Details of the Target

General Information of Target

Target ID LDTP12312
Target Name Ras-related protein Rab-18 (RAB18)
Gene Name RAB18
Gene ID 22931
Synonyms
Ras-related protein Rab-18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSD
SLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKI
RLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVVMRE
YHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGR
QLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDIS
DFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARN
SCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAP
PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS
EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA
LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAER
LSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTENRRITHISAEQK
RRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDE
IEELNAAINLCQQQLPATGVPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFE
SFNGMVSTASVHTLRQTSLAWLDQYCSLPALRPTVLNSLRQLGTSTSILTDPGRIPEQAT
RAVTEGTLGKPL
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Apical cell membrane
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Also required for maintaining endoplasmic reticulum structure. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration.
Uniprot ID
Q9NP72
Ensemble ID
ENST00000356940.11
HGNC ID
HGNC:14244

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KARPAS422 SNV: p.Q67P .
REH SNV: p.G200V .
SW1783 SNV: p.D125N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K138(10.00); K142(10.00); K48(7.69); K58(8.04)  LDD0277  [2]
IPM
 Probe Info  		C160(0.00); C155(0.00); C110(0.00)  LDD0241  [3]
DBIA
 Probe Info  		C139(1.56)  LDD3310  [4]
DA-P3
 Probe Info  		5.31  LDD0179  [5]
HPAP
 Probe Info  		4.32  LDD0064  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		C155(0.00); C110(0.00)  LDD0032  [8]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [9]
IPIAA_L
 Probe Info  		C110(0.00); C155(0.00)  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		C110(0.00); C155(0.00); C160(0.00)  LDD0037  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		C110(0.00); C155(0.00)  LDD2226  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
Acrolein
 Probe Info  		C155(0.00); C160(0.00)  LDD0217  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
W1
 Probe Info  		N.A.  LDD0236  [3]
AOyne
 Probe Info  		14.20  LDD0443  [15]
NAIA_5
 Probe Info  		C110(0.00); C160(0.00); C155(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C235
 Probe Info  		20.25  LDD1908  [16]
C285
 Probe Info  		20.39  LDD1955  [16]
FFF probe11
 Probe Info  		9.81  LDD0472  [17]
FFF probe13
 Probe Info  		5.39  LDD0476  [17]
FFF probe3
 Probe Info  		20.00  LDD0464  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C110(1.04); C155(0.98); C160(0.96)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C110(1.03); C155(0.91); C160(0.95)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C110(0.85); C155(0.95); C160(1.08)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C110(0.96); C155(1.09); C160(1.12)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C110(0.95); C155(0.97); C160(0.93)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C110(1.00); C160(1.06)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C110(0.83); C155(1.05); C160(0.98)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C110(1.00); C155(0.90); C160(0.92)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C110(0.79); C155(0.80); C160(1.05)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C110(1.02); C155(0.90); C160(1.01)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C110(0.95); C155(1.06); C160(1.18)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C110(1.04); C155(0.94); C160(1.03)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C110(1.04); C155(1.01); C160(1.00)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C110(1.07); C160(1.05)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C110(1.02); C155(0.97); C160(1.18); C155(1.22)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C110(0.97); C155(1.09); C160(0.99)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C110(1.05); C155(0.98); C160(0.87)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C110(0.82); C155(0.91); C160(0.97)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C110(0.95); C155(1.11); C160(0.95)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C110(1.12); C155(1.01); C160(0.98)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C110(0.87); C155(1.02); C160(0.98)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C110(0.99); C155(0.93); C160(1.02)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C110(0.93); C160(0.98)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C110(1.03); C155(1.00); C160(1.24); C155(1.02)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C110(0.97); C155(1.01); C160(0.99)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C110(1.07); C155(0.94); C160(0.93)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C110(0.80); C155(0.99); C160(1.06)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C110(0.97); C155(1.06); C160(1.00)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C110(1.06); C155(1.00); C160(1.00)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C110(1.00); C155(0.96); C160(0.94)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C110(0.92); C160(0.97)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C110(1.09); C155(0.91); C160(1.03)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C110(1.00); C155(0.99); C160(1.06); C155(1.09)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C110(1.08); C155(1.07); C160(1.02)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C110(1.00); C155(0.91); C160(0.92)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C110(0.87); C155(0.96); C160(0.95)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C110(1.06); C155(1.01); C160(1.17)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C110(1.00); C155(0.97); C160(1.01)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C110(1.07); C155(1.00); C160(0.89)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C110(1.03); C160(0.95)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C110(0.92); C155(0.98); C160(1.16); C155(1.18)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C110(1.10); C155(0.98); C160(0.96)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C110(1.08); C155(0.85); C160(0.97)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C110(1.13); C155(0.80); C160(0.91)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C110(0.85); C155(0.89); C160(1.06)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C110(1.12); C155(1.01); C160(1.03)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C110(1.01); C155(0.96); C160(1.02)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C110(1.06); C155(0.85); C160(0.91)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C110(1.14); C160(1.01)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C110(0.93); C155(1.00); C160(1.15); C155(1.33)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C110(1.21); C155(1.19); C160(1.00)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C110(1.01); C155(0.95); C160(0.91)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C110(0.86); C155(1.06); C160(1.06)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C110(1.19); C155(1.00); C160(0.92)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C110(0.97); C155(0.96); C160(0.99)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C110(1.04); C155(1.03); C160(1.01)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C110(1.01); C155(1.00); C160(0.97)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C110(0.99); C160(0.96)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C110(0.99); C155(1.07); C160(1.11); C155(1.33)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C110(1.10); C160(0.95)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C110(0.99); C155(1.09); C160(1.11); C155(1.18)  LDD1569  [18]
