Details of the Target
General Information of Target
| Target ID | LDTP07986 | |||||
|---|---|---|---|---|---|---|
| Target Name | RAS guanyl-releasing protein 2 (RASGRP2) | |||||
| Gene Name | RASGRP2 | |||||
| Gene ID | 10235 | |||||
| Synonyms |
CDC25L; MCG7; RAS guanyl-releasing protein 2; Calcium and DAG-regulated guanine nucleotide exchange factor I; CalDAG-GEFI; Cdc25-like protein; hCDC25L; F25B3.3 kinase-like protein |
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| 3D Structure | ||||||
| Sequence |
MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY
QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLID IDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHS FVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNF NTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFR FPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDL LSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQ ALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEM VSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQC KDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTV EDGVFDIHL |
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| Target Bioclass |
Other
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| Family |
RASGRP family
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| Subcellular location |
Cytoplasm, cytosol
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| Function |
Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
Johansson_61 Probe Info |
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_(10.57) | LDD1485 | [1] | |
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HPAP Probe Info |
 |
4.00 | LDD0064 | [2] | |
|
DBIA Probe Info |
 |
C296(7.45); C11(19.01); C76(4.10) | LDD0209 | [3] | |
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4-Iodoacetamidophenylacetylene Probe Info |
 |
N.A. | LDD0038 | [4] | |
|
IA-alkyne Probe Info |
 |
C296(0.00); C20(0.00) | LDD0166 | [5] | |
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Lodoacetamide azide Probe Info |
 |
C11(0.00); C20(0.00) | LDD0037 | [4] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0569 | Fragment7 | Jurkat | _(10.57) | LDD1485 | [1] |
| LDCM0022 | KB02 | 697 | C610(1.21); C73(2.74) | LDD2245 | [6] |
| LDCM0023 | KB03 | Jurkat | C296(7.45); C11(19.01); C76(4.10) | LDD0209 | [3] |
| LDCM0024 | KB05 | MOLM-13 | C610(1.23); C76(6.52) | LDD3333 | [6] |
| LDCM0014 | Panhematin | hPBMC | 4.00 | LDD0064 | [2] |
References