.4
 LDTP18484  Torsin-4A (TOR4A) 4.3
 LDTP11324  RNA-binding protein 4 (RBM4) 4.3
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 4.2
 LDTP07986  RAS guanyl-releasing protein 2 (RASGRP2) 4.0
 LDTP03526  High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) 4.0
 LDTP04972  Small ribosomal subunit protein uS13 (RPS18) 3.8
 LDTP10684  RNA-binding protein 14 (RBM14) 3.8
 LDTP17065  Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2) 3.8
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) 3.3
 LDTP01611  Formin-like protein 1 (FMNL1) 3.2
 LDTP01206  Vesicle-trafficking protein SEC22b (SEC22B) 3.1
 LDTP18098  Transmembrane protein 40 (TMEM40) 3.1
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 3.0

References

1 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651