 LDCM0248  AKOS034007472 HEK-293T C110(1.02); C155(0.97); C160(1.01)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C110(1.00); C155(1.02); C160(1.00)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C110(1.09); C155(1.07); C160(1.09); C155(0.94)  LDD1514  [18]
 LDCM0156  Aniline NCI-H1299 12.60  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C155(0.98)  LDD2227  [11]
 LDCM0367  CL1 HEK-293T C110(0.91); C155(1.02); C160(0.94)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C110(1.28); C155(1.09); C160(0.97)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C110(0.98); C155(0.97); C160(0.90)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C110(0.93); C155(1.01); C160(0.99)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C110(1.21); C155(0.99); C160(0.95)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C110(0.96); C155(0.97); C160(1.09)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C110(1.08); C155(1.06); C160(0.94)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C110(0.86); C155(1.00); C160(1.02)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C110(1.21); C155(1.07); C160(1.05)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C110(0.89); C155(0.91); C160(1.01)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C110(0.95); C155(0.93); C160(0.98)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C110(0.93); C155(1.00); C160(1.00)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C110(1.08); C160(1.08)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C110(1.05); C155(1.02); C160(0.94)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C110(0.86); C155(0.89); C160(0.91)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C110(1.03); C155(1.01); C160(0.95)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C110(0.97); C155(0.96); C160(0.93)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C110(1.18); C155(0.59); C160(0.89)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C110(0.81); C155(0.93); C160(0.96)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C110(1.11); C155(1.05); C160(0.90)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C110(1.03); C155(0.93); C160(1.02)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C110(1.29); C155(0.97); C160(0.97)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C110(0.82); C155(0.89); C160(0.99)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C110(0.96); C155(1.07); C160(1.40); C155(1.10)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C110(1.04); C155(0.94); C160(0.94)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C110(0.93); C155(1.02); C160(0.96)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C110(1.29); C155(0.87); C160(0.95)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C110(0.96); C155(0.95); C160(0.90)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C110(1.05); C155(0.81); C160(0.94)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C110(0.95); C155(1.09); C160(0.96)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C110(1.18); C155(1.07); C160(1.00)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C110(0.83); C155(0.91); C160(0.93)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C110(1.00); C155(1.00); C160(0.97)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C110(0.89); C155(0.92); C160(0.93)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C110(1.03); C155(1.04); C160(1.01)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C110(0.89); C155(0.96); C160(0.89)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C110(1.03); C155(1.04); C160(0.96)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C110(1.15); C155(1.08); C160(0.98)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C110(1.16); C155(1.02); C160(0.96)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C110(0.89); C155(0.98); C160(1.19)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C110(1.18); C155(1.01); C160(0.90)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C110(1.12); C155(1.26); C160(1.16)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C110(1.06); C155(1.17); C160(1.00)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C110(1.16); C155(1.07); C160(1.14)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C110(0.97); C160(1.11)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C110(0.94); C155(1.17); C160(1.35); C155(1.21)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C110(0.96); C155(1.02); C160(0.83)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C110(1.02); C155(0.91); C160(0.99)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C110(0.96); C155(0.91); C160(0.98)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C110(1.05); C155(1.06); C160(0.96)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C110(1.07); C155(0.89); C160(0.99)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C110(0.85); C155(0.91); C160(0.97)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C110(1.05); C155(0.94); C160(0.97)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C110(0.99); C155(1.06); C160(1.13)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C110(1.05); C155(1.20); C160(1.19)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C110(1.09); C155(1.11); C160(0.93)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C110(1.16); C155(0.99); C160(0.97)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C110(1.07); C160(1.00)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C110(0.92); C155(1.08); C160(1.17); C155(1.03)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C110(1.07); C155(0.91); C160(0.89)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C110(1.02); C155(0.89); C160(0.90)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C110(1.02); C155(0.99); C160(0.99)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C110(1.12); C155(1.04); C160(1.01)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C110(1.05); C155(1.07); C160(0.97)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C110(1.05); C155(1.01); C160(0.92)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C110(0.80); C155(1.00); C160(1.09)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C110(1.11); C155(1.12); C160(1.21)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C110(1.13); C155(1.14); C160(0.90)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C110(1.12); C155(1.08); C160(1.11)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C110(1.15); C160(1.11)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C110(0.92); C155(1.18); C160(1.29); C155(1.21)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C110(0.98); C155(0.97); C160(0.88)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C110(1.34); C155(1.06); C160(1.11)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C110(1.18); C155(1.00); C160(0.95)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C110(1.19); C155(1.02); C160(0.94)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C110(0.77); C155(1.09); C160(0.90)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C110(1.14); C155(1.13); C160(0.90)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C110(0.96); C155(1.01); C160(0.92)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C110(1.13); C155(1.22); C160(1.03)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C110(1.13); C155(1.07); C160(0.85)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C110(1.01); C155(1.10); C160(0.95)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C110(1.11); C160(1.00)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C110(1.01); C155(1.02); C160(0.94)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C110(1.05); C155(1.19); C160(1.23); C155(1.00)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C110(0.85); C155(0.99); C160(0.97)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C110(1.04); C155(0.79); C160(0.96)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C110(0.80); C155(0.92); C160(0.97)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C110(1.03); C155(1.04); C160(0.89)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C110(1.07); C155(1.15); C160(1.03)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C110(1.08); C155(1.11); C160(0.94)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C110(0.93); C155(1.07); C160(0.98)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C110(1.07); C155(1.05); C160(1.09)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C110(1.04); C155(1.08); C160(1.12)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C110(0.87); C155(1.08); C160(1.03)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C110(1.02); C155(1.07); C160(0.95)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C110(1.16); C160(1.06)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C110(0.98); C155(1.11); C160(1.16); C155(0.97)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C110(0.99); C155(0.96); C160(0.97)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C110(1.09); C155(0.94); C160(1.14)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C110(1.14); C155(1.07); C160(1.02)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C110(0.79); C155(1.14); C160(0.94)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C110(1.04); C155(1.04); C160(0.94)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C110(0.97); C155(0.99); C160(1.05)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C110(1.17); C155(1.06); C160(0.83)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C110(1.21); C155(1.07); C160(1.19)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C110(0.99); C155(1.12); C160(1.11)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C110(1.06); C155(1.01); C160(0.98)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C110(1.07); C160(1.03)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C110(0.94); C155(1.25); C160(1.09); C155(0.93)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C110(0.94); C155(1.00); C160(1.00)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C110(1.06); C155(0.97); C160(0.91)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C110(1.20); C155(0.97); C160(0.98)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C110(1.04); C155(1.02); C160(1.04)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C110(1.00); C155(1.08); C160(1.06)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C110(1.03); C155(1.15); C160(1.08)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C110(1.22); C155(1.25); C160(0.79)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C110(0.91); C155(0.93); C160(0.91)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C110(1.10); C155(1.11); C160(1.12)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C110(0.95); C155(1.13); C160(1.06)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C110(1.13); C155(1.12); C160(0.97)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C110(0.99); C160(0.91)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C110(0.79); C155(1.18); C160(1.31); C155(1.07)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C110(0.89); C155(0.99); C160(0.95)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C110(1.22); C155(1.07); C160(0.91)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C110(0.97); C155(0.91); C160(0.92)  LDD1697  [18]
 LDCM0028  Dobutamine HEK-293T 4.82  LDD0180  [5]
 LDCM0027  Dopamine HEK-293T 5.31  LDD0179  [5]
 LDCM0495  E2913 HEK-293T C110(1.09); C155(0.75); C160(0.92)  LDD1698  [18]
 LDCM0625  F8 Ramos C110(1.05); 0.42  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C110(0.87); 1.35  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C110(0.14); 0.63  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C110(0.78); 2.65  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C110(0.82)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C110(1.61); 1.81  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C110(1.12); 1.44  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C110(1.29); 1.20  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C110(0.40); 1.11  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C110(1.40); 0.88  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C110(0.71); 0.72  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C110(0.35); 1.09  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C110(0.59); 1.09  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C110(0.51); 0.43  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C110(0.87); C155(0.96); C160(0.94)  LDD1671  [18]
 LDCM0596  Fragment38 Ramos C110(0.81); 1.05  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C110(1.00); 0.47  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C110(1.29); C155(0.93); C160(0.88)  LDD1631  [18]
 LDCM0610  Fragment52 Ramos C110(0.58); 0.74  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C110(1.03); 1.89  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C110(1.25); 1.08  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C110(0.87)  LDD2188  [19]
 LDCM0022  KB02 HEK-293T C155(0.82); C160(1.00); C110(1.14); C155(0.99)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C155(1.08); C160(1.00); C110(1.11); C155(1.08)  LDD1497  [18]
 LDCM0024  KB05 COLO792 C139(1.56)  LDD3310  [4]
 LDCM0032  Oleacein HEK-293T 5.30  LDD0184  [5]
 LDCM0014  Panhematin hPBMC 4.32  LDD0064  [6]
 LDCM0029  Quercetin HEK-293T 7.60  LDD0181  [5]
 LDCM0131  RA190 MM1.R C110(1.22); C155(0.92); C160(0.92)  LDD0304  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tax1-binding protein 1 (TAX1BP1) . Q86VP1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